Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: Comparison of pharmacokinetic, haemodynamic and EEG effects

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 6, 1997, Pages 827-837

  Van Schaick, E A ^a   Kulkarni, C ^a,c   Von Frijtag Drabbe Kunzel J K ^a   Mathot R A A ^a,d   Cristalli, G ^b   Ijzerman, A P ^a   Danhof, M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF CAMERINO   (Italy)

^c ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

^d Pharmacy of the Hospitals of the Hague   (Netherlands)

Author keywords

Adenosine A1 receptors; Conscious rats; EEG; Heart rate; Pharmacodynamics; Pharmacokinetics

Indexed keywords

6 N (4 SULFOPHENYL)ADENOSINE; 6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BRAIN CORTEX; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; ELECTROENCEPHALOGRAM; HEART RATE; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; LIPOPHILICITY; MALE; NONHUMAN; PHARMACODYNAMICS; PLASMA PROTEIN BINDING; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

EID: 0030777067     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005124     Document Type: Article

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