-
1
-
-
84939138844
-
Deaths: Leading causes for 2011
-
Heron M. Deaths: Leading causes for 2011. Natl Vital Stat Rep. 2015; 64:1-96.
-
(2015)
Natl Vital Stat Rep.
, vol.64
, pp. 1-96
-
-
Heron, M.1
-
2
-
-
77955293901
-
Dorsal Ruffle Microdomains Potentiate Met Receptor Tyrosine Kinase Signaling and Down-regulation
-
Abella JV, Parachoniak CA, Sangwan V, Park M. Dorsal Ruffle Microdomains Potentiate Met Receptor Tyrosine Kinase Signaling and Down-regulation. J Biol Chem. 2010; 285:24956-24967.
-
(2010)
J Biol Chem.
, vol.285
, pp. 24956-24967
-
-
Abella, J.V.1
Parachoniak, C.A.2
Sangwan, V.3
Park, M.4
-
3
-
-
80054686286
-
Tumor Metastasis: Molecular Insights and Evolving Paradigms
-
Valastyan S, Weinberg RA. Tumor Metastasis: Molecular Insights and Evolving Paradigms. Cell. 2011; 147:275-292.
-
(2011)
Cell.
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
4
-
-
84941201227
-
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
-
Waclaw B, Bozic I, Pittman ME, Hruban RH, Vogelstein B, Nowak MA. A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity. Nature. 2015; 525:261-264.
-
(2015)
Nature.
, vol.525
, pp. 261-264
-
-
Waclaw, B.1
Bozic, I.2
Pittman, M.E.3
Hruban, R.H.4
Vogelstein, B.5
Nowak, M.A.6
-
6
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014; 15:178-196.
-
(2014)
Nat Rev Mol Cell Biol.
, vol.15
, pp. 178-196
-
-
Lamouille, S.1
Xu, J.2
Derynck, R.3
-
7
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer. 2010; 10:130-137.
-
(2010)
Nat Rev Cancer.
, vol.10
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
8
-
-
84938342028
-
A historical overview of protein kinases and their targeted small molecule inhibitors
-
Roskoski Jr R. A historical overview of protein kinases and their targeted small molecule inhibitors. Pharmacol Res. 2015; 100:1-23.
-
(2015)
Pharmacol Res.
, vol.100
, pp. 1-23
-
-
Roskoski, R.1
-
10
-
-
84875914687
-
MET As a Possible Target for Non- Small-Cell Lung Cancer
-
Sadiq AA, Salgia R. MET As a Possible Target for Non- Small-Cell Lung Cancer. J Clin Oncol. 2013; 31:1089-1096.
-
(2013)
J Clin Oncol.
, vol.31
, pp. 1089-1096
-
-
Sadiq, A.A.1
Salgia, R.2
-
11
-
-
84896091512
-
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
-
Arteaga CL, Engelman JA. ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics. Cancer Cell. 2014; 25:282-303.
-
(2014)
Cancer Cell.
, vol.25
, pp. 282-303
-
-
Arteaga, C.L.1
Engelman, J.A.2
-
12
-
-
84924243839
-
Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets
-
Chang K, Karnad A, Zhao S and Freeman JW. Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets. Oncotarget. 2015; 6:3507-3518. doi: 10.18632/oncotarget.3420.
-
(2015)
Oncotarget.
, vol.6
, pp. 3507-3518
-
-
Chang, K.1
Karnad, A.2
Zhao, S.3
Freeman, J.W.4
-
13
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012; 487:505-509.
-
(2012)
Nature.
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
Penuel, E.4
Burton, L.5
Chan, E.6
Peng, J.7
Lin, E.8
Wang, Y.9
Sosman, J.10
Ribas, A.11
Li, J.12
Moffat, J.13
-
14
-
-
80052793410
-
A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors
-
Sasaki T, Koivunen J, Ogino A, Yanagita M, Nikiforow S, Zheng W, Lathan C, Marcoux JP, Du J, Okuda K, Capelletti M, Shimamura T, Ercan D, et al. A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors. Cancer Res. 2011; 71:6051-6060.
-
(2011)
Cancer Res.
, vol.71
, pp. 6051-6060
-
-
Sasaki, T.1
Koivunen, J.2
Ogino, A.3
Yanagita, M.4
Nikiforow, S.5
Zheng, W.6
Lathan, C.7
Marcoux, J.P.8
Du, J.9
Okuda, K.10
Capelletti, M.11
Shimamura, T.12
Ercan, D.13
-
15
-
-
34249075147
-
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale C-M, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, et al. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling. Science. 2007; 316:1039-1043.
-
(2007)
Science.
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
-
16
-
-
84924266469
-
A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer
-
Wilson FH, Johannessen CM, Piccioni F, Tamayo P, Kim JW, Van Allen EM, Corsello SM, Capelletti M, Calles A, Butaney M, Sharifnia T, Gabriel SB, Mesirov JP, et al. A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer. Cancer Cell. 2015; 27:397-408.
-
(2015)
Cancer Cell.
, vol.27
, pp. 397-408
-
-
Wilson, F.H.1
Johannessen, C.M.2
Piccioni, F.3
Tamayo, P.4
Kim, J.W.5
Van Allen, E.M.6
Corsello, S.M.7
Capelletti, M.8
Calles, A.9
Butaney, M.10
Sharifnia, T.11
Gabriel, S.B.12
Mesirov, J.P.13
-
17
-
-
84921390342
-
Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells
-
Petti C, Picco G, Martelli ML, Trisolini E, Bucci E, Perera T, Isella C, Medico E. Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells. Oncotarget. 2014; 6:221-233. doi: 10.18632/oncotarget.2771.
-
(2014)
Oncotarget.
, vol.6
, pp. 221-233
-
-
Petti, C.1
Picco, G.2
Martelli, M.L.3
Trisolini, E.4
Bucci, E.5
Perera, T.6
Isella, C.7
Medico, E.8
-
18
-
-
1242340302
-
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
-
Halestrap A, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflug Arch Eur J Phy. 2004; 447:619-628.
-
(2004)
Pflug Arch Eur J Phy.
, vol.447
, pp. 619-628
-
-
Halestrap, A.1
Meredith, D.2
-
19
-
-
0034663601
-
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
-
Dimmer K-S, Friedrich B, Lang F, Deitmer JW, BröEr S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J. 2000; 350:219-227.
-
(2000)
Biochem J.
, vol.350
, pp. 219-227
-
-
Dimmer, K-S.1
Friedrich, B.2
Lang, F.3
Deitmer, J.W.4
Bröer, S.5
-
20
-
-
7144253117
-
Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3
-
Wilson MC, Jackson VN, Heddle C, Price NT, Pilegaard H, Juel C, Bonen A, Montgomery I, Hutter OF, Halestrap AP. Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J Biol Chem. 1998; 273:15920-15926.
-
(1998)
J Biol Chem.
, vol.273
, pp. 15920-15926
-
-
Wilson, M.C.1
Jackson, V.N.2
Heddle, C.3
Price, N.T.4
Pilegaard, H.5
Juel, C.6
Bonen, A.7
Montgomery, I.8
Hutter, O.F.9
Halestrap, A.P.10
-
21
-
-
84941258811
-
Proton channels and exchangers in cancer
-
Spugnini EP, Sonveaux P, Stock C, Perez-Sayans M, De Milito A, Avnet S, Garcìa AG, Harguindey S, Fais S. Proton channels and exchangers in cancer. BBA-Biomembranes. 2015; 1848:2715-2726.
-
(2015)
BBA-Biomembranes.
, vol.1848
, pp. 2715-2726
-
-
Spugnini, E.P.1
Sonveaux, P.2
Stock, C.3
Perez-Sayans, M.4
De Milito, A.5
Avnet, S.6
Garcìa, A.G.7
Harguindey, S.8
Fais, S.9
-
22
-
-
33645969256
-
SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
-
Gupta N, Martin PM, Prasad PD, Ganapathy V. SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sci. 2006; 78:2419-2425.
-
(2006)
Life Sci.
, vol.78
, pp. 2419-2425
-
-
Gupta, N.1
Martin, P.M.2
Prasad, P.D.3
Ganapathy, V.4
-
23
-
-
79955725303
-
Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines
-
Hussien R, Brooks GA. Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Physiol Genomics. 2011; 43:255-264.
-
(2011)
Physiol Genomics.
, vol.43
, pp. 255-264
-
-
Hussien, R.1
Brooks, G.A.2
-
24
-
-
33751091519
-
The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma
-
Fang J, Quinones QJ, Holman TL, Morowitz MJ, Wang Q, Zhao H, Sivo F, Maris JM, Wahl ML. The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma. Mol Pharmacol. 2006; 70:2108-2115.
-
(2006)
Mol Pharmacol.
, vol.70
, pp. 2108-2115
-
-
Fang, J.1
Quinones, Q.J.2
Holman, T.L.3
Morowitz, M.J.4
Wang, Q.5
Zhao, H.6
Sivo, F.7
Maris, J.M.8
Wahl, M.L.9
-
25
-
-
84903734412
-
Prognostic Significance of Lactate/Proton Symporters MCT1, MCT4, and Their Chaperone CD147 Expressions in Urothelial Carcinoma of the Bladder
-
Choi J-W, Kim Y, Lee J-H, Kim Y-S. Prognostic Significance of Lactate/Proton Symporters MCT1, MCT4, and Their Chaperone CD147 Expressions in Urothelial Carcinoma of the Bladder. Urology. 2014; 84:245.e249-245.e215.
-
(2014)
Urology.
, vol.84
, pp. 245.e249-245.e215
-
-
Choi, J-W.1
Kim, Y.2
Lee, J-H.3
Kim, Y-S.4
-
26
-
-
84916224406
-
Expression of lactate/H(+) symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses
-
Kim Y, Choi JW, Lee JH, Kim YS. Expression of lactate/H(+) symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses. Hum Pathol. 2015; 46:104-112.
-
(2015)
Hum Pathol.
, vol.46
, pp. 104-112
-
-
Kim, Y.1
Choi, J.W.2
Lee, J.H.3
Kim, Y.S.4
-
27
-
-
84953410803
-
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
-
Pinheiro C, Granja S, Longatto-Filho A, Faria AM, Fragoso MC, Lovisolo SM, Lerario AM, Almeida MQ, Baltazar F, Zerbini MC. Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors. Oncotarget. 2015; 6:44403-44421. doi: 10.18632/oncotarget.5623.
-
(2015)
Oncotarget.
, vol.6
, pp. 44403-44421
-
-
Pinheiro, C.1
Granja, S.2
Longatto-Filho, A.3
Faria, A.M.4
Fragoso, M.C.5
Lovisolo, S.M.6
Lerario, A.M.7
Almeida, M.Q.8
Baltazar, F.9
Zerbini, M.C.10
-
28
-
-
79953329777
-
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-kB/IL-8 Pathway that Drives Tumor Angiogenesis
-
Vegran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-kB/IL-8 Pathway that Drives Tumor Angiogenesis. Cancer Res. 2011; 71: 2550-2560.
-
(2011)
Cancer Res.
, vol.71
, pp. 2550-2560
-
-
Vegran, F.1
Boidot, R.2
Michiels, C.3
Sonveaux, P.4
Feron, O.5
-
29
-
-
84858120137
-
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactateinduced HIF-1 activation and tumor angiogenesis
-
Sonveaux P, Copetti T, De Saedeleer CJ, Vegran Fdr, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frãcrart Fo, Gallez B, Ribeiro A, Michiels C, et al. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactateinduced HIF-1 activation and tumor angiogenesis. PLoS One. 2012; 7:e33418.
-
(2012)
PLoS One.
, vol.7
, pp. e33418
-
-
Sonveaux, P.1
Copetti, T.2
De Saedeleer, C.J.3
Vegran, F4
Verrax, J.5
Kennedy, K.M.6
Moon, E.J.7
Dhup, S.8
Danhier, P.9
Fo, F.10
Gallez, B.11
Ribeiro, A.12
Michiels, C.13
-
30
-
-
84907060300
-
Definition of PKC-a, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
-
Hsu Y-H, Yao J, Chan L-C, Wu T-J, Hsu JL, Fang Y-F, Wei Y, Wu Y, Huang W-C, Liu C-L, Chang Y-C, Wang M-Y, Li C-W, et al. Definition of PKC-a, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer. Cancer Res. 2014; 74:4822-4835.
-
(2014)
Cancer Res.
, vol.74
, pp. 4822-4835
-
-
Hsu, Y-H.1
Yao, J.2
Chan, L-C.3
Wu, T-J.4
Hsu, J.L.5
Fang, Y-F.6
Wei, Y.7
Wu, Y.8
Huang, W-C.9
Liu, C-L.10
Chang, Y-C.11
Wang, M-Y.12
Li, C-W.13
-
31
-
-
84875837439
-
Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer
-
Knight JF, Lesurf R, Zhao H, Pinnaduwage D, Davis RR, Saleh SM, Zuo D, Naujokas MA, Chughtai N, Herschkowitz JI, Prat A, Mulligan AM, Muller WJ, et al. Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer. P Natl Acad Sci U S A. 2013; 110:E1301-1310.
-
(2013)
P Natl Acad Sci U S A.
, vol.110
, pp. E1301-1310
-
-
Knight, J.F.1
Lesurf, R.2
Zhao, H.3
Pinnaduwage, D.4
Davis, R.R.5
Saleh, S.M.6
Zuo, D.7
Naujokas, M.A.8
Chughtai, N.9
Herschkowitz, J.I.10
Prat, A.11
Mulligan, A.M.12
Muller, W.J.13
-
32
-
-
84859873169
-
cMET and phospho-cMET protein levels in breast cancers and survival outcomes
-
Raghav KP, Wang W, Liu S, Chavez-MacGregor M, Meng X, Hortobagyi GN, Mills GB, Meric-Bernstam F, Blumenschein GR Jr, Gonzalez-Angulo AM. cMET and phospho-cMET protein levels in breast cancers and survival outcomes. Clin Cancer Res. 2012; 18:2269-2277.
-
(2012)
Clin Cancer Res.
, vol.18
, pp. 2269-2277
-
-
Raghav, K.P.1
Wang, W.2
Liu, S.3
Chavez-MacGregor, M.4
Meng, X.5
Hortobagyi, G.N.6
Mills, G.B.7
Meric-Bernstam, F.8
Blumenschein, G.R.9
Gonzalez-Angulo, A.M.10
-
33
-
-
84871962904
-
Targeted MET inhibition in castrationresistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone
-
Ryan CJ, Rosenthal M, Ng S, Alumkal J, Picus J, Gravis G, Fizazi K, Forget F, Machiels JP, Srinivas S, Zhu M, Tang R, Oliner KS, et al. Targeted MET inhibition in castrationresistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res. 2013; 19:215-224.
-
(2013)
Clin Cancer Res.
, vol.19
, pp. 215-224
-
-
Ryan, C.J.1
Rosenthal, M.2
Ng, S.3
Alumkal, J.4
Picus, J.5
Gravis, G.6
Fizazi, K.7
Forget, F.8
Machiels, J.P.9
Srinivas, S.10
Zhu, M.11
Tang, R.12
Oliner, K.S.13
-
34
-
-
84908419450
-
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis
-
Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014; 4:1310-1325.
-
(2014)
Cancer Discov.
, vol.4
, pp. 1310-1325
-
-
Lucas, J.M.1
Heinlein, C.2
Kim, T.3
Hernandez, S.A.4
Malik, M.S.5
True, L.D.6
Morrissey, C.7
Corey, E.8
Montgomery, B.9
Mostaghel, E.10
Clegg, N.11
Coleman, I.12
Brown, C.M.13
-
35
-
-
0034254638
-
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
-
Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000; 19:3896-3904.
-
(2000)
EMBO J.
, vol.19
, pp. 3896-3904
-
-
Kirk, P.1
Wilson, M.C.2
Heddle, C.3
Brown, M.H.4
Barclay, A.N.5
Halestrap, A.P.6
-
36
-
-
0034525940
-
Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle
-
Manning Fox JE, Meredith D, Halestrap AP. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000; 529:285-293.
-
(2000)
J Physiol.
, vol.529
, pp. 285-293
-
-
Manning Fox, J.E.1
Meredith, D.2
Halestrap, A.P.3
-
37
-
-
53749107434
-
Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ß-Hydroxybutyric Acid
-
Morris M, Felmlee M. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse ß-Hydroxybutyric Acid. The AAPS Journal. 2008; 10: 311-321.
-
(2008)
The AAPS Journal.
, vol.10
, pp. 311-321
-
-
Morris, M.1
Felmlee, M.2
-
38
-
-
84896701206
-
Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
-
Polanski R, Hodgkinson CL, Fusi A, Nonaka D, Priest L, Kelly P, Trapani F, Bishop PW, White A, Critchlow SE, Smith PD, Blackhall F, Dive C,et al. Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer. Clin Cancer Res. 2014; 20:926-937.
-
(2014)
Clin Cancer Res.
, vol.20
, pp. 926-937
-
-
Polanski, R.1
Hodgkinson, C.L.2
Fusi, A.3
Nonaka, D.4
Priest, L.5
Kelly, P.6
Trapani, F.7
Bishop, P.W.8
White, A.9
Critchlow, S.E.10
Smith, P.D.11
Blackhall, F.12
Dive, C.13
-
39
-
-
80053640489
-
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
-
Le Floch R, Chiche J, Marchiq I, Naiken T, Ilk K, Murray CM, Critchlow SE, Roux Dl, Simon M-P, Pouyssãcgur J. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. P Natl Acad Sci USA. 2011; 108:16663-16668.
-
(2011)
P Natl Acad Sci USA.
, vol.108
, pp. 16663-16668
-
-
Le Floch, R.1
Chiche, J.2
Marchiq, I.3
Naiken, T.4
Ilk, K.5
Murray, C.M.6
Critchlow, S.E.7
Roux, D.L.8
Simon, M-P.9
Pouyssãcgur, J.10
-
40
-
-
84973553372
-
Abstract 3224: Pre-clinical targeting of the metabolic phenotype of lymphoma by AZD3965, a selective inhibitor of monocarboxylate transporter 1 (MCT1)
-
Critchlow SE, Hopcroft L, Mooney L, Curtis N, Whalley N, Zhong H, Logie A, Revill M, Xie L, Zhang J, Yu D-H, Murray C, Smith PD. Abstract 3224: Pre-clinical targeting of the metabolic phenotype of lymphoma by AZD3965, a selective inhibitor of monocarboxylate transporter 1 (MCT1). Cancer Res. 2012; 72:3224.
-
(2012)
Cancer Res.
, vol.72
, pp. 3224
-
-
Critchlow, S.E.1
Hopcroft, L.2
Mooney, L.3
Curtis, N.4
Whalley, N.5
Zhong, H.6
Logie, A.7
Revill, M.8
Xie, L.9
Zhang, J.10
Yu, D-H.11
Murray, C.12
Smith, P.D.13
-
41
-
-
84893860311
-
Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
-
Doherty JR, Yang C, Scott KEN, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, et al. Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis. Cancer Res. 2014; 74:908-920.
-
(2014)
Cancer Res.
, vol.74
, pp. 908-920
-
-
Doherty, J.R.1
Yang, C.2
Scott, K.E.N.3
Cameron, M.D.4
Fallahi, M.5
Li, W.6
Hall, M.A.7
Amelio, A.L.8
Mishra, J.K.9
Li, F.10
Tortosa, M.11
Genau, H.M.12
Rounbehler, R.J.13
-
42
-
-
84868258397
-
Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG
-
Lacoste C, Herve J, Bou Nader M, Dos Santos A, Moniaux N, Valogne Y, Montjean R, Dorseuil O, Samuel D, Cassio D, Portulano C, Carrasco N, Brechot C, et al. Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG. Cancer Res. 2012; 72:5505-5515.
-
(2012)
Cancer Res.
, vol.72
, pp. 5505-5515
-
-
Lacoste, C.1
Herve, J.2
Bou Nader, M.3
Dos Santos, A.4
Moniaux, N.5
Valogne, Y.6
Montjean, R.7
Dorseuil, O.8
Samuel, D.9
Cassio, D.10
Portulano, C.11
Carrasco, N.12
Brechot, C.13
-
43
-
-
0035845485
-
Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase
-
Furge KA, Kiewlich D, Le P, Vo MN, Faure M, Howlett AR, Lipson KE, Vande Woude GF, Webb CP. Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase. P Natl Acad Sci U S A. 2001; 98:10722-10727.
-
(2001)
P Natl Acad Sci U S A.
, vol.98
, pp. 10722-10727
-
-
Furge, K.A.1
Kiewlich, D.2
Le, P.3
Vo, M.N.4
Faure, M.5
Howlett, A.R.6
Lipson, K.E.7
Vande Woude, G.F.8
Webb, C.P.9
-
44
-
-
84903785242
-
Four individually druggable MET hotspots mediate HGF-driven tumor progression
-
Basilico C, Hultberg A, Blanchetot C, de Jonge N, Festjens E, Hanssens V, Osepa SI, De Boeck G, Mira A, Cazzanti M, Morello V, Dreier T, Saunders M, et al. Four individually druggable MET hotspots mediate HGF-driven tumor progression. J Clin Invest. 2014; 124:3172-3186.
-
(2014)
J Clin Invest.
, vol.124
, pp. 3172-3186
-
-
Basilico, C.1
Hultberg, A.2
Blanchetot, C.3
de Jonge, N.4
Festjens, E.5
Hanssens, V.6
Osepa, S.I.7
De Boeck, G.8
Mira, A.9
Cazzanti, M.10
Morello, V.11
Dreier, T.12
Saunders, M.13
-
45
-
-
0032558793
-
Evidence for a role of Met- HGF/SF during Ras-mediated tumorigenesis/metastasis
-
Webb CP, Taylor GA, Jeffers M, Fiscella M, Oskarsson M, Resau JH, Vande Woude GF. Evidence for a role of Met- HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene. 1998; 17:2019-2025.
-
(1998)
Oncogene.
, vol.17
, pp. 2019-2025
-
-
Webb, C.P.1
Taylor, G.A.2
Jeffers, M.3
Fiscella, M.4
Oskarsson, M.5
Resau, J.H.6
Vande Woude, G.F.7
-
46
-
-
0024376173
-
ras Oncogenes in Human Cancer: A Review
-
Bos JL. ras Oncogenes in Human Cancer: A Review. Cancer Res. 1989; 49:4682-4689.
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
47
-
-
67650999875
-
The basics of epithelialmesenchymal transition
-
Kalluri R, Weinberg RA. The basics of epithelialmesenchymal transition. J Clin Invest. 2009; 119:1420-1428.
-
(2009)
J Clin Invest.
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
|