메뉴 건너뛰기




Volumn 49, Issue 7, 1997, Pages 627-638

Human jejunal effective permeability and its correlation with preclinical drug absorption models

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; GLUCOSE; GLYCOPROTEIN P; LEUCINE; LEVODOPA; METOPROLOL; PHENAZONE;

EID: 0030797273     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06084.x     Document Type: Review
Times cited : (188)

References (107)
  • 2
    • 0028948839 scopus 로고
    • Theoretical considerations in the correlation of in vitro drug product dissolution and in vivo bioavailability: A basis for a biopharmaceutics drug classification
    • Amidon, G. L., Lennernäs, H., Shah, V. P., Crison, J. (1995) Theoretical considerations in the correlation of in vitro drug product dissolution and in vivo bioavailability: a basis for a biopharmaceutics drug classification. Pharm. Res. 12: 413-420
    • (1995) Pharm. Res. , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernäs, H.2    Shah, V.P.3    Crison, J.4
  • 3
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson, P., Karlsson, J. (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 3: 880-885
    • (1991) Biochem. Biophys. Res. Commun. , vol.3 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 4
    • 0027312774 scopus 로고
    • Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments
    • Artursson, P., Ungell, A-L., Löfroth, J-E. (1993) Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm. Res. 10: 1123-1129
    • (1993) Pharm. Res. , vol.10 , pp. 1123-1129
    • Artursson, P.1    Ungell, A.-L.2    Löfroth, J.-E.3
  • 5
    • 85036484861 scopus 로고
    • Microdialysis for the quantitaive study of the distribution kinetics of the anti-epileptic drug, carbamazepine, to the brain
    • Seignosse, France Sept. 17-20 1994
    • Belle, van K., Ebinger G., Michotte Y. (1994) Microdialysis for the quantitaive study of the distribution kinetics of the anti-epileptic drug, carbamazepine, to the brain. Proc. 6th Int. Conference on In Vivo Methods. Seignosse, France Sept. 17-20 1994
    • (1994) Proc. 6th Int. Conference on in Vivo Methods
    • Van Belle, K.1    Ebinger, G.2    Michotte, Y.3
  • 6
    • 0030002504 scopus 로고    scopus 로고
    • The importance of drug metabolism and antitransport processes: A paradigm shift in oral drug delivery
    • Benet L. Z., Wu, C-Y., Hebert, M. F., Wacher, V. J. (1996) The importance of drug metabolism and antitransport processes: A paradigm shift in oral drug delivery. J. Contr. Rel. 39: 139-143
    • (1996) J. Contr. Rel. , vol.39 , pp. 139-143
    • Benet, L.Z.1    Wu, C.-Y.2    Hebert, M.F.3    Wacher, V.J.4
  • 7
    • 0021965327 scopus 로고
    • Regional differences in the lipid composition and fluidity of rat colonic brush-border membranes
    • Brasitus, H. A., Dudeja, P. K. (1985) Regional differences in the lipid composition and fluidity of rat colonic brush-border membranes. Biochim. Biophys. Acta 819: 10-17
    • (1985) Biochim. Biophys. Acta , vol.819 , pp. 10-17
    • Brasitus, H.A.1    Dudeja, P.K.2
  • 8
    • 0027267598 scopus 로고
    • Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells
    • Burton, P. S., Conradi, R. A., Hilgers, A. R., Ho, N. F. H. (1993) Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells. Biochem. Biophys. Res. Commun. 190: 760-766
    • (1993) Biochem. Biophys. Res. Commun. , vol.190 , pp. 760-766
    • Burton, P.S.1    Conradi, R.A.2    Hilgers, A.R.3    Ho, N.F.H.4
  • 9
    • 0030458462 scopus 로고    scopus 로고
    • How structural features influence the biomembrane permeability of peptides
    • Burton, P. S., Conradi, R. A., Ho, N. F. H., Hilgers, A. R., Borchardt, R. T. (1996) How structural features influence the biomembrane permeability of peptides. J. Pharm. Sci. 85: 1336-1340
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1336-1340
    • Burton, P.S.1    Conradi, R.A.2    Ho, N.F.H.3    Hilgers, A.R.4    Borchardt, R.T.5
  • 11
    • 0017410222 scopus 로고
    • Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals
    • Chadwick, V. S., Phillips, S. F., Hofmann, A. F. (1977) Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals. Gastroenterology 73: 247-251
    • (1977) Gastroenterology , vol.73 , pp. 247-251
    • Chadwick, V.S.1    Phillips, S.F.2    Hofmann, A.F.3
  • 12
    • 0028270064 scopus 로고
    • Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides
    • Chikhale, E. G., Ng K-Y., Burton, P. S., Borchardt, R. T. (1994) Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharm. Res. 11: 412-419
    • (1994) Pharm. Res. , vol.11 , pp. 412-419
    • Chikhale, E.G.1    Ng, K.-Y.2    Burton, P.S.3    Borchardt, R.T.4
  • 13
    • 0026513211 scopus 로고
    • The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability
    • Conradi, R. A., Hilgers, A. R., Ho, N. F. H., Burton, P. S. (1992) The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability. Pharm. Res. 9: 435-439
    • (1992) Pharm. Res. , vol.9 , pp. 435-439
    • Conradi, R.A.1    Hilgers, A.R.2    Ho, N.F.H.3    Burton, P.S.4
  • 14
    • 0023577560 scopus 로고
    • Transport across epithelial membranes
    • Cooper, E. R., Kasting, G. (1987) Transport across epithelial membranes. J. Contr. Rel. 6: 23-35
    • (1987) J. Contr. Rel. , vol.6 , pp. 23-35
    • Cooper, E.R.1    Kasting, G.2
  • 15
    • 0024544045 scopus 로고
    • The three multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal humans tissues
    • Croop, J. M., Raymond, M., Haber, D., Devault, A., Arceci, R. J., Gros, P., Houseman, D. (1989) The three multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal humans tissues. Mol. Cell Biol. 9: 1346-1350
    • (1989) Mol. Cell Biol. , vol.9 , pp. 1346-1350
    • Croop, J.M.1    Raymond, M.2    Haber, D.3    Devault, A.4    Arceci, R.J.5    Gros, P.6    Houseman, D.7
  • 18
    • 0025344378 scopus 로고
    • Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferase in rat and human hepatic and extrahepatic tissues
    • De Waizers I. (1990) Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferase in rat and human hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 253: 387-394
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 387-394
    • De Waizers, I.1
  • 19
    • 0029077886 scopus 로고
    • News and views: How to be physiological
    • Diamond, J. M. (1995) News and views: How to be physiological. Nature 376: 117-8
    • (1995) Nature , vol.376 , pp. 117-118
    • Diamond, J.M.1
  • 20
    • 0001608810 scopus 로고
    • Animal models for drug absorption
    • Welling, P. G., Tse, F. L. S., Dighe, S. V. (eds) Marcel Dekker
    • Dressman, J., Yamada, T. (1991) Animal models for drug absorption. In: Welling, P. G., Tse, F. L. S., Dighe, S. V. (eds) Pharmaceutical Bioequivalence, Marcel Dekker. p. 250.
    • (1991) Pharmaceutical Bioequivalence , pp. 250
    • Dressman, J.1    Yamada, T.2
  • 21
    • 0028840557 scopus 로고
    • Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption
    • Fagerholm, U., Lennernäs, H. (1995) Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption. Eur J. Pharm. Sci. 3: 247-253
    • (1995) Eur J. Pharm. Sci. , vol.3 , pp. 247-253
    • Fagerholm, U.1    Lennernäs, H.2
  • 22
    • 0028818676 scopus 로고
    • The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum
    • Fagerholm, U., Borgström, L., Ahrenstedt, Ö., Lennernäs H. (1995) The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum. J. Drug Targeting 3: 191-200
    • (1995) J. Drug Targeting , vol.3 , pp. 191-200
    • Fagerholm, U.1    Borgström, L.2    Ahrenstedt, Ö.3    Lennernäs, H.4
  • 23
    • 0242287624 scopus 로고    scopus 로고
    • The correlation between rat and human small intestinal permeability to drugs with different physico-chemical properties
    • Fagerholm, U., Johansson, M., Lennernäs, H. (1996) The correlation between rat and human small intestinal permeability to drugs with different physico-chemical properties. Pharm. Res. 13: 1335-1341
    • (1996) Pharm. Res. , vol.13 , pp. 1335-1341
    • Fagerholm, U.1    Johansson, M.2    Lennernäs, H.3
  • 24
    • 0027275691 scopus 로고
    • Effect of D-glucose on intestinal permeability and its passive absorption in human small intestine in vivo
    • Fine, K. D., Santa Ana, C. A., Porter, J. L., Fordtran, J. S. (1993) Effect of D-glucose on intestinal permeability and its passive absorption in human small intestine in vivo. Gastroenterology 105: 1117-1125
    • (1993) Gastroenterology , vol.105 , pp. 1117-1125
    • Fine, K.D.1    Santa Ana, C.A.2    Porter, J.L.3    Fordtran, J.S.4
  • 25
    • 0013594791 scopus 로고
    • Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo
    • Fine, K. D., Santa Ana, C. A., Porter, J. L., Fordtran, J. S. (1994) Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo. Gastroenterology 109: 1391-1396
    • (1994) Gastroenterology , vol.109 , pp. 1391-1396
    • Fine, K.D.1    Santa Ana, C.A.2    Porter, J.L.3    Fordtran, J.S.4
  • 26
    • 0016053262 scopus 로고
    • Mass transport phenomena and models: Theoretical concepts
    • Flynn, G. L., Yalkowsky, S. H., Roseman, T. J. (1974) Mass transport phenomena and models: theoretical concepts. J. Pharm. Sci. 63: 479-509
    • (1974) J. Pharm. Sci. , vol.63 , pp. 479-509
    • Flynn, G.L.1    Yalkowsky, S.H.2    Roseman, T.J.3
  • 27
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • Ford, J. M., Hait, W. N. (1990) Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 42: 155-199
    • (1990) Pharmacol. Rev. , vol.42 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 28
    • 0029986277 scopus 로고    scopus 로고
    • Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro and in vivo correlation
    • Fricker, G., Drewe, J., Huwyle, J., Gutman, H., Beglinger, C. (1996) Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro and in vivo correlation. Br. J. Pharmacol. 118: 1841-1847
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1841-1847
    • Fricker, G.1    Drewe, J.2    Huwyle, J.3    Gutman, H.4    Beglinger, C.5
  • 29
    • 0026442154 scopus 로고
    • Intestinal water absorption from select carbohydrate solutions in humans
    • Gisolfi, C. V., Summers, R. W., Schedl, P., Bleiler, T. L. (1992) Intestinal water absorption from select carbohydrate solutions in humans. J. Appl. Physiol. 73: 2142-2150
    • (1992) J. Appl. Physiol. , vol.73 , pp. 2142-2150
    • Gisolfi, C.V.1    Summers, R.W.2    Schedl, P.3    Bleiler, T.L.4
  • 30
    • 0028348967 scopus 로고
    • Pharmacokinetic considerations in rational drug design
    • Gumbleton, M., Sneader, W. (1994) Pharmacokinetic considerations in rational drug design. Clin. Pharmacokin. 26: 161-168
    • (1994) Clin. Pharmacokin. , vol.26 , pp. 161-168
    • Gumbleton, M.1    Sneader, W.2
  • 31
    • 0029999340 scopus 로고    scopus 로고
    • Direct demonstration of small intestinal secretion and site-dependent absorption of the β-blocker talinolol in humans
    • Gramatté, T., Oertel, R., Terhaag, B., Kirch, W. (1996) Direct demonstration of small intestinal secretion and site-dependent absorption of the β-blocker talinolol in humans. Clin. Pharmacol. Ther. 59: 541-549
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 541-549
    • Gramatté, T.1    Oertel, R.2    Terhaag, B.3    Kirch, W.4
  • 32
    • 0002698633 scopus 로고
    • Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans
    • Crouthamel, W., Sarapu, A. C. (eds) In Situ and In Vivo Approaches. American Pharmaceutical Association, Washington D.C.
    • Ho, N. F. H., Park, J. Y., Ni, P. F., Higuchi W. I. (1983) Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans. In: Crouthamel, W., Sarapu, A. C. (eds) Animal Models for Oral Drug Delivery in Man; In Situ and In Vivo Approaches. American Pharmaceutical Association, Washington D.C., pp 27-106
    • (1983) Animal Models for Oral Drug Delivery in Man , pp. 27-106
    • Ho, N.F.H.1    Park, J.Y.2    Ni, P.F.3    Higuchi, W.I.4
  • 33
    • 0030588585 scopus 로고    scopus 로고
    • Carrier-mediated transport and efflux mechanisms in Caco-2 cells
    • Hidalgo, I. J., Li, J. (1996) Carrier-mediated transport and efflux mechanisms in Caco-2 cells. Adv. Drug Del. Rev. 22: 53-66
    • (1996) Adv. Drug Del. Rev. , vol.22 , pp. 53-66
    • Hidalgo, I.J.1    Li, J.2
  • 34
    • 0021273701 scopus 로고
    • Solvent drag in jejunal absorption of salicylic acid and antipyrine obtained by in situ single-pass perfusion method in rat
    • Hirasawa, T., Muraoka, T., Karino, A., Hayashi, M., Awazu, S. (1984) Solvent drag in jejunal absorption of salicylic acid and antipyrine obtained by in situ single-pass perfusion method in rat. J. Pharmacobiodyn. 7: 246-253
    • (1984) J. Pharmacobiodyn. , vol.7 , pp. 246-253
    • Hirasawa, T.1    Muraoka, T.2    Karino, A.3    Hayashi, M.4    Awazu, S.5
  • 35
    • 0024603496 scopus 로고
    • Polyethylene glycol 900 permeability of rat intestinal and colonic segments in vivo and brush border membrane vesicles in vitro
    • Hollander, D., Koyama, S., Dadufalza, V., Tran, D. Q., Krugliak, P., Ma, T., Ling, K-Y. (1989) Polyethylene glycol 900 permeability of rat intestinal and colonic segments in vivo and brush border membrane vesicles in vitro. J. Lab. Clin. Med. 113: 505-515
    • (1989) J. Lab. Clin. Med. , vol.113 , pp. 505-515
    • Hollander, D.1    Koyama, S.2    Dadufalza, V.3    Tran, D.Q.4    Krugliak, P.5    Ma, T.6    Ling, K.-Y.7
  • 36
    • 0025668535 scopus 로고
    • Mechanism of L-a-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)
    • Hu, M., Borchardt, R. T (1990). Mechanism of L-a-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm. Res. 7: 1313-1319
    • (1990) Pharm. Res. , vol.7 , pp. 1313-1319
    • Hu, M.1    Borchardt, R.T.2
  • 37
    • 0025966854 scopus 로고
    • Comparison of rat and human intestinal perfusion models for assessing efficacy of oral rehydration solutions
    • Hunt, J. B., Elliott, R. J., Farthing, M. J. G. (1991) Comparison of rat and human intestinal perfusion models for assessing efficacy of oral rehydration solutions. Aliment. Pharmacol. Ther. 5: 49-59
    • (1991) Aliment. Pharmacol. Ther. , vol.5 , pp. 49-59
    • Hunt, J.B.1    Elliott, R.J.2    Farthing, M.J.G.3
  • 39
    • 0024378474 scopus 로고
    • A new technique for segmental jejunal perfusion in man
    • Knutson, L., Odlind, B., Hällgren, R. (1989) A new technique for segmental jejunal perfusion in man. Am. J. Gastroenterol. 84: 1278-1284
    • (1989) Am. J. Gastroenterol. , vol.84 , pp. 1278-1284
    • Knutson, L.1    Odlind, B.2    Hällgren, R.3
  • 40
    • 0025216985 scopus 로고
    • The jejunal secretion of histamine is increased in active Crohn's disease
    • Knutson, L., Ahrenstedt, Ö. B., Odlind, B., Hällgren, R. (1990) The jejunal secretion of histamine is increased in active Crohn's disease. Gastroenterology 98: 849-854
    • (1990) Gastroenterology , vol.98 , pp. 849-854
    • Knutson, L.1    Ahrenstedt, Ö.B.2    Odlind, B.3    Hällgren, R.4
  • 41
    • 0025719746 scopus 로고
    • First-pass metabolism of cyclosporin by the gut
    • Kolars, J .C., Awni, W. M., Merion, R. M., Watkins, P. B. (1991) First-pass metabolism of cyclosporin by the gut. Lancet 338: 1488-1490
    • (1991) Lancet , vol.338 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.M.2    Merion, R.M.3    Watkins, P.B.4
  • 42
    • 0018850819 scopus 로고
    • Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
    • Komiya, I., Park, J. Y., Kamani, A., Ho, N. F. H., Higuchi, W. I. (1980) Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int. J. Pharmaceut. 4: 249-262
    • (1980) Int. J. Pharmaceut. , vol.4 , pp. 249-262
    • Komiya, I.1    Park, J.Y.2    Kamani, A.3    Ho, N.F.H.4    Higuchi, W.I.5
  • 43
    • 0027998369 scopus 로고
    • Determinants of apical membrane permeabilities of barrier epithelia
    • Lande, M. B., Priver, N. A., Zeidel, M. L (1994) Determinants of apical membrane permeabilities of barrier epithelia. Am. J. Physiol. 267: C367-C374
    • (1994) Am. J. Physiol. , vol.267
    • Lande, M.B.1    Priver, N.A.2    Zeidel, M.L.3
  • 44
    • 0029045414 scopus 로고
    • The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons
    • Lande, M. B., Donovan, J. M., Zeidel, M. L (1995) The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons. J. Gen. Physiol. 106: 67-84
    • (1995) J. Gen. Physiol. , vol.106 , pp. 67-84
    • Lande, M.B.1    Donovan, J.M.2    Zeidel, M.L.3
  • 45
    • 0026795241 scopus 로고
    • Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man
    • Lennernäs, H., Ahrenstedt, Ö., Hällgren, R., Knutson, L., Ryde, M., Paalzow, L.K. (1992) Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm. Res. 9: 1243-1251
    • (1992) Pharm. Res. , vol.9 , pp. 1243-1251
    • Lennernäs, H.1    Ahrenstedt, Ö.2    Hällgren, R.3    Knutson, L.4    Ryde, M.5    Paalzow, L.K.6
  • 47
    • 0028141584 scopus 로고
    • Gastrointestinal absorption mechanisms: A comparison between animal and human models
    • Lennernäs, H. (1994) Gastrointestinal absorption mechanisms: a comparison between animal and human models. Eur J. Pharm. Sci. 2: 39-43
    • (1994) Eur J. Pharm. Sci. , vol.2 , pp. 39-43
    • Lennernäs, H.1
  • 48
    • 0029557644 scopus 로고
    • Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?
    • Lennernäs, H. (1995) Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation? Pharm. Res. 12: 1573-82
    • (1995) Pharm. Res. , vol.12 , pp. 1573-1582
    • Lennernäs, H.1
  • 49
    • 0027178256 scopus 로고
    • Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat
    • Lennernäs, H., Regårdh, C. G. (1993) Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat. Pharm. Res. 5: 727-731
    • (1993) Pharm. Res. , vol.5 , pp. 727-731
    • Lennernäs, H.1    Regårdh, C.G.2
  • 50
    • 0027315394 scopus 로고
    • Presystemic elimination of pafenolol in the rat after oral and ip administration and identification of the main metabolite in both rats and humans
    • Lennernäs, H., Renberg, L., Hoffman, K-J., Regårdh, C. G. (1993) Presystemic elimination of pafenolol in the rat after oral and ip administration and identification of the main metabolite in both rats and humans. Drug Metabol. Disp. 21: 435-440
    • (1993) Drug Metabol. Disp. , vol.21 , pp. 435-440
    • Lennernäs, H.1    Renberg, L.2    Hoffman, K.-J.3    Regårdh, C.G.4
  • 51
    • 0028307188 scopus 로고
    • Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat
    • Lennernäs, H., Ahrenstedt, Ö., Ungell, A-L. (1994) Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat. Br. J. Clin. Pharmacol. 37: 589-596
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 589-596
    • Lennernäs, H.1    Ahrenstedt, Ö.2    Ungell, A.-L.3
  • 52
    • 0344383697 scopus 로고
    • Human effective permeability data for furosemide, hydrochlorthiazide, ketoprofen and naproxen to be used in the proposed biopharmaceutical classification for IR-products
    • Lennernäs, H., Knutson, L., Knutson, T., Lesko, L., Salmonson, T., Amidon, G. L. (1995a) Human effective permeability data for furosemide, hydrochlorthiazide, ketoprofen and naproxen to be used in the proposed biopharmaceutical classification for IR-products. Pharm. Res. 12: 396
    • (1995) Pharm. Res. , vol.12 , pp. 396
    • Lennernäs, H.1    Knutson, L.2    Knutson, T.3    Lesko, L.4    Salmonson, T.5    Amidon, G.L.6
  • 53
    • 0345402723 scopus 로고
    • Human effective permeabilitiy data for atenolol, metoprolol and carbamazepine to be used in the proposed biopharmaceutical classification for IR-products
    • Lennernäs, H., Knutson, L., Knutson, T., Lesko, L., Salmonson, T., Amidon, G. L. (1995b) Human effective permeabilitiy data for atenolol, metoprolol and carbamazepine to be used in the proposed biopharmaceutical classification for IR-products. Pharm. Res. 12: 295
    • (1995) Pharm. Res. , vol.12 , pp. 295
    • Lennernäs, H.1    Knutson, L.2    Knutson, T.3    Lesko, L.4    Salmonson, T.5    Amidon, G.L.6
  • 54
    • 0029562752 scopus 로고
    • Permeability and clearance views of drug absorption: A commentary
    • Lennernäs, H., Crison, J., Amidon, G. L. (1995c) Permeability and clearance views of drug absorption: a commentary. J. Pharmacokin. Biopharm. 23: 333-337
    • (1995) J. Pharmacokin. Biopharm. , vol.23 , pp. 333-337
    • Lennernäs, H.1    Crison, J.2    Amidon, G.L.3
  • 55
    • 0028925908 scopus 로고
    • Regional rectal perfusion, a new in vivo approach to study rectal drug absorption in man
    • Lennernäs, H., Fagerholm, U., Raab, Y., Gerdin, B., Hällgren, R. (1995d) Regional rectal perfusion, a new in vivo approach to study rectal drug absorption in man. Pharm. Res. 12: 426-432
    • (1995) Pharm. Res. , vol.12 , pp. 426-432
    • Lennernäs, H.1    Fagerholm, U.2    Raab, Y.3    Gerdin, B.4    Hällgren, R.5
  • 56
    • 0030023536 scopus 로고    scopus 로고
    • Correlation between paracellular and transcellular drug permeability in the human jejunum and Caco-2 monolayers
    • Lennernäs, H., Palm, K., Fagerholm, U., Artursson, P. (1996a) Correlation between paracellular and transcellular drug permeability in the human jejunum and Caco-2 monolayers. Int. J. Pharm. 127: 103-107
    • (1996) Int. J. Pharm. , vol.127 , pp. 103-107
    • Lennernäs, H.1    Palm, K.2    Fagerholm, U.3    Artursson, P.4
  • 58
    • 7844238478 scopus 로고    scopus 로고
    • Human jejunal permeabilities comparison to a-methyldopa and L-dopa: Two carrier mediated drugs
    • Lennernäs, H., Knutson, L., Lesko, L., Salmonson, T., Amidon, G. L. (1996c) Human jejunal permeabilities comparison to a-methyldopa and L-dopa: two carrier mediated drugs. Pharm. Res. 13: S-329
    • (1996) Pharm. Res. , vol.13
    • Lennernäs, H.1    Knutson, L.2    Lesko, L.3    Salmonson, T.4    Amidon, G.L.5
  • 59
    • 0030790029 scopus 로고    scopus 로고
    • A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: In-vivo permeability estimation
    • Lennernäs, H., Lee, I-D, Fagerholm, U., Amidon, G. L. (1997a) A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation. J. Pharm. Pharmacol. 49: 682-686
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 682-686
    • Lennernäs, H.1    Lee, I.-D.2    Fagerholm, U.3    Amidon, G.L.4
  • 60
    • 0030905160 scopus 로고    scopus 로고
    • Correlation of effective drug permeability measurements in vitro using the Ussing chamber and the human jejunal perfusion
    • Lennernäs, H., Nylander, S., Ungell, A-L. (1997b) Correlation of effective drug permeability measurements in vitro using the Ussing chamber and the human jejunal perfusion. Pharm. Res. 14: 667-671
    • (1997) Pharm. Res. , vol.14 , pp. 667-671
    • Lennernäs, H.1    Nylander, S.2    Ungell, A.-L.3
  • 61
    • 0040976533 scopus 로고
    • Physicochemical properties and gastrointestinal absorption of drugs
    • Lien, E. J. (1970) Physicochemical properties and gastrointestinal absorption of drugs. Drug Intell. Clin. Pharmacol. 4: 7-9
    • (1970) Drug Intell. Clin. Pharmacol. , vol.4 , pp. 7-9
    • Lien, E.J.1
  • 62
    • 0007243812 scopus 로고
    • The relationship between chemical structure and drug absorption, distribution and excretion
    • Maas, J. (ed.) Drug Medical Chemistry IV, Amsterdam
    • Lien, E. J. (1974) The relationship between chemical structure and drug absorption, distribution and excretion. In: Maas, J. (ed.) Drug Medical Chemistry IV, Proceedings of the 4th Int. Symp. on Med. Chem. Amsterdam, pp 319-342
    • (1974) Proceedings of the 4th Int. Symp. on Med. Chem. , pp. 319-342
    • Lien, E.J.1
  • 64
    • 0023510866 scopus 로고
    • Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
    • Madara, J. L., Pappenheimer, J. R. (1987) Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100: 149-164
    • (1987) J. Membr. Biol. , vol.100 , pp. 149-164
    • Madara, J.L.1    Pappenheimer, J.R.2
  • 65
    • 0000798128 scopus 로고
    • The functional morphology of the mucosa of the small intestine
    • Johnson, L. R. (ed.) Raven Press, New York
    • Madara, J. L., Trier, J. S. (1994) The functional morphology of the mucosa of the small intestine. In: Johnson, L. R. (ed.) Physiology of the Gastrointestinal Tract, 3rd edn. Raven Press, New York
    • (1994) Physiology of the Gastrointestinal Tract, 3rd Edn.
    • Madara, J.L.1    Trier, J.S.2
  • 67
    • 0019422355 scopus 로고
    • A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry
    • Martin, Y. C. (1981) A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry. J. Med. Chem. 24: 229-237
    • (1981) J. Med. Chem. , vol.24 , pp. 229-237
    • Martin, Y.C.1
  • 68
    • 0015028201 scopus 로고
    • Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at a variable flow rates
    • Modigliani, R., Bernier, J. J. (1971) Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at a variable flow rates. Gut 12: 184-193
    • (1971) Gut , vol.12 , pp. 184-193
    • Modigliani, R.1    Bernier, J.J.2
  • 69
    • 0028000156 scopus 로고
    • The influence of net water absorption on the permeability of antipyrine and levodopa in the human jejunum
    • Nilsson, D., Fagerholm, U., Lennernäs, H. (1994) The influence of net water absorption on the permeability of antipyrine and levodopa in the human jejunum. Pharm. Res. 11: 1541-1545
    • (1994) Pharm. Res. , vol.11 , pp. 1541-1545
    • Nilsson, D.1    Fagerholm, U.2    Lennernäs, H.3
  • 70
    • 0029875543 scopus 로고    scopus 로고
    • The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system
    • Nerurkar, M. M., Burton, P. S., Borchardt, R. T. (1996) The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm. Res. 13: 528-534
    • (1996) Pharm. Res. , vol.13 , pp. 528-534
    • Nerurkar, M.M.1    Burton, P.S.2    Borchardt, R.T.3
  • 71
    • 34250426181 scopus 로고
    • The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat
    • Ochsenfahrt, H., Winne, D. (1974) The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat. Naunyn Schmiederbergs Arch. Pharmacol. 281: 175-196
    • (1974) Naunyn Schmiederbergs Arch. Pharmacol. , vol.281 , pp. 175-196
    • Ochsenfahrt, H.1    Winne, D.2
  • 72
    • 0023276344 scopus 로고
    • Intestinal absorption of a-methyldopa: In vitro mechanistic studies in rat small intestinal segments
    • Osiecka, I., Cortese, M., Porter, P. A., Borchardt, R. T., Fix, J. A., Gardner, C. R. (1987) Intestinal absorption of a-methyldopa: in vitro mechanistic studies in rat small intestinal segments. J. Pharmacol. Exp. Ther. 242: 443-449
    • (1987) J. Pharmacol. Exp. Ther. , vol.242 , pp. 443-449
    • Osiecka, I.1    Cortese, M.2    Porter, P.A.3    Borchardt, R.T.4    Fix, J.A.5    Gardner, C.R.6
  • 73
    • 0002824050 scopus 로고
    • Ueber die allgemeinen osmotischen Eigenschaften der Zelle, ihre vermutlichen Ursachen und ihre Bedeutung für die Physiologie
    • Overton, E. (1899) Ueber die allgemeinen osmotischen Eigenschaften der Zelle, ihre vermutlichen Ursachen und ihre Bedeutung für die Physiologie. Vierteljahrsschr. Naturforsch. Ges. Zuerich. 44: 88-135
    • (1899) Vierteljahrsschr. Naturforsch. Ges. Zuerich. , vol.44 , pp. 88-135
    • Overton, E.1
  • 75
    • 0023520885 scopus 로고
    • Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters
    • Pappenheimer, J. R. (1987) Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters. J. Membr. Biol. 100: 137-148
    • (1987) J. Membr. Biol. , vol.100 , pp. 137-148
    • Pappenheimer, J.R.1
  • 76
    • 0027441979 scopus 로고
    • On the coupling of membrane digestion with intestinal absorption of sugars and amino acids
    • Pappenheimer, J. R. (1993) On the coupling of membrane digestion with intestinal absorption of sugars and amino acids. Am. J. Physiol. 265: G409-417
    • (1993) Am. J. Physiol. , vol.265
    • Pappenheimer, J.R.1
  • 77
    • 0023521841 scopus 로고
    • Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat
    • Pappenheimer, J. R., Reiss, K. Z. (1987) Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J. Membr. Biol. 100: 123-136
    • (1987) J. Membr. Biol. , vol.100 , pp. 123-136
    • Pappenheimer, J.R.1    Reiss, K.Z.2
  • 78
    • 0028204841 scopus 로고
    • Intestinal absorption and excretion of octapeptides composed of D amino acids
    • Pappenheimer, J. R., Dahl, C. E., Karnovsky, M. L., Maggio, J. E. (1994) Intestinal absorption and excretion of octapeptides composed of D amino acids. Proc. Natl Acad. Sci. 91: 1942-1945
    • (1994) Proc. Natl Acad. Sci. , vol.91 , pp. 1942-1945
    • Pappenheimer, J.R.1    Dahl, C.E.2    Karnovsky, M.L.3    Maggio, J.E.4
  • 79
    • 0025329190 scopus 로고
    • Comparison of in vitro and in vivo models of drug transcytosisi through the blood brain barrier
    • Pardridge, W. M., Triguero, D., Yang, J., Cancilla, P. A. (1990) Comparison of in vitro and in vivo models of drug transcytosisi through the blood brain barrier. J. Pharmacol. Exp. Ther. 253: 884-891
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 884-891
    • Pardridge, W.M.1    Triguero, D.2    Yang, J.3    Cancilla, P.A.4
  • 81
    • 0013897940 scopus 로고
    • Occlusion of the jejunum for intestinal perfusion in man
    • Phillips, S. F., Summerskill, W. H. J. (1966) Occlusion of the jejunum for intestinal perfusion in man Mayo Clin. Proc. 41: 224-231
    • (1966) Mayo Clin. Proc. , vol.41 , pp. 224-231
    • Phillips, S.F.1    Summerskill, W.H.J.2
  • 82
    • 0002833727 scopus 로고
    • Intestinal water and electrolyte transport
    • Johnson, J. L (ed.) Raven Press, New York
    • Powell, D. W. (1987) Intestinal water and electrolyte transport In: Johnson, J. L (ed.) Physiology of the Gastrointestinal Tract, Raven Press, New York, pp 1267-1306
    • (1987) Physiology of the Gastrointestinal Tract , pp. 1267-1306
    • Powell, D.W.1
  • 84
    • 0027763397 scopus 로고
    • Luminal nutrients alter tight-junction permeability in the rat jejunum: An in vivo perfusion model
    • Sadowski, D. C., Meddings, J. B. (1993) Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model. Can. J. Physiol. Pharmacol. 71: 835-839
    • (1993) Can. J. Physiol. Pharmacol. , vol.71 , pp. 835-839
    • Sadowski, D.C.1    Meddings, J.B.2
  • 86
    • 0029149609 scopus 로고
    • Paracellular intestinal transport of six-carbon sugars is negligible in the rat
    • Schwartz, R. M., Furne, J. K., Levitt, M. D (1995). Paracellular intestinal transport of six-carbon sugars is negligible in the rat. Gastroenterology 109: 1206-1213
    • (1995) Gastroenterology , vol.109 , pp. 1206-1213
    • Schwartz, R.M.1    Furne, J.K.2    Levitt, M.D.3
  • 87
    • 0027363718 scopus 로고
    • Nutrient-induced changes in the permeability of the rat jejunal mucosa
    • See, N., Bass, P. (1993) Nutrient-induced changes in the permeability of the rat jejunal mucosa. J. Pharm. Sci. 82: 721-4
    • (1993) J. Pharm. Sci. , vol.82 , pp. 721-724
    • See, N.1    Bass, P.2
  • 88
    • 0014876556 scopus 로고
    • Further studies on the pertfusion method for measuring intestinal absorption in man: The effects of a proximal occlusive balloon and a mixing segment
    • Sladen, G. E., Dawson, A. M: (1970) Further studies on the pertfusion method for measuring intestinal absorption in man: the effects of a proximal occlusive balloon and a mixing segment. Gut 11: 947-954
    • (1970) Gut , vol.11 , pp. 947-954
    • Sladen, G.E.1    Dawson, A.M.2
  • 89
    • 0029865450 scopus 로고    scopus 로고
    • Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
    • Smith, D. A., Jones, B. C., Walker, D. K. (1996) Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics. Med. Res. Rev. 16: 243-266
    • (1996) Med. Res. Rev. , vol.16 , pp. 243-266
    • Smith, D.A.1    Jones, B.C.2    Walker, D.K.3
  • 91
    • 0018894692 scopus 로고
    • Passage of molecules through the wall of the gastrointestinal tract
    • Sundquist, T., Magnusson, K-E., Spödahl, I., Tagesson, C. (1980) Passage of molecules through the wall of the gastrointestinal tract. Gut 21: 208-214
    • (1980) Gut , vol.21 , pp. 208-214
    • Sundquist, T.1    Magnusson, K.-E.2    Spödahl, I.3    Tagesson, C.4
  • 92
    • 0022454140 scopus 로고
    • Sites and mechanisms of intestinal drug absorption
    • Taylor, D. C (1986). Sites and mechanisms of intestinal drug absorption. Pharm. Int. 6: 179-183
    • (1986) Pharm. Int. , vol.6 , pp. 179-183
    • Taylor, D.C.1
  • 95
    • 0023447098 scopus 로고
    • Cellular localization of the multi-drug resistance gene product P-glycoprotein in normal human tissues
    • Thiebaud, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., Willingham, M.C. (1987) Cellular localization of the multi-drug resistance gene product P-glycoprotein in normal human tissues. Proc. Natl Acad. Sci. 84: 7735-7738
    • (1987) Proc. Natl Acad. Sci. , vol.84 , pp. 7735-7738
    • Thiebaud, F.1    Tsuruo, T.2    Hamada, H.3    Gottesman, M.M.4    Pastan, I.5    Willingham, M.C.6
  • 96
    • 0029782485 scopus 로고    scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • Tsuji, A., Tamai, I. (1996) Carrier-mediated intestinal transport of drugs. Pharm. Res. 13: 963-977
    • (1996) Pharm. Res. , vol.13 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 97
    • 0029078054 scopus 로고
    • The effect of surgical bowel manipulation and anaesthesia on intestinal glucose absorption in rats
    • Uhing, M. R., Kimura, R. E. (1995a ) The effect of surgical bowel manipulation and anaesthesia on intestinal glucose absorption in rats. J. Clin. Invest. 95: 2790-2798
    • (1995) J. Clin. Invest. , vol.95 , pp. 2790-2798
    • Uhing, M.R.1    Kimura, R.E.2
  • 98
    • 0029047852 scopus 로고
    • Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats
    • Uhing, M. R., Kimura, R. E. (1995b) Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats. J. Clin. Invest. 95: 2799-2805
    • (1995) J. Clin. Invest. , vol.95 , pp. 2799-2805
    • Uhing, M.R.1    Kimura, R.E.2
  • 99
    • 21144467893 scopus 로고
    • Hydrogen-bonding capacity and brain penetration
    • van de Waterbeemd, H., Kansy, M. (1992) Hydrogen-bonding capacity and brain penetration. Chimia 299-303
    • (1992) Chimia , pp. 299-303
    • Van De Waterbeemd, H.1    Kansy, M.2
  • 101
    • 0024467119 scopus 로고
    • Contribution of the intestine to the first-pass metabolism of felodipine in the rat
    • Wang, S-X., Sutfin, T. A., Bäärnhilem, C., Regårdh, C. G. (1989) Contribution of the intestine to the first-pass metabolism of felodipine in the rat. J. Pharmacol. Exp. Ther. 250: 632-636
    • (1989) J. Pharmacol. Exp. Ther. , vol.250 , pp. 632-636
    • Wang, S.-X.1    Sutfin, T.A.2    Bäärnhilem, C.3    Regårdh, C.G.4
  • 102
    • 0030481554 scopus 로고    scopus 로고
    • Estimation of Caco-2 cell permeability using calculated molecular descriptors
    • Waterbeemd, H., Camenisch, Folkers, G., Raevsky O. A. (1996) Estimation of Caco-2 cell permeability using calculated molecular descriptors. Quant. Struct. Act. Relat. 15: 480-490
    • (1996) Quant. Struct. Act. Relat. , vol.15 , pp. 480-490
    • Waterbeemd, H.1    Camenisch2    Folkers, G.3    Raevsky, O.A.4
  • 103
    • 34250426181 scopus 로고
    • The contribution of solvent drag to the intestinal absorption of the basic drugs aminopyrine and antipyrine from the jejunum of the rat
    • Winne, D. (1974a) The contribution of solvent drag to the intestinal absorption of the basic drugs aminopyrine and antipyrine from the jejunum of the rat. Naunyn Schmiedebergs Arch. Pharmacol. 281: 175-196
    • (1974) Naunyn Schmiedebergs Arch. Pharmacol. , vol.281 , pp. 175-196
    • Winne, D.1
  • 104
    • 34250416118 scopus 로고
    • The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat
    • Winne, D. (1974b) The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat. Naunyn Schmiedebergs Arch. Pharmacol. 281: 197-217
    • (1974) Naunyn Schmiedebergs Arch. Pharmacol. , vol.281 , pp. 197-217
    • Winne, D.1
  • 105
    • 15444343251 scopus 로고
    • Role of blood flow in intestinal permeation
    • T. Z. Csáky (ed.) Springer-Verlag, Berlin
    • Winne, D. (1984) Role of blood flow in intestinal permeation. In: T. Z. Csáky (ed.) Pharmacology of Intestinal Permeation II, Springer-Verlag, Berlin, pp 301-347
    • (1984) Pharmacology of Intestinal Permeation II , pp. 301-347
    • Winne, D.1
  • 107


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.