Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis

FASEB Journal

Volumn 30, Issue 1, 2016, Pages 81-92

  Spaethling, Jennifer M ^a   Sanchez Alavez, Manuel ^c   Lee, JaeHee ^a   Xia, Feng C ^c   Dueck, Hannah ^a   Wang, Wenshan ^b   Fisher, Stephen A ^a   Sul, Jai Yoon ^a   Seale, Patrick ^b   Kim, Junhyong ^a   Bartfai, Tamas ^c   Eberwine, James ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Brown fat; Drug targets; GPCR; In vivo validation; Thermogenesis

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; ADRENERGIC RECEPTOR; ATRIAL NATRIURETIC FACTOR; BETA 3 ADRENERGIC RECEPTOR; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CHEMOKINE; CYTOKINE; ENDOTHELIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GASTRIC INHIBITORY POLYPEPTIDE; HORMONE; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 1BETA; LEPTIN; MESSENGER RNA; NEUROPEPTIDE; NEUROTRANSMITTER; SECRETIN; SOMATOMEDIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTOME; UNCOUPLING PROTEIN 1; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INDIRECT CALORIMETRY; MALE; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE CELL ANALYSIS; TELEMETRY; THERMOGENESIS; TRANSCRIPTOMICS; ANIMAL; CYTOLOGY; MITOCHONDRION; OBESITY; PHYSIOLOGY; VALIDATION STUDY;

ADIPOCYTES, BROWN; ADIPOSE TISSUE, BROWN; ANIMALS; HOMEOSTASIS; ION CHANNELS; MALE; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OBESITY; THERMOGENESIS; TRANSCRIPTOME;

EID: 84973454263     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-273797     Document Type: Article

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