메뉴 건너뛰기




Volumn 94, Issue , 2016, Pages 4-14

Systems pharmacology – Towards the modeling of network interactions

Author keywords

Adaptive systems; Convergence; Disease progression; Hysteresis; Interdependency; Multi stationarity; Non adaptive systems; Non linearity; Oscillation; Resilience; Synergy; Variability

Indexed keywords

ARTICLE; BIOLOGY; CONCENTRATION RESPONSE; DISEASE COURSE; DRUG BINDING; DRUG DEVELOPMENT; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG RESEARCH; DRUG TARGETING; FEEDBACK SYSTEM; HYSTERESIS; MODEL; PHARMACODYNAMICS; PHARMACOKINETICS; PHYSIOLOGY; PRIORITY JOURNAL; STEADY STATE; ANIMAL; BIOLOGICAL MODEL; CLINICAL PHARMACOLOGY; HUMAN; PROCEDURES; SYSTEMS BIOLOGY; TRENDS;

EID: 84971619918     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2016.04.027     Document Type: Article
Times cited : (102)

References (77)
  • 1
    • 84894024419 scopus 로고    scopus 로고
    • Towards evidence-based dosing regimens in children on the basis of population pharmacokinetic pharmacodynamic modelling
    • Admiraal, R., van Kesteren, C., Boelens, J.J., Bredius, R.G., Tibboel, D., Knibbe, C.A., Towards evidence-based dosing regimens in children on the basis of population pharmacokinetic pharmacodynamic modelling. Arch. Dis. Child. 99 (2014), 267–272.
    • (2014) Arch. Dis. Child. , vol.99 , pp. 267-272
    • Admiraal, R.1    van Kesteren, C.2    Boelens, J.J.3    Bredius, R.G.4    Tibboel, D.5    Knibbe, C.A.6
  • 2
    • 84929263565 scopus 로고    scopus 로고
    • Current HER2 testing recommendations and clinical relevance as a predictor of response to targeted therapy
    • Ballinger, T.J., Sanders, M.E., Abramson, V.G., Current HER2 testing recommendations and clinical relevance as a predictor of response to targeted therapy. Clin. Breast Cancer 15 (2015), 171–180.
    • (2015) Clin. Breast Cancer , vol.15 , pp. 171-180
    • Ballinger, T.J.1    Sanders, M.E.2    Abramson, V.G.3
  • 3
    • 0028361591 scopus 로고
    • Pharmacodynamic models of nitroglycerin-induced hemodynamic tolerance in experimental heart failure
    • Bauer, J.A., Fung, H.L., Pharmacodynamic models of nitroglycerin-induced hemodynamic tolerance in experimental heart failure. Pharm. Res. 11 (1994), 816–823.
    • (1994) Pharm. Res. , vol.11 , pp. 816-823
    • Bauer, J.A.1    Fung, H.L.2
  • 4
    • 0036286631 scopus 로고    scopus 로고
    • Energy balance for analysis of complex metabolic networks
    • Beard, D.A., Liang, S.D., Qian, H., Energy balance for analysis of complex metabolic networks. Biophys. J. 83 (2002), 79–86.
    • (2002) Biophys. J. , vol.83 , pp. 79-86
    • Beard, D.A.1    Liang, S.D.2    Qian, H.3
  • 5
    • 84946384873 scopus 로고
    • The toxicity of poisons applied jointly
    • Bliss, C.I., The toxicity of poisons applied jointly. Ann. Appl. Biol. 26 (1939), 585–615.
    • (1939) Ann. Appl. Biol. , vol.26 , pp. 585-615
    • Bliss, C.I.1
  • 6
    • 0031936583 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor
    • Cox, E.H., Kerbusch, T., Van der Graaf, P.H., Danhof, M., Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor. J. Pharmacol. Exp. Ther. 284 (1998), 1095–1103.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 1095-1103
    • Cox, E.H.1    Kerbusch, T.2    Van der Graaf, P.H.3    Danhof, M.4
  • 7
    • 0031829642 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: assessment of rapid functional adaptation
    • Cox, E.H., Kuipers, J.A., Danhof, M., Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: assessment of rapid functional adaptation. Br. J. Pharmacol. 124 (1998), 1534–1540.
    • (1998) Br. J. Pharmacol. , vol.124 , pp. 1534-1540
    • Cox, E.H.1    Kuipers, J.A.2    Danhof, M.3
  • 9
    • 84942505656 scopus 로고    scopus 로고
    • Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models
    • Danhof, M., Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models. J. Pharmacokinet. Pharmacodyn. 42 (2015), 447–462.
    • (2015) J. Pharmacokinet. Pharmacodyn. , vol.42 , pp. 447-462
    • Danhof, M.1
  • 10
    • 0021276082 scopus 로고
    • Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex
    • Danhof, M., Levy, G., Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex. J. Pharmacol. Exp. Ther. 229 (1984), 44–50.
    • (1984) J. Pharmacol. Exp. Ther. , vol.229 , pp. 44-50
    • Danhof, M.1    Levy, G.2
  • 11
    • 33847028671 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis
    • Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A., Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis. Annu. Rev. Pharmacol. Toxicol. 47 (2007), 357–400.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 357-400
    • Danhof, M.1    de Jongh, J.2    De Lange, E.C.3    Della Pasqua, O.4    Ploeger, B.A.5    Voskuyl, R.A.6
  • 12
    • 41349119550 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research
    • Danhof, M., de Lange, E.C., Della Pasqua, O.E., Ploeger, B.A., Voskuyl, R.A., Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research. Trends Pharmacol. Sci. 29 (2008), 186–191.
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 186-191
    • Danhof, M.1    de Lange, E.C.2    Della Pasqua, O.E.3    Ploeger, B.A.4    Voskuyl, R.A.5
  • 13
    • 0027769745 scopus 로고
    • Comparison of four basic models of indirect pharmacodynamic responses
    • Dayneka, N.L., Garg, V., Jusko, W.J., Comparison of four basic models of indirect pharmacodynamic responses. J. Pharmacokinet. Biopharm. 21 (1993), 457–478.
    • (1993) J. Pharmacokinet. Biopharm. , vol.21 , pp. 457-478
    • Dayneka, N.L.1    Garg, V.2    Jusko, W.J.3
  • 14
    • 84931098560 scopus 로고    scopus 로고
    • Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration
    • De Cock, R.F., Allegaert, K., Brussee, J.M., Sherwin, C.M., Mulla, H., de Hoog, M., van den Anker, J.N., Danhof, M., Knibbe, C.A., Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration. Pharm. Res. 31 (2014), 2643–2654.
    • (2014) Pharm. Res. , vol.31 , pp. 2643-2654
    • De Cock, R.F.1    Allegaert, K.2    Brussee, J.M.3    Sherwin, C.M.4    Mulla, H.5    de Hoog, M.6    van den Anker, J.N.7    Danhof, M.8    Knibbe, C.A.9
  • 15
    • 33745779941 scopus 로고    scopus 로고
    • A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying type 2 diabetes mellitus
    • de Winter, W., DeJongh, J., Post, T., Ploeger, B., Urquhart, R., Moules, I., Eckland, D., Danhof, M., A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying type 2 diabetes mellitus. J. Pharmacokinet. Pharmacodyn. 33 (2006), 313–343.
    • (2006) J. Pharmacokinet. Pharmacodyn. , vol.33 , pp. 313-343
    • de Winter, W.1    DeJongh, J.2    Post, T.3    Ploeger, B.4    Urquhart, R.5    Moules, I.6    Eckland, D.7    Danhof, M.8
  • 17
    • 79956222044 scopus 로고    scopus 로고
    • Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats
    • Fang, J., DuBois, D.C., He, Y., Almon, R.R., Jusko, W.J., Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats. J. Pharmacokinet. Pharmacodyn. 38 (2011), 293–316.
    • (2011) J. Pharmacokinet. Pharmacodyn. , vol.38 , pp. 293-316
    • Fang, J.1    DuBois, D.C.2    He, Y.3    Almon, R.R.4    Jusko, W.J.5
  • 18
    • 84991546237 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetic models of small molecules and therapeutic antibodies: mini-review on fundamental concepts and applications
    • Ferl, G.Z., Theil, F.P., Wong, H., Physiologically-based pharmacokinetic models of small molecules and therapeutic antibodies: mini-review on fundamental concepts and applications. Biopharm. Drug Dispos., 2015.
    • (2015) Biopharm. Drug Dispos.
    • Ferl, G.Z.1    Theil, F.P.2    Wong, H.3
  • 19
    • 0027750786 scopus 로고
    • A mathematical model for dynamics of cardiovascular drug action: application to intravenous dihydropyridines in healthy volunteers
    • Francheteau, P., Steimer, J.L., Merdjan, H., Guerret, M., Dubray, C., A mathematical model for dynamics of cardiovascular drug action: application to intravenous dihydropyridines in healthy volunteers. J. Pharmacokinet. Biopharm. 21 (1993), 489–514.
    • (1993) J. Pharmacokinet. Biopharm. , vol.21 , pp. 489-514
    • Francheteau, P.1    Steimer, J.L.2    Merdjan, H.3    Guerret, M.4    Dubray, C.5
  • 20
    • 0033840732 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor “knockdown” in vivo
    • A, I.J.
    • Garrido, M., Gubbens-Stibbe, J., Tukker, E., Cox, E., von Frijtag, J., Kunzel, D., A, I.J., Danhof, M., van der Graaf, P.H., Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor “knockdown” in vivo. Pharm. Res. 17 (2000), 653–659.
    • (2000) Pharm. Res. , vol.17 , pp. 653-659
    • Garrido, M.1    Gubbens-Stibbe, J.2    Tukker, E.3    Cox, E.4    von Frijtag, J.5    Kunzel, D.6    Danhof, M.7    van der Graaf, P.H.8
  • 22
    • 84864231551 scopus 로고    scopus 로고
    • INDI: a computational framework for inferring drug interactions and their associated recommendations
    • Gottlieb, A., Stein, G.Y., Oron, Y., Ruppin, E., Sharan, R., INDI: a computational framework for inferring drug interactions and their associated recommendations. Mol. Syst. Biol., 8, 2012, 592.
    • (2012) Mol. Syst. Biol. , vol.8 , pp. 592
    • Gottlieb, A.1    Stein, G.Y.2    Oron, Y.3    Ruppin, E.4    Sharan, R.5
  • 23
    • 84899060421 scopus 로고    scopus 로고
    • Methods for pharmacokinetic analysis in young children
    • Himebauch, A.S., Zuppa, A., Methods for pharmacokinetic analysis in young children. Expert Opin. Drug Metab. Toxicol. 10 (2014), 497–509.
    • (2014) Expert Opin. Drug Metab. Toxicol. , vol.10 , pp. 497-509
    • Himebauch, A.S.1    Zuppa, A.2
  • 24
    • 0002143544 scopus 로고
    • Complex adaptive systems
    • Holland, J.H., Complex adaptive systems. Daedalus 121 (1992), 17–30.
    • (1992) Daedalus , vol.121 , pp. 17-30
    • Holland, J.H.1
  • 25
    • 33748946079 scopus 로고    scopus 로고
    • Studying complex adaptive systems
    • Holland, J.H., Studying complex adaptive systems. J. Syst. Sci. Complex. 19 (2006), 1–8.
    • (2006) J. Syst. Sci. Complex. , vol.19 , pp. 1-8
    • Holland, J.H.1
  • 26
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming, P., Sinning, C., Meyer, A., Drugs, their targets and the nature and number of drug targets. Nat. Rev. Drug Discov. 5 (2006), 821–834.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 28
  • 29
    • 0029163294 scopus 로고
    • Pharmacokinetics and receptor-mediated pharmacodynamics of corticosteroids
    • Jusko, W.J., Pharmacokinetics and receptor-mediated pharmacodynamics of corticosteroids. Toxicology 102 (1995), 189–196.
    • (1995) Toxicology , vol.102 , pp. 189-196
    • Jusko, W.J.1
  • 30
    • 0027943266 scopus 로고
    • Physiologic indirect response models characterize diverse types of pharmacodynamic effects
    • Jusko, W.J., Ko, H.C., Physiologic indirect response models characterize diverse types of pharmacodynamic effects. Clin. Pharmacol. Ther. 56 (1994), 406–419.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 406-419
    • Jusko, W.J.1    Ko, H.C.2
  • 31
    • 0023114637 scopus 로고
    • Nifedipine. Relationship between pharmacokinetics and pharmacodynamics
    • Kleinbloesem, C.H., van Brummelen, P., Breimer, D.D., Nifedipine. Relationship between pharmacokinetics and pharmacodynamics. Clin. Pharmacokinet. 12 (1987), 12–29.
    • (1987) Clin. Pharmacokinet. , vol.12 , pp. 12-29
    • Kleinbloesem, C.H.1    van Brummelen, P.2    Breimer, D.D.3
  • 34
    • 84922116880 scopus 로고    scopus 로고
    • Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs
    • Koizumi, Y., Iwami, S., Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs. Theor. Biol. Med. Model., 11, 2014, 41.
    • (2014) Theor. Biol. Med. Model. , vol.11 , pp. 41
    • Koizumi, Y.1    Iwami, S.2
  • 36
    • 3042548087 scopus 로고    scopus 로고
    • Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
    • Lemaire, V., Tobin, F.L., Greller, L.D., Cho, C.R., Suva, L.J., Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. J. Theor. Biol. 229 (2004), 293–309.
    • (2004) J. Theor. Biol. , vol.229 , pp. 293-309
    • Lemaire, V.1    Tobin, F.L.2    Greller, L.D.3    Cho, C.R.4    Suva, L.J.5
  • 37
    • 0013909219 scopus 로고
    • Kinetics of pharmacologic effects
    • Levy, G., Kinetics of pharmacologic effects. Clin. Pharmacol. Ther. 7 (1966), 362–372.
    • (1966) Clin. Pharmacol. Ther. , vol.7 , pp. 362-372
    • Levy, G.1
  • 38
    • 84868317121 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic modeling in inflammation
    • Lon, H.K., Liu, D., Jusko, W.J., Pharmacokinetic/pharmacodynamic modeling in inflammation. Crit. Rev. Biomed. Eng. 40 (2012), 295–312.
    • (2012) Crit. Rev. Biomed. Eng. , vol.40 , pp. 295-312
    • Lon, H.K.1    Liu, D.2    Jusko, W.J.3
  • 39
    • 33645119673 scopus 로고    scopus 로고
    • Prediction of headache response in migraine treatment
    • Maas, H.J., Danhof, M., Della Pasqua, O.E., Prediction of headache response in migraine treatment. Cephalalgia 26 (2006), 416–422.
    • (2006) Cephalalgia , vol.26 , pp. 416-422
    • Maas, H.J.1    Danhof, M.2    Della Pasqua, O.E.3
  • 40
    • 0026513875 scopus 로고
    • In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil
    • Mandema, J.W., Tukker, E., Danhof, M., In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil. J. Pharmacol. Exp. Ther. 260 (1992), 36–44.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 36-44
    • Mandema, J.W.1    Tukker, E.2    Danhof, M.3
  • 41
    • 84910646137 scopus 로고    scopus 로고
    • Systems biology, complexity, and the impact on antiepileptic drug discovery
    • Margineanu, D.G., Systems biology, complexity, and the impact on antiepileptic drug discovery. Epilepsy Behav. 38 (2014), 131–142.
    • (2014) Epilepsy Behav. , vol.38 , pp. 131-142
    • Margineanu, D.G.1
  • 42
    • 0029048215 scopus 로고
    • Prolactin release after remoxipride by an integrated pharmacokinetic-pharmacodynamic model with intra- and interindividual aspects
    • Movin-Osswald, G., Hammarlund-Udenaes, M., Prolactin release after remoxipride by an integrated pharmacokinetic-pharmacodynamic model with intra- and interindividual aspects. J. Pharmacol. Exp. Ther. 274 (1995), 921–927.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 921-927
    • Movin-Osswald, G.1    Hammarlund-Udenaes, M.2
  • 43
    • 0014441225 scopus 로고
    • Kinetics of pharmacologic effects in man: the anticoagulant action of warfarin
    • Nagashima, R., O'Reilly, R.A., Levy, G., Kinetics of pharmacologic effects in man: the anticoagulant action of warfarin. Clin. Pharmacol. Ther. 10 (1969), 22–35.
    • (1969) Clin. Pharmacol. Ther. , vol.10 , pp. 22-35
    • Nagashima, R.1    O'Reilly, R.A.2    Levy, G.3
  • 44
    • 84901501830 scopus 로고    scopus 로고
    • Molecular testing in breast cancer
    • Paoletti, C., Hayes, D.F., Molecular testing in breast cancer. Annu. Rev. Med. 65 (2014), 95–110.
    • (2014) Annu. Rev. Med. , vol.65 , pp. 95-110
    • Paoletti, C.1    Hayes, D.F.2
  • 45
    • 67649306822 scopus 로고    scopus 로고
    • Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling
    • Ploeger, B.A., van der Graaf, P.H., Danhof, M., Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling. Drug Metab. Pharmacokinet. 24 (2009), 3–15.
    • (2009) Drug Metab. Pharmacokinet. , vol.24 , pp. 3-15
    • Ploeger, B.A.1    van der Graaf, P.H.2    Danhof, M.3
  • 46
    • 23744516690 scopus 로고    scopus 로고
    • Disease system analysis: basic disease progression models in degenerative disease
    • Post, T.M., Freijer, J.I., DeJongh, J., Danhof, M., Disease system analysis: basic disease progression models in degenerative disease. Pharm. Res. 22 (2005), 1038–1049.
    • (2005) Pharm. Res. , vol.22 , pp. 1038-1049
    • Post, T.M.1    Freijer, J.I.2    DeJongh, J.3    Danhof, M.4
  • 48
    • 0036021823 scopus 로고    scopus 로고
    • Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats
    • Ramakrishnan, R., DuBois, D.C., Almon, R.R., Pyszczynski, N.A., Jusko, W.J., Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats. J. Pharmacokinet. Pharmacodyn. 29 (2002), 1–24.
    • (2002) J. Pharmacokinet. Pharmacodyn. , vol.29 , pp. 1-24
    • Ramakrishnan, R.1    DuBois, D.C.2    Almon, R.R.3    Pyszczynski, N.A.4    Jusko, W.J.5
  • 49
    • 79951765993 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetics in drug development and regulatory science
    • Rowland, M., Peck, C., Tucker, G., Physiologically-based pharmacokinetics in drug development and regulatory science. Annu. Rev. Pharmacol. Toxicol. 51 (2011), 45–73.
    • (2011) Annu. Rev. Pharmacol. Toxicol. , vol.51 , pp. 45-73
    • Rowland, M.1    Peck, C.2    Tucker, G.3
  • 50
    • 84946239939 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches: a systematic review of published models, applications, and model verification
    • Sager, J.E., Yu, J., Ragueneau-Majlessi, I., Isoherranen, N., Physiologically based pharmacokinetic (PBPK) modeling and simulation approaches: a systematic review of published models, applications, and model verification. Drug Metab. Dispos. 43 (2015), 1823–1837.
    • (2015) Drug Metab. Dispos. , vol.43 , pp. 1823-1837
    • Sager, J.E.1    Yu, J.2    Ragueneau-Majlessi, I.3    Isoherranen, N.4
  • 51
    • 54249107905 scopus 로고    scopus 로고
    • Failure is an option: learning from unsuccessful proof-of-concept trials
    • Schafer, S., Kolkhof, P., Failure is an option: learning from unsuccessful proof-of-concept trials. Drug Discov. Today 13 (2008), 913–916.
    • (2008) Drug Discov. Today , vol.13 , pp. 913-916
    • Schafer, S.1    Kolkhof, P.2
  • 53
    • 0031742890 scopus 로고    scopus 로고
    • Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena
    • Sharma, A., Ebling, W.F., Jusko, W.J., Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena. J. Pharm. Sci. 87 (1998), 1577–1584.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1577-1584
    • Sharma, A.1    Ebling, W.F.2    Jusko, W.J.3
  • 54
    • 0018394195 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine
    • Sheiner, L.B., Stanski, D.R., Vozeh, S., Miller, R.D., Ham, J., Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin. Pharmacol. Ther. 25 (1979), 358–371.
    • (1979) Clin. Pharmacol. Ther. , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 55
    • 84942193841 scopus 로고    scopus 로고
    • Optimization of dosing regimens and dosing in special populations
    • Sime, F.B., Roberts, M.S., Roberts, J.A., Optimization of dosing regimens and dosing in special populations. Clin. Microbiol. Infect. 21 (2015), 886–893.
    • (2015) Clin. Microbiol. Infect. , vol.21 , pp. 886-893
    • Sime, F.B.1    Roberts, M.S.2    Roberts, J.A.3
  • 56
    • 84910074506 scopus 로고    scopus 로고
    • The neuroscience of depression: implications for assessment and intervention
    • Singh, M.K., Gotlib, I.H., The neuroscience of depression: implications for assessment and intervention. Behav. Res. Ther. 62 (2014), 60–73.
    • (2014) Behav. Res. Ther. , vol.62 , pp. 60-73
    • Singh, M.K.1    Gotlib, I.H.2
  • 58
    • 84915790897 scopus 로고    scopus 로고
    • Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling
    • Snelder, N., Ploeger, B.A., Luttringer, O., Rigel, D.F., Fu, F., Beil, M., Stanski, D.R., Danhof, M., Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling. Br. J. Pharmacol. 171 (2014), 5076–5092.
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 5076-5092
    • Snelder, N.1    Ploeger, B.A.2    Luttringer, O.3    Rigel, D.F.4    Fu, F.5    Beil, M.6    Stanski, D.R.7    Danhof, M.8
  • 59
    • 84870441696 scopus 로고    scopus 로고
    • Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans
    • Stevens, J., Ploeger, B.A., Hammarlund-Udenaes, M., Osswald, G., van der Graaf, P.H., Danhof, M., de Lange, E.C., Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans. J. Pharmacokinet. Pharmacodyn. 39 (2012), 463–477.
    • (2012) J. Pharmacokinet. Pharmacodyn. , vol.39 , pp. 463-477
    • Stevens, J.1    Ploeger, B.A.2    Hammarlund-Udenaes, M.3    Osswald, G.4    van der Graaf, P.H.5    Danhof, M.6    de Lange, E.C.7
  • 60
    • 79959484646 scopus 로고    scopus 로고
    • A semiphysiological population model for prediction of the pharmacokinetics of drugs under liver and renal disease conditions
    • Strougo, A., Yassen, A., Krauwinkel, W., Danhof, M., Freijer, J., A semiphysiological population model for prediction of the pharmacokinetics of drugs under liver and renal disease conditions. Drug Metab. Dispos. 39 (2011), 1278–1287.
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1278-1287
    • Strougo, A.1    Yassen, A.2    Krauwinkel, W.3    Danhof, M.4    Freijer, J.5
  • 61
    • 84861483762 scopus 로고    scopus 로고
    • First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development
    • Strougo, A., Eissing, T., Yassen, A., Willmann, S., Danhof, M., Freijer, J., First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development. J. Pharmacokinet. Pharmacodyn. 39 (2012), 195–203.
    • (2012) J. Pharmacokinet. Pharmacodyn. , vol.39 , pp. 195-203
    • Strougo, A.1    Eissing, T.2    Yassen, A.3    Willmann, S.4    Danhof, M.5    Freijer, J.6
  • 63
    • 0030842321 scopus 로고    scopus 로고
    • Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling
    • Van der Graaf, P.H., Danhof, M., Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling. Int. J. Clin. Pharmacol. Ther. 35 (1997), 442–446.
    • (1997) Int. J. Clin. Pharmacol. Ther. , vol.35 , pp. 442-446
    • Van der Graaf, P.H.1    Danhof, M.2
  • 64
    • 0032789519 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo
    • Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M., Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo. J. Pharmacol. Exp. Ther. 290 (1999), 702–709.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 702-709
    • Van der Graaf, P.H.1    Van Schaick, E.A.2    Visser, S.A.3    De Greef, H.J.4    Ijzerman, A.P.5    Danhof, M.6
  • 66
    • 77953806651 scopus 로고    scopus 로고
    • Multiscale modeling in drug discovery and development: future opportunities and present challenges
    • Vicini, P., Multiscale modeling in drug discovery and development: future opportunities and present challenges. Clin. Pharmacol. Ther. 88 (2010), 126–129.
    • (2010) Clin. Pharmacol. Ther. , vol.88 , pp. 126-129
    • Vicini, P.1
  • 67
    • 0037216664 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations
    • Visser, S.A., Wolters, F.L., Gubbens-Stibbe, J.M., Tukker, E., Van Der Graaf, P.H., Peletier, L.A., Danhof, M., Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations. J. Pharmacol. Exp. Ther. 304 (2003), 88–101.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 88-101
    • Visser, S.A.1    Wolters, F.L.2    Gubbens-Stibbe, J.M.3    Tukker, E.4    Van Der Graaf, P.H.5    Peletier, L.A.6    Danhof, M.7
  • 68
    • 0003445619 scopus 로고
    • General System Theory: Foundations, Development, Applications
    • George Braziller New York (revised edition 1976)
    • von Bertalanffy, K.L., General System Theory: Foundations, Development, Applications. 1968, George Braziller, New York 0-8076-0453-4 (revised edition 1976).
    • (1968)
    • von Bertalanffy, K.L.1
  • 69
    • 84929687706 scopus 로고    scopus 로고
    • Dynamic network communication as a unifying neural basis for cognition, development, aging, and disease
    • Voytek, B., Knight, R.T., Dynamic network communication as a unifying neural basis for cognition, development, aging, and disease. Biol. Psychiatry 77 (2015), 1089–1097.
    • (2015) Biol. Psychiatry , vol.77 , pp. 1089-1097
    • Voytek, B.1    Knight, R.T.2
  • 70
    • 84862768064 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats
    • Westerhout, J., Ploeger, B., Smeets, J., Danhof, M., de Lange, E.C., Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats. AAPS J. 14 (2012), 543–553.
    • (2012) AAPS J. , vol.14 , pp. 543-553
    • Westerhout, J.1    Ploeger, B.2    Smeets, J.3    Danhof, M.4    de Lange, E.C.5
  • 71
    • 77749338894 scopus 로고    scopus 로고
    • Degeneracy: a link between evolvability, robustness and complexity in biological systems
    • Whitacre, J.M., Degeneracy: a link between evolvability, robustness and complexity in biological systems. Theor. Biol. Med. Model., 7, 2010, 6.
    • (2010) Theor. Biol. Med. Model. , vol.7 , pp. 6
    • Whitacre, J.M.1
  • 72
    • 33744949597 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers
    • Yassen, A., Olofsen, E., Romberg, R., Sarton, E., Danhof, M., Dahan, A., Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers. Anesthesiology 104 (2006), 1232–1242.
    • (2006) Anesthesiology , vol.104 , pp. 1232-1242
    • Yassen, A.1    Olofsen, E.2    Romberg, R.3    Sarton, E.4    Danhof, M.5    Dahan, A.6
  • 73
    • 38049160238 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats
    • Yassen, A., Olofsen, E., Kan, J., Dahan, A., Danhof, M., Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats. Pharm. Res. 25 (2008), 183–193.
    • (2008) Pharm. Res. , vol.25 , pp. 183-193
    • Yassen, A.1    Olofsen, E.2    Kan, J.3    Dahan, A.4    Danhof, M.5
  • 74
    • 34447620283 scopus 로고    scopus 로고
    • Artificial neural networks based on principal component analysis input selection for clinical pattern recognition analysis
    • Zhang, Y.X., Artificial neural networks based on principal component analysis input selection for clinical pattern recognition analysis. Talanta 73 (2007), 68–75.
    • (2007) Talanta , vol.73 , pp. 68-75
    • Zhang, Y.X.1
  • 76
    • 1342344538 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats
    • Zuideveld, K.P., Van der Graaf, P.H., Newgreen, D., Thurlow, R., Petty, N., Jordan, P., Peletier, L.A., Danhof, M., Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats. J. Pharmacol. Exp. Ther. 308 (2004), 1012–1020.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 1012-1020
    • Zuideveld, K.P.1    Van der Graaf, P.H.2    Newgreen, D.3    Thurlow, R.4    Petty, N.5    Jordan, P.6    Peletier, L.A.7    Danhof, M.8
  • 77
    • 34848838605 scopus 로고    scopus 로고
    • Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man
    • Zuideveld, K.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M., Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man. Pharm. Res. 24 (2007), 2031–2039.
    • (2007) Pharm. Res. , vol.24 , pp. 2031-2039
    • Zuideveld, K.P.1    Van der Graaf, P.H.2    Peletier, L.A.3    Danhof, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.