Brown adipose tissue: More than an effector of thermogenesis?

Annals of the New York Academy of Sciences

Volumn 856, Issue , 1998, Pages 171-187

  Cannon, Barbara ^a   Houstek, Josef ^b   Nedergaard, Jan ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; FATTY ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NORADRENALIN; PROSTAGLANDIN E; THYROXINE;

ADIPOCYTE; BROWN ADIPOSE TISSUE; CONFERENCE PAPER; ENDOCRINE GLAND; FATTY ACID OXIDATION; FEVER; HUMAN; MITOCHONDRION; NONHUMAN; THERMOGENESIS; THERMOREGULATION;

MUS MUSCULUS;

EID: 0031771002     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb08325.x     Document Type: Article

References (67)

1. SZÉKELY, M., Z. SZELÉNYI & I. SÜMEGI. 1973. Brown adipose tissue as a source of heat during pyrogen-induced fever. Acta Physiol. Acad. Sci. Hung. 43: 83-88.
2. NEDERGAARD, J. 1992. Brown adipose tissue thermogenesis and fever. In Neuro-Immunology of Fever. T. Bartfai & D. Ottoson, Eds. : 235-247. Pergamon Press. Oxford.
3. SMITH, R. E. & B. A. HORWITZ. 1969. Brown fat and thermogenesis. Physiol. Rev. 49: 330-425.
4. NEDERGAARD, J. & O. LINDBERG. 1982. The brown fat cell. Int. Rev. Cytol. 74: 187-286.
5. NICHOLLS, D. G. & R. M. LOCKE. 1984. Thermogenic mechanisms in brown fat. Physiol. Rev. 64: 1-64.
6. CANNON, B. & J. NEDERGAARD. 1985. The biochemistry of an inefficient tissue: Brown adipose tissue. Essays Biochem. 20: 110-164.
7. HIMMS-HAGEN, J. 1989. Brown adipose tissue thermogenesis and obesity. Prog. Lipid Res. 28: 67-115.
8. NEDERGAARD, J. & B. CANNON. 1992. The uncoupling protein thermogenin and mitochondrial thermogenesis. In New Comprehensive Biochemistry, Vol. 23. Molecular Mechanisms in Bioenergetics. L. Ernster, Eds. : 385-420. Elsevier. Amsterdam.
9. NEDERGAARD, J., D. HERRON, A. JACOBSSON, S. REHNMARK & B. CANNON. 1995. Norepinephrine as a morphogen? Its unique interaction with brown adipose tissue. Int. J. Dev. Biol. 39: 827-837.
10. LARROUY, D., P. LAHARRAGUE, G. CARRERA, N. VIGUERIE-BASCANDS, C. LEVI-MEYRUEIS, C. FLEURY, C. PECQUEUR, M. NIBBELINK, M. ANDRE, L. CASTEILLA & D. RICQUIER. 1997. Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver. Biochem. Biophys. Res. Commun. 235: 760-764.
11. FLEURY, C., M. NEVEROVA, S. COLLINS, S. RAIMBAULT, O. CHAMPIGNY, C. LEVI-MEYRUEIS, F. BOUILLAUD, M. F. SELDIN, R. S. SURWIT, D. RICQUIER & C. H. WARDEN. 1997. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15: 269-272.
12. ARNOLD, J., R. A. LITTLE & N. J. ROTHWELL. 1989. Energy balance and brown adipose tissue thermogenesis during chronic endotoxemia in rats. J. Appl. Physiol. 66: 1970-1975.
13. NEDERGAARD, J., A. DICKER & B. CANNON. 1997. The interaction between thyroid and brown-fat thermogenesis. Central of peripheral effects? Ann. N.Y. Acad. Sci. 813: 712-717.
14. BLATTEIS, C. M. 1976. Fever: Exchange of shivering by nonshivering pyrogenesis in coldacclimated guinea pigs. J. Appl. Physiol. 40: 29-34.
15. MCCARTHY, P. L. 1997. Fever in infants and children. In Fever. Basic Mechanisms and Management. P. A. Mackowiak, Eds. : 351-362. Lippincott - Raven. Philadelphia and New York.
16. VILLARROYA, F., A. FELIPE & T. MAMPEL. 1986. Sequential changes in brown adipose tissue composition, cytochrome oxidase activity and GDP binding throughout pregnancy and lactation in the rat. Biochim. Biophys. Acta 882: 187-191.
17. MARTIN, I., M. GIRALT, O. VINAS, R. IGLESIAS, T. MAMPEL & F. VILLAROYA. 1989. Adaptive decrease in expression of the mRNA for uncoupling protein and subunit II of cytochrome c oxidase in rat brown adipose tissue during pregnancy and lactation. Biochem. J. 263: 965-968.
18. SIMROSE, R. L. & J. E. FEWELL. 1995. Body temperature response to IL-1β in pregnant rats. Am. J. Physiol. 269: R1179-R1182.
19. ZEISBERGER, E., G. MERKER & S. BLAHSER. 1981. Fever response in the guinea pig before and after parturition. Brain Res. 212: 379-392.
20. HULL, D., J. MCINTYRE & J. VINTER. 1992. Maternal fever at parturition and its effects on the newborn rabbit. J. Dev. Physiol. 18: 87-92.
21. NEDERGAARD, J., E. CONNOLLY & B. CANNON. 1986. Brown adipose tissue in the mammalian neonate. In Brown Adipose Tissue. P. Trayhurn & D. G. Nicholls, Eds. : 152-213. Edward Arnold Ltd. London.
22. BLATTEIS, C. M. & K. A. SMITH. 1979. Hypothalamic sensitivity to leukocyte pyrogen of adult and new-born guinea pigs. J. Physiol. (Lond.) 296: 177-192.
23. K. E. COOPER. 1979. Development of fever in the newborn lamb. Am. J. Physiol. 236: R184-R187.
24. SZEKELY, M. & Z. SZELENYI. 1979. Age-related differences in thermoregulatory responses to endotoxins in rabbits. Acta Physiol. Acad. Sci. Hung. 54: 389-400.
25. NISHIO, A. & S. KANOH. 1980. Development changes in the febrile response to endotoxin in rabbit. Jpn. J. Physiol. 30: 645-653.
26. HULL, D., J. MCINTYRE & J. VINTER. 1993. Age-related changes in endotoxin sensitivity and the febrile response of newborn rabbits. Biol. Neonate 63: 370-379.
27. DASCOMBE, M. J., A. HARDWICK, R. A. LEFEUVRE & N. J. ROTHWELL. 1989. Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats. Int. J. Obes. 13: 367-373.
28. ROSENTHAL, M., J. ROTH, B. STORR & E. ZEISBERGER. 1996. Fever response in lean (Fa/-) and obese (fa/fa) Zucker rats and its lack to repeated injections of LPS. Physiol. Behav. 59: 787-793.
29. ROTHWELL, N. J. & M. J. STOCK. 1982. Effect of chronic food restriction on energy balance, thermogenic capacity and brown-adipose-tissue activity in the rat. Biosci. Rep. 2: 543550.
30. SHIDO, O., T. NAGASAKA & T. WATANABE. 1989. Blunted febrile response to intravenous endotoxin in starved rats. J. Appl. Physiol. 67: 963-969.
31. KLEITMAN, N. & E. SATINOFF. 1981. Behavioral responses to pyrogen in cold-stressed and starved newborn rabbits. Am. J. Physiol. 241: R167-R171.
32. 1-adrenoceptor density in brown adipose tissue indicates recruitment drive in hypothyroid rats. Am. J. Physiol. 263: E654-E662.
33. MACARI, M., I. R. PELA & C. A. SILVA. 1987. The development of a febrile response to pyrogen in the thyroid-deficient rabbit. Can. J. Pharmacol. 65: 1325-1328.
34. MCDONALD, R. B., B. A. HORWITZ, J. S. HAMILTON & J. S. STERN. 1988. Cold- and norepinephrine-induced thermogenesis in younger and older Fischer 344 rats. Am. J. Physiol. 254: R457-R462.
35. SCARPACE, P. J., M. MATHENY & S. E. BORST. 1992. Thermogenesis and mitochondrial GDP binding with age in response to the novel agonist CGP-12177A. Am. J. Physiol. 262: E185-E190.
36. BENDER, B. S. & P. J. SCARPACE. 1997. Fever in the elderly. In Fever. Basic Mechanisms and Management, P. A. Mackowiak, Eds. : 363-374. Lippinkott - Raven. Philadelphia and New York.
37. ENERBÄCK, S., A. JACOBSSON, E. M. SIMPSON, C. GUERRA, H. YAMASHITA, M.-E. HARPER & L. P. KOZAK. 1997. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387: 90-94.
38. LOWELL, B. B., V. S. SUSULIC, A. HAMANN, J. A. LAWITTS, J. HIMMS-HAGEN, B. B. BOYER, L. P. KOZAK & J. S. FLIER. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366: 740-742.
39. JEPSON, M. M., D. J. MILLWARD, N. J. ROTHWELL & M. J. STOCK. 1988. Involvement of sympathetic nervous system and brown fat in endotoxin-induced fever in rats. Am. J. Physiol. 255: E617-E620.
40. DASCOMBE, M. J., N. J. ROTHWELL, B. O. SAGAY & M. J. STOCK. 1989. Pyrogenic and thermogenic effects of interleukin 1β in the rat. Am. J. Physiol. 256: E7-E11.
41. REHNMARK, S., M. NÉCHAD, D. HERRON, B. CANNON & J. NEDERGAARD. 1990. α- and β-Adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J. Biol. Chem. 265: 16464-16471.
42. NÉCHAD, M., E. RUKA & J. THIBAULT. 1994. Production of nerve growth factor by brown fat in culture: Relation with the in vivo developmental stage of the tissue. Comp. Biochem. Physiol. 107: 381-388.
43. YAMASHITA, H., N. SATO, T. KIZAKI, S. OH-ISHI, M. SEGAWA, D. SAITOH, Y. OHIRA & H. OHNO. 1995. Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture. Cell Growth Differ. 6: 1457-1462.
44. LOWELL, B. B., A. NAPOLITANO, P. USHER, A. G. DULLOO, B. S. ROSEN, B. M. SPIEGELMAN & J. S. FLIER. 1990. Reduced adipsin expression in murine obesity: Effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. Endocrinology 126: 1514-1520.
45. ONYIA, J. E., T. A. LIBERMANN, J. BIDWELL, D. ARNOLD, Y. TU, P. MCCLELLAND & J. M. HOCK. 1997. Parathyroid hormone (1-34)-mediated interleukin-6 induction. J. Cell. Biochem. 67: 265-274.
46. FANTUZZI, G. & C. A. DINARELLO. 1996. The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice. J. Leukoc. Biol. 59: 489-193.
47. BLATTEIS, C. M. 1975. Postnatal development of pyrogenic sensitivity in guinea pigs. J. Appl. Physiol. 39: 251-257.
48. BLATTEIS, C. M. 1976. Effect of propranolol on endotoxin-induced pyrogenesis in newborn and adult guinea pigs. J. Appl. Physiol. 40: 35-39.
49. JENNINGS, G. & M. ELIA. 1987. Effect of E. coli endotoxin on temperature, oxygen consumption and brown adipose tissue thermogenesis in rats and mice. Biosci. Rep. 7: 517-523.
50. HARRIS, W. H., D. O. FOSTER & B. E. NADEAU. 1985. Evidence for a contribution by brown adipose tissue to the development of fever in the young rabbit. Can. J. Physiol. Pharmacol. 63: 595-598.
51. JEPSON, M. M., M. Cox, P. C. BATES, N. J. ROTHWELL, M. J. STOCK, E. B. CADY & D. J. MILLWARD. 1987. Regional blood flow and skeletal muscle energy status in endotoxemic rats. Am. J. Physiol. 252: E581-E587.
52. ARNOLD, J., J. J. CHOO, R. A. LITTLE & N. J. ROTHWELL. 1990. Dopamine β-hydrolase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues. Circ. Shock 31: 387-394.
53. COOPER, A. L., R. B. FITZGEORGE, A. BASKERVILLE, R. A. LITTLE & N. J. ROTHWELL. 1989. Bacterial infection (Legionella pneumophila) stimulates fever, metabolic rate and brown adipose tissue activity in the guinea pig. Life Sci. 45: 843-847.
54. SCARPACE, P. J., M. MATHENY, B. S. BENDER & S. E. BORST. 1992. Impaired febrile response with age: Role of thermogenesis in brown adipose tissue. Proc. Soc. Exp. Biol. Med. 200: 353-358.
55. ROTHWELL, N. J. 1989. CRF is involved in the pyrogenic and thermogenic effects of interleukin 1β in the rat. Am. J. Physiol. 256: E111-E115.
56. BUSBRIDGE, N. J., M. J. DASCOMBE, S. HOPKINS & N. J. ROTHWELL. 1989. Acute central effects of interleukin-6 on body temperature, thermogenesis and food intake in the rat. Proc. Nutr. Soc. 48: 48A.
57. 1-evoked hyperthermia in rats. Am. J. Physiol. 260: R59-R66.
58. FYDA, D. M., K. E. COOPER & W. L. VEALE. 1991. Nucleus tractus solitarii lesions alter the metabolic and hyperthermic response to central prostaglandin El in the rat. J. Physiol. (Lond.) 442: 337-349.
59. MONDA, M., S. AMARO & B. DE LUCA. 1994. Non-shivering thermogenesis during prostaglandin El fever in rats: Role of the cerebral cortex. Brain Res. 651: 148-154.
60. MONDA, M., S. AMARO, A. SULLO & B. DE LUCA. 1994. Posterior hypothalamic activity and cortical control during the PGE1 hyperthermia. NeuroReport 6: 135-139.
61. 2 into the anterior hypothalamic preoptic area activates brown adipose tissue thermogenesis in the rat. Brain Res. 528: 138-142.
62. HART, J. S., O. HEROUX & F. DEPOCAS. 1956. Cold acclimation and the electromyogram of unanesthetized rats. J. Appl. Physiol. 9: 404-408.
63. SUNDIN, U. & B. CANNON. 1980. GDP-binding to the brown fat mitochondria of developing and cold-adapted rats. Comp. Biochem. Physiol. 65B: 463-471.
64. SZÉKELY, M. 1970. Effects of thyroxine treatment of different duration on oxygen consumption and body temperature at different ambient temperatures in the rat. Acta Physiol. Acad. Sci. Hung. 37: 51-55.
65. BURYSEK, L., P. TVRDIK & J. HOUSTEK. 1993. Expression of interleukin-1α and interleukin-1 receptor type I genes in murine brown adipose tissue. FEBS Lett. 334: 229-232.
66. BURYSEK, L. & J. HOUSTEK. 1996. Multifactorial induction of gene expression and nuclear localization of mouse interleukin 1α. Cytokine 8: 460-467.
67. BURYSEK, L. & J. HOUSTEK. 1997. β-Adrenergic stimulation of interleukin-α and interleukin-6 expression in mouse brown adipocytes. FEBS Lett. 411: 83-86.