A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells

Biochemical and Biophysical Research Communications

Volumn 475, Issue 3, 2016, Pages 295-300

  Pham, Hung ^a   Hui, Hongxiang ^b,c   Morvaridi, Susan ^a   Cai, Jiena ^c   Zhang, Sanqi ^d   Tan, Jun ^e,f   Wu, Vincent ^g   Levin, Nancy ^h   Knudsen, Beatrice ^a,b   Goddard, William A ^e   Pandol, Stephen J ^a,b,g,h   Abrol, Ravinder ^a,b,e,h  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d XI'AN JIAOTONG UNIVERSITY   (China)

^e CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^f CHONGQING UNIVERSITY   (China)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h GIRx Metabolics Inc   (United States)

Author keywords

Diabetes; Enteroendocrine L cell; GLP 1; GPCR structure prediction; Gut receptors; Virtual ligand screening

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; TAS2R38 RECEPTOR; UNCLASSIFIED DRUG; LIGAND; TASTE RECEPTORS, TYPE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BITTER TASTE; CONTROLLED STUDY; DOSE RESPONSE; ENTEROENDOCRINE CELL; GENE SILENCING; GENETIC TRANSCRIPTION; HAPLOTYPE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; L CELL LINE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; TASTE BUD; AGONISTS; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DIABETES MELLITUS, TYPE 2; METABOLISM; MOLECULARLY TARGETED THERAPY;

ANIMALS; CELL LINE; DIABETES MELLITUS, TYPE 2; ENTEROENDOCRINE CELLS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; LIGANDS; MALE; MICE, INBRED BALB C; MOLECULAR TARGETED THERAPY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84971654866     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.04.149     Document Type: Article

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