Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution

Protein Engineering, Design and Selection

Volumn 23, Issue 4, 2010, Pages 175-184

  Zahnd, Christian ^a,d   Sarkar, Casim A ^b,c   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MOLECULAR PARTNERS AG   (Switzerland)

Author keywords

affinity maturation; kinetic simulation; off rate; off rate selection; selection strategy

Indexed keywords

AFFINITY MATURATION; KINETIC SIMULATION; OFF RATE; OFF-RATE SELECTION; SELECTION STRATEGIES;

ANTIGENS; BINDERS; COMPETITION; LIBRARIES; OPTIMIZATION; PLASMA SIMULATION; STOCHASTIC MODELS;

EXPERIMENTS;

BIOTIN; ANTIGEN; PEPTIDE LIBRARY;

ARTICLE; BINDING AFFINITY; BIOTINYLATION; EVOLUTION; MATURATION; MOLECULE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RIBOSOME; SIMULATION; STOCHASTIC MODEL; ANTIBODY AFFINITY; CHEMISTRY; COMPUTER SIMULATION; DIRECTED MOLECULAR EVOLUTION; KINETICS;

ANTIBODY AFFINITY; ANTIGENS; COMPUTER SIMULATION; DIRECTED MOLECULAR EVOLUTION; KINETICS; PEPTIDE LIBRARY;

EID: 77954636166     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp087     Document Type: Article

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