The action mechanism of daptomycin

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 24, 2016, Pages 6253-6268

  Taylor, Scott D ^a   Palmer, Michael ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Bacterial membranes; Calcium dependent lipopeptide antibiotics; Membrane potential

Indexed keywords

CARDIOLIPIN; DAPTOMYCIN; DIHEXANOYL PHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLGLYCEROL; DIOLEOYLPHOSPHATIDYLCHOLINE; DIOLEOYLPHOSPHATIDYLGLYCEROL; LIPOTEICHOIC ACID; MEMBRANE ASSOCIATED TRANSCRIPTIONAL REGULATOR LIARS; PEPTIDE; PEPTIDOGLYCAN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; POLYPEPTIDE ANTIBIOTIC AGENT; TSUSHIMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; BINDING SITE; CALCIUM BINDING SITE; CELL DIVISION; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; COMMUNITY ACQUIRED PNEUMONIA; DEPLETION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOCARDITIS; FATTY ACID SYNTHESIS; LIPOGENESIS; MACROMOLECULE; MEMBRANE BINDING; MEMBRANE DEPOLARIZATION; MEMBRANE FUSION; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; OLIGOMERIZATION; PHYSICAL CHEMISTRY; PROTEIN SYNTHESIS; SKIN AND SKIN STRUCTURE INFECTION; SKIN INFECTION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; CONFORMATION; DRUG EFFECTS; GRAM POSITIVE BACTERIUM; MICROBIAL SENSITIVITY TEST;

ANTI-BACTERIAL AGENTS; DAPTOMYCIN; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84973539379     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.05.052     Document Type: Article

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