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Volumn 74, Issue 17, 2014, Pages 4822-4835

Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; PROTEIN KINASE C ALPHA; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SCATTER FACTOR RECEPTOR;

EID: 84907060300     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0584     Document Type: Article
Times cited : (59)

References (49)
  • 2
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011;121:2750-67.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6
  • 4
    • 78649663247 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Disease entity or title of convenience?
    • Carey L, Winer E, Viale G, Cameron D, Gianni L. Triple-negative breast cancer: disease entity or title of convenience? Nat Rev Clin Oncol 2010;7:683-92.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 683-692
    • Carey, L.1    Winer, E.2    Viale, G.3    Cameron, D.4    Gianni, L.5
  • 5
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR, Andre F, Tordai A, Mejia JA, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 2008;26: 1275-81.
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3    Andre, F.4    Tordai, A.5    Mejia, J.A.6
  • 6
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. Stem cell concepts renew cancer research. Blood 2008;112: 4793-807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 8
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park CY, Tseng D, Weissman IL. Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ther 2009;17:219-30.
    • (2009) Mol Ther , vol.17 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 9
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009;138:645-59.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 11
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1:555-67.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5    Brown, M.6
  • 13
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell 2008;132:681-96.
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 14
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A 2009;106:13820-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5    Sjolund, A.6
  • 15
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009;360:790-800.
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 16
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits ofhuman breast tumours
    • Cancer Genome Atlas N. Comprehensive molecular portraits ofhuman breast tumours. Nature 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 17
    • 84856071447 scopus 로고    scopus 로고
    • Phase I, dose-escalation study of BKM120, an oral pan-Class i PI3K inhibitor, in patients with advanced solid tumors
    • Bendell JC, Rodon J, Burris HA, de Jonge M, Verweij J, Birle D, et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012;30: 282-90.
    • (2012) J Clin Oncol , vol.30 , pp. 282-290
    • Bendell, J.C.1    Rodon, J.2    Burris, H.A.3    De Jonge, M.4    Verweij, J.5    Birle, D.6
  • 18
    • 84861992072 scopus 로고    scopus 로고
    • A phase i study evaluating GDC-0941, an oral phosphoinositide-3 kinase (PI3K) inhibitor, in patients with advanced solid tumors or multiple myeloma
    • Moreno Garcia V. A phase I study evaluating GDC-0941, an oral phosphoinositide-3 kinase (PI3K) inhibitor, in patients with advanced solid tumors or multiple myeloma. J Clin Oncol 2011;29: a3021.
    • (2011) J Clin Oncol , vol.29 , pp. a3021
    • Moreno Garcia, V.1
  • 19
    • 80054740282 scopus 로고    scopus 로고
    • A first-in-human phase i study to evaluate GDC-0980, an oral PI3K/mTOR inhibitor, administered QD in patients with advanced solid tumors
    • Wagner A. A first-in-human phase I study to evaluate GDC-0980, an oral PI3K/mTOR inhibitor, administered QD in patients with advanced solid tumors. J Clin Oncol 2011;29:a3020.
    • (2011) J Clin Oncol , vol.29 , pp. a3020
    • Wagner, A.1
  • 20
    • 83255162603 scopus 로고    scopus 로고
    • First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors
    • Yap TA. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol 2011;29: 4688-95.
    • (2011) J Clin Oncol , vol.29 , pp. 4688-4695
    • Yap, T.A.1
  • 21
    • 33749537080 scopus 로고    scopus 로고
    • Principles and effects of microRNA-mediated post-transcriptional gene regulation
    • Engels BM, Hutvagner G. Principles and effects of microRNA-mediated post-transcriptional gene regulation. Oncogene 2006;25: 6163-9.
    • (2006) Oncogene , vol.25 , pp. 6163-6169
    • Engels, B.M.1    Hutvagner, G.2
  • 22
    • 58149181363 scopus 로고    scopus 로고
    • Cell Line Data Base: Structure and recent improvements towards molecular authentication of human cell lines
    • Romano P, Manniello A, Aresu O, Armento M, Cesaro M, Parodi B. Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines. Nucleic Acids Res 2009;37: D925-32.
    • (2009) Nucleic Acids Res , vol.37 , pp. D925-D932
    • Romano, P.1    Manniello, A.2    Aresu, O.3    Armento, M.4    Cesaro, M.5    Parodi, B.6
  • 23
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012;483:603-7.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1    Caponigro, G.2    Stransky, N.3    Venkatesan, K.4    Margolin, A.A.5    Kim, S.6
  • 24
    • 84862630475 scopus 로고    scopus 로고
    • NetWalker: A contextual network analysis tool for functional genomics
    • Komurov K, Dursun S, Erdin S, Ram PT. NetWalker: a contextual network analysis tool for functional genomics. BMC Genomics 2012;13:282.
    • (2012) BMC Genomics , vol.13 , pp. 282
    • Komurov, K.1    Dursun, S.2    Erdin, S.3    Ram, P.T.4
  • 27
    • 0031149725 scopus 로고    scopus 로고
    • High-efficiency blotting of proteins of diverse sizes following sodium dodecyl sulfate-polyacrylamide gel electro-phoresis
    • Bolt MW, Mahoney PA. High-efficiency blotting of proteins of diverse sizes following sodium dodecyl sulfate-polyacrylamide gel electro-phoresis. Anal Biochem 1997;247:185-92.
    • (1997) Anal Biochem , vol.247 , pp. 185-192
    • Bolt, M.W.1    Mahoney, P.A.2
  • 29
    • 76549129820 scopus 로고    scopus 로고
    • Drug combination studies and their synergy quantification using the Chou-Talalay method
    • Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010;70:440-6.
    • (2010) Cancer Res , vol.70 , pp. 440-446
    • Chou, T.C.1
  • 30
    • 84863728707 scopus 로고    scopus 로고
    • Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia
    • Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, et al. Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nat Med 2012;18:1118-22.
    • (2012) Nat Med , vol.18 , pp. 1118-1122
    • Kentsis, A.1    Reed, C.2    Rice, K.L.3    Sanda, T.4    Rodig, S.J.5    Tholouli, E.6
  • 31
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007;67:4408-17.
    • (2007) Cancer Res , vol.67 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3    Arango, M.E.4    McDonnell, S.R.5    Yamazaki, S.6
  • 32
    • 77957184531 scopus 로고
    • Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents
    • Kedderis LB, Bozigian HP, Kleeman JM, Hall RL, Palmer TE, Harrison SD Jr, et al. Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents. Fundam Appl Toxicol 1995;25:201-17.
    • (1995) Fundam Appl Toxicol , vol.25 , pp. 201-217
    • Kedderis, L.B.1    Bozigian, H.P.2    Kleeman, J.M.3    Hall, R.L.4    Palmer, T.E.5    Harrison, S.D.6
  • 33
    • 84861712323 scopus 로고    scopus 로고
    • Vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia
    • Tan KB, Ling LU, Bunte RM, Chng WJ, Chiu GN. In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. J Control Release 2012;160:290-8.
    • (2012) J Control Release , vol.160 , pp. 290-298
    • Tan, K.B.1    Ling, L.U.2    Bunte, R.M.3    Chng, W.J.4    Chiu, G.N.5
  • 35
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 2011;13:317-23.
    • (2011) Nat Cell Biol , vol.13 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6
  • 36
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients
    • Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q, et al. An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients. Breast Cancer Res Treat 2010;123:725-31.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1    Lanczky, A.2    Eklund, A.C.3    Denkert, C.4    Budczies, J.5    Li, Q.6
  • 37
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 38
    • 84883621632 scopus 로고    scopus 로고
    • Protein kinase Ca is a central signaling node and therapeutic target for breast cancer stem cells
    • Tam Wai L, Lu H, Buikhuisen J, Soh Boon S, Lim E, Reinhardt F, et al. Protein kinase Ca is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 2013;24:347-64.
    • (2013) Cancer Cell , vol.24 , pp. 347-364
    • Tam Wai, L.1    Lu, H.2    Buikhuisen, J.3    Soh Boon, S.4    Lim, E.5    Reinhardt, F.6
  • 39
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 2008;26:3785-90.
    • (2008) J Clin Oncol , vol.26 , pp. 3785-3790
    • Ashworth, A.1
  • 40
    • 70249110095 scopus 로고    scopus 로고
    • BiPar Sciences presents interim phase 2 results for PARP inhibitor BSI-201 at San Antonio Breast Cancer Symposium
    • BiPar Sciences presents interim phase 2 results for PARP inhibitor BSI-201 at San Antonio Breast Cancer Symposium. Cancer Biol Ther 2009;8:2-3.
    • (2009) Cancer Biol Ther , vol.8 , pp. 2-3
  • 41
    • 84883054717 scopus 로고    scopus 로고
    • A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer
    • Liu JF, Tolaney SM, Birrer M, Fleming GF, Buss MK, Dahlberg SE, et al. A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer. Eur J Cancer 2013;49:2972-8.
    • (2013) Eur J Cancer , vol.49 , pp. 2972-2978
    • Liu, J.F.1    Tolaney, S.M.2    Birrer, M.3    Fleming, G.F.4    Buss, M.K.5    Dahlberg, S.E.6
  • 42
    • 77957578141 scopus 로고    scopus 로고
    • Targeted therapies: PARP inhibitor olaparib is safe and effective in patients with BRCA1 and BRCA2 mutations
    • Hutchinson L. Targeted therapies: PARP inhibitor olaparib is safe and effective in patients with BRCA1 and BRCA2 mutations. Nat Rev Clin Oncol 2010;7:549.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 549
    • Hutchinson, L.1
  • 43
    • 84884509017 scopus 로고    scopus 로고
    • Phase i trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first-or second-line treatment of patients with metastatic triple-negative breast cancer
    • Dent RA, Lindeman GJ, Clemons M, Wildiers H, Chan A, McCarthy NJ, et al. Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first-or second-line treatment of patients with metastatic triple-negative breast cancer. Breast Cancer Res 2013;15:R88.
    • (2013) Breast Cancer Res , vol.15 , pp. R88
    • Dent, R.A.1    Lindeman, G.J.2    Clemons, M.3    Wildiers, H.4    Chan, A.5    McCarthy, N.J.6
  • 44
    • 84866681744 scopus 로고    scopus 로고
    • PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition
    • Ibrahim YH, Garcia-Garcia C, Serra V, He L, Torres-Lockhart K, Prat A, et al. PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov 2012;2:1036-47.
    • (2012) Cancer Discov , vol.2 , pp. 1036-1047
    • Ibrahim, Y.H.1    Garcia-Garcia, C.2    Serra, V.3    He, L.4    Torres-Lockhart, K.5    Prat, A.6
  • 45
    • 34547566701 scopus 로고    scopus 로고
    • Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes
    • Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, et al. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 2007;12: 160-70.
    • (2007) Cancer Cell , vol.12 , pp. 160-170
    • Ince, T.A.1    Richardson, A.L.2    Bell, G.W.3    Saitoh, M.4    Godar, S.5    Karnoub, A.E.6
  • 46
    • 84881499406 scopus 로고    scopus 로고
    • A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells
    • Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, et al. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell 2013;24:182-96.
    • (2013) Cancer Cell , vol.24 , pp. 182-196
    • Petrocca, F.1    Altschuler, G.2    Tan, S.M.3    Mendillo, M.L.4    Yan, H.5    Jerry, D.J.6
  • 47
    • 70350235064 scopus 로고    scopus 로고
    • Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer
    • Speers C, Tsimelzon A, Sexton K, Herrick AM, Gutierrez C, Culhane A, et al. Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. Clin Cancer Res 2009; 15:6327-40.
    • (2009) Clin Cancer Res , vol.15 , pp. 6327-6340
    • Speers, C.1    Tsimelzon, A.2    Sexton, K.3    Herrick, A.M.4    Gutierrez, C.5    Culhane, A.6
  • 48
    • 0023526075 scopus 로고
    • Immuno-logical quantitation of phospholipid/Ca2-dependent protein kinase of human mammary carcinoma cells: Inverse relationship to estrogen receptors
    • Borner C, Wyss R, Regazzi R, Eppenberger U, Fabbro D. Immuno-logical quantitation of phospholipid/Ca2-dependent protein kinase of human mammary carcinoma cells: inverse relationship to estrogen receptors. Int J Cancer 1987;40:344-8.
    • (1987) Int J Cancer , vol.40 , pp. 344-348
    • Borner, C.1    Wyss, R.2    Regazzi, R.3    Eppenberger, U.4    Fabbro, D.5
  • 49
    • 0033821711 scopus 로고    scopus 로고
    • Stable transfection of protein kinase C alpha cDNA in hormone dependent breast cancer cell lines
    • Tonetti DA, Chisamore MJ, Grdina W, Schurz H, Jordan VC. Stable transfection of protein kinase C alpha cDNA in hormone dependent breast cancer cell lines. Br J Cancer 2000;83:782-91.
    • (2000) Br J Cancer , vol.83 , pp. 782-791
    • Tonetti, D.A.1    Chisamore, M.J.2    Grdina, W.3    Schurz, H.4    Jordan, V.C.5


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