Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: Assessment of rapid functional adaptation

British Journal of Pharmacology

Volumn 124, Issue 7, 1998, Pages 1534-1540

  Cox, E H ^a   Kuipers, J A ^a   Danhof, M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Alfentanil; EEG; Opiates; Pharmacokinetic pharmacodynamic modelling; Tolerance

Indexed keywords

ALFENTANIL; MU OPIATE RECEPTOR;

ADAPTATION; ANIMAL EXPERIMENT; ARTERIAL BLOOD; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG INFUSION; ELECTROENCEPHALOGRAM; GAS CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOLECULAR MODEL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; STEADY STATE;

ADAPTATION, PHYSIOLOGICAL; ALFENTANIL; ANALGESICS, OPIOID; ANIMALS; ELECTROENCEPHALOGRAPHY; HALF-LIFE; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR;

EID: 0031829642     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701972     Document Type: Article

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