메뉴 건너뛰기




Volumn 193, Issue 2, 2016, Pages 116-130

Macrophages, inflammation, and lung cancer

Author keywords

Immunosuppression; Inflammation; Lung cancer; Tumor progression; Tumor associated macrophages

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; TUMOR MARKER;

EID: 84975801964     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201508-1545CI     Document Type: Review
Times cited : (223)

References (132)
  • 1
    • 17644427902 scopus 로고    scopus 로고
    • American Cancer Society, [accessed 2015 Jul 13]
    • American Cancer Society. Cancer facts and figures. 2015 [accessed 2015 Jul 13]. Available from: Http://www.cancer.org/research/ cancerfactsstatistics/cancerfactsfigures2015/.
    • (2015) Cancer Facts and Figures
  • 2
    • 19844362355 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer
    • Giaccone G. Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer. J Clin Oncol 2005;23:3235-3242.
    • (2005) J Clin Oncol , vol.23 , pp. 3235-3242
    • Giaccone, G.1
  • 4
    • 84887497121 scopus 로고    scopus 로고
    • The quest to overcome resistance to EGFRtargeted therapies in cancer
    • Chong CR, Jänne PA. The quest to overcome resistance to EGFRtargeted therapies in cancer. Nat Med 2013;19:1389-1400.
    • (2013) Nat Med , vol.19 , pp. 1389-1400
    • Chong, C.R.1    Jänne, P.A.2
  • 6
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011;144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 78650929413 scopus 로고    scopus 로고
    • Immunotherapy as a strategy for the treatment of non-small-cell lung cancer
    • Holt GE, Podack ER, Raez LE. Immunotherapy as a strategy for the treatment of non-small-cell lung cancer. Therapy 2011;8:43-54.
    • (2011) Therapy , vol.8 , pp. 43-54
    • Holt, G.E.1    Podack, E.R.2    Raez, L.E.3
  • 8
    • 77957114732 scopus 로고    scopus 로고
    • Targeting the immune system in non-small-cell lung cancer: Bridging the gap between promising concept and therapeutic reality
    • Kelly RJ, Gulley JL, Giaccone G. Targeting the immune system in non-small-cell lung cancer: Bridging the gap between promising concept and therapeutic reality. Clin Lung Cancer 2010;11:228-237.
    • (2010) Clin Lung Cancer , vol.11 , pp. 228-237
    • Kelly, R.J.1    Gulley, J.L.2    Giaccone, G.3
  • 9
    • 0022979412 scopus 로고
    • Intratumoral Bacillus Calmette-Guérin immunotherapy prior to surgery for carcinoma of the lung: Results of a prospective randomized trial
    • Matthay RA, Mahler DA, Beck GJ, Loke J, Baue AE, Carter DC, Mitchell MS. Intratumoral Bacillus Calmette-Guérin immunotherapy prior to surgery for carcinoma of the lung: Results of a prospective randomized trial. Cancer Res 1986;46:5963-5968.
    • (1986) Cancer Res , vol.46 , pp. 5963-5968
    • Matthay, R.A.1    Mahler, D.A.2    Beck, G.J.3    Loke, J.4    Baue, A.E.5    Carter, D.C.6    Mitchell, M.S.7
  • 11
    • 84893568071 scopus 로고    scopus 로고
    • New modalities of cancer treatment for NSCLC: Focus on immunotherapy
    • Davies M. New modalities of cancer treatment for NSCLC: Focus on immunotherapy. Cancer Manag Res 2014;6:63-75.
    • (2014) Cancer Manag Res , vol.6 , pp. 63-75
    • Davies, M.1
  • 13
    • 84893764922 scopus 로고    scopus 로고
    • Tobacco smoking and environmental risk factors for chronic obstructive pulmonary disease
    • Salvi S. Tobacco smoking and environmental risk factors for chronic obstructive pulmonary disease. Clin Chest Med 2014;35:17-27.
    • (2014) Clin Chest Med , vol.35 , pp. 17-27
    • Salvi, S.1
  • 14
    • 84897162058 scopus 로고    scopus 로고
    • Obesity, energy balance, and cancer: A mechanistic perspective
    • Hursting SD. Obesity, energy balance, and cancer: A mechanistic perspective. Cancer Treat Res 2014;159:21-33.
    • (2014) Cancer Treat Res , vol.159 , pp. 21-33
    • Hursting, S.D.1
  • 16
    • 84908217604 scopus 로고    scopus 로고
    • Diabetes and cancer: Associations, mechanisms, and implications for medical practice
    • Xu CX, Zhu HH, Zhu YM. Diabetes and cancer: Associations, mechanisms, and implications for medical practice. World J Diabetes 2014;5:372-380.
    • (2014) World J Diabetes , vol.5 , pp. 372-380
    • Xu, C.X.1    Zhu, H.H.2    Zhu, Y.M.3
  • 18
    • 0033831517 scopus 로고    scopus 로고
    • Infections as a major preventable cause of human cancer
    • Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med 2000;248:171-183.
    • (2000) J Intern Med , vol.248 , pp. 171-183
    • Kuper, H.1    Adami, H.O.2    Trichopoulos, D.3
  • 21
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow?. Lancet 2001;357:539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 22
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 23
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002;23: 549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 24
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: Balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-237.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 27
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008;8:958-969.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 28
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006;66:605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 29
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • Bingle L, Brown NJ, Lewis CE. The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies. J Pathol 2002;196:254-265.
    • (2002) J Pathol , vol.196 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 31
    • 84867504992 scopus 로고    scopus 로고
    • The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer
    • Edin S, Wikberg ML, Dahlin AM, Rutegard J, Öberg A, Oldenborg PA, Palmqvist R. The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. Plos One 2012;7:e47045.
    • (2012) Plos One , vol.7 , pp. e47045
    • Edin, S.1    Wikberg, M.L.2    Dahlin, A.M.3    Rutegard, J.4    Öberg, A.5    Oldenborg, P.A.6    Palmqvist, R.7
  • 33
    • 79952595097 scopus 로고    scopus 로고
    • The role of JNK in the development of hepatocellular carcinoma
    • Das M, Garlick DS, Greiner DL, Davis RJ. The role of JNK in the development of hepatocellular carcinoma. Genes Dev 2011;25: 634-645.
    • (2011) Genes Dev , vol.25 , pp. 634-645
    • Das, M.1    Garlick, D.S.2    Greiner, D.L.3    Davis, R.J.4
  • 34
  • 35
    • 23844478990 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression associated with severity of PanIN lesions: A possible link between chronic pancreatitis and pancreatic cancer
    • Albazaz R, Verbeke CS, Rahman SH, McMahon MJ. Cyclooxygenase-2 expression associated with severity of PanIN lesions: A possible link between chronic pancreatitis and pancreatic cancer. Pancreatology 2005;5:361-369.
    • (2005) Pancreatology , vol.5 , pp. 361-369
    • Albazaz, R.1    Verbeke, C.S.2    Rahman, S.H.3    McMahon, M.J.4
  • 37
    • 0025092693 scopus 로고
    • Ulcerative colitis and colorectal cancer: A population-based study
    • Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer: A population-based study. N Engl J Med 1990;323:1228-1233.
    • (1990) N Engl J Med , vol.323 , pp. 1228-1233
    • Ekbom, A.1    Helmick, C.2    Zack, M.3    Adami, H.O.4
  • 38
    • 79955564023 scopus 로고    scopus 로고
    • Intestinal inflammation and cancer
    • Ullman TA, Itzkowitz SH. Intestinal inflammation and cancer. Gastroenterology 2011;140:1807-1816.
    • (2011) Gastroenterology , vol.140 , pp. 1807-1816
    • Ullman, T.A.1    Itzkowitz, S.H.2
  • 39
    • 43049157905 scopus 로고    scopus 로고
    • Inflammation in the development of lung cancer: Epidemiological evidence
    • Engels EA. Inflammation in the development of lung cancer: Epidemiological evidence. Expert Rev Anticancer Ther 2008;8: 605-615.
    • (2008) Expert Rev Anticancer Ther , vol.8 , pp. 605-615
    • Engels, E.A.1
  • 40
    • 53549108591 scopus 로고    scopus 로고
    • Common origins of lung cancer and COPD
    • Houghton AM, Mouded M, Shapiro SD. Common origins of lung cancer and COPD. Nat Med 2008;14:1023-1024.
    • (2008) Nat Med , vol.14 , pp. 1023-1024
    • Houghton, A.M.1    Mouded, M.2    Shapiro, S.D.3
  • 42
    • 0032112771 scopus 로고    scopus 로고
    • Nitric oxide and oxygen radicals in infection, inflammation, and cancer
    • Maeda H, Akaike T. Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc) 1998;63: 854-865.
    • (1998) Biochemistry (Mosc) , vol.63 , pp. 854-865
    • Maeda, H.1    Akaike, T.2
  • 43
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005;7:211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 44
    • 7944223098 scopus 로고    scopus 로고
    • Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    • Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 2004;6: 447-458.
    • (2004) Cancer Cell , vol.6 , pp. 447-458
    • Sparmann, A.1    Bar-Sagi, D.2
  • 46
    • 34948852371 scopus 로고    scopus 로고
    • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
    • Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 2007;13:1211-1218.
    • (2007) Nat Med , vol.13 , pp. 1211-1218
    • Soucek, L.1    Lawlor, E.R.2    Soto, D.3    Shchors, K.4    Swigart, L.B.5    Evan, G.I.6
  • 47
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004;4: 540-550.
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 48
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003;425:307-311.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 49
    • 2342591450 scopus 로고    scopus 로고
    • The significance of cancer cell expression of the chemokine receptor CXCR4
    • Balkwill F. The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 2004;14:171-179.
    • (2004) Semin Cancer Biol , vol.14 , pp. 171-179
    • Balkwill, F.1
  • 53
    • 0033903714 scopus 로고    scopus 로고
    • Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
    • Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, Koike M, Inadera H, Matsushima K. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res 2000;6:3282-3289.
    • (2000) Clin Cancer Res , vol.6 , pp. 3282-3289
    • Ueno, T.1    Toi, M.2    Saji, H.3    Muta, M.4    Bando, H.5    Kuroi, K.6    Koike, M.7    Inadera, H.8    Matsushima, K.9
  • 55
    • 0037145727 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas
    • Ohta M, Kitadai Y, Tanaka S, Yoshihara M, Yasui W, Mukaida N, Haruma K, Chayama K. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. Int J Cancer 2002;102:220-224.
    • (2002) Int J Cancer , vol.102 , pp. 220-224
    • Ohta, M.1    Kitadai, Y.2    Tanaka, S.3    Yoshihara, M.4    Yasui, W.5    Mukaida, N.6    Haruma, K.7    Chayama, K.8
  • 56
    • 0028902228 scopus 로고
    • CSF-1 and its receptor in ovarian, endometrial and breast cancer
    • Kacinski BM. CSF-1 and its receptor in ovarian, endometrial and breast cancer. Ann Med 1995;27:79-85.
    • (1995) Ann Med , vol.27 , pp. 79-85
    • Kacinski, B.M.1
  • 57
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006;441:431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 58
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 60
    • 81555202006 scopus 로고    scopus 로고
    • M2- polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma
    • Zhang B, Yao G, Zhang Y, Gao J, Yang B, Rao Z, Gao J. M2- polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma. Clinics (Sao Paulo) 2011;66: 1879-1886.
    • (2011) Clinics (Sao Paulo) , vol.66 , pp. 1879-1886
    • Zhang, B.1    Yao, G.2    Zhang, Y.3    Gao, J.4    Yang, B.5    Rao, Z.6    Gao, J.7
  • 65
    • 44349151470 scopus 로고    scopus 로고
    • Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours
    • Toffoli S, Michiels C. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours. FEBS J 2008;275: 2991-3002.
    • (2008) FEBS J , vol.275 , pp. 2991-3002
    • Toffoli, S.1    Michiels, C.2
  • 66
    • 59849127984 scopus 로고    scopus 로고
    • Hypoxia regulates inflammatory gene expression in endothelial cells
    • Flamant L, Toffoli S, Raes M, Michiels C. Hypoxia regulates inflammatory gene expression in endothelial cells. Exp Cell Res 2009;315:733-747.
    • (2009) Exp Cell Res , vol.315 , pp. 733-747
    • Flamant, L.1    Toffoli, S.2    Raes, M.3    Michiels, C.4
  • 67
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010;29:625-634.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 69
    • 79961174606 scopus 로고    scopus 로고
    • Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-kappaB
    • Tafani M, Schito L, Pellegrini L, Villanova L, Marfe G, Anwar T, Rosa R, Indelicato M, Fini M, Pucci B, et al. Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-kappaB. Carcinogenesis 2011;32:1167-1175.
    • (2011) Carcinogenesis , vol.32 , pp. 1167-1175
    • Tafani, M.1    Schito, L.2    Pellegrini, L.3    Villanova, L.4    Marfe, G.5    Anwar, T.6    Rosa, R.7    Indelicato, M.8    Fini, M.9    Pucci, B.10
  • 70
    • 77957570183 scopus 로고    scopus 로고
    • Inhibiting NF-kB activation by small molecules as a therapeutic strategy
    • Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-kB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta 2010;1799:775-787.
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 775-787
    • Gupta, S.C.1    Sundaram, C.2    Reuter, S.3    Aggarwal, B.B.4
  • 71
    • 42149099408 scopus 로고    scopus 로고
    • Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms
    • Biswas SK, Sica A, Lewis CE. Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms. J Immunol 2008;180:2011-2017.
    • (2008) J Immunol , vol.180 , pp. 2011-2017
    • Biswas, S.K.1    Sica, A.2    Lewis, C.E.3
  • 75
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004;4:71-78.
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 80
    • 18544378009 scopus 로고    scopus 로고
    • Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activationregulated chemokine in ovarian carcinoma
    • Schutyser E, Struyf S, Proost P, Opdenakker G, Laureys G, Verhasselt B, Peperstraete L, Van de Putte I, Saccani A, Allavena P, et al. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activationregulated chemokine in ovarian carcinoma. J Biol Chem 2002;277: 24584-24593.
    • (2002) J Biol Chem , vol.277 , pp. 24584-24593
    • Schutyser, E.1    Struyf, S.2    Proost, P.3    Opdenakker, G.4    Laureys, G.5    Verhasselt, B.6    Peperstraete, L.7    Van De Putte, I.8    Saccani, A.9    Allavena, P.10
  • 81
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages
    • Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A. Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages. J Immunol 2000;164:762-767.
    • (2000) J Immunol , vol.164 , pp. 762-767
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3    Polentarutti, N.4    Vecchi, A.5    Van Damme, J.6    Mantovani, A.7
  • 82
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, Zheng L. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009;206:1327-1337.
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5    Wu, C.6    Zheng, L.7
  • 84
    • 84866948348 scopus 로고    scopus 로고
    • Host indoleamine 2,3-dioxygenase: Contribution to systemic acquired tumor tolerance
    • Johnson TS, Munn DH. Host indoleamine 2,3-dioxygenase: Contribution to systemic acquired tumor tolerance. Immunol Invest 2012;41:765-797.
    • (2012) Immunol Invest , vol.41 , pp. 765-797
    • Johnson, T.S.1    Munn, D.H.2
  • 85
    • 0037314662 scopus 로고    scopus 로고
    • Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
    • Chen JJ, Yao PL, Yuan A, Hong TM, Shun CT, Kuo ML, Lee YC, Yang PC. Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 2003;9:729-737.
    • (2003) Clin Cancer Res , vol.9 , pp. 729-737
    • Chen, J.J.1    Yao, P.L.2    Yuan, A.3    Hong, T.M.4    Shun, C.T.5    Kuo, M.L.6    Lee, Y.C.7    Yang, P.C.8
  • 87
    • 0037454777 scopus 로고    scopus 로고
    • Infiltrating immune cells, but not tumour cells, express fasl in non-small cell lung cancer: No association with prognosis identified in 3-year follow-up
    • Toomey D, Smyth G, Condron C, Kelly J, Byrne AM, Kay E, Conroy RM, Broe P, Bouchier-Hayes D. Infiltrating immune cells, but not tumour cells, express fasl in non-small cell lung cancer: no association with prognosis identified in 3-year follow-up. Int J Cancer 2003;103:408-412.
    • (2003) Int J Cancer , vol.103 , pp. 408-412
    • Toomey, D.1    Smyth, G.2    Condron, C.3    Kelly, J.4    Byrne, A.M.5    Kay, E.6    Conroy, R.M.7    Broe, P.8    Bouchier-Hayes, D.9
  • 88
    • 32644466544 scopus 로고    scopus 로고
    • Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer
    • Welsh TJ, Green RH, Richardson D, Waller DA, O'Byrne KJ, Bradding P. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 2005;23:8959-8967.
    • (2005) J Clin Oncol , vol.23 , pp. 8959-8967
    • Welsh, T.J.1    Green, R.H.2    Richardson, D.3    Waller, D.A.4    O'byrne, K.J.5    Bradding, P.6
  • 89
    • 77952416002 scopus 로고    scopus 로고
    • The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer
    • Dai F, Liu L, Che G, Yu N, Pu Q, Zhang S, Ma J, Ma L, You Z. The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer. BMC Cancer 2010;10:220.
    • (2010) BMC Cancer , vol.10 , pp. 220
    • Dai, F.1    Liu, L.2    Che, G.3    Yu, N.4    Pu, Q.5    Zhang, S.6    Ma, J.7    Ma, L.8    You, Z.9
  • 90
    • 40849118333 scopus 로고    scopus 로고
    • High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer
    • Kim DW, Min HS, Lee KH, Kim YJ, Oh DY, Jeon YK, Lee SH, Im SA, Chung DH, Kim YT, et al. High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer. Br J Cancer 2008;98:1118-1124.
    • (2008) Br J Cancer , vol.98 , pp. 1118-1124
    • Kim, D.W.1    Min, H.S.2    Lee, K.H.3    Kim, Y.J.4    Oh, D.Y.5    Jeon, Y.K.6    Lee, S.H.7    Im, S.A.8    Chung, D.H.9    Kim, Y.T.10
  • 91
    • 53149083361 scopus 로고    scopus 로고
    • Predominant infiltration of macrophages and CD8(1) T cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer
    • Kawai O, Ishii G, Kubota K, Murata Y, Naito Y, Mizuno T, Aokage K, Saijo N, Nishiwaki Y, Gemma A, et al. Predominant infiltration of macrophages and CD8(1) T cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer. Cancer 2008;113:1387-1395.
    • (2008) Cancer , vol.113 , pp. 1387-1395
    • Kawai, O.1    Ishii, G.2    Kubota, K.3    Murata, Y.4    Naito, Y.5    Mizuno, T.6    Aokage, K.7    Saijo, N.8    Nishiwaki, Y.9    Gemma, A.10
  • 92
    • 69549112977 scopus 로고    scopus 로고
    • The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma
    • Al-Shibli K, Al-Saad S, Donnem T, Persson M, Bremnes RM, Busund LT. The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma. Histopathology 2009;55:301-312.
    • (2009) Histopathology , vol.55 , pp. 301-312
    • Al-Shibli, K.1    Al-Saad, S.2    Donnem, T.3    Persson, M.4    Bremnes, R.M.5    Busund, L.T.6
  • 93
    • 84878970558 scopus 로고    scopus 로고
    • Tumor-associated neutrophils and macrophages in non-small cell lung cancer: No immediate impact on patient outcome
    • Carus A, Ladekarl M, Hager H, Pilegaard H, Nielsen PS, Donskov F. Tumor-associated neutrophils and macrophages in non-small cell lung cancer: no immediate impact on patient outcome. Lung Cancer 2013;81:130-137.
    • (2013) Lung Cancer , vol.81 , pp. 130-137
    • Carus, A.1    Ladekarl, M.2    Hager, H.3    Pilegaard, H.4    Nielsen, P.S.5    Donskov, F.6
  • 94
    • 84930958641 scopus 로고    scopus 로고
    • Understanding the mysterious M2 macrophage through activation markers and effector mechanisms
    • Roszer T. Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators Inflamm 2015;2015:816460.
    • (2015) Mediators Inflamm , vol.2015 , pp. 816460
    • Roszer, T.1
  • 95
    • 77952937103 scopus 로고    scopus 로고
    • The M1 form of tumorassociated macrophages in non-small cell lung cancer is positively associated with survival time
    • Ma J, Liu L, Che G, Yu N, Dai F, You Z. The M1 form of tumorassociated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 2010;10:112.
    • (2010) BMC Cancer , vol.10 , pp. 112
    • Ma, J.1    Liu, L.2    Che, G.3    Yu, N.4    Dai, F.5    You, Z.6
  • 96
    • 83455203338 scopus 로고    scopus 로고
    • Identification and manipulation of tumor associated macrophages in human cancers
    • Heusinkveld M, van der Burg SH. Identification and manipulation of tumor associated macrophages in human cancers. J Transl Med 2011;9:216.
    • (2011) J Transl Med , vol.9 , pp. 216
    • Heusinkveld, M.1    Van Der Burg, S.H.2
  • 97
    • 84868030361 scopus 로고    scopus 로고
    • Tumor-associated macrophages: Function, phenotype, and link to prognosis in human lung cancer
    • Quatromoni JG, Eruslanov E. Tumor-associated macrophages: Function, phenotype, and link to prognosis in human lung cancer. Am J Transl Res 2012;4:376-389.
    • (2012) Am J Transl Res , vol.4 , pp. 376-389
    • Quatromoni, J.G.1    Eruslanov, E.2
  • 98
    • 58849166142 scopus 로고    scopus 로고
    • Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival
    • Ohri CM, Shikotra A, Green RH, Waller DA, Bradding P. Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival. Eur Respir J 2009;33: 118-126.
    • (2009) Eur Respir J , vol.33 , pp. 118-126
    • Ohri, C.M.1    Shikotra, A.2    Green, R.H.3    Waller, D.A.4    Bradding, P.5
  • 100
    • 84893412268 scopus 로고    scopus 로고
    • Circulating CD141CD2041 cells predict postoperative recurrence in non-small-cell lung cancer patients
    • Maeda R, Ishii G, Neri S, Aoyagi K, Haga H, Sasaki H, Nagai K, Ochiai A. Circulating CD141CD2041 cells predict postoperative recurrence in non-small-cell lung cancer patients. J Thorac Oncol 2014;9:179-188.
    • (2014) J Thorac Oncol , vol.9 , pp. 179-188
    • Maeda, R.1    Ishii, G.2    Neri, S.3    Aoyagi, K.4    Haga, H.5    Sasaki, H.6    Nagai, K.7    Ochiai, A.8
  • 101
    • 84872445265 scopus 로고    scopus 로고
    • Neutralizing tumor-promoting chronic inflammation: A magic bullet?
    • Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: A magic bullet?. Science 2013;339:286-291.
    • (2013) Science , vol.339 , pp. 286-291
    • Coussens, L.M.1    Zitvogel, L.2    Palucka, A.K.3
  • 102
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: A molecular target for colorectal cancer prevention
    • Brown JR, DuBois RN. COX-2: A molecular target for colorectal cancer prevention. J Clin Oncol 2005;23:2840-2855.
    • (2005) J Clin Oncol , vol.23 , pp. 2840-2855
    • Brown, J.R.1    Dubois, R.N.2
  • 103
    • 39749149266 scopus 로고    scopus 로고
    • Eicosanoid modulation in advanced lung cancer: Cyclooxygenase-2 expression is a positive predictive factor for celecoxib 1 chemotherapy: Cancer and Leukemia Group B Trial 30203
    • Edelman MJ, Watson D, Wang X, Morrison C, Kratzke RA, Jewell S, Hodgson L, Mauer AM, Gajra A, Masters GA, et al. Eicosanoid modulation in advanced lung cancer: Cyclooxygenase-2 expression is a positive predictive factor for celecoxib 1 chemotherapy: Cancer and Leukemia Group B Trial 30203. J Clin Oncol 2008;26: 848-855.
    • (2008) J Clin Oncol , vol.26 , pp. 848-855
    • Edelman, M.J.1    Watson, D.2    Wang, X.3    Morrison, C.4    Kratzke, R.A.5    Jewell, S.6    Hodgson, L.7    Mauer, A.M.8    Gajra, A.9    Masters, G.A.10
  • 104
    • 41949113169 scopus 로고    scopus 로고
    • Preoperative treatment with a nonsteroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer
    • Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K, Lundholm K. Preoperative treatment with a nonsteroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. Cancer Immun 2008;8:5.
    • (2008) Cancer Immun , vol.8 , pp. 5
    • Lönnroth, C.1    Andersson, M.2    Arvidsson, A.3    Nordgren, S.4    Brevinge, H.5    Lagerstedt, K.6    Lundholm, K.7
  • 106
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 2012;21:836-847.
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3    Miller, G.4    Bar-Sagi, D.5
  • 108
    • 84880772300 scopus 로고    scopus 로고
    • MicroRNA-mediated control of macrophages and its implications for cancer
    • Squadrito ML, Etzrodt M, De Palma M, Pittet MJ. MicroRNA-mediated control of macrophages and its implications for cancer. Trends Immunol 2013;34:350-359.
    • (2013) Trends Immunol , vol.34 , pp. 350-359
    • Squadrito, M.L.1    Etzrodt, M.2    De Palma, M.3    Pittet, M.J.4
  • 110
    • 84886943971 scopus 로고    scopus 로고
    • Role of c-MYC in tumor-associated macrophages and cancer progression
    • Pello OM, Andrés V. Role of c-MYC in tumor-associated macrophages and cancer progression. OncoImmunology 2013;2: E22984.
    • (2013) OncoImmunology , vol.2 , pp. e22984
    • Pello, O.M.1    Andrés, V.2
  • 111
    • 84867580439 scopus 로고    scopus 로고
    • Macrophage polarization induced by neuropeptide methionine enkephalin (MENK) promotes tumoricidal responses
    • Chen W, Liu J, Meng J, Lu C, Li X, Wang E, Shan F. Macrophage polarization induced by neuropeptide methionine enkephalin (MENK) promotes tumoricidal responses. Cancer Immunol Immunother 2012;61:1755-1768.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1755-1768
    • Chen, W.1    Liu, J.2    Meng, J.3    Lu, C.4    Li, X.5    Wang, E.6    Shan, F.7
  • 112
    • 84904061702 scopus 로고    scopus 로고
    • Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis
    • Lizotte PH, Baird JR, Stevens CA, Lauer P, Green WR, Brockstedt DG, Fiering SN. Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis. OncoImmunology 2014;3:e28926.
    • (2014) OncoImmunology , vol.3 , pp. e28926
    • Lizotte, P.H.1    Baird, J.R.2    Stevens, C.A.3    Lauer, P.4    Green, W.R.5    Brockstedt, D.G.6    Fiering, S.N.7
  • 114
    • 67651160649 scopus 로고    scopus 로고
    • CD4(1) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM. CD4(1) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009;16:91-102.
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • Denardo, D.G.1    Barreto, J.B.2    Andreu, P.3    Vasquez, L.4    Tawfik, D.5    Kolhatkar, N.6    Coussens, L.M.7
  • 116
    • 84890787945 scopus 로고    scopus 로고
    • Targeting the immune system in the treatment of non-small-cell lung cancer
    • Rangachari D, Brahmer JR. Targeting the immune system in the treatment of non-small-cell lung cancer. Curr Treat Options Oncol 2013;14:580-594.
    • (2013) Curr Treat Options Oncol , vol.14 , pp. 580-594
    • Rangachari, D.1    Brahmer, J.R.2
  • 117
    • 84890933630 scopus 로고    scopus 로고
    • Update on immune checkpoint inhibitors in lung cancer
    • Creelan BC. Update on immune checkpoint inhibitors in lung cancer. Cancer Contr 2014;21:80-89.
    • (2014) Cancer Contr , vol.21 , pp. 80-89
    • Creelan, B.C.1
  • 118
    • 84902596900 scopus 로고    scopus 로고
    • Engineered tumorinfiltrating macrophages as gene delivery vehicles for interferon-a activates immunity and inhibits breast cancer progression
    • Escobar G, Gentner B, Naldini L, Mazzieri R. Engineered tumorinfiltrating macrophages as gene delivery vehicles for interferon-a activates immunity and inhibits breast cancer progression. OncoImmunology 2014;3:e28696.
    • (2014) OncoImmunology , vol.3 , pp. e28696
    • Escobar, G.1    Gentner, B.2    Naldini, L.3    Mazzieri, R.4
  • 120
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013;23:277-286.
    • (2013) Cancer Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 122
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM, Lynch TJ. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013;24:75-83.
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Lu, H.8    Cuillerot, J.M.9    Lynch, T.J.10
  • 123
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 2012;30: 2046-2054.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Neal, J.8    Lu, H.9    Cuillerot, J.M.10
  • 124
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • Rizvi NA, Mazières J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial. Lancet Oncol 2015;16:257-265.
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazières, J.2    Planchard, D.3    Stinchcombe, T.E.4    Dy, G.K.5    Antonia, S.J.6    Horn, L.7    Lena, H.8    Minenza, E.9    Mennecier, B.10
  • 126
    • 84881121899 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFRpositive non-small cell lung cancer
    • Belani CP, Nemunaitis JJ, Chachoua A, Eisenberg PD, Raez LE, Cuevas JD, Mather CB, Benner RJ, Meech SJ. Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFRpositive non-small cell lung cancer. Cancer Biol Ther 2013;14: 557-563.
    • (2013) Cancer Biol Ther , vol.14 , pp. 557-563
    • Belani, C.P.1    Nemunaitis, J.J.2    Chachoua, A.3    Eisenberg, P.D.4    Raez, L.E.5    Cuevas, J.D.6    Mather, C.B.7    Benner, R.J.8    Meech, S.J.9
  • 127
    • 79960110662 scopus 로고    scopus 로고
    • Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer
    • Hirsh V, Paz-Ares L, Boyer M, Rosell R, Middleton G, Eberhardt WE, Szczesna A, Reiterer P, Saleh M, Arrieta O, et al. Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2011;29:2667-2674.
    • (2011) J Clin Oncol , vol.29 , pp. 2667-2674
    • Hirsh, V.1    Paz-Ares, L.2    Boyer, M.3    Rosell, R.4    Middleton, G.5    Eberhardt, W.E.6    Szczesna, A.7    Reiterer, P.8    Saleh, M.9    Arrieta, O.10
  • 129
    • 0030926495 scopus 로고    scopus 로고
    • A phase III randomized study of interleukin-2 lymphokine-activated killer cell immunotherapy combined with chemotherapy or radiotherapy after curative or noncurative resection of primary lung carcinoma
    • Kimura H, Yamaguchi Y. A phase III randomized study of interleukin-2 lymphokine-activated killer cell immunotherapy combined with chemotherapy or radiotherapy after curative or noncurative resection of primary lung carcinoma. Cancer 1997;80:42-49.
    • (1997) Cancer , vol.80 , pp. 42-49
    • Kimura, H.1    Yamaguchi, Y.2
  • 131
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: In vivo veritas. J Clin Invest 2012;122:787-795.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 132
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: An immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: An immunologic functional perspective. Annu Rev Immunol 2009;27:451-483.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.