Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients

Clinical Biochemistry

Volumn 42, Issue 7-8, 2009, Pages 584-588

  Ben Ali, Samir ^a   Kallel, Amani ^a   Ftouhi, Bochra ^a   Sediri, Yousra ^a   Feki, Moncef ^a   Slimane, Hadia ^a   Jemaa, Riadh ^a   Kaabachi, Naziha ^a  

^a LA RABTA HOSPITAL   (Tunisia)

Author keywords

Leptin; Leptin gene; Obesity; Polymorphism

Indexed keywords

ENDONUCLEASE; INSULIN; LEPTIN; LIPID;

ADULT; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIGESTION; FEMALE; G 2548A GENE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUNISIA;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; FEMALE; HUMANS; LEPTIN; LINEAR MODELS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; TUNISIA;

EID: 63649124935     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2008.11.001     Document Type: Article

References (31)

1. Kopelman P.G. Obesity as a medical problem. Nature 404 (2000) 635-643
2. Moll P.P., Burns T.L., and Lauer R.M. The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study. Am J Hum Genet 49 (1991) 1243-1255
3. Pe'russe L., Chagnon Y.C., Weisnagel S.J., et al. The human obesity gene map: the 2000 update. Obes Res 9 (2001) 135-168
4. Hirschhorn J.N., and Daly M.J. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6 (2005) 95-108
5. Liu Y.J., Liu X.G., Wang L., et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet. 17 (2008) 1803-1813
6. Campfield L.A., Smith F., Guiez Y., Devos R., and Burn P. Recombinant mouse OB proteins: evidence for a peripheral signal linking adiposity and central neural networks. Science 269 (1995) 546-549
7. Hallaas J., Gajiwala K.S., Maffei M., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
8. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
9. Masuzaki H., Ogawa Y., Isse N., et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 5 (1995) 5-12
10. Green E.D., Maffei M., Braden V.V., et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 5 (1995) 5-12
11. Isse N., Ogawa Y., Tamura N., et al. Structural organisation and chromosomal assignment of the human obese gene. J Biol Chem 270 (1995) 27728-27733
12. Li W.D., Reed D.R., and Lee J.H. Sequence variants in the 5′ flanking region of the leptin gene are associated with obesity in women. Ann Hum Genet 63 (1999) 227-234
13. Mammés O., Betoulle D., Aubert R., et al. Novel polymorphisms in the 5′ region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity. Diabetes 47 (1998) 487-489
14. Mammés O., Betoulle D., Aubert R., Herbeth B., Siest G., and Fumeron F. Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Ann Hum Genet 64 (2000) 391-394
15. Le Stunff C., Le Bihan C., Schork N.J., and Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 49 (2000) 2106-2200
16. Hoffsted J., Eriksson P., Mottagui-Tabar S., and Arner P. A polymorphism in the leptin gene promotor region (- 2548 g/a) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 34 (2002) 355-359
17. World Health Organisation. Physical status: the use and interpretation anthropometry: Report of a WHO Expert Committee, WHO Technical Report Series, no. 854, (1995), WHO, Geneva 321-344
18. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
19. Friedwald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972) 499-502
20. Marcadet A., O'Connel P., and Cohen D. Standardized Southern blot workshop techniques. In: Dupont B. (Ed). Histocompatibility testing (1987), Springer, New York 587-590
21. Portolés O., Sorli J.V., Francés F., et al. Effect of genetic variation in the leptin gene promotor and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur J Epidemiol 21 (2006) 605-612
22. Duarte S.F., Francischetti E.A., Genelhu V.A., Cabello P.H., and Pimentel M.M. LEPR p.Q223R, β3-AR p.W64R and LEP c.-2548G > A gene variants in obese Brazilian subjects. Genet Mol Res 6 (2007) 1035-1043
23. Wang T.N., Huang M.C., Chang W.T., et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity 14 (2006) 183-187
24. Maffei M., Halaas J., Ravussin E., et al. Leptin levels in human and rodents: measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nat Med 1 (1995) 1155-1161
25. Considine R.V., Sinha M.K., Heiman M.L., et al. Serum immunoreactive leptin concentrations in normal weight and obese humans. N Eng J Med 334 (1996) 292-295
26. Isidori A.M., Strollo F., Morè M., et al. Leptin and aging: correlation with endocrine changes in male and female healthy adult population of different body weights. J Clin Endocrinol Metab 85 (2000) 1954-1962
27. Wabitsch M., jensen P.B., Blum W.F., et al. Insulin and cortisol promote leptin production in cultural human fat cells. Diabetes 45 (1996) 1435-1438
28. Yiannakouris N., Melistas L., Yannakoulia M., Mungal K., and Mantzoros C.S. The -2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. Hormones 2 (2003) 229-236
29. Poitou C., Lacorte J.M., Coupaye M., et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg 15 (2005) 11-23
30. Hinuy H.M., Hirata M.H., Forti N., et al. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arq Bras Endocrinol Metab 52 (2008) 611-616
31. Hager J., Clement K., Francke S., et al. A polymorphism in the 5′ untranslated region of the human leptin gene was associated with lower leptin levels. Int J Obes Relat Metab Disord 22 (1998) 200-205