Clostridium difficile PSI polysaccharide: Synthesis of pentasaccharide repeating block, conjugation to exotoxin B subunit, and detection of natural anti-PSI IgG antibodies in horse serum

Carbohydrate Research

Volumn 378, Issue , 2013, Pages 15-25

  Jiao, Yuening ^a   Ma, Zuchao ^a   Hodgins, Doug ^a   Pequegnat, Brittany ^a   Bertolo, Lisa ^a   Arroyo, Luis ^a   Monteiro, Mario A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Anti PSI IgG antibodies; C. difficile PSI polysaccharide; C. difficile Toxin B conjugate; Clostridium difficile; Vaccine

Indexed keywords

ANTIBODIES; CELL MEMBRANES; CHEMICAL DETECTION; RANDOM PROCESSES; STOCHASTIC SYSTEMS; VACCINES;

BUILDING BLOCKES; C. DIFFICILE TOXIN B CONJUGATE; CELL SURFACES; CLOSTRIDIUM DIFFICILE; PENTASACCHARIDE REPEATING UNIT; PENTASACCHARIDES; REDUCING ENDS; SYNTHESIS STRATEGY;

CLOSTRIDIUM;

BACTERIAL POLYSACCHARIDE; BACTERIAL VACCINE; CLOSTRIDIUM DIFFICILE TOXIN B; IMMUNOGLOBULIN G ANTIBODY; MONOSACCHARIDE; PENTASACCHARIDE;

ANIMAL TISSUE; ARTICLE; CARBOHYDRATE SYNTHESIS; CELL SURFACE; CLOSTRIDIUM DIFFICILE; CONJUGATION; HORSE; MOLECULAR WEIGHT; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; STATISTICS; SYNTHESIS;

CLOSTRIDIUM DIFFICILE; EQUIDAE;

ANTI-PSI IGG ANTIBODIES; C. DIFFICILE PSI POLYSACCHARIDE; C. DIFFICILE TOXIN B CONJUGATE; CLOSTRIDIUM DIFFICILE; VACCINE;

ANIMALS; CARBOHYDRATE SEQUENCE; CHEMISTRY TECHNIQUES, SYNTHETIC; CLOSTRIDIUM DIFFICILE; CYSTEINE ENDOPEPTIDASES; GLYCOSYLATION; HORSES; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; POLYSACCHARIDES, BACTERIAL;

EID: 84885020626     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2013.03.018     Document Type: Article

References (27)

1. Blossom, D. B.; McDonald, L. C. Clin. Infect. Dis. 2007, 45, 222-227.
2. Gaynes, R.; Rimland, D.; Killum, E.; Lowery, H. K.; Johnson, T. M.; Killgore, G.; Tenover, F. C. Clin. Infect. Dis. 2004, 38, 640-645.
3. Knoop, F. C.; Owens, M.; Crocker, I. C. Clin. Microbiol. Rev. 1993, 6, 251-265.
4. Bartlett, J. G. Ann. Intern. Med. 2006, 145, 758-764.
5. Kyne, L.; Hamel, M. B.; Polavaram, R.; Kelly, C. P. Clin. Infect. Dis. 2002, 34, 346-353.
6. Hauri, A. M.; Zaiss, N. H.; Witte, W.; Weller, G. B. Eurosurveillance 2009, 14, 1-4.
7. Miller, M. A. Clin. Infect. Dis. 2007, 45, 122-128.
8. Musher, D. M.; Aslam, S.; Logan, N.; Nallacheru, S.; Bhaila, I.; Borchert, F.; Hamill, R. J. Clin. Infect. Dis. 2005, 40, 1586-1590.
9. Rebeaud, F.; Bachmann, M. F. Expert Rev. Vaccines 2012, 11, 469-479.
10. Ganeshapillai, J.; Vinogradov, E.; Rousseau, J.; Weese, J. S.; Monteiro, M. A. Carbohydr. Res. 2008, 343, 703-710.
11. Monteiro, M. A.; Ganeshapillai, J. Novel polysaccharide immunogens from Clostridium difficile. WO 2009/033268A1 (2009); US 2010/0330125A1 (2010); NZ 583750 (2012).
12. Bertolo, L.; Boncheff, A.; Chen, Y. H.; Ma, Z.; Wakeford, T.; Friendship, R. M.; Rosseau, J.; Weese, J. S.; Chu, M.; Mallozzi, M.; Vedantam, G.; Monteiro, M. A. Carbohydr. Res. 2012, 354, 79-86.
13. Monteiro, M. A.; Ma, Z.; Bertolo, L.; Jiao, Y.; Arroyo, L.; Hodgins, D.; Mallozzi, M.; Vedantam, G.; Sagermann, S.; Sundsmo, J.; Chow, H. Exp. Rev. Vaccines 2013, 12, 421-431.
14. Danieli, R.; Lay, L.; Proietti, D.; Berti, F.; Costantino, P.; Adamo, R. Org. Lett. 2011, 13, 378-381.
15. Oberli, M. A.; Hecht, M. L.; Bindschadler, P.; Adibekian, A.; Adam, T.; Seeberger, P. H. Chem. Biol. 2011, 18, 580-588.
16. Adamo, R.; Romano, M. R.; Berti, F.; Leuzzi, R.; Tontini, M.; Danieli, E.; Cappelletti, E.; Cakici, O. S.; Swennen, E.; Pinto, V.; Brogioni, B.; Proietti, D.; Galeotti, C. L.; Lay, L.; Monteiro, M. A.; Scarselli, M.; Costantino, P. ACS Chem. Biol. 2012, 7, 1420-1428.
17. Reid, C. W.; Vinogradov, E.; Li, J.; Jarrell, H. C.; Logan, S. M.; Brisson, J. R. Carbohydr. Res. 2012, 354, 65-73.
18. Martin, C. E.; Weishaupt, M. W.; Seeberger, P. H. Chem. Commun. (Camb.) 2011, 47, 10260-10262.
19. Jacquinet, J.-C. Carbohydr. Res. 2004, 339, 349-359.
20. Wendeln, C.; Heile, A.; Arlinghaus, H. F.; Ravoo, B. J. Langmuir 2010, 26, 4933-4940.
21. Biswas, G.; Jeon, O.; Lee, W. S.; Kim, D.-C.; Kim, K.-T.; Lee, S.; Chang, S. S.; Chung, S.-K. Chem. Eur. J. 2008, 14, 9161-9168.
22. Lefeber, D. J.; Kamerling, J. P.; Vliegenthart, J. F. G. Chem. Eur. J. 2001, 7, 4411-4421.
23. Tozuka, H.; Ota, M.; Kofujita, H.; Takahashi, K. J. Wood Sci. 2005, 51, 48-59.
24. Pfeifer, G.; Schirmer, J.; Leemhuis, J.; Busch, C.; Meyer, D. K.; Aktories, K.; Barth, H. J. Biol. Chem. 2003, 278, 44535-44541.
25. Zhang, J.; Zhu, Y.; Kong, F. Carbohydr. Res. 2001, 336, 229-235.
26. Sarkar, S.; Lombardo, S. A.; Herner, D. N.; Talan, R. S.; Wall, K. A.; Sucheck, S. J. J. Am. Chem. Soc. 2010, 132, 17236-17246.
27. Chen, W.; Gu, L.; Zhang, W.; Motari, E.; Cai, L.; Styslinger, T. J.; Wang, P. G. ACS Chem. Biol. 2011, 6, 185-191.