Treatment paradigms for retinal and macular diseases using 3-D retina cultures derived from human reporter pluripotent stem cell lines

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 5, 2016, Pages ORSFl1-ORSFl11

  Kaewkhaw, Rossukon ^a,b   Swaroop, Manju ^c   Homma, Kohei ^a,f   Nakamura, Jutaro ^a,g   Brooks, Matthew ^a   Kaya, Koray Dogan ^a   Chaitankar, Vijender ^a   Michael, Sam ^c   Tawa, Gregory ^c   Zou, Jizhong ^d   Rao, Mahendra ^e   Zheng, Wei ^c   Cogliati, Tiziana ^a   Swaroop, Anand ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e New York Stem Cell Foundation   (United States)

^f NIPPON MEDICAL SCHOOL   (Japan)

^g YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Chemical screens; Disease modeling; Drug discovery; Fluorescent reporter; High throughput screening; Human retina development; Next generation sequencing; Photoreceptor; Three dimensional organoid culture; Transcriptome

Indexed keywords

CRISPR ASSOCIATED PROTEIN; GAMMA INTERFERON RECEPTOR 1; GREEN FLUORESCENT PROTEIN; NEUROGENIN 2; NOTCH1 RECEPTOR; PHALLOIDIN; RHODOPSIN; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTOME; ZINC FINGER NUCLEASE;

AGE RELATED MACULAR DEGENERATION; ARTICLE; CELL SIGNALING ASSAY; DNA LIBRARY; FLUORESCENCE ACTIVATED CELL SORTING; FOLLOW UP; GENE EXPRESSION; GENE REGULATORY NETWORK; HIGH THROUGHPUT SCREENING; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NEXT GENERATION SEQUENCING; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RETINA DEVELOPMENT; RETINA GANGLION CELL; RETINAL INNER NUCLEAR LAYER; RETINAL NEUROEPITHELIAL LAYER; STEM CELL CULTURE; STEM CELL TRANSPLANTATION; THREE DIMENSIONAL IMAGING; TOXICITY; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; MACULAR DEGENERATION; METABOLISM; PHYSIOLOGY; PROCEDURES; REPORTER GENE; RETINA; RETINA NERVE CELL; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; TISSUE CULTURE TECHNIQUE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENES, REPORTER; HUMANS; MACULAR DEGENERATION; PLURIPOTENT STEM CELLS; RETINA; RETINAL DEGENERATION; RETINAL NEURONS; RETINAL PIGMENT EPITHELIUM; TISSUE CULTURE TECHNIQUES;

EID: 84974602144     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-17639     Document Type: Article

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