Effect of divalent cations on the structure of the antibiotic daptomycin

European Biophysics Journal

Volumn 37, Issue 4, 2008, Pages 421-433

  Ho, Steven W ^a   Jung, David ^a   Calhoun, Jennifer R ^b   Lear, James D ^b   Okon, Mark ^a   Scott, Walter R P ^a   Hancock, Robert E W ^a   Straus, Suzana K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Analytical ultracentrifugation; Ca2+ binding; Daptomycin; Mg2+ binding; Molecular dynamics (MD) simulation; NMR; Nuclear overhauser enhancement (NOE)

Indexed keywords

ASPARTIC ACID; CALCIUM ION; DAPTOMYCIN; MAGNESIUM ION; MONOMER; TRYPTOPHAN;

ARTICLE; BINDING SITE; CALCIUM BINDING; CARBON NUCLEAR MAGNETIC RESONANCE; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG STRUCTURE; MICELLE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NUCLEAR OVERHAUSER EFFECT; OLIGOMERIZATION; SIMULATION; STRUCTURE ANALYSIS; ULTRACENTRIFUGATION;

ALGORITHMS; ANTI-INFECTIVE AGENTS; BINDING SITES; CALCIUM; CATIONS, DIVALENT; COMPUTER SIMULATION; DAPTOMYCIN; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MODELS, STATISTICAL; MOLECULAR CONFORMATION; PEPTIDES; PROTEIN CONFORMATION; ULTRACENTRIFUGATION;

EID: 41049113315     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-007-0227-2     Document Type: Article

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