Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells

Oncotarget

Volumn 7, Issue 12, 2016, Pages 13902-13916

  Phuong, Nguyen Thi Thuy ^a   Kim, Sang Kyum ^b   Im, Ji Hye ^a   Yang, Jin Won ^a   Choi, Min Chang ^a   Lim, Sung Chul ^c   Lee, Kwang Yeol ^d   Kim, Young Mi ^e   Yoon, Jeong Hoon ^f   Kang, Keon Wook ^a  

^a Seoul National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Chosun University   (South Korea)

^d Chonnam National University   (South Korea)

^e Hanyang University   (South Korea)

^f Wonkwang University   (South Korea)

Author keywords

MAT2A; MiR 146b; NF B; PTEN; Tamoxifen resistance

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 2; MICRORNA; MICRORNA 146A; MICRORNA 146B; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C FOS; PROTEIN C JUN; SOMATOMEDIN C; SYNAPTOTAGMIN I; TAMOXIFEN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR JUND; TRANSCRIPTION FACTOR NRF1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; MAT2A PROTEIN, HUMAN; MIRN146 MICRORNA, HUMAN; PTEN PROTEIN, HUMAN; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR NRF2; TUMOR MARKER;

ARTICLE; BINDING SITE; BREAST CANCER CELL LINE; CANCER RESISTANCE; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; UPREGULATION; APOPTOSIS; BREAST TUMOR; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; BIOMARKERS, TUMOR; BREAST NEOPLASMS; CELL PROLIFERATION; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; METHIONINE ADENOSYLTRANSFERASE; MICRORNAS; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PTEN PHOSPHOHYDROLASE; S-ADENOSYLMETHIONINE; SIGNAL TRANSDUCTION; TAMOXIFEN; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 84971654738     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5298     Document Type: Article

References (50)

1. Petrangeli E, Lubrano C, Ortolani F, Ravenna L, Vacca A, Sciacchitano S, Frati L, Gulino A. Estrogen receptors: new perspectives in breast cancer management. J Steroid Biochem Mol Biol. 1994; 49: 327-331.
2. Ali S, Coombes RC. Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer. 2002; 2:101-112.
3. Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007; 45: 1306-1312.
4. Lu SC, Mato JM. Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Alcohol. 2005; 35: 227-234.
5. Mato J, Alvarez L, Ortiz P, Pajares MA. S-adenosylmethionine synthesis: Molecular mechanisms and clinical implications. Pharmacol Ther. 1997; 73: 265-280.
6. Cai J, Sun W, Hwang J, Stain SC, Lu SC. Changes in S-adenosylmethionine synthetase in human liver cancer: Molecular characterization and significance. Hepatology. 1996; 24: 1090-1097.
7. Cai J, Mao Z, Hwang J-J, Lu SC. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer research. 1998; 58: 1444-1450.
8. Lu SC, Mato JM. S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol. 2008; 23: S73-S77.
9. Huang Z-Z, Mao Z, Cai J, Lu SC. Changes in methionine adenosyltransferase during liver regeneration in the rat. American Journal of Physiology-Gastrointestinal and Liver Physiology. 1998; 275: G14-G21.
10. Tobeña R, Horikawa S, Calvo V, Alemany S. Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation. Biochem J. 1996; 319: 929-933.
11. Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, LiT, SodirNM, Chen YH, Josef-Lenz H, LairdPW. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterol. 2007; 133: 207-218.
12. Phuong NTT, Kim SK, Lim SC, Kim HS, Kim TH, Lee KY, Ahn S-G, Yoon J-H, Kang KW. Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells. Breast cancer research and treatment. 2011; 130: 73-83.
13. Yang H, Huang Z-Z, Zeng Z, Chen C, Selby RR, Lu SC. Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2001; 280: G184-G190.
14. Choi HK, Yang JW, Roh SH, Han CY, Kang KW. Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells. Endocr Relat Cancer. 2007; 14: 293-303.
15. Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE, Nicholson RI. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology. 2003; 144: 1032-1044.
16. Jeong HG, Pokharel YR, Lim SC, Hwang YP, Han EH, Yoon J-H, Ahn S-G, Lee KY, Kang KW. Novel role of Pin1 induction in type II collagen-mediated rheumatoid arthritis. J Immunol. 2009; 183: 6689-6697.
17. Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K. Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Cancer research. 2009; 69: 2766-2774.
18. Lapidus RG, Nass SJ, Butash KA, Parl FF, Weitzman SA, Graff JG, Herman JG, Davidson NE. Mapping of ER gene CpG island methylation by methylation-specific polymerase chain reaction. Cancer research. 1998; 58: 2515-2519.
19. Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, Bussaglia E, Prat J, Harkes IC, Repasky EA. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. Journal of the National Cancer Institute. 2000; 92: 564-569.
20. Horwitz KB, Mockus MB, Lessey BA. Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance. Cell. 1982; 28: 633-642.
21. Karey KP, Sirbasku DA. Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17β-estradiol. Cancer research. 1988; 48: 4083-4092.
22. Yang H, Sadda MR, Yu V, Zeng Y, Lee TD, Ou X, Chen L, Lu SC. Induction of Human Methionine Adenosyltransferase 2A Expression by Tumor Necrosis Factor α ROLE OF NF-κB AND AP-1. Journal of Biological Chemistry. 2003; 278: 50887-50896.
23. Heping Y, Tony W, Jian P, Jose MM, Shelly CL. Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells. Biochemical Journal. 2011; 436: 507-516.
24. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. cell. 2004; 116: 281-297.
25. Bhaumik D, Scott G, Schokrpur S, Patil C, Campisi J, Benz C. Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells. Oncogene. 2008; 27: 5643-5647.
26. Giacinti L, Claudio PP, Lopez M, Giordano A. Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist. 2006; 11: 1-8.
27. Vandermoere F, El Yazidi-Belkoura I, Adriaenssens E, Lemoine J, Hondermarck H. The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-κB activation induced via interaction between Akt and IκB kinase-β in breast cancer cells. Oncogene. 2005; 24: 5482-5491.
28. Saitoh M, Ohmichi M, Takahashi K, Kawagoe J, Ohta T, Doshida M, Takahashi T, Igarashi H, Mori-Abe A, Du B. Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-κB cascade in human breast cancer cells. Endocrinology. 2005; 146: 4917-4925.
29. Song L, Xiong H, Li J, Liao W, Wang L, Wu J, Li M. Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-κB Pathway in Human Non-Small Cell Lung Cancer. Clinical Cancer Research. 2011; 17: 1839-1849.
30. Kloo B, Nagel D, Pfeifer M, Grau M, Düwel M, Vincendeau M, Dörken B, Lenz P, Lenz G, Krappmann D. Critical role of PI3K signaling for NF-κB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A. 2011; 108: 272-277.
31. Chao X, Zao J, Xiao-Yi G, Li-Jun M, Tao S. Blocking of PI3K/AKT induces apoptosis by its effect on NF-κB activity in gastric carcinoma cell line SGC7901. Biomed Pharmacother. 2010; 64: 600-604.
32. Kim SK, Yang JW, Kim MR, Roh SH, Kim HG, Lee KY, Jeong HG, Kang KW. Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. Free Radic Biol Med. 2008; 45: 537-546.
33. Kim MR, Choi HS, Yang JW, Park BC, Kim J-A, Kang KW. Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression. Mol Cancer Ther. 2009; 8: 2163-2171.
34. Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM. Bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene in Drosophila. Cell. 2003; 113: 25-36.
35. Cuellar TL, McManus MT. MicroRNAs and endocrine biology. J Endocrinol. 2005; 187: 327-332.
36. Ma Y, Li W, Wang H. Roles of miRNA in the initiation and development of colorectal carcinoma. Curr Pharm Des. 2013; 19: 1253-1261.
37. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ. A microRNA polycistron as a potential human oncogene. Nature. 2005; 435: 828-833.
38. Eades G, Yang M, Yao Y, Zhang Y, Zhou Q. miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. Journal of Biological Chemistry. 2011; 286: 40725-40733.
39. Rushworth SA. Targeting the oncogenic role of miRNA in human cancer using naturally occurring compounds. Br J Pharmacol. 2011; 162: 346-348.
40. Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR. Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer research. 2009; 69: 1279-1283.
41. Liu R, Liu C, Chen D, Yang W-H Liu, X Liu C-G, Dugas CM, Tang F, Zheng P, Liu Y. Foxp3 controls an miR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer research. 2015; 75: 1703-1713.
42. Yao Q, Cao Z, Tu C, Zhao Y, Liu H, Zhang S. MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2. Cancer letters. 2013; 335: 219-224.
43. Taganov KD, Boldin MP, Chang K-J D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006; 103: 12481-12486.
44. Yang X, Yan L, Davidson N. DNA methylation in breast cancer. Endocrine-related cancer. 2001; 8: 115-127.
45. Stambolic V, Suzuki A, De La Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998; 95: 29-39.
46. Fry MJ. Phosphoinositide -kinase signalling in breast cancer: how big a role might it play?. Breast Cancer Res. 2001; 3: 304-312.
47. Ahmad S, Singh N, Glazer RI. Role of AKT1 in 17β-estradiol-and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells. Biochem Pharmacol. 1999; 58: 425-430.
48. Jordan NJ, Gee JM, Barrow D, Wakeling AE, Nicholson RI. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast cancer research and treatment. 2004; 87: 167-180.
49. Frogne T, Jepsen J, Larsen S, Fog C, Brockdorff B, Lykkesfeldt A. Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. Endocr Relat Cancer. 2005; 12: 599-614.
50. Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res. 1999; 253: 210-229.