-
1
-
-
0025239287
-
Enhanced local production of complement components in the small intestines in Crohn's disease
-
Ahrenstedt, Ö., Knutson, L., Nilsson, B., Nilsson-Ekdahl, K., Odlind, B., Hällgren, R. (1990) Enhanced local production of complement components in the small intestines in Crohn's disease. N. Eng. J. Med. 322: 1345-1349
-
(1990)
N. Eng. J. Med.
, vol.322
, pp. 1345-1349
-
-
Ahrenstedt, Ö.1
Knutson, L.2
Nilsson, B.3
Nilsson-Ekdahl, K.4
Odlind, B.5
Hällgren, R.6
-
2
-
-
0028948839
-
Theoretical considerations in the correlation of in vitro drug product dissolution and in vivo bioavailability: A basis for a biopharmaceutics drug classification
-
Amidon, G. L., Lennernäs, H., Shah, V. P., Crison, J. (1995) Theoretical considerations in the correlation of in vitro drug product dissolution and in vivo bioavailability: a basis for a biopharmaceutics drug classification. Pharm. Res. 12: 413-420
-
(1995)
Pharm. Res.
, vol.12
, pp. 413-420
-
-
Amidon, G.L.1
Lennernäs, H.2
Shah, V.P.3
Crison, J.4
-
3
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
Artursson, P., Karlsson, J. (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 3: 880-885
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.3
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
4
-
-
0027312774
-
Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments
-
Artursson, P., Ungell, A-L., Löfroth, J-E. (1993) Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm. Res. 10: 1123-1129
-
(1993)
Pharm. Res.
, vol.10
, pp. 1123-1129
-
-
Artursson, P.1
Ungell, A.-L.2
Löfroth, J.-E.3
-
5
-
-
85036484861
-
Microdialysis for the quantitaive study of the distribution kinetics of the anti-epileptic drug, carbamazepine, to the brain
-
Seignosse, France Sept. 17-20 1994
-
Belle, van K., Ebinger G., Michotte Y. (1994) Microdialysis for the quantitaive study of the distribution kinetics of the anti-epileptic drug, carbamazepine, to the brain. Proc. 6th Int. Conference on In Vivo Methods. Seignosse, France Sept. 17-20 1994
-
(1994)
Proc. 6th Int. Conference on in Vivo Methods
-
-
Van Belle, K.1
Ebinger, G.2
Michotte, Y.3
-
6
-
-
0030002504
-
The importance of drug metabolism and antitransport processes: A paradigm shift in oral drug delivery
-
Benet L. Z., Wu, C-Y., Hebert, M. F., Wacher, V. J. (1996) The importance of drug metabolism and antitransport processes: A paradigm shift in oral drug delivery. J. Contr. Rel. 39: 139-143
-
(1996)
J. Contr. Rel.
, vol.39
, pp. 139-143
-
-
Benet, L.Z.1
Wu, C.-Y.2
Hebert, M.F.3
Wacher, V.J.4
-
7
-
-
0021965327
-
Regional differences in the lipid composition and fluidity of rat colonic brush-border membranes
-
Brasitus, H. A., Dudeja, P. K. (1985) Regional differences in the lipid composition and fluidity of rat colonic brush-border membranes. Biochim. Biophys. Acta 819: 10-17
-
(1985)
Biochim. Biophys. Acta
, vol.819
, pp. 10-17
-
-
Brasitus, H.A.1
Dudeja, P.K.2
-
8
-
-
0027267598
-
Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells
-
Burton, P. S., Conradi, R. A., Hilgers, A. R., Ho, N. F. H. (1993) Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells. Biochem. Biophys. Res. Commun. 190: 760-766
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.190
, pp. 760-766
-
-
Burton, P.S.1
Conradi, R.A.2
Hilgers, A.R.3
Ho, N.F.H.4
-
9
-
-
0030458462
-
How structural features influence the biomembrane permeability of peptides
-
Burton, P. S., Conradi, R. A., Ho, N. F. H., Hilgers, A. R., Borchardt, R. T. (1996) How structural features influence the biomembrane permeability of peptides. J. Pharm. Sci. 85: 1336-1340
-
(1996)
J. Pharm. Sci.
, vol.85
, pp. 1336-1340
-
-
Burton, P.S.1
Conradi, R.A.2
Ho, N.F.H.3
Hilgers, A.R.4
Borchardt, R.T.5
-
10
-
-
0030829862
-
A new approach for direct in vivo dissolution studies of low soluble drugs
-
in press
-
Bönlökke, L., Christensen F. N., Knutson L., Kristensen H. G., Lennernäs H. (1997) A new approach for direct in vivo dissolution studies of low soluble drugs. Pharm. Res. in press
-
(1997)
Pharm. Res.
-
-
Bönlökke, L.1
Christensen, F.N.2
Knutson, L.3
Kristensen, H.G.4
Lennernäs, H.5
-
11
-
-
0017410222
-
Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals
-
Chadwick, V. S., Phillips, S. F., Hofmann, A. F. (1977) Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals. Gastroenterology 73: 247-251
-
(1977)
Gastroenterology
, vol.73
, pp. 247-251
-
-
Chadwick, V.S.1
Phillips, S.F.2
Hofmann, A.F.3
-
12
-
-
0028270064
-
Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides
-
Chikhale, E. G., Ng K-Y., Burton, P. S., Borchardt, R. T. (1994) Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharm. Res. 11: 412-419
-
(1994)
Pharm. Res.
, vol.11
, pp. 412-419
-
-
Chikhale, E.G.1
Ng, K.-Y.2
Burton, P.S.3
Borchardt, R.T.4
-
13
-
-
0026513211
-
The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability
-
Conradi, R. A., Hilgers, A. R., Ho, N. F. H., Burton, P. S. (1992) The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability. Pharm. Res. 9: 435-439
-
(1992)
Pharm. Res.
, vol.9
, pp. 435-439
-
-
Conradi, R.A.1
Hilgers, A.R.2
Ho, N.F.H.3
Burton, P.S.4
-
14
-
-
0023577560
-
Transport across epithelial membranes
-
Cooper, E. R., Kasting, G. (1987) Transport across epithelial membranes. J. Contr. Rel. 6: 23-35
-
(1987)
J. Contr. Rel.
, vol.6
, pp. 23-35
-
-
Cooper, E.R.1
Kasting, G.2
-
15
-
-
0024544045
-
The three multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal humans tissues
-
Croop, J. M., Raymond, M., Haber, D., Devault, A., Arceci, R. J., Gros, P., Houseman, D. (1989) The three multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal humans tissues. Mol. Cell Biol. 9: 1346-1350
-
(1989)
Mol. Cell Biol.
, vol.9
, pp. 1346-1350
-
-
Croop, J.M.1
Raymond, M.2
Haber, D.3
Devault, A.4
Arceci, R.J.5
Gros, P.6
Houseman, D.7
-
16
-
-
0020044438
-
Studies of different metabolic pathways of antipyrine in man
-
Danhof, M., van Zuilen, A., Boeijinga, J. K., Breimer, D. D. (1982) Studies of different metabolic pathways of antipyrine in man. Eur. J. Clin. Pharmacol. 21: 433-441
-
(1982)
Eur. J. Clin. Pharmacol.
, vol.21
, pp. 433-441
-
-
Danhof, M.1
Van Zuilen, A.2
Boeijinga, J.K.3
Breimer, D.D.4
-
17
-
-
0026719204
-
Drug transfer across the blood-brain barrier: Correlation between in vitro and in vivo models
-
Dehouck, M-P., Jolliet-Riant P., Bree, F., Fruchart J-C., Cecchelli, R., Tillement, J-P. (1992) Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models. J. Neurochem. 58: 1790-1797
-
(1992)
J. Neurochem.
, vol.58
, pp. 1790-1797
-
-
Dehouck, M.-P.1
Jolliet-Riant, P.2
Bree, F.3
Fruchart, J.-C.4
Cecchelli, R.5
Tillement, J.-P.6
-
18
-
-
0025344378
-
Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferase in rat and human hepatic and extrahepatic tissues
-
De Waizers I. (1990) Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferase in rat and human hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 253: 387-394
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.253
, pp. 387-394
-
-
De Waizers, I.1
-
19
-
-
0029077886
-
News and views: How to be physiological
-
Diamond, J. M. (1995) News and views: How to be physiological. Nature 376: 117-8
-
(1995)
Nature
, vol.376
, pp. 117-118
-
-
Diamond, J.M.1
-
20
-
-
0001608810
-
Animal models for drug absorption
-
Welling, P. G., Tse, F. L. S., Dighe, S. V. (eds) Marcel Dekker
-
Dressman, J., Yamada, T. (1991) Animal models for drug absorption. In: Welling, P. G., Tse, F. L. S., Dighe, S. V. (eds) Pharmaceutical Bioequivalence, Marcel Dekker. p. 250.
-
(1991)
Pharmaceutical Bioequivalence
, pp. 250
-
-
Dressman, J.1
Yamada, T.2
-
21
-
-
0028840557
-
Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption
-
Fagerholm, U., Lennernäs, H. (1995) Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption. Eur J. Pharm. Sci. 3: 247-253
-
(1995)
Eur J. Pharm. Sci.
, vol.3
, pp. 247-253
-
-
Fagerholm, U.1
Lennernäs, H.2
-
22
-
-
0028818676
-
The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum
-
Fagerholm, U., Borgström, L., Ahrenstedt, Ö., Lennernäs H. (1995) The lack of effect of induced net fluid absorption on the in vivo permeability of terbutaline in the human jejunum. J. Drug Targeting 3: 191-200
-
(1995)
J. Drug Targeting
, vol.3
, pp. 191-200
-
-
Fagerholm, U.1
Borgström, L.2
Ahrenstedt, Ö.3
Lennernäs, H.4
-
23
-
-
0242287624
-
The correlation between rat and human small intestinal permeability to drugs with different physico-chemical properties
-
Fagerholm, U., Johansson, M., Lennernäs, H. (1996) The correlation between rat and human small intestinal permeability to drugs with different physico-chemical properties. Pharm. Res. 13: 1335-1341
-
(1996)
Pharm. Res.
, vol.13
, pp. 1335-1341
-
-
Fagerholm, U.1
Johansson, M.2
Lennernäs, H.3
-
24
-
-
0027275691
-
Effect of D-glucose on intestinal permeability and its passive absorption in human small intestine in vivo
-
Fine, K. D., Santa Ana, C. A., Porter, J. L., Fordtran, J. S. (1993) Effect of D-glucose on intestinal permeability and its passive absorption in human small intestine in vivo. Gastroenterology 105: 1117-1125
-
(1993)
Gastroenterology
, vol.105
, pp. 1117-1125
-
-
Fine, K.D.1
Santa Ana, C.A.2
Porter, J.L.3
Fordtran, J.S.4
-
25
-
-
0013594791
-
Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo
-
Fine, K. D., Santa Ana, C. A., Porter, J. L., Fordtran, J. S. (1994) Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo. Gastroenterology 109: 1391-1396
-
(1994)
Gastroenterology
, vol.109
, pp. 1391-1396
-
-
Fine, K.D.1
Santa Ana, C.A.2
Porter, J.L.3
Fordtran, J.S.4
-
26
-
-
0016053262
-
Mass transport phenomena and models: Theoretical concepts
-
Flynn, G. L., Yalkowsky, S. H., Roseman, T. J. (1974) Mass transport phenomena and models: theoretical concepts. J. Pharm. Sci. 63: 479-509
-
(1974)
J. Pharm. Sci.
, vol.63
, pp. 479-509
-
-
Flynn, G.L.1
Yalkowsky, S.H.2
Roseman, T.J.3
-
27
-
-
0025007511
-
Pharmacology of drugs that alter multidrug resistance in cancer
-
Ford, J. M., Hait, W. N. (1990) Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol. Rev. 42: 155-199
-
(1990)
Pharmacol. Rev.
, vol.42
, pp. 155-199
-
-
Ford, J.M.1
Hait, W.N.2
-
28
-
-
0029986277
-
Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro and in vivo correlation
-
Fricker, G., Drewe, J., Huwyle, J., Gutman, H., Beglinger, C. (1996) Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro and in vivo correlation. Br. J. Pharmacol. 118: 1841-1847
-
(1996)
Br. J. Pharmacol.
, vol.118
, pp. 1841-1847
-
-
Fricker, G.1
Drewe, J.2
Huwyle, J.3
Gutman, H.4
Beglinger, C.5
-
29
-
-
0026442154
-
Intestinal water absorption from select carbohydrate solutions in humans
-
Gisolfi, C. V., Summers, R. W., Schedl, P., Bleiler, T. L. (1992) Intestinal water absorption from select carbohydrate solutions in humans. J. Appl. Physiol. 73: 2142-2150
-
(1992)
J. Appl. Physiol.
, vol.73
, pp. 2142-2150
-
-
Gisolfi, C.V.1
Summers, R.W.2
Schedl, P.3
Bleiler, T.L.4
-
30
-
-
0028348967
-
Pharmacokinetic considerations in rational drug design
-
Gumbleton, M., Sneader, W. (1994) Pharmacokinetic considerations in rational drug design. Clin. Pharmacokin. 26: 161-168
-
(1994)
Clin. Pharmacokin.
, vol.26
, pp. 161-168
-
-
Gumbleton, M.1
Sneader, W.2
-
31
-
-
0029999340
-
Direct demonstration of small intestinal secretion and site-dependent absorption of the β-blocker talinolol in humans
-
Gramatté, T., Oertel, R., Terhaag, B., Kirch, W. (1996) Direct demonstration of small intestinal secretion and site-dependent absorption of the β-blocker talinolol in humans. Clin. Pharmacol. Ther. 59: 541-549
-
(1996)
Clin. Pharmacol. Ther.
, vol.59
, pp. 541-549
-
-
Gramatté, T.1
Oertel, R.2
Terhaag, B.3
Kirch, W.4
-
32
-
-
0002698633
-
Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans
-
Crouthamel, W., Sarapu, A. C. (eds) In Situ and In Vivo Approaches. American Pharmaceutical Association, Washington D.C.
-
Ho, N. F. H., Park, J. Y., Ni, P. F., Higuchi W. I. (1983) Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans. In: Crouthamel, W., Sarapu, A. C. (eds) Animal Models for Oral Drug Delivery in Man; In Situ and In Vivo Approaches. American Pharmaceutical Association, Washington D.C., pp 27-106
-
(1983)
Animal Models for Oral Drug Delivery in Man
, pp. 27-106
-
-
Ho, N.F.H.1
Park, J.Y.2
Ni, P.F.3
Higuchi, W.I.4
-
33
-
-
0030588585
-
Carrier-mediated transport and efflux mechanisms in Caco-2 cells
-
Hidalgo, I. J., Li, J. (1996) Carrier-mediated transport and efflux mechanisms in Caco-2 cells. Adv. Drug Del. Rev. 22: 53-66
-
(1996)
Adv. Drug Del. Rev.
, vol.22
, pp. 53-66
-
-
Hidalgo, I.J.1
Li, J.2
-
34
-
-
0021273701
-
Solvent drag in jejunal absorption of salicylic acid and antipyrine obtained by in situ single-pass perfusion method in rat
-
Hirasawa, T., Muraoka, T., Karino, A., Hayashi, M., Awazu, S. (1984) Solvent drag in jejunal absorption of salicylic acid and antipyrine obtained by in situ single-pass perfusion method in rat. J. Pharmacobiodyn. 7: 246-253
-
(1984)
J. Pharmacobiodyn.
, vol.7
, pp. 246-253
-
-
Hirasawa, T.1
Muraoka, T.2
Karino, A.3
Hayashi, M.4
Awazu, S.5
-
35
-
-
0024603496
-
Polyethylene glycol 900 permeability of rat intestinal and colonic segments in vivo and brush border membrane vesicles in vitro
-
Hollander, D., Koyama, S., Dadufalza, V., Tran, D. Q., Krugliak, P., Ma, T., Ling, K-Y. (1989) Polyethylene glycol 900 permeability of rat intestinal and colonic segments in vivo and brush border membrane vesicles in vitro. J. Lab. Clin. Med. 113: 505-515
-
(1989)
J. Lab. Clin. Med.
, vol.113
, pp. 505-515
-
-
Hollander, D.1
Koyama, S.2
Dadufalza, V.3
Tran, D.Q.4
Krugliak, P.5
Ma, T.6
Ling, K.-Y.7
-
36
-
-
0025668535
-
Mechanism of L-a-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)
-
Hu, M., Borchardt, R. T (1990). Mechanism of L-a-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm. Res. 7: 1313-1319
-
(1990)
Pharm. Res.
, vol.7
, pp. 1313-1319
-
-
Hu, M.1
Borchardt, R.T.2
-
37
-
-
0025966854
-
Comparison of rat and human intestinal perfusion models for assessing efficacy of oral rehydration solutions
-
Hunt, J. B., Elliott, R. J., Farthing, M. J. G. (1991) Comparison of rat and human intestinal perfusion models for assessing efficacy of oral rehydration solutions. Aliment. Pharmacol. Ther. 5: 49-59
-
(1991)
Aliment. Pharmacol. Ther.
, vol.5
, pp. 49-59
-
-
Hunt, J.B.1
Elliott, R.J.2
Farthing, M.J.G.3
-
39
-
-
0024378474
-
A new technique for segmental jejunal perfusion in man
-
Knutson, L., Odlind, B., Hällgren, R. (1989) A new technique for segmental jejunal perfusion in man. Am. J. Gastroenterol. 84: 1278-1284
-
(1989)
Am. J. Gastroenterol.
, vol.84
, pp. 1278-1284
-
-
Knutson, L.1
Odlind, B.2
Hällgren, R.3
-
40
-
-
0025216985
-
The jejunal secretion of histamine is increased in active Crohn's disease
-
Knutson, L., Ahrenstedt, Ö. B., Odlind, B., Hällgren, R. (1990) The jejunal secretion of histamine is increased in active Crohn's disease. Gastroenterology 98: 849-854
-
(1990)
Gastroenterology
, vol.98
, pp. 849-854
-
-
Knutson, L.1
Ahrenstedt, Ö.B.2
Odlind, B.3
Hällgren, R.4
-
41
-
-
0025719746
-
First-pass metabolism of cyclosporin by the gut
-
Kolars, J .C., Awni, W. M., Merion, R. M., Watkins, P. B. (1991) First-pass metabolism of cyclosporin by the gut. Lancet 338: 1488-1490
-
(1991)
Lancet
, vol.338
, pp. 1488-1490
-
-
Kolars, J.C.1
Awni, W.M.2
Merion, R.M.3
Watkins, P.B.4
-
42
-
-
0018850819
-
Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
-
Komiya, I., Park, J. Y., Kamani, A., Ho, N. F. H., Higuchi, W. I. (1980) Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int. J. Pharmaceut. 4: 249-262
-
(1980)
Int. J. Pharmaceut.
, vol.4
, pp. 249-262
-
-
Komiya, I.1
Park, J.Y.2
Kamani, A.3
Ho, N.F.H.4
Higuchi, W.I.5
-
43
-
-
0027998369
-
Determinants of apical membrane permeabilities of barrier epithelia
-
Lande, M. B., Priver, N. A., Zeidel, M. L (1994) Determinants of apical membrane permeabilities of barrier epithelia. Am. J. Physiol. 267: C367-C374
-
(1994)
Am. J. Physiol.
, vol.267
-
-
Lande, M.B.1
Priver, N.A.2
Zeidel, M.L.3
-
44
-
-
0029045414
-
The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons
-
Lande, M. B., Donovan, J. M., Zeidel, M. L (1995) The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons. J. Gen. Physiol. 106: 67-84
-
(1995)
J. Gen. Physiol.
, vol.106
, pp. 67-84
-
-
Lande, M.B.1
Donovan, J.M.2
Zeidel, M.L.3
-
45
-
-
0026795241
-
Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man
-
Lennernäs, H., Ahrenstedt, Ö., Hällgren, R., Knutson, L., Ryde, M., Paalzow, L.K. (1992) Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm. Res. 9: 1243-1251
-
(1992)
Pharm. Res.
, vol.9
, pp. 1243-1251
-
-
Lennernäs, H.1
Ahrenstedt, Ö.2
Hällgren, R.3
Knutson, L.4
Ryde, M.5
Paalzow, L.K.6
-
46
-
-
0027497673
-
The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man
-
Lennernäs, H., Nilsson, D., Aquilonius, S-M., Ahrenstedt, Ö., Knutson, L., Paalzow, L. K. (1993a) The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man. Br. J. Clin. Pharmacol. 35: 243-250
-
(1993)
Br. J. Clin. Pharmacol.
, vol.35
, pp. 243-250
-
-
Lennernäs, H.1
Nilsson, D.2
Aquilonius, S.-M.3
Ahrenstedt, Ö.4
Knutson, L.5
Paalzow, L.K.6
-
47
-
-
0028141584
-
Gastrointestinal absorption mechanisms: A comparison between animal and human models
-
Lennernäs, H. (1994) Gastrointestinal absorption mechanisms: a comparison between animal and human models. Eur J. Pharm. Sci. 2: 39-43
-
(1994)
Eur J. Pharm. Sci.
, vol.2
, pp. 39-43
-
-
Lennernäs, H.1
-
48
-
-
0029557644
-
Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?
-
Lennernäs, H. (1995) Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation? Pharm. Res. 12: 1573-82
-
(1995)
Pharm. Res.
, vol.12
, pp. 1573-1582
-
-
Lennernäs, H.1
-
49
-
-
0027178256
-
Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat
-
Lennernäs, H., Regårdh, C. G. (1993) Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat. Pharm. Res. 5: 727-731
-
(1993)
Pharm. Res.
, vol.5
, pp. 727-731
-
-
Lennernäs, H.1
Regårdh, C.G.2
-
50
-
-
0027315394
-
Presystemic elimination of pafenolol in the rat after oral and ip administration and identification of the main metabolite in both rats and humans
-
Lennernäs, H., Renberg, L., Hoffman, K-J., Regårdh, C. G. (1993) Presystemic elimination of pafenolol in the rat after oral and ip administration and identification of the main metabolite in both rats and humans. Drug Metabol. Disp. 21: 435-440
-
(1993)
Drug Metabol. Disp.
, vol.21
, pp. 435-440
-
-
Lennernäs, H.1
Renberg, L.2
Hoffman, K.-J.3
Regårdh, C.G.4
-
51
-
-
0028307188
-
Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat
-
Lennernäs, H., Ahrenstedt, Ö., Ungell, A-L. (1994) Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat. Br. J. Clin. Pharmacol. 37: 589-596
-
(1994)
Br. J. Clin. Pharmacol.
, vol.37
, pp. 589-596
-
-
Lennernäs, H.1
Ahrenstedt, Ö.2
Ungell, A.-L.3
-
52
-
-
0344383697
-
Human effective permeability data for furosemide, hydrochlorthiazide, ketoprofen and naproxen to be used in the proposed biopharmaceutical classification for IR-products
-
Lennernäs, H., Knutson, L., Knutson, T., Lesko, L., Salmonson, T., Amidon, G. L. (1995a) Human effective permeability data for furosemide, hydrochlorthiazide, ketoprofen and naproxen to be used in the proposed biopharmaceutical classification for IR-products. Pharm. Res. 12: 396
-
(1995)
Pharm. Res.
, vol.12
, pp. 396
-
-
Lennernäs, H.1
Knutson, L.2
Knutson, T.3
Lesko, L.4
Salmonson, T.5
Amidon, G.L.6
-
53
-
-
0345402723
-
Human effective permeabilitiy data for atenolol, metoprolol and carbamazepine to be used in the proposed biopharmaceutical classification for IR-products
-
Lennernäs, H., Knutson, L., Knutson, T., Lesko, L., Salmonson, T., Amidon, G. L. (1995b) Human effective permeabilitiy data for atenolol, metoprolol and carbamazepine to be used in the proposed biopharmaceutical classification for IR-products. Pharm. Res. 12: 295
-
(1995)
Pharm. Res.
, vol.12
, pp. 295
-
-
Lennernäs, H.1
Knutson, L.2
Knutson, T.3
Lesko, L.4
Salmonson, T.5
Amidon, G.L.6
-
54
-
-
0029562752
-
Permeability and clearance views of drug absorption: A commentary
-
Lennernäs, H., Crison, J., Amidon, G. L. (1995c) Permeability and clearance views of drug absorption: a commentary. J. Pharmacokin. Biopharm. 23: 333-337
-
(1995)
J. Pharmacokin. Biopharm.
, vol.23
, pp. 333-337
-
-
Lennernäs, H.1
Crison, J.2
Amidon, G.L.3
-
55
-
-
0028925908
-
Regional rectal perfusion, a new in vivo approach to study rectal drug absorption in man
-
Lennernäs, H., Fagerholm, U., Raab, Y., Gerdin, B., Hällgren, R. (1995d) Regional rectal perfusion, a new in vivo approach to study rectal drug absorption in man. Pharm. Res. 12: 426-432
-
(1995)
Pharm. Res.
, vol.12
, pp. 426-432
-
-
Lennernäs, H.1
Fagerholm, U.2
Raab, Y.3
Gerdin, B.4
Hällgren, R.5
-
56
-
-
0030023536
-
Correlation between paracellular and transcellular drug permeability in the human jejunum and Caco-2 monolayers
-
Lennernäs, H., Palm, K., Fagerholm, U., Artursson, P. (1996a) Correlation between paracellular and transcellular drug permeability in the human jejunum and Caco-2 monolayers. Int. J. Pharm. 127: 103-107
-
(1996)
Int. J. Pharm.
, vol.127
, pp. 103-107
-
-
Lennernäs, H.1
Palm, K.2
Fagerholm, U.3
Artursson, P.4
-
58
-
-
7844238478
-
Human jejunal permeabilities comparison to a-methyldopa and L-dopa: Two carrier mediated drugs
-
Lennernäs, H., Knutson, L., Lesko, L., Salmonson, T., Amidon, G. L. (1996c) Human jejunal permeabilities comparison to a-methyldopa and L-dopa: two carrier mediated drugs. Pharm. Res. 13: S-329
-
(1996)
Pharm. Res.
, vol.13
-
-
Lennernäs, H.1
Knutson, L.2
Lesko, L.3
Salmonson, T.4
Amidon, G.L.5
-
59
-
-
0030790029
-
A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: In-vivo permeability estimation
-
Lennernäs, H., Lee, I-D, Fagerholm, U., Amidon, G. L. (1997a) A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation. J. Pharm. Pharmacol. 49: 682-686
-
(1997)
J. Pharm. Pharmacol.
, vol.49
, pp. 682-686
-
-
Lennernäs, H.1
Lee, I.-D.2
Fagerholm, U.3
Amidon, G.L.4
-
60
-
-
0030905160
-
Correlation of effective drug permeability measurements in vitro using the Ussing chamber and the human jejunal perfusion
-
Lennernäs, H., Nylander, S., Ungell, A-L. (1997b) Correlation of effective drug permeability measurements in vitro using the Ussing chamber and the human jejunal perfusion. Pharm. Res. 14: 667-671
-
(1997)
Pharm. Res.
, vol.14
, pp. 667-671
-
-
Lennernäs, H.1
Nylander, S.2
Ungell, A.-L.3
-
61
-
-
0040976533
-
Physicochemical properties and gastrointestinal absorption of drugs
-
Lien, E. J. (1970) Physicochemical properties and gastrointestinal absorption of drugs. Drug Intell. Clin. Pharmacol. 4: 7-9
-
(1970)
Drug Intell. Clin. Pharmacol.
, vol.4
, pp. 7-9
-
-
Lien, E.J.1
-
62
-
-
0007243812
-
The relationship between chemical structure and drug absorption, distribution and excretion
-
Maas, J. (ed.) Drug Medical Chemistry IV, Amsterdam
-
Lien, E. J. (1974) The relationship between chemical structure and drug absorption, distribution and excretion. In: Maas, J. (ed.) Drug Medical Chemistry IV, Proceedings of the 4th Int. Symp. on Med. Chem. Amsterdam, pp 319-342
-
(1974)
Proceedings of the 4th Int. Symp. on Med. Chem.
, pp. 319-342
-
-
Lien, E.J.1
-
63
-
-
0029804297
-
Jejunal permeability and hepatic extraction of fluvastatin in humans
-
Lindahl, A., Sandström, R. Ungell, A-L., Abrahmsson, B., Knutson, L., Knutson, T., Lennernäs, H. (1996) Jejunal permeability and hepatic extraction of fluvastatin in humans. Clin. Pharmacol. Ther. 60: 493-503
-
(1996)
Clin. Pharmacol. Ther.
, vol.60
, pp. 493-503
-
-
Lindahl, A.1
Sandström, R.2
Ungell, A.-L.3
Abrahmsson, B.4
Knutson, L.5
Knutson, T.6
Lennernäs, H.7
-
64
-
-
0023510866
-
Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
-
Madara, J. L., Pappenheimer, J. R. (1987) Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100: 149-164
-
(1987)
J. Membr. Biol.
, vol.100
, pp. 149-164
-
-
Madara, J.L.1
Pappenheimer, J.R.2
-
65
-
-
0000798128
-
The functional morphology of the mucosa of the small intestine
-
Johnson, L. R. (ed.) Raven Press, New York
-
Madara, J. L., Trier, J. S. (1994) The functional morphology of the mucosa of the small intestine. In: Johnson, L. R. (ed.) Physiology of the Gastrointestinal Tract, 3rd edn. Raven Press, New York
-
(1994)
Physiology of the Gastrointestinal Tract, 3rd Edn.
-
-
Madara, J.L.1
Trier, J.S.2
-
66
-
-
0022966466
-
The effect of pH and concentration on alpha-methyldopa absorption in man
-
Merfeld, A. E., Mlodozeniec, A. R., Cortese, M. A., Rhodes, J. B., Dressman, J. B., Amidon, G. L. (1986) The effect of pH and concentration on alpha-methyldopa absorption in man. J. Pharm. Pharmacol. 38: 815-822
-
(1986)
J. Pharm. Pharmacol.
, vol.38
, pp. 815-822
-
-
Merfeld, A.E.1
Mlodozeniec, A.R.2
Cortese, M.A.3
Rhodes, J.B.4
Dressman, J.B.5
Amidon, G.L.6
-
67
-
-
0019422355
-
A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry
-
Martin, Y. C. (1981) A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry. J. Med. Chem. 24: 229-237
-
(1981)
J. Med. Chem.
, vol.24
, pp. 229-237
-
-
Martin, Y.C.1
-
68
-
-
0015028201
-
Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at a variable flow rates
-
Modigliani, R., Bernier, J. J. (1971) Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at a variable flow rates. Gut 12: 184-193
-
(1971)
Gut
, vol.12
, pp. 184-193
-
-
Modigliani, R.1
Bernier, J.J.2
-
69
-
-
0028000156
-
The influence of net water absorption on the permeability of antipyrine and levodopa in the human jejunum
-
Nilsson, D., Fagerholm, U., Lennernäs, H. (1994) The influence of net water absorption on the permeability of antipyrine and levodopa in the human jejunum. Pharm. Res. 11: 1541-1545
-
(1994)
Pharm. Res.
, vol.11
, pp. 1541-1545
-
-
Nilsson, D.1
Fagerholm, U.2
Lennernäs, H.3
-
70
-
-
0029875543
-
The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system
-
Nerurkar, M. M., Burton, P. S., Borchardt, R. T. (1996) The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm. Res. 13: 528-534
-
(1996)
Pharm. Res.
, vol.13
, pp. 528-534
-
-
Nerurkar, M.M.1
Burton, P.S.2
Borchardt, R.T.3
-
71
-
-
34250426181
-
The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat
-
Ochsenfahrt, H., Winne, D. (1974) The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat. Naunyn Schmiederbergs Arch. Pharmacol. 281: 175-196
-
(1974)
Naunyn Schmiederbergs Arch. Pharmacol.
, vol.281
, pp. 175-196
-
-
Ochsenfahrt, H.1
Winne, D.2
-
72
-
-
0023276344
-
Intestinal absorption of a-methyldopa: In vitro mechanistic studies in rat small intestinal segments
-
Osiecka, I., Cortese, M., Porter, P. A., Borchardt, R. T., Fix, J. A., Gardner, C. R. (1987) Intestinal absorption of a-methyldopa: in vitro mechanistic studies in rat small intestinal segments. J. Pharmacol. Exp. Ther. 242: 443-449
-
(1987)
J. Pharmacol. Exp. Ther.
, vol.242
, pp. 443-449
-
-
Osiecka, I.1
Cortese, M.2
Porter, P.A.3
Borchardt, R.T.4
Fix, J.A.5
Gardner, C.R.6
-
73
-
-
0002824050
-
Ueber die allgemeinen osmotischen Eigenschaften der Zelle, ihre vermutlichen Ursachen und ihre Bedeutung für die Physiologie
-
Overton, E. (1899) Ueber die allgemeinen osmotischen Eigenschaften der Zelle, ihre vermutlichen Ursachen und ihre Bedeutung für die Physiologie. Vierteljahrsschr. Naturforsch. Ges. Zuerich. 44: 88-135
-
(1899)
Vierteljahrsschr. Naturforsch. Ges. Zuerich.
, vol.44
, pp. 88-135
-
-
Overton, E.1
-
74
-
-
0030030608
-
Correlation of drug absorption with molecular surface properties
-
Palm, K., Luthman, K. Ungell, A-L. Strandlund, G., Artursson, P. (1996) Correlation of drug absorption with molecular surface properties. J. Pharm. Sci. 85: 32-39
-
(1996)
J. Pharm. Sci.
, vol.85
, pp. 32-39
-
-
Palm, K.1
Luthman, K.2
Ungell, A.-L.3
Strandlund, G.4
Artursson, P.5
-
75
-
-
0023520885
-
Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters
-
Pappenheimer, J. R. (1987) Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters. J. Membr. Biol. 100: 137-148
-
(1987)
J. Membr. Biol.
, vol.100
, pp. 137-148
-
-
Pappenheimer, J.R.1
-
76
-
-
0027441979
-
On the coupling of membrane digestion with intestinal absorption of sugars and amino acids
-
Pappenheimer, J. R. (1993) On the coupling of membrane digestion with intestinal absorption of sugars and amino acids. Am. J. Physiol. 265: G409-417
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Pappenheimer, J.R.1
-
77
-
-
0023521841
-
Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat
-
Pappenheimer, J. R., Reiss, K. Z. (1987) Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J. Membr. Biol. 100: 123-136
-
(1987)
J. Membr. Biol.
, vol.100
, pp. 123-136
-
-
Pappenheimer, J.R.1
Reiss, K.Z.2
-
78
-
-
0028204841
-
Intestinal absorption and excretion of octapeptides composed of D amino acids
-
Pappenheimer, J. R., Dahl, C. E., Karnovsky, M. L., Maggio, J. E. (1994) Intestinal absorption and excretion of octapeptides composed of D amino acids. Proc. Natl Acad. Sci. 91: 1942-1945
-
(1994)
Proc. Natl Acad. Sci.
, vol.91
, pp. 1942-1945
-
-
Pappenheimer, J.R.1
Dahl, C.E.2
Karnovsky, M.L.3
Maggio, J.E.4
-
79
-
-
0025329190
-
Comparison of in vitro and in vivo models of drug transcytosisi through the blood brain barrier
-
Pardridge, W. M., Triguero, D., Yang, J., Cancilla, P. A. (1990) Comparison of in vitro and in vivo models of drug transcytosisi through the blood brain barrier. J. Pharmacol. Exp. Ther. 253: 884-891
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.253
, pp. 884-891
-
-
Pardridge, W.M.1
Triguero, D.2
Yang, J.3
Cancilla, P.A.4
-
81
-
-
0013897940
-
Occlusion of the jejunum for intestinal perfusion in man
-
Phillips, S. F., Summerskill, W. H. J. (1966) Occlusion of the jejunum for intestinal perfusion in man Mayo Clin. Proc. 41: 224-231
-
(1966)
Mayo Clin. Proc.
, vol.41
, pp. 224-231
-
-
Phillips, S.F.1
Summerskill, W.H.J.2
-
82
-
-
0002833727
-
Intestinal water and electrolyte transport
-
Johnson, J. L (ed.) Raven Press, New York
-
Powell, D. W. (1987) Intestinal water and electrolyte transport In: Johnson, J. L (ed.) Physiology of the Gastrointestinal Tract, Raven Press, New York, pp 1267-1306
-
(1987)
Physiology of the Gastrointestinal Tract
, pp. 1267-1306
-
-
Powell, D.W.1
-
84
-
-
0027763397
-
Luminal nutrients alter tight-junction permeability in the rat jejunum: An in vivo perfusion model
-
Sadowski, D. C., Meddings, J. B. (1993) Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model. Can. J. Physiol. Pharmacol. 71: 835-839
-
(1993)
Can. J. Physiol. Pharmacol.
, vol.71
, pp. 835-839
-
-
Sadowski, D.C.1
Meddings, J.B.2
-
85
-
-
0029964082
-
Chemical approaches to improve the oral bioavailability of peptidergic molecules
-
Samanen, J., Wilson, G., Smith, P. L., Lee, C-P., Bondinell, W., Ku, T., Rhodes, G., Nichols, A. (1996) Chemical approaches to improve the oral bioavailability of peptidergic molecules. J. Pharm. Pharmacol. 48: 119-125
-
(1996)
J. Pharm. Pharmacol.
, vol.48
, pp. 119-125
-
-
Samanen, J.1
Wilson, G.2
Smith, P.L.3
Lee, C.-P.4
Bondinell, W.5
Ku, T.6
Rhodes, G.7
Nichols, A.8
-
86
-
-
0029149609
-
Paracellular intestinal transport of six-carbon sugars is negligible in the rat
-
Schwartz, R. M., Furne, J. K., Levitt, M. D (1995). Paracellular intestinal transport of six-carbon sugars is negligible in the rat. Gastroenterology 109: 1206-1213
-
(1995)
Gastroenterology
, vol.109
, pp. 1206-1213
-
-
Schwartz, R.M.1
Furne, J.K.2
Levitt, M.D.3
-
87
-
-
0027363718
-
Nutrient-induced changes in the permeability of the rat jejunal mucosa
-
See, N., Bass, P. (1993) Nutrient-induced changes in the permeability of the rat jejunal mucosa. J. Pharm. Sci. 82: 721-4
-
(1993)
J. Pharm. Sci.
, vol.82
, pp. 721-724
-
-
See, N.1
Bass, P.2
-
88
-
-
0014876556
-
Further studies on the pertfusion method for measuring intestinal absorption in man: The effects of a proximal occlusive balloon and a mixing segment
-
Sladen, G. E., Dawson, A. M: (1970) Further studies on the pertfusion method for measuring intestinal absorption in man: the effects of a proximal occlusive balloon and a mixing segment. Gut 11: 947-954
-
(1970)
Gut
, vol.11
, pp. 947-954
-
-
Sladen, G.E.1
Dawson, A.M.2
-
89
-
-
0029865450
-
Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
-
Smith, D. A., Jones, B. C., Walker, D. K. (1996) Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics. Med. Res. Rev. 16: 243-266
-
(1996)
Med. Res. Rev.
, vol.16
, pp. 243-266
-
-
Smith, D.A.1
Jones, B.C.2
Walker, D.K.3
-
91
-
-
0018894692
-
Passage of molecules through the wall of the gastrointestinal tract
-
Sundquist, T., Magnusson, K-E., Spödahl, I., Tagesson, C. (1980) Passage of molecules through the wall of the gastrointestinal tract. Gut 21: 208-214
-
(1980)
Gut
, vol.21
, pp. 208-214
-
-
Sundquist, T.1
Magnusson, K.-E.2
Spödahl, I.3
Tagesson, C.4
-
92
-
-
0022454140
-
Sites and mechanisms of intestinal drug absorption
-
Taylor, D. C (1986). Sites and mechanisms of intestinal drug absorption. Pharm. Int. 6: 179-183
-
(1986)
Pharm. Int.
, vol.6
, pp. 179-183
-
-
Taylor, D.C.1
-
93
-
-
0141907178
-
-
Hardy, J. G., Davis S.S., Wilson, C.G. (eds) Ellis Horwood Ltd, Chichester
-
Taylor, D. C., Lynch, J., Leahy, D. E. (1990) In: Hardy, J. G., Davis S.S., Wilson, C.G. (eds) Drug Delivery to the Gastrointestinal Tract. Ellis Horwood Ltd, Chichester, pp 133-145
-
(1990)
Drug Delivery to the Gastrointestinal Tract
, pp. 133-145
-
-
Taylor, D.C.1
Lynch, J.2
Leahy, D.E.3
-
94
-
-
0029881811
-
Lipophilicity in molecular modelling
-
Testa, B., Carrupt, P-A., Gaillard, P., Billois, F., Weber, P. (1996) Lipophilicity in molecular modelling. Pharm. Res. 13: 335-343
-
(1996)
Pharm. Res.
, vol.13
, pp. 335-343
-
-
Testa, B.1
Carrupt, P.-A.2
Gaillard, P.3
Billois, F.4
Weber, P.5
-
95
-
-
0023447098
-
Cellular localization of the multi-drug resistance gene product P-glycoprotein in normal human tissues
-
Thiebaud, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., Willingham, M.C. (1987) Cellular localization of the multi-drug resistance gene product P-glycoprotein in normal human tissues. Proc. Natl Acad. Sci. 84: 7735-7738
-
(1987)
Proc. Natl Acad. Sci.
, vol.84
, pp. 7735-7738
-
-
Thiebaud, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
96
-
-
0029782485
-
Carrier-mediated intestinal transport of drugs
-
Tsuji, A., Tamai, I. (1996) Carrier-mediated intestinal transport of drugs. Pharm. Res. 13: 963-977
-
(1996)
Pharm. Res.
, vol.13
, pp. 963-977
-
-
Tsuji, A.1
Tamai, I.2
-
97
-
-
0029078054
-
The effect of surgical bowel manipulation and anaesthesia on intestinal glucose absorption in rats
-
Uhing, M. R., Kimura, R. E. (1995a ) The effect of surgical bowel manipulation and anaesthesia on intestinal glucose absorption in rats. J. Clin. Invest. 95: 2790-2798
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2790-2798
-
-
Uhing, M.R.1
Kimura, R.E.2
-
98
-
-
0029047852
-
Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats
-
Uhing, M. R., Kimura, R. E. (1995b) Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats. J. Clin. Invest. 95: 2799-2805
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2799-2805
-
-
Uhing, M.R.1
Kimura, R.E.2
-
99
-
-
21144467893
-
Hydrogen-bonding capacity and brain penetration
-
van de Waterbeemd, H., Kansy, M. (1992) Hydrogen-bonding capacity and brain penetration. Chimia 299-303
-
(1992)
Chimia
, pp. 299-303
-
-
Van De Waterbeemd, H.1
Kansy, M.2
-
100
-
-
0024829366
-
The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into central nervous system
-
Van Bree, J. B. M. M., Baljet A.V., van Geyt A., de Boer A. G., Danhof M., Breimer D. D. (1989) The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into central nervous system. J. Pharmacokin. Biopharm. 17: 441-462
-
(1989)
J. Pharmacokin. Biopharm.
, vol.17
, pp. 441-462
-
-
Van Bree, J.B.M.M.1
Baljet, A.V.2
Van Geyt, A.3
De Boer, A.G.4
Danhof, M.5
Breimer, D.D.6
-
101
-
-
0024467119
-
Contribution of the intestine to the first-pass metabolism of felodipine in the rat
-
Wang, S-X., Sutfin, T. A., Bäärnhilem, C., Regårdh, C. G. (1989) Contribution of the intestine to the first-pass metabolism of felodipine in the rat. J. Pharmacol. Exp. Ther. 250: 632-636
-
(1989)
J. Pharmacol. Exp. Ther.
, vol.250
, pp. 632-636
-
-
Wang, S.-X.1
Sutfin, T.A.2
Bäärnhilem, C.3
Regårdh, C.G.4
-
102
-
-
0030481554
-
Estimation of Caco-2 cell permeability using calculated molecular descriptors
-
Waterbeemd, H., Camenisch, Folkers, G., Raevsky O. A. (1996) Estimation of Caco-2 cell permeability using calculated molecular descriptors. Quant. Struct. Act. Relat. 15: 480-490
-
(1996)
Quant. Struct. Act. Relat.
, vol.15
, pp. 480-490
-
-
Waterbeemd, H.1
Camenisch2
Folkers, G.3
Raevsky, O.A.4
-
103
-
-
34250426181
-
The contribution of solvent drag to the intestinal absorption of the basic drugs aminopyrine and antipyrine from the jejunum of the rat
-
Winne, D. (1974a) The contribution of solvent drag to the intestinal absorption of the basic drugs aminopyrine and antipyrine from the jejunum of the rat. Naunyn Schmiedebergs Arch. Pharmacol. 281: 175-196
-
(1974)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.281
, pp. 175-196
-
-
Winne, D.1
-
104
-
-
34250416118
-
The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat
-
Winne, D. (1974b) The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat. Naunyn Schmiedebergs Arch. Pharmacol. 281: 197-217
-
(1974)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.281
, pp. 197-217
-
-
Winne, D.1
-
105
-
-
15444343251
-
Role of blood flow in intestinal permeation
-
T. Z. Csáky (ed.) Springer-Verlag, Berlin
-
Winne, D. (1984) Role of blood flow in intestinal permeation. In: T. Z. Csáky (ed.) Pharmacology of Intestinal Permeation II, Springer-Verlag, Berlin, pp 301-347
-
(1984)
Pharmacology of Intestinal Permeation II
, pp. 301-347
-
-
Winne, D.1
-
106
-
-
0026764698
-
Reversal of multidrug resistance
-
Woodcock, D. M., Linsenmeyer, M. E., Chojnowski, G., Kriegler, A. B., Nink, V., Webster, L. K., Sawyer, W. H. (1992) Reversal of multidrug resistance. Br. J. Cancer 66: 62-68
-
(1992)
Br. J. Cancer
, vol.66
, pp. 62-68
-
-
Woodcock, D.M.1
Linsenmeyer, M.E.2
Chojnowski, G.3
Kriegler, A.B.4
Nink, V.5
Webster, L.K.6
Sawyer, W.H.7
-
107
-
-
0028820208
-
Differentiation of absorption, first-pass gut and hepatic metabolism in man: Studies with cyclosporine
-
Wu, C. Y., Benet, L. Z., Hebert, M. F., Gupta, S. K., Rowland, M., Gomez, D. Y., Wacher, V. J. (1995) Differentiation of absorption, first-pass gut and hepatic metabolism in man: studies with cyclosporine. Clin. Pharmacol. Ther. 58: 492-497
-
(1995)
Clin. Pharmacol. Ther.
, vol.58
, pp. 492-497
-
-
Wu, C.Y.1
Benet, L.Z.2
Hebert, M.F.3
Gupta, S.K.4
Rowland, M.5
Gomez, D.Y.6
Wacher, V.J.7
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