Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 38, Issue 3, 2011, Pages 293-316

  Fang, Jing ^a   Dubois, Debra C ^a   He, Yang ^a   Almon, Richard R ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Body weight; Food intake; Free fatty acids; Glucocorticoids; Glucose; Insulin; Methylprednisolone; Pharmacodynamics

Indexed keywords

CORTICOSTERONE; FATTY ACID; GLUCOSE; INSULIN; METHYLPREDNISOLONE SODIUM SUCCINATE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CALORIC INTAKE; COMPARTMENT MODEL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; GLYCEMIC CONTROL; HYPERINSULINEMIA; INHIBITION KINETICS; INSULIN BLOOD LEVEL; INSULIN RELEASE; LOW DRUG DOSE; MALE; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; WEIGHT CHANGE; WEIGHT REDUCTION;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CORTICOSTERONE; EATING; FATTY ACIDS, NONESTERIFIED; FEEDBACK, PHYSIOLOGICAL; GLYCEMIC INDEX; HYPERINSULINISM; INSULIN; MALE; METHYLPREDNISOLONE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; WEIGHT LOSS;

EID: 79956222044     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-011-9194-4     Document Type: Article

References (53)

1. M McMahon J Gerich R Rizza 1988 Effects of glucocorticoids on carbohydrate metabolism Diabetes Metab Rev 4 17 30 3278872 10.1002/dmr. 5610040105 1:CAS:528:DyaK3cXlvVCktr4%3D (Pubitemid 18072099)
2. A Ogawa JH Johnson M Ohneda CT McAllister L Inman T Alam RH Unger 1992 Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes J Clin Invest 90 497 504 1644920 10.1172/JCI115886 1:CAS:528: DyaK38XlsVersro%3D
3. L Stojanovska G Rosella J Proietto 1990 Evolution of dexamethasone- induced insulin resistance in rats Am J Physiol 258 E748 E756 2185660 1:CAS:528:DyaK3cXktFyjs7c%3D
4. A Rafacho VA Giozzet AC Boschero JR Bosqueiro 2008 Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance Pancreas 36 284 293 18362843 10.1097/MPA.0b013e31815ba826 1:CAS:528:DC%2BD1cXkvVentbs%3D (Pubitemid 351440934)
5. C Opherk F Tronche C Kellendonk D Kohlmuller A Schulze W Schmid G Schutz 2004 Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus Mol Endocrinol 18 1346 1353 15031319 10.1210/me.2003-0283 1:CAS:528:DC%2BD2cXksl2ju7o%3D (Pubitemid 38692174)
6. TW Gettys PM Watson IL Taylor S Collins 1997 RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice Int J Obes Relat Metab Disord 21 865 873 9347404 10.1038/sj.ijo.0800479 1:CAS:528:DyaK2sXmvFyqtL4%3D (Pubitemid 27427475)
7. VG Selyatitskaya OI Kuz'minova SV Odintsov 2002 Development of insulin resistance in experimental animals during long-term glucocorticoid treatment Bull Exp Biol Med 133 339 341 12124639 10.1023/A:1016281501423 1:CAS:528:DC%2BD38XltFKju7s%3D (Pubitemid 35189706)
8. CB Landersdorfer WJ Jusko 2008 Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus Clin Pharmacokinet 47 417 448 18563953 10.2165/00003088- 200847070-00001 1:CAS:528:DC%2BD1cXpslWqtLc%3D (Pubitemid 351861956)
9. SE Kahn RL Hull KM Utzschneider 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 840 846 17167471 10.1038/nature05482 1:CAS:528:DC%2BD28XhtlShtrzP (Pubitemid 46024990)
10. B Mlinar J Marc A Janez M Pfeifer 2007 Molecular mechanisms of insulin resistance and associated diseases Clin Chim Acta 375 20 35 16956601 10.1016/j.cca.2006.07.005 1:CAS:528:DC%2BD28XhtFWiu7vK (Pubitemid 44584240)
11. J Buren YC Lai M Lundgren JW Eriksson J Jensen 2008 Insulin action and signalling in fat and muscle from dexamethasone-treated rats Arch Biochem Biophys 474 91 101 18328801 10.1016/j.abb.2008.02.034 1:CAS:528: DC%2BD1cXmsVakt74%3D
12. CA Chu SM Sherck K Igawa DK Sindelar DW Neal M Emshwiller AD Cherrington 2002 Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs Am J Physiol Endocrinol Metab 282 E402 E411 11788373 1:CAS:528:DC%2BD38XhtFGitLg%3D
13. X Chen N Iqbal G Boden 1999 The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects J Clin Invest 103 365 372 9927497 10.1172/JCI5479 1:CAS:528:DyaK1MXovVKmsA%3D%3D (Pubitemid 29069986)
14. JR Williamson RA Kreisberg PW Felts 1966 Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver Proc Natl Acad Sci USA 56 247 254 4381783 10.1073/pnas.56.1.247 1:CAS:528:DyaF28XksF2hsbo%3D
15. J Delarue C Magnan 2007 Free fatty acids and insulin resistance Curr Opin Clin Nutr Metab Care 10 142 148 17285001 10.1097/MCO.0b013e328042ba90 1:CAS:528:DC%2BD2sXjs1ylsr0%3D (Pubitemid 46220305)
16. N Nicod V Giusti C Besse L Tappy 2003 Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers Obes Res 11 625 631 12740452 10.1038/oby.2003.90 1:CAS:528:DC%2BD3sXksVOgt7w%3D (Pubitemid 41151613)
17. JY Jin WJ Jusko 2009 Pharmacodynamics of glucose regulation by methylprednisolone. II. Normal rats Biopharm Drug Dispos 30 35 48 19156669 10.1002/bdd.642 1:CAS:528:DC%2BD1MXisFGjsLc%3D
18. JY Jin WJ Jusko 2009 Pharmacodynamics of glucose regulation by methylprednisolone. I. Adrenalectomized rats Biopharm Drug Dispos 30 21 34 19156931 10.1002/bdd.643 1:CAS:528:DC%2BD1MXisFGjsLY%3D
19. MF Dallman SE la Fleur NC Pecoraro F Gomez H Houshyar SF Akana 2004 Minireview: glucocorticoids-food intake, abdominal obesity, and wealthy nations in 2004 Endocrinology 145 2633 2638 15044359 10.1210/en.2004-0037 1:CAS:528:DC%2BD2cXkt12gtL8%3D (Pubitemid 38686208)
20. S Okada DA York GA Bray 1992 Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity Am J Physiol 262 R1106 R1110 1621865 1:CAS:528:DyaK38XkvVyjs74%3D
21. SC Langley DA York 1990 Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats Am J Physiol 259 R539 R544 2204281 1:CAS:528:DyaK3cXlvVCqt7o%3D
22. M Novelli A Pocai C Chiellini M Maffei P Masiello 2008 Free fatty acids as mediators of adaptive compensatory responses to insulin resistance in dexamethasone-treated rats Diabetes Metab Res Rev 24 155 164 18058844 10.1002/dmrr.785 1:CAS:528:DC%2BD1cXjtlemtrY%3D (Pubitemid 351284761)
23. M Barbera V Fierabracci M Novelli M Bombara P Masiello E Bergamini V De Tata 2001 Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment Eur J Endocrinol 145 799 806 11720907 10.1530/eje.0.1450799 1:CAS:528: DC%2BD3MXpt1GhtLk%3D (Pubitemid 33133689)
24. P De Vos R Saladin J Auwerx B Staels 1995 Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake J Biol Chem 270 15958 15961 7608151 10.1074/jbc.270.15.8971
25. DB Haughey WJ Jusko 1988 Analysis of methylprednisolone, methylprednisone and corticosterone for assessment of methylprednisolone disposition in the rat J Chromatogr 430 241 248 3235500 10.1016/S0378-4347(00)83159-X 1:CAS:528:DyaL1cXls1eltr8%3D
26. P D'Orazio RW Burnett N Fogh-Andersen E Jacobs K Kuwa WR Kulpmann L Larsson A Lewenstam AH Maas G Mager JW Naskalski AO Okorodudu 2005 Approved IFCC recommendation on reporting results for blood glucose (abbreviated) Clin Chem 51 1573 1576 16120945 10.1373/clinchem.2005.051979 (Pubitemid 41233089)
27. CB Landersdorfer DC DuBois RR Almon WJ Jusko 2009 Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats J Pharmacol Exp Ther 328 644 651 18971370 10.1124/jpet.108.144766 1:CAS:528:DC%2BD1MXhs1Kgs78%3D
28. D'Argenio DZ, Schumitzky A, Wang X (2009) ADAPT 5 user's guide: pharmacokinetic/pharmacodynamic systems analysis software. BioMedical Simulations Resource, Los Angeles
29. Dallman M, Bhatnagar S (2001) Chronic stress and energy balance: role of the hypothalamo/pituitary/adrenal axis. In: McEwen BS (ed) Handbook of physiology, section 7: the endocrine system, vol VII. Oxford University Press, New York, pp 179-210
30. L Devenport A Knehans A Sundstrom T Thomas 1989 Corticosterone's dual metabolic actions Life Sci 45 1389 1396 2796609 10.1016/0024-3205(89)90026-X 1:CAS:528:DyaL1MXmtV2gs70%3D (Pubitemid 19248167)
31. R Ramakrishnan DC DuBois RR Almon NA Pyszczynski WJ Jusko 2002 Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats J Pharmacokinet Pharmacodyn 29 1 24 12194533 10.1023/A:1015765201129 1:CAS:528: DC%2BD38XmslGmu7k%3D (Pubitemid 34831930)
32. JJ Lima N Matsushima N Kissoon J Wang JE Sylvester WJ Jusko 2004 Modeling the metabolic effects of terbutaline in beta2-adrenergic receptor diplotypes Clin Pharmacol Ther 76 27 37 15229461 10.1016/j.clpt.2004.03.006 1:CAS:528:DC%2BD2cXlsVaqtro%3D (Pubitemid 38844731)
33. D Qi B Rodrigues 2007 Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism Am J Physiol Endocrinol Metab 292 E654 E667 17077342 10.1152/ajpendo.00453.2006 1:CAS:528:DC%2BD2sXjsFeqsbo%3D (Pubitemid 46411042)
34. BG Slavin JM Ong PA Kern 1994 Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes J Lipid Res 35 1535 1541 7806967 1:CAS:528:DyaK2cXlvFKgsr0%3D (Pubitemid 24291214)
35. JM Ong RB Simsolo B Saffari PA Kern 1992 The regulation of lipoprotein lipase gene expression by dexamethasone in isolated rat adipocytes Endocrinology 130 2310 2316 1547742 10.1210/en.130.4.2310 1:CAS:528:DyaK38XisVyktrg%3D
36. G Boden 2005 Free fatty acids and insulin secretion in humans Curr Diab Rep 5 167 170 15929861 10.1007/s11892-005-0004-5 1:CAS:528:DC%2BD2MXhtFSkt7jI (Pubitemid 41599940)
37. CJ Nolan MS Madiraju V Delghingaro-Augusto ML Peyot M Prentki 2006 Fatty acid signaling in the beta-cell and insulin secretion Diabetes 55 Suppl 2 S16 S23 17130640 10.2337/db06-S003 1:CAS:528:DC%2BD28XhtlSisr7K (Pubitemid 44927028)
38. R Pelkonen TA Miettinen MR Taskinen EA Nikkila 1968 Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin Diabetes 17 76 82 5635728 1:CAS:528:DyaF1cXmslWgsA%3D%3D
39. SR Crespin WB Greenough III D Steinberg 1973 Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect J Clin Invest 52 1979 1984 4719673 10.1172/JCI107382 1:CAS:528:DyaE3sXkvFSisro%3D
40. YP Zhou VE Grill 1994 Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle J Clin Invest 93 870 876 8113418 10.1172/JCI117042 1:CAS:528:DyaK2cXktVWntb4%3D (Pubitemid 24072831)
41. Y Sako VE Grill 1990 A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation Endocrinology 127 1580 1589 1698143 10.1210/endo-127-4-1580 1:CAS:528:DyaK3cXlvVGisrs%3D (Pubitemid 20315212)
42. DT Stein V Esser BE Stevenson KE Lane JH Whiteside MB Daniels S Chen JD McGarry 1996 Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat J Clin Invest 97 2728 2735 8675683 10.1172/JCI118727 1:CAS:528:DyaK28XjvVWksrk%3D (Pubitemid 26197087)
43. RH Unger 1995 Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications Diabetes 44 863 870 7621989 10.2337/diabetes.44.8.863 1:CAS:528:DyaK2MXnsVSnsbo%3D
44. G Boden 2001 Free fatty acids-the link between obesity and insulin resistance Endocr Pract 7 44 51 11250769 1:STN:280:DC%2BD38visV2msA%3D%3D (Pubitemid 32834246)
45. A Roy RS Parker 2006 Dynamic modeling of free fatty acid, glucose, and insulin: an extended "minimal model" Diabetes Technol Ther 8 617 626 17109593 10.1089/dia.2006.8.617 1:CAS:528:DC%2BD28Xht1Smt7bL (Pubitemid 44871491)
46. RN Bergman LS Phillips C Cobelli 1981 Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose J Clin Invest 68 1456 1467 7033284 10.1172/JCI110398 1:CAS:528:DyaL38XpslOrsw%3D%3D (Pubitemid 12194400)
47. BV Howard I Klimes B Vasquez D Brady M Nagulesparan RH Unger 1984 The antilipolytic action of insulin in obese subjects with resistance to its glucoregulatory action J Clin Endocrinol Metab 58 544 548 6363441 10.1210/jcem-58-3-544 1:STN:280:DyaL2c7htF2lug%3D%3D (Pubitemid 14166162)
48. C Isaksson J Gabrielsson K Wallenius LA Peletier H Toreson 2009 Turnover modeling of non-esterified fatty acids in rats after multiple intravenous infusions of nicotinic acid Dose Response 7 247 269 19809543 10.2203/dose-response.08-028.Isaksson 1:CAS:528:DC%2BC3cXnt1KntLc%3D
49. EA van Schaick HJ de Greef AP Ijzerman M Danhof 1997 Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists J Pharmacokinet Biopharm 25 673 694 9697077 10.1023/A:1025777700413 (Pubitemid 28358090)
50. PH Van der Graaf EA Van Schaick SA Visser HJ De Greef AP Ijzerman M Danhof 1999 Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo J Pharmacol Exp Ther 290 702 709 10411581 (Pubitemid 29344565)
51. M Nawano A Oku K Ueta I Umebayashi T Ishirahara K Arakawa A Saito M Anai M Kikuchi T Asano 2000 Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats Am J Physiol Endocrinol Metab 278 E535 E543 10710509 1:CAS:528:DC%2BD3cXhvV2qur0%3D
52. S Sato K Katayama M Kakemi T Koizumi 1988 A kinetic study of chlorpromazine on the hyperglycemic response in rats. II. Effect of chlorpromazine on plasma glucose J Pharmacobiodyn 11 492 503 3054051 1:CAS:528:DyaL1cXlsVantrs%3D
53. R Hayashi H Wada K Ito IM Adcock 2004 Effects of glucocorticoids on gene transcription Eur J Pharmacol 500 51 62 15464020 10.1016/j.ejphar.2004.07.011 1:CAS:528:DC%2BD2cXotFCltbc%3D (Pubitemid 39303996)