Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

Nature Communications

Volumn 7, Issue , 2016, Pages

  Broecker, Felix ^a,b   Hanske, Jonas ^a,b   Martin, Christopher E ^a,b   Baek, Ju Yuel ^a,c   Wahlbrink, Annette ^a   Wojcik, Felix ^a,d   Hartmann, Laura ^a,e   Rademacher, Christoph ^a,b   Anish, Chakkumkal ^a,f   Seeberger, Peter H ^a,b  

^a MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Vaxxilon Deutschland GmbH   (Germany)

^d PRINCETON UNIVERSITY   (United States)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f Janssen Research and Development   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; DISACCHARIDE; EPITOPE; GLYCAN; IMMUNOGLOBULIN G ANTIBODY; PENTASACCHARIDE; POLYSACCHARIDE; BACTERIAL ANTIGEN; BACTERIUM ANTIBODY; GLYCOCONJUGATE; RECOMBINANT VACCINE;

ANTIBODY; ANTIGEN; BACTERIUM; CARBOHYDRATE; CELLS AND CELL COMPONENTS; COMPLEXITY; IMMUNE RESPONSE; PEPTIDE; VACCINE;

ANIMAL EXPERIMENT; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS REACTION; DISSOCIATION CONSTANT; DRUG BINDING; ENTROPY; EPITOPE MAPPING; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; POLYACRYLAMIDE GEL ELECTROPHORESIS; STOICHIOMETRY; SURFACE PLASMON RESONANCE; ANIMAL; ANTIBODY PRODUCTION; BLOOD; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; FEMALE; HOST PATHOGEN INTERACTION; IMMUNIZATION; IMMUNOLOGY; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PROCEDURES; PSEUDOMEMBRANOUS COLITIS; WESTERN BLOTTING;

CLOSTRIDIUM DIFFICILE; MUS;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; ANTIGENS, BACTERIAL; BLOTTING, WESTERN; CLOSTRIDIUM DIFFICILE; DISACCHARIDES; ENTEROCOLITIS, PSEUDOMEMBRANOUS; EPITOPES, T-LYMPHOCYTE; FEMALE; GLYCOCONJUGATES; HOST-PATHOGEN INTERACTIONS; IMMUNIZATION; MICE, INBRED C57BL; MOLECULAR STRUCTURE; POLYSACCHARIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VACCINES, SYNTHETIC;

EID: 84973402346     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11224     Document Type: Article

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