Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with L-lysine

Journal of Experimental Medicine

Volumn 193, Issue 9, 2001, Pages 1067-1076

  Peschel, Andreas ^a,b   Jack, Ralph W ^a,c,f   Otto, Michael ^a,g   Collins, L Vincent ^d   Staubitz, Petra ^a   Nicholson, Graeme ^a   Kalbacher, Hubert ^a   Nieuwenhuizen, Willem F ^e   Jung, Günther ^a,c   Tarkowski, Andrej ^d   Van Kessel, Kok P M ^b   Van Strijp, Jos A G ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c EMC MICROCOLLECTIONS GMBH   (Germany)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e TNO   (Netherlands)

^f CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Host defense peptides; Innate immunity; Oxygen independent killing; Phospholipids; Staphylococcus aureus virulence

Indexed keywords

ANTIBIOTIC AGENT; DEFENSIN; GALLIDERMIN; GRAMICIDIN D; GRAMICIDIN S; LYSINE; MAGAININ 2; MELITTIN; MEMBRANE LIPID; NISIN; PHOSPHATIDYLGLYCEROL; PROTEGRIN; TACHYPLESIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRULENCE FACTOR MPRF;

ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COUNT; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; FEMALE; GENE INACTIVATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; SURFACE CHARGE;

ALPHA-DEFENSINS; AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; CELL MEMBRANE; DEFENSINS; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; ESTERIFICATION; GENES, BACTERIAL; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEPTIDES; PHOSPHATIDYLGLYCEROLS; STAPHYLOCOCCUS AUREUS; SWINE; VIRULENCE;

EID: 0035821289     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.9.1067     Document Type: Article

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