Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine

Drug Discovery Today

Volumn 21, Issue 9, 2016, Pages 1489-1494

  Yoshii, Tatsuyuki ^a   Geng, Yingying ^a   Peyton, Shelly ^b   Mercurio, Arthur M ^c   Rotello, Vincent M ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b University of Massachusetts   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; NANOMATERIAL;

BIOMECHANICS; HUMAN; NANOMEDICINE; NEOPLASM; PATHOLOGY; PHYSIOLOGY; TUMOR MICROENVIRONMENT;

BIOMECHANICAL PHENOMENA; HUMANS; INTEGRINS; NANOMEDICINE; NANOSTRUCTURES; NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84971638462     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2016.05.011     Document Type: Review

References (55)

1. 1 Hynes, R.O., Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002), 673–687.
2. 2 Seguin, L., et al. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 25 (2015), 234–240.
3. 3 Kreso, A., Dick, J.E., Evolution of the cancer stem cell model. Cell Stem Cell 14 (2014), 275–291.
4. 4 Visvader, J.E., Lindeman, G.J., Cancer stem cells: current status and evolving complexities. Cell Stem Cell 10 (2012), 717–728.
5. 5 Farahani, E., et al. Cell adhesion molecules and their relation to (cancer) cell stemness. Carcinogenesis 35 (2014), 747–759.
6. 6 Lathia, J.D., et al. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell 6 (2010), 421–432.
7. 7 Chang, C., et al. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. Genes Dev. 29 (2015), 1–6.
8. 8 Plaks, V., et al. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?. Cell Stem Cell 16 (2015), 225–238.
9. 9 Desgrosellier, J.S., et al. Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev. Cell 30 (2014), 295–308.
10. 3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat. Cell Biol. 16 (2014), 457–468.
11. 11 Psaila, B., Lyden, D., The metastatic niche: adapting the foreign soil. Nat. Rev. Cancer 9 (2009), 285–293.
12. 12 Oskarsson, T., et al. Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14 (2014), 306–321.
13. 13 Colombo, M., et al. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30 (2014), 255–289.
14. 14 Minciacchi, V.R., et al. Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin. Cell Dev. Biol. 40 (2015), 41–51.
15. 15 Hoshino, A., et al. Tumour exosome integrins determine organotropic metastasis. Nature 527 (2015), 329–335.
16. 16 Lee, E.C., et al. The integrin α6β4 is a laminin receptor. J. Cell Biol. 117 (1992), 671–678.
17. 17 Elizabeth, A., et al. Mobilization and activation of a signaling competent α6β4 integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 24 (2005), 413–423.
18. 18 Caswell, P.T., et al. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 10 (2009), 843–853.
19. 19 Semenza, G.L., The hypoxic tumor microenvironment: a driving force for breast cancer progression. Biochim. Biophys. Acta 1863 (2016), 382–391.
20. 20 Yoon, S., et al. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the α6β4 integrin. Cancer Res. 65 (2005), 2761–2769.
21. 21 Duda, D.G., et al. Malignant cells facilitate lung metastasis by bringing their own soil. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 21677–21682.
22. 22 Paszek, M.J., et al. Tensional homeostasis and the malignant phenotype. Cancer Cell 8 (2005), 241–254.
23. 23 Provenzano, P.P., et al. Collagen reorganization at the tumor–stromal interface facilitates local invasion. BMC Med., 4, 2006, 38.
24. 24 Levental, K.R., et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139 (2009), 891–906.
25. 25 Chaudhuri, O., et al. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat. Mater. 13 (2014), 970–988.
26. 26 Shaw, L.M., et al. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91 (1997), 949–960.
27. 27 Samuel, M.S., et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 19 (2011), 776–791.
28. 28 Seo, B.R., et al. Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci. Transl. Med., 7, 2015, 310ra130.
29. 29 Conklin, M.W., Keely, P.J., Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adh. Migr. 6 (2012), 249–260.
30. 30 Fenner, J., et al. Macroscopic stiffness of breast tumors predicts metastasis. Sci. Rep., 4, 2014, 10.1038/srep05512.
31. 31 Budday, S., et al. Mechanical properties of gray and white matter brain tissue by indentation. J. Mech. Behav. Biomed. Mater. 46 (2015), 318–330.
32. 32 Luque, T., et al. Local micromechanical properties of decellularized lung scaffolds measured with atomic force microscopy. Acta Biomater. 9 (2013), 6852–6859.
33. 33 Jansen, L.E., Mechanics of intact bone marrow. J. Mech. Behav. Biomed. Mater. 50 (2015), 299–307.
34. 34 Herrick, W.G., et al. PEG-phosphorylcholine hydrogels as tunable and versatile platforms for mechanobiology. Biomacromolecules 14 (2013), 2294–2304.
35. 35 Barney, L.E., et al. A cell-ECM screening method to predict breast cancer metastasis. Integr. Biol. 7 (2015), 198–212.
36. 36 Kostic, A., et al. Differential matrix rigidity response in breast cancer cell lines correlates with the tissue tropism. PLoS One, 4, 2009, e6361.
37. 37 McGrail, D.J., et al. Actomyosin tension as a determinant of metastatic cancer mechanical tropism. Phys. Biol., 12, 2015 026001.
38. 38 Ehsan, S.M., et al. A three-dimensional in vitro model of tumor cell intravasation. Integr. Biol. 6 (2014), 603–610.
39. 39 Villasante, A., et al. Bioengineered human tumor within a bone niche. Biomaterials 35 (2014), 5785–5794.
40. 40 Dupont, S., et al. Role of YAP/TAZ in mechanotransduction. Nature 474 (2011), 179–183.
41. 41 Vishnoi, M., et al. Circulating tumor cells from a 4-dimensional lung cancer model are resistant to cisplatin. J. Thorac. Cardiovasc. Surg. 148 (2014), 1056–1063 discussion 1063-1054.
42. 42 Kenny, H.A., et al. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat. Commun., 6, 2015, 6220.
43. 43 van de Wetering, M., et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161 (2015), 933–945.
44. 44 Tilghman, R.W., et al. Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One, 5, 2010, e12905.
45. 45 Zustiak, S., et al. Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugss. Biotechnol. Bioeng. 111 (2014), 396–403.
46. 46 Nguyen, T.V., et al. Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening. Biomaterials 35 (2014), 5749–5759.
47. 47 Lin, C.H., et al. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Mol. Biol. Cell 26 (2015), 3946–3953.
48. 48 Nel, A.E., et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 8 (2009), 543–557.
49. 49 Cui, W., et al. Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth. Nanomedicine 8 (2012), 46–53.
50. 50 Tang, R., et al. Rapid coating of surfaces with functionalized nanoparticles for regulation of cell behavior. Adv. Mater. 26 (2014), 3310–3314.
51. 51 Grzincic, E.M., Murphy, C.J., Gold nanorods indirectly promote migration of metastatic human breast cancer cells in three-dimensional cultures. ACS Nano 9 (2015), 6801–6816.
52. 52 Peer, D., et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotech. 2 (2007), 751–760.
53. 53 De Vlieghere, E., et al. Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells. Biomaterials 54 (2015), 148–157.
54. 54 Liu, Y., et al. Gd-met allofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat. Commun., 6, 2015, 5988.
55. 55 Fiorillo, M., et al. Graphene oxide selectively targets cancer stem cells, across multiple tumor types: implications for non-toxic cancer treatment, via “differentiation-based nano-therapy”. Oncotarget 6 (2015), 3553–3562.