Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of staphylococcus aureus

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Peleg, Anton Y ^a,b,c   Miyakis, Spiros ^c,d,e   Ward, Doyle V ^f   Earl, Ashlee M ^f   Rubio, Aileen ^g   Cameron, David R ^a   Pillai, Satish ^c,d   Moellering, Robert C ^c,d   Eliopoulos, George M ^c,d  

^a MONASH UNIVERSITY   (Australia)

^b ALFRED HOSPITAL   (Australia)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g Cubist Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN; CARDIOLIPIN SYNTHASE; CYTIDINE DIPHOSPHATE DIACYLGLYCEROL INOSITOL 3 PHOSPHATIDYLTRANSFERASE; DAPTOMYCIN; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATION; CLS2 GENE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME SYNTHESIS; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; HUMAN; HUMAN CELL; LIPID MEMBRANE; MPRF GENE; PGSA GENE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; BACTERIAL GENOME; BIOLOGICAL MODEL; CELL WALL; CHEMISTRY; DNA SEQUENCE; DRUG EFFECT; GENETICS; HOSPITAL LABORATORY; ISOLATION AND PURIFICATION; LIPID METABOLISM; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PATIENT;

STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; CELL WALL; DAPTOMYCIN; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; HUMANS; LABORATORIES, HOSPITAL; LIPID METABOLISM; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; PATIENTS; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84855416641     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028316     Document Type: Article

References (33)

1. Collignon P, Nimmo GR, Gottlieb T, Gosbell IB, (2005) Staphylococcus aureus bacteremia, Australia. Emerg Infect Dis 11: 554-561.
2. Fowler VG Jr, Boucher HW, Corey GR, Abrutyn E, Karchmer AW, et al. (2006) Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N Engl J Med 355: 653-665.
3. Howden BP, Davies JK, Johnson PD, Stinear TP, Grayson ML, (2010) Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications. Clin Microbiol Rev 23: 99-139.
4. Jung D, Powers JP, Straus SK, Hancock RE, (2008) Lipid-specific binding of the calcium-dependent antibiotic daptomycin leads to changes in lipid polymorphism of model membranes. Chem Phys Lipids 154: 120-128.
5. Cotroneo N, Harris R, Perlmutter N, Beveridge T, Silverman JA, (2008) Daptomycin exerts bactericidal activity without lysis of Staphylococcus aureus. Antimicrob Agents Chemother 52: 2223-2225.
6. Hayden MK, Rezai K, Hayes RA, Lolans K, Quinn JP, et al. (2005) Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus. J Clin Microbiol 43: 5285-5287.
7. Marty FM, Yeh WW, Wennersten CB, Venkataraman L, Albano E, et al. (2006) Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. J Clin Microbiol 44: 595-597.
8. Skiest DJ, (2006) Treatment failure resulting from resistance of Staphylococcus aureus to daptomycin. J Clin Microbiol 44: 655-656.
9. Ernst CM, Staubitz P, Mishra NN, Yang SJ, Hornig G, et al. (2009) The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS Pathog 5: e1000660.
10. Yang SJ, Kreiswirth BN, Sakoulas G, Yeaman MR, Xiong YQ, et al. (2009) Enhanced expression of dltABCD is associated with the development of daptomycin nonsusceptibility in a clinical endocarditis isolate of Staphylococcus aureus. J Infect Dis 200: 1916-1920.
11. Friedman L, Alder JD, Silverman JA, (2006) Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus. Antimicrob Agents Chemother 50: 2137-2145.
12. Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, et al. (2009) Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 53: 2312-2318.
13. Muthaiyan A, Silverman JA, Jayaswal RK, Wilkinson BJ, (2008) Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization. Antimicrob Agents Chemother 52: 980-990.
14. Boyle-Vavra S, Jones M, Gourley BL, Holmes M, Ruf R, et al. (2011) Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failure. Antimicrob Agents Chemother 55: 2018-2025.
15. Sakoulas G, Alder J, Thauvin-Eliopoulos C, Moellering RC Jr, Eliopoulos GM, (2006) Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin. Antimicrob Agents Chemother 50: 1581-1585.
16. Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, et al. (2009) Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nat Methods 6: 67-69.
17. Li L, Stoeckert CJ Jr, Roos DS, (2003) OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res 13: 2178-2189.
18. Edgar RC, (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32: 1792-1797.
19. Capella-Gutierrez S, Silla-Martinez JM, Gabaldon T, (2009) trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Bioinformatics 25: 1972-1973.
20. Price MN, Dehal PS, Arkin AP, (2009) FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Mol Biol Evol 26: 1641-1650.
21. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG, (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38: 1008-1015.
22. Krogh A, Larsson B, von Heijne G, Sonnhammer EL, (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305: 567-580.
23. Bligh EG, Dyer WJ, (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917.
24. Enright MC, Robinson DA, Randle G, Feil EJ, Grundmann H, et al. (2002) The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci U S A 99: 7687-7692.
25. Straus SK, Hancock RE, (2006) Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides. Biochim Biophys Acta 1758: 1215-1223.
26. Jones T, Yeaman MR, Sakoulas G, Yang SJ, Proctor RA, et al. (2008) Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding. Antimicrob Agents Chemother 52: 269-278.
27. Camargo IL, Neoh HM, Cui L, Hiramatsu K, (2008) Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype. Antimicrob Agents Chemother 52: 4289-4299.
28. Short SA, White DC, (1972) Biosynthesis of cardiolipin from phosphatidylglycerol in Staphylococcus aureus. J Bacteriol 109: 820-826.
29. Arias CA, Panesso D, McGrath DM, Qin X, Mojica MF, et al. (2011) Genetic basis for in vivo daptomycin resistance in enterococci. N Engl J Med 365: 892-900.
30. Palmer KL, Daniel A, Hardy C, Silverman J, Gilmore MS, (2011) Genetic basis for daptomycin resistance in enterococci. Antimicrob Agents Chemother 55: 3345-3356.
31. Hachmann AB, Sevim E, Gaballa A, Popham DL, Antelmann H, et al. (2009) Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis. Antimicrob Agents Chemother 55: 4326-4337.
32. Yang SJ, Nast CC, Mishra NN, Yeaman MR, Fey PD, et al. (2010) Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. Antimicrob Agents Chemother 54: 3079-3085.
33. Bertsche U, Weidenmaier C, Kuehner D, Yang SJ, Baur S, et al. (2011) Correlation of Daptomycin Resistance in a Clinical Staphylococcus aureus Strain with Increased Cell Wall Teichoic Acid Production and D-Alanylation. Antimicrob Agents Chemother 55: 3922-3928.