Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 18, 2016, Pages 5012-5017

  Deckert, Annika ^a,b   Waudby, Christopher A ^a,b   Wlodarski, Tomasz ^a,b   Wentink, Anne S ^a,b   Wang, Xiaolin ^a,b   Kirkpatrick, John P ^a,b   Paton, Jack F S ^a,b   Camilloni, Carlo ^c   Kukic, Predrag ^c   Dobson, Christopher M ^c   Vendruscolo, Michele ^c   Cabrita, Lisa D ^a,b   Christodoulou, John ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cotranslational folding; Nascent chain; NMR spectroscopy; Ribosome; synuclein

Indexed keywords

ALPHA SYNUCLEIN; CHAPERONE; INTRINSICALLY DISORDERED PROTEIN; RIBOSOME PROTEIN; TRIGGER FACTOR; UNCLASSIFIED DRUG; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL SURFACE; MOLECULAR DYNAMICS; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITY CONTROL; RIBOSOME; RIBOSOME NASCENT CHAIN COMPLEX; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; MOLECULAR DOCKING; PROTEIN DOMAIN; SURFACE PROPERTY; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; BINDING SITES; COMPUTER SIMULATION; MODELS, CHEMICAL; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAINS; RIBOSOMES; SURFACE PROPERTIES;

EID: 84970996447     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519124113     Document Type: Article

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