메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GADOLINIUM METALLOFULLERENOL NANOMATERIAL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PACLITAXEL; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; FULLERENE DERIVATIVE; GADOLINIUM; HIF1A PROTEIN, HUMAN; NANOMATERIAL;

EID: 84923166604     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6988     Document Type: Article
Times cited : (174)

References (52)
  • 1
    • 84866532149 scopus 로고    scopus 로고
    • Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine
    • Kang, S. G. et al. Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine. Proc. Natl Acad. Sci. USA 109, 15431-15436 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 15431-15436
    • Kang, S.G.1
  • 2
    • 36849067019 scopus 로고    scopus 로고
    • Nanocarriers as an emerging platform for cancer therapy
    • Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2, 751-760 (2007).
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 751-760
    • Peer, D.1
  • 3
    • 84881454232 scopus 로고    scopus 로고
    • Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance
    • Ge, Z. & Liu, S. Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance. Chem. Soc. Rev. 42, 7289-7325 (2013).
    • (2013) Chem. Soc. Rev. , vol.42 , pp. 7289-7325
    • Ge, Z.1    Liu, S.2
  • 4
    • 33745166633 scopus 로고    scopus 로고
    • Periodical variation of electronic properties in polyhydroxylated metallofullerene materials
    • Tang, J. et al. Periodical variation of electronic properties in polyhydroxylated metallofullerene materials. Adv. Mater. 18, 1458-1462 (2006).
    • (2006) Adv. Mater. , vol.18 , pp. 1458-1462
    • Tang, J.1
  • 5
    • 33645775271 scopus 로고    scopus 로고
    • Development of water-soluble metallofullerenes as X-ray contrast media
    • Miyamoto, A., Okimoto, H., Shinohara, H. & Shibamoto, Y. Development of water-soluble metallofullerenes as X-ray contrast media. Eur. Radiol. 16, 1050-1053 (2006).
    • (2006) Eur. Radiol. , vol.16 , pp. 1050-1053
    • Miyamoto, A.1    Okimoto, H.2    Shinohara, H.3    Shibamoto, Y.4
  • 6
    • 84887110350 scopus 로고    scopus 로고
    • Morphologically virus-Like fullerenol nanoparticles act as the dualfunctional nanoadjuvant for HIV-1 vaccine
    • Xu, L. et al. Morphologically virus-Like fullerenol nanoparticles act as the dualfunctional nanoadjuvant for HIV-1 vaccine. Adv. Mater. 25, 5928-5936 (2013).
    • (2013) Adv. Mater. , vol.25 , pp. 5928-5936
    • Xu, L.1
  • 7
    • 67349260747 scopus 로고    scopus 로고
    • The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/ Th2 cytokines and induction of TNF-alpha mediated cellular immunity
    • Liu, Y. et al. The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/ Th2 cytokines and induction of TNF-alpha mediated cellular immunity. Biomaterials 30, 3934-3945 (2009).
    • (2009) Biomaterials , vol.30 , pp. 3934-3945
    • Liu, Y.1
  • 8
    • 84855836038 scopus 로고    scopus 로고
    • Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: Imprisoning instead of poisoning cancer cells
    • Meng, H. et al. Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells. Nanomedicine 8, 136-146 (2012).
    • (2012) Nanomedicine , vol.8 , pp. 136-146
    • Meng, H.1
  • 9
    • 27544502160 scopus 로고    scopus 로고
    • Multihydroxylated [Gd@C82(OH) 22]n nanoparticles: Antineoplastic activity of high efficiency and low toxicity
    • Chen, C. et al. Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicity. Nano Lett. 5, 2050-2057 (2005).
    • (2005) Nano Lett. , vol.5 , pp. 2050-2057
    • Chen, C.1
  • 10
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers, H. The cancer stem cell: premises, promises and challenges. Nat. Med. 17, 313-319 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 313-319
    • Clevers, H.1
  • 11
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen, D. X., Bos, P. D. & Massagué, J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9, 274-284 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massagué, J.3
  • 12
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park, C. Y., Tseng, D. & Weissman, I. L. Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol. Ther. 17, 219-230 (2009).
    • (2009) Mol. Ther. , vol.17 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 13
    • 84872197199 scopus 로고    scopus 로고
    • Breast cancer heterogeneity: Need to review current treatment strategies
    • Malik, F., Korkaya, H., Clouthier, S. G. & Wicha, M. S. Breast cancer heterogeneity: need to review current treatment strategies. Curr. Breast Cancer Rep. 4, 225-231 (2012).
    • (2012) Curr. Breast Cancer Rep. , vol.4 , pp. 225-231
    • Malik, F.1    Korkaya, H.2    Clouthier, S.G.3    Wicha, M.S.4
  • 14
    • 80755169604 scopus 로고    scopus 로고
    • Triple-negative breast cancers and the human mammary epithelial cell hierarchy
    • Ganesan, S., Karantza, V., Oza, J. & Toppmeyer, D. Triple-negative breast cancers and the human mammary epithelial cell hierarchy. Breast Dis. 32, 49-61 (2010).
    • (2010) Breast Dis. , vol.32 , pp. 49-61
    • Ganesan, S.1    Karantza, V.2    Oza, J.3    Toppmeyer, D.4
  • 15
    • 84870904472 scopus 로고    scopus 로고
    • Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer
    • Alkatout, I. et al. Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer. Exp. Mol. Pathol. 94, 168-173 (2012).
    • (2012) Exp. Mol. Pathol. , vol.94 , pp. 168-173
    • Alkatout, I.1
  • 16
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009).
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 17
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559-1564 (2011).
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 18
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea - A paradigm shift
    • Wicha, M. S., Liu, S. & Dontu, G. Cancer stem cells: an old idea - A paradigm shift. Cancer Res. 66, 1883-1890 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 19
    • 19944385283 scopus 로고    scopus 로고
    • Tuning electronic properties of metallic atom in bondage to a nanospace
    • Tang, J. et al. Tuning electronic properties of metallic atom in bondage to a nanospace. J Phys. Chem. B 109, 8779-8785 (2005).
    • (2005) J Phys. Chem. B , vol.109 , pp. 8779-8785
    • Tang, J.1
  • 20
    • 84555202678 scopus 로고    scopus 로고
    • The structural stability of polyhydroxylated C60(OH) 24: Density functional theory characterizations
    • He, H., Zheng, L., Jin, P. & Yang, M. The structural stability of polyhydroxylated C60(OH)24: Density functional theory characterizations. Comput. Theor. Chem. 974, 16-20 (2011).
    • (2011) Comput. Theor. Chem. , vol.974 , pp. 16-20
    • He, H.1    Zheng, L.2    Jin, P.3    Yang, M.4
  • 21
    • 77953291042 scopus 로고    scopus 로고
    • Most stable structures of polyhydroxylated endohedral metallofullerene Gd@C82(OH) x (x?1-24) from density function theory
    • Zhang, J. et al. Most stable structures of polyhydroxylated endohedral metallofullerene Gd@C82(OH)x (x?1-24) from density function theory. Chem. Phys. Lett. 492, 68-70 (2010).
    • (2010) Chem. Phys. Lett. , vol.492 , pp. 68-70
    • Zhang, J.1
  • 22
    • 73249145214 scopus 로고    scopus 로고
    • Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis
    • Lao, F. et al. Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis. ACS Nano 3, 3358-3368 (2009).
    • (2009) ACS Nano , vol.3 , pp. 3358-3368
    • Lao, F.1
  • 23
    • 56449101145 scopus 로고    scopus 로고
    • The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials
    • Yin, J. J. et al. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials 30, 611-621 (2009).
    • (2009) Biomaterials , vol.30 , pp. 611-621
    • Yin, J.J.1
  • 24
    • 24644503098 scopus 로고    scopus 로고
    • Blast2GO: A universal tool for annotation, visualization and analysis in functional genomics research
    • Conesa, A. et al. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21, 3674-3676 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 3674-3676
    • Conesa, A.1
  • 25
    • 80051625243 scopus 로고    scopus 로고
    • Oxygen sensing, homeostasis, and disease
    • Semenza, G. L. Oxygen sensing, homeostasis, and disease. N. Engl J. Med. 365, 537-547 (2011).
    • (2011) N. Engl J. Med. , vol.365 , pp. 537-547
    • Semenza, G.L.1
  • 26
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008).
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 27
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta, P. B., Chaffer, C. L. & Weinberg, R. A. Cancer stem cells: mirage or reality? Nat. Med. 15, 1010-1012 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 28
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu, F. et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131, 1109-1123 (2007).
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1
  • 29
    • 84884769367 scopus 로고    scopus 로고
    • ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer
    • Chen, D. et al. ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer. Cancer Res. 73, 5821-5833 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 5821-5833
    • Chen, D.1
  • 30
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier, C. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1
  • 31
    • 84857407549 scopus 로고    scopus 로고
    • Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    • Conley, S. J. et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl Acad. Sci. USA 109, 2784-2789 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2784-2789
    • Conley, S.J.1
  • 32
    • 84888639681 scopus 로고    scopus 로고
    • The roles of TGFb in the tumour microenvironment
    • Pickup, M., Novitskiy, S. & Moses, H. L. The roles of TGFb in the tumour microenvironment. Nat. Rev. Cancer 13, 788-799 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 788-799
    • Pickup, M.1    Novitskiy, S.2    Moses, H.L.3
  • 33
    • 77952330272 scopus 로고    scopus 로고
    • Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma
    • Pistollato, F. et al. Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells 28, 851-862 (2010).
    • (2010) Stem Cells , vol.28 , pp. 851-862
    • Pistollato, F.1
  • 34
    • 84863715929 scopus 로고    scopus 로고
    • Cancer stem cells and their potential implications for the treatment of solid tumors
    • Grotenhuis, B. A., Wijnhoven, B. P. & van Lanschot, J. J. Cancer stem cells and their potential implications for the treatment of solid tumors. J. Surg. Oncol. 106, 209-215 (2012).
    • (2012) J. Surg. Oncol. , vol.106 , pp. 209-215
    • Grotenhuis, B.A.1    Wijnhoven, B.P.2    Van Lanschot, J.J.3
  • 35
    • 77957591579 scopus 로고    scopus 로고
    • Targeting breast cancer stem cells
    • Liu, S. & Wicha, M. S. Targeting breast cancer stem cells. J. Clin. Oncol. 28, 4006-4012 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4006-4012
    • Liu, S.1    Wicha, M.S.2
  • 36
    • 84867787091 scopus 로고    scopus 로고
    • Oxygen versus reactive oxygen in the regulation of HIF-1a: The balance tips
    • Hagen, T. Oxygen versus reactive oxygen in the regulation of HIF-1a: the balance tips. Biochem. Res. Int. 2012, 436981 (2012).
    • (2012) Biochem. Res. Int. , vol.2012 , pp. 436981
    • Hagen, T.1
  • 37
    • 27144528715 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
    • Doege, K., Heine, S., Jensen, I., Jelkmann, W. & Metzen, E. Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact. Blood 106, 2311-2317 (2005).
    • (2005) Blood , vol.106 , pp. 2311-2317
    • Doege, K.1    Heine, S.2    Jensen, I.3    Jelkmann, W.4    Metzen, E.5
  • 38
    • 34547914798 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger hypoxia-inducible factordependent extension of the replicative life span during hypoxia
    • Bell, E. L., Klimova, T. A., Eisenbart, J., Schumacker, P. T. & Chandel, N. S. Mitochondrial reactive oxygen species trigger hypoxia-inducible factordependent extension of the replicative life span during hypoxia. Mol. Cell Biol. 27, 5737-5745 (2007).
    • (2007) Mol. Cell Biol. , vol.27 , pp. 5737-5745
    • Bell, E.L.1    Klimova, T.A.2    Eisenbart, J.3    Schumacker, P.T.4    Chandel, N.S.5
  • 39
    • 84872341338 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate transforming growth factor-b signaling
    • Jain, M. et al. Mitochondrial reactive oxygen species regulate transforming growth factor-b signaling. J. Biol. Chem. 288, 770-777 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 770-777
    • Jain, M.1
  • 40
    • 30444452092 scopus 로고    scopus 로고
    • Spectroscopic and photophysical properties of a highly derivatized C60 fullerol
    • Vileno, B. et al. Spectroscopic and photophysical properties of a highly derivatized C60 fullerol. Adv. Funct. Mater. 16, 120-128 (2006).
    • (2006) Adv. Funct. Mater. , vol.16 , pp. 120-128
    • Vileno, B.1
  • 41
    • 34547578164 scopus 로고    scopus 로고
    • Fullerol cluster formation in aqueous solutions: Implications for environmental release
    • Brant, J. A., Robichaund, C. O. & Wiesner, M. Fullerol cluster formation in aqueous solutions: Implications for environmental release. J. Colloid Interface Sci. 314, 281-288 (2007).
    • (2007) J. Colloid Interface Sci. , vol.314 , pp. 281-288
    • Brant, J.A.1    Robichaund, C.O.2    Wiesner, M.3
  • 42
    • 84903730916 scopus 로고    scopus 로고
    • A precision structural model for fullerenols
    • Wang, Z. Z. et al. A precision structural model for fullerenols. Chem. Sci. 5, 2940-2948 (2014).
    • (2014) Chem. Sci. , vol.5 , pp. 2940-2948
    • Wang, Z.Z.1
  • 43
    • 65649139650 scopus 로고    scopus 로고
    • Fullerenol: A new nanopharmaceutic?
    • Aleksandar, D. & Gordana, B. Fullerenol: A new nanopharmaceutic? Arch. Oncol. 16, 42-45 (2008).
    • (2008) Arch. Oncol. , vol.16 , pp. 42-45
    • Aleksandar, D.1    Gordana, B.2
  • 44
    • 77955769029 scopus 로고    scopus 로고
    • Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods
    • Qiu, Y. et al. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. Biomaterials 31, 7606-7619 (2010).
    • (2010) Biomaterials , vol.31 , pp. 7606-7619
    • Qiu, Y.1
  • 45
    • 73949087550 scopus 로고    scopus 로고
    • Effect of surface properties on nanoparticle-cell interactions
    • Ayush, V. & Francesco, S. Effect of surface properties on nanoparticle-cell interactions. Small. 6, 12-21 (2010).
    • (2010) Small , vol.6 , pp. 12-21
    • Ayush, V.1    Francesco, S.2
  • 46
    • 32144458905 scopus 로고    scopus 로고
    • Antioxidative function and biodistribution of [Gd@C82(OH) 22]n nanoparticles in tumor-bearing mice
    • Wang, J. et al. Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice. Biochem. Pharmacol. 71, 872-881 (2006).
    • (2006) Biochem. Pharmacol , vol.71 , pp. 872-881
    • Wang, J.1
  • 47
    • 66449095667 scopus 로고    scopus 로고
    • A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis
    • Valastyan, S. et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137, 1032-1046 (2009).
    • (2009) Cell , vol.137 , pp. 1032-1046
    • Valastyan, S.1
  • 48
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682-688 (2007).
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 49
    • 77951978532 scopus 로고    scopus 로고
    • Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
    • Chan, C. H. et al. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat. Cell Biol. 12, 457-467 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 457-467
    • Chan, C.H.1
  • 50
    • 84855813448 scopus 로고    scopus 로고
    • A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    • Png, K. J. et al. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 481, 190-194 (2011).
    • (2011) Nature , vol.481 , pp. 190-194
    • Png, K.J.1
  • 51
    • 80052594392 scopus 로고    scopus 로고
    • BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment
    • Lang, J. Y. et al. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 20, 341-356 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 341-356
    • Lang, J.Y.1
  • 52
    • 84864026356 scopus 로고    scopus 로고
    • MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells
    • Liu, S. L. et al. MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet. 8, e1002751 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002751
    • Liu, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.