Highly engineered biocatalysts for efficient small molecule pharmaceutical synthesis

Current Opinion in Biotechnology

Volumn 42, Issue , 2016, Pages 152-158

  Lalonde, Jim ^a  

^a R and D Project Development and Management   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSTS; COMPUTATIONAL EFFICIENCY; ENZYMES; STEREOCHEMISTRY;

CHIRAL ALCOHOLS; CYCLOPROPANATION; EFFICIENT SYNTHESIS; PHARMACEUTICAL SYNTHESIS; SMALL MOLECULES; STRUCTURAL MODELING;

SYNTHESIS (CHEMICAL);

AMIDASE; AMINE DEHYDROGENASE; AMINOTRANSFERASE; CYTOCHROME P450; KETONE; MEVINOLIN; MILNACIPRAN; MONOCOLIN J; RIVASTIGMINE; SIMVASTATIN; SITAGLIPTIN; STRICTOSIDINE; UNCLASSIFIED DRUG; VERNAKALANT; ALCOHOL DERIVATIVE; AMINE; DRUG; ENZYME; MOLECULAR LIBRARY;

BIOCATALYST; CYCLOPROPANATION; DRUG PURITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ENGINEERING; ENZYME STABILITY; GENETIC VARIABILITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEREOCHEMISTRY; TRANSAMINATION; ANIMAL; BIOCATALYSIS; CHEMISTRY; DRUG DEVELOPMENT; DRUG INDUSTRY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLIC ENGINEERING; METABOLISM; MOLECULAR LIBRARY; PROCEDURES; SYNTHESIS; TRENDS;

ALCOHOLS; AMINES; ANIMALS; BIOCATALYSIS; DRUG DISCOVERY; DRUG INDUSTRY; ENZYMES AND COENZYMES; HUMANS; METABOLIC ENGINEERING; PHARMACEUTICAL PREPARATIONS; SMALL MOLECULE LIBRARIES;

EID: 84971357091     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2016.04.023     Document Type: Review

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