Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells

Biochemical Journal

Volumn 436, Issue 2, 2011, Pages 507-516

  Yang, Heping ^a   Li, Tony W H ^a   Peng, Jian ^a   Mato, José M ^b   Lu, Shelly C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

c Myb; Colon cancer; E2F; Insulin like growth factor 1 (IGF 1); Methionine adenosyltransferase 2A; Yin and Yang 1 (YY1)

Indexed keywords

CIS ACTING ELEMENT; DEOXYRIBONUCLEASE I; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 2A; PROTEIN C JUN; PROTEIN C MYB; SOMATOMEDIN C; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR MAFG; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG; UPSTREAM STIMULATORY FACTOR;

ARTICLE; CANCER CELL; COLON CANCER; ENZYME ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

COLONIC NEOPLASMS; HT29 CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; METHIONINE ADENOSYLTRANSFERASE; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 79956012402     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101754     Document Type: Article

References (26)

1. Jemal, A., Thomas, A., Murray, T. and Thun, M. (2002) Cancer Statistics, 2002. CA Cancer J. Clin. 52, 23-47
2. Piard, F., Chapusot, C., Ecarnot-Laubriet, A., Ponnelle, T. and Martin, L. (2002) Molecular markers of heterogeneity in colorectal cancers and adenomas. Eur J. Cancer Prevention 11, 85-97 (Pubitemid 34233082)
3. Roberts, R. B., Min, L., Washington, M. K., Olsen, S. J., Settle, S. H., Coffey, R. J. and Threadgill, D. W. (2002) Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 99, 1521-1526
4. Reinmuth, N., Fan, F., Liu, W., Parikh, A. A., Stoeltzing, O., Jung, Y. D., Bucana, C. D., Radinsky, R., Gallick, G. E. and Ellis, L. M. (2002) Impact of insulin-like growth factor receptor-1 function on angiogenesis, growth, and metastasis of colon cancer. Lab. Invest. 82, 1377-1389
5. Sekharam, M., Zhao, H., Sun, M., Fang, Q., Zhang, Q., Yuan, Z., Dan, H.C., Boulware, D., Cheng, J. Q. and Coppola, D. (2003) Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. Cancer Res. 63, 7708-7716
6. LeRoith, D. and Roberts, Jr, C. T. (2003) The insulin-like growth factor system and cancer. Cancer Lett. 195, 127-137 (Pubitemid 36588961)
7. Chen, H., Xia, M., Lin, M., Yang, H., Kuhlenkamp, J., Li, T., Sodir, N. M., Chen, Y. H., Josef-Lenz, H., Laird, P.W. et al. (2007) Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology 133, 207-218 (Pubitemid 47039238)
8. Lu, S. C. and Mato, J. M. (2008) S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J. Gastroenterol. Hepatol. 1, S73-S77
9. Yang, H., Huang, Z. Z., Zeng, Z. H., Chen, C. J., Selby, R. R. and Lu, S. C. (2001) Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. Am. J. Physiol. Gastroinstest. Liver Physiol. 280, G184-G190
10. Yang, H., Sadda, M. R., Yu, V., Zeng, Y., Lee, T. D., Ou, X., Chen, L. and Lu, S. C. (2003) Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor α. Role of NF-κB and AP-1. J. Biol. Chem. 278, 50887-50896
11. Mao, Z., Liu, S., Cai, J., Huang, Z. Z. and Lu, S. C. (1998) Cloning and functional characterization of the 5′-flanking region of human methionine adenosyltransferase 2A gene. Biochem. Biophys. Res. Commun. 248, 479-484
12. Yang, H., Huang, Z. Z., Wang, J. H. and Lu, S. C. (2001) The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. FASEB J. 15, 1507-1516
13. Yang, H., Magilnick, N., Ou, X. P. and Lu, S. C. (2005) Tumor necrosis factor α induces coordinated activation of rat GSH activation of rat GSH synthetic enzymes via nuclear factor κB and activator protein-1. Biochem. J. 391, 399-408
14. Cai, J., Sun, W. M., Hwang, J. J., Stain, S. C. and Lu, S. C. (1996) Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. Hepatology 24, 1090-1097
15. Ramani, K., Yang, H. P., Xia, M., Iglesias Ara, A., Mato, J. M. and Lu, S. C. (2008) Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2α and 2β. Hepatology 47, 521-531
16. Pollak, M. (2008) Insulin and insulin-like growth factor signaling. Nat. Rev. Cancer 8, 915-928
17. Eychene, A., Rocques, N. and Pouponnot, C. (2008) A new MAFia in cancer. Nat. Rev. Cancer 8, 683-693
18. Blank, V. (2008) Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? J. Mol. Biol. 376, 913-925
19. Wu, S., Murai, S., Kataoka, K. and Miyagishi, M. (2008) Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1. Biochem. Biophys. Res. Commun. 365, 75-81
20. Zheng, C., Ren, Z., Wang, H., Zhang, W., Kalvakolanu, D. V., Tian, Z. and Xiao, W. (2009) E2F1 Induces tumor cell survival via nuclear factor-κB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 69, 2324-2341
21. Liu, W., Liu, Y. and Lowe, Jr, W. L. (2001) The role of phosphatidylinositol 3-kinase and the mitogen-activated protein kinases in insulin-like growth factor-I-mediated effects in vascular endothelial cells. Endocrinology 142, 1710-1719 (Pubitemid 32405925)
22. Liu, Y., Ludes-Meyers, J., Zhang, Y., Munoz-Medellin, D., Kim, H. T., Lu, C., Ge, G., Schiff, R., Hilsenbeck, S. G., Osborne, C. K. and Brown, P. H. (2002) Inhibition of AP-1 transcription factor causes blockage of multiple signal transduction pathways and inhibits breast cancer growth. Oncogene 21, 7680-7689
23. Shen, W. H., Yin, Y., Broussard, S. R., McCusker, R. H., Freund, G. G., Dantzer, R. and Kelley, K. W. (2004) Tumor necrosis factor α inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis. J. Biol. Chem. 279, 7438-7446
24. Sui, G. (2009) The regulation of YY1 in tumorigenesis and its targeting potential in cancer therapy. Mol. Cell. Pharmacol. 1, 157-176
25. Ramsay, R. G. and Gonda, T. J. (2008) MYB function in normal and cancer cells. Nat. Rev. Cancer 8, 523-534
26. Reiss, K., Ferber, A., Travali, S., Porcu, P., Phillips, P. D. and Baserga, R. (1991) The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism. Cancer Res. 51, 5997-6000