IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures from Human Embryonic Stem Cells

Stem Cells

Volumn 33, Issue 8, 2015, Pages 2416-2430

  Mellough, Carla B ^a   Collin, Joseph ^a   Khazim, Mahmoud ^a   White, Kathryn ^b   Sernagor, Evelyne ^a   Steel, David H W ^a,c   Lako, Majlinda ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c SUNDERLAND EYE INFIRMARY   (United Kingdom)

Author keywords

Differentiation; Human pluripotent stem cells; IGF 1; Neural retina; Retinal pigmented epithelium

Indexed keywords

CYCLIN D1; SOMATOMEDIN C; TRANSCRIPTION FACTOR SOX2; IGF1 PROTEIN, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA; EMBRYO; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LENS; OPTIC DISK CUP; PHENOTYPE; PHOTORECEPTOR CELL; PHOTORECEPTOR INNER SEGMENT; PHOTORECEPTOR OUTER SEGMENT; PHOTOTRANSDUCTION; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RETINA CONE; RETINA GANGLION CELL; RETINA NEUROEPITHELIAL LAYER; RETINA ROD; SIGNAL TRANSDUCTION; STEM CELL EXPANSION; CELL LINE; CYTOLOGY; DRUG EFFECTS; HUMAN EMBRYONIC STEM CELL; METABOLISM; RETINAL PIGMENT EPITHELIUM;

VERTEBRATA;

CELL DIFFERENTIATION; CELL LINE; HUMAN EMBRYONIC STEM CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

EID: 84937633480     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2023     Document Type: Article

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