Development of a concise, asymmetric synthesis of a smoothened receptor (smo) inhibitor: Enzymatic transamination of a 4-piperidinone with dynamic kinetic resolution

Organic Letters

Volumn 16, Issue 3, 2014, Pages 860-863

  Peng, Zhihui ^a   Wong, John W ^a   Hansen, Eric C ^a   Puchlopek Dermenci, Angela L A ^a   Clarke, Hugh J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PIPERIDONE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; KINETICS; STEREOISOMERISM; SYNTHESIS;

CATALYSIS; HUMANS; KINETICS; MOLECULAR STRUCTURE; PIPERIDONES; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM;

EID: 84893855937     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol403630g     Document Type: Article

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