Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2

Stem Cells

Volumn 32, Issue 6, 2014, Pages 1480-1492

  Phillips, M Joseph ^a,b   Perez, Enio T ^a   Martin, Jessica M ^a   Reshel, Samantha T ^a   Wallace, Kyle A ^a   Capowski, Elizabeth E ^a   Singh, Ruchira ^a,b   Wright, Lynda S ^a   Clark, Eric M ^a   Barney, Patrick M ^a   Stewart, Ron ^d   Dickerson, Sarah J ^e   Miller, Michael J ^e   Percin, E Ferda ^f   Thomson, James A ^b,c,d,g   Gamm, David M ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d MORGRIDGE INSTITUTE FOR RESEARCH   (United States)

^e Cellular Dynamics International Inc   (United States)

^f GAZI UNIVERSITY   (Turkey)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Homeobox genes; human induced pluripotent stem cells; Neurogenesis; Retina; Transcription factors; VSX2 protein

Indexed keywords

HOMEODOMAIN PROTEIN; UNCLASSIFIED DRUG; VISUAL SYSTEM HOMEOBOX 2; TRANSCRIPTION FACTOR; TRANSCRIPTOME; VSX2 PROTEIN, HUMAN;

ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE CONTROL; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MICROPHTHALMIA; PHENOTYPE; PHOTORECEPTOR; PIGMENT EPITHELIUM; PLURIPOTENT STEM CELL; RETINA BIPOLAR GANGLION CELL; RETINA DEVELOPMENT; RETINA NEUROEPITHELIAL LAYER; RNA SEQUENCE; SIBLING; WILD TYPE; ADULT; AMINO ACID SUBSTITUTION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CELL LINEAGE; EMBRYOLOGY; GENETICS; HEK293 CELL LINE; METABOLISM; MORPHOGENESIS; MOUSE; MUTATION; PATHOLOGY; PHOTORECEPTOR CELL; RETINA; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ADULT; AMINO ACID SUBSTITUTION; ANIMALS; BODY PATTERNING; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PHOTORECEPTOR CELLS; RETINA; RETINAL BIPOLAR CELLS; RETINAL PIGMENT EPITHELIUM; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84901439386     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1667     Document Type: Article

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