Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6248-6251

  He, Yong ^a   Li, Jing ^a   Yin, Nin ^a   Herradura, Prudencio S ^a   Martel, Larry ^a   Zhang, Yanzhi ^a   Pearson, Andre L ^a   Kulkarni, Vidya ^a   Mascio, Carmela ^a   Howland, Karen ^a   Silverman, Jared A ^a   Keith, Dennis D ^a   Metcalf, Chester A ^a  

^a CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

Antibacterial; Daptomycin; Pulmonary surfactant

Indexed keywords

ALANINE; ASPARAGINE; CEFTRIAXONE; DAPTOMYCIN; HUMAN SERUM ALBUMIN; LUNG SURFACTANT; SERINE; TRYPTOPHAN DERIVATIVE;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; PROTEIN BINDING; STAPHYLOCOCCUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; DAPTOMYCIN; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PULMONARY SURFACTANTS; STAPHYLOCOCCUS AUREUS; TRYPTOPHAN;

EID: 84866376326     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.013     Document Type: Article

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