Impaired leptin gene expression and release in cultured preadipocytes isolated from individuals born with low birth weight

Diabetes

Volumn 63, Issue 1, 2014, Pages 111-121

  Schultz, Ninna S ^a   Broholm, Christa ^a   Gillberg, Linn ^a   Mortensen, Brynjulf ^b   Jørgensen, Sine W ^a,b   Schultz, Heidi S ^c,d   Scheele, Camilla ^a   Wojtaszewski, Jørgen F P ^e   Pedersen, Bente K ^a   Vaag, Allan ^a,b  

^a Rigshospitalet   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d NOVO NORDISK A S   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID BINDING PROTEIN 4; GLUCOSE TRANSPORTER 4; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ABDOMINAL SUBCUTANEOUS FAT; ADULT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION; HUMAN; LOW BIRTH WEIGHT; MALE; PRIORITY JOURNAL; PROADIPOCYTE; PROMOTER REGION; PROTEIN SECRETION; PYROSEQUENCING; RISK FACTOR; YOUNG ADULT;

EID: 84891779946     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0621     Document Type: Article

References (46)

1. Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull 2001; 60:5-20
2. Poulsen P, Vaag AA, Kyvik KO, Møller Jensen D, Beck-Nielsen H. Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 1997;40:439-446
3. Bo S, Cavallo-Perin P, Scaglione L, Ciccone G, Pagano G. Low birthweight and metabolic abnormalities in twins with increased susceptibility to Type 2 diabetes mellitus. Diabet Med 2000;17:365-370
4. Kanaka-Gantenbein C. Fetal origins of adult diabetes. Ann N Y Acad Sci 2010;1205:99-105
5. Carey GB. Mechanisms regulating adipocyte lipolysis. Adv Exp Med Biol 1998;441:157-170
6. Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome-an allostatic perspective. Biochim Biophys Acta 2010;1801:338-349
7. Lane MD, Tang QQ, Jiang MS. Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. Biochem Biophys Res Commun 1999;266:677-683
8. Rosen ED, Hsu CH, Wang X, et al. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 2002;16:22-26
9. Sewter C, Blows F, Considine R, Vidal-Puig A, O'Rahilly S. Differential effects of adiposity on peroxisomal proliferator-activated receptor gamma1 and gamma2 messenger ribonucleic acid expression in human adipocytes. J Clin Endocrinol Metab 2002;87:4203-4207
10. Fajas L, Auboeuf D, Raspé E, et al. The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 1997;272: 18779-18789
11. Christy RJ, Yang VW, Ntambi JM, et al. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev 1989;3:1323-1335
12. Gong DW, Bi S, Pratley RE, Weintraub BD. Genomic structure and promoter analysis of the human obese gene. J Biol Chem 1996;271:3971-3974
13. Djiane J, Attig L. Role of leptin during perinatal metabolic programming and obesity. J Physiol Pharmacol 2008;59(Suppl. 1):55-63
14. Melzner I, Scott V, Dorsch K, et al. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. J Biol Chem 2002;277:45420-45427
15. Friedman JM. Obesity in the new millennium. Nature 2000;404:632-634
16. Ikeda Y, Hama S, Kajimoto K, Okuno T, Tsuchiya H, Kogure K. Quantitative comparison of adipocytokine gene expression during adipocyte maturation in non-obese and obese rats. Biol Pharm Bull 2011;34:865-870
17. Singhal A, Farooqi IS, O'Rahilly S, Cole TJ, Fewtrell M, Lucas A. Early nutrition and leptin concentrations in later life. Am J Clin Nutr 2002;75: 993-999
18. Jensen CB, Storgaard H, Dela F, Holst JJ, Madsbad S, Vaag AA. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. Diabetes 2002;51:1271-1280
19. Brøns C, Jensen CB, Storgaard H, et al. Mitochondrial function in skeletal muscle is normal and unrelated to insulin action in young men born with low birth weight. J Clin Endocrinol Metab 2008;93:3885-3892
20. Alibegovic AC, Højbjerre L, Sonne MP, et al. Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight. Am J Physiol Endocrinol Metab 2010;298:E555-E564
21. Mortensen B, Hingst JR, Frederiksen N, et al. Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle. Am J Physiol Endocrinol Metab 2013;304:E1379-E1390
22. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223
23. Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 1975;35:609-616
24. van Harmelen V, Dicker A, Rydén M, et al. Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes. Diabetes 2002;51:2029-2036
25. Dicker A, Aström G, Sjölin E, Hauner H, Arner P, van Harmelen V. The influence of preadipocyte differentiation capacity on lipolysis in human mature adipocytes. Horm Metab Res 2007;39:282-287
26. Cawthorn WP, Scheller EL, MacDougald OA. Adipose tissue stem cells meet preadipocyte commitment: going back to the future. J Lipid Res 2012;53:227-246
27. Brzoska M, Geiger H, Gauer S, Baer P. Epithelial differentiation of human adipose tissue-derived adult stem cells. Biochem Biophys Res Commun 2005;330:142-150
28. Yoshimura K, Shigeura T, Matsumoto D, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 2006;208:64-76
29. Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol 2001;189:54-63
30. Mitchell JB, McIntosh K, Zvonic S, et al. Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 2006;24:376-385
31. Ozanne SE, Jensen CB, Tingey KJ, et al. Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes? Diabetologia 2006; 49:2993-2999
32. Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, et al. Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ 2012;19:1003-1012
33. Rasmussen EL, Malis C, Jensen CB, et al. Altered fat tissue distribution in young adult men who had low birth weight. Diabetes Care 2005;28:151-153
34. Vaag AA, Grunnet LG, Arora GP, Brøns C. The thrifty phenotype hypothesis revisited. Diabetologia 2012;55:2085-2088
35. Brøns C, Jacobsen S, Hiscock N, et al. Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects. Am J Physiol Endocrinol Metab 2012;302: E43-E51
36. Ibáñez L, Ong K, Dunger DB, de Zegher F. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestationalage children. J Clin Endocrinol Metab 2006;91:2153-2158
37. Havel PJ, Townsend R, Chaump L, Teff K. High-fat meals reduce 24-h circulating leptin concentrations in women. Diabetes 1999;48:334-341
38. Harwood HJ Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology 2012;63:57-75
39. Rosenbaum M, Leibel RL. Clinical review 107: role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. J Clin Endocrinol Metab 1999;84:1784-1789
40. Sarr O, Yang K, Regnault TR. In utero programming of later adiposity: the role of fetal growth restriction. J Pregnancy 2012;2012:134758
41. De Smet C, Lurquin C, Lethé B, Martelange V, Boon T. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol 1999;19:7327-7335
42. Eden S, Cedar H. Role of DNA methylation in the regulation of transcription. Curr Opin Genet Dev 1994;4:255-259
43. Mikkelsen TS, Xu Z, Zhang X, et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell 2010;143:156-169
44. Zhang Q, Ramlee MK, Brunmeir R, Villanueva CJ, Halperin D, Xu F. Dynamic and distinct histone modifications modulate the expression of key adipogenesis regulatory genes. Cell Cycle 2012;11:4310-4322
45. Brøns C, Lilleøre SK, Jensen CB, Toubro S, Vaag A, Astrup A. Increased nocturnal fat oxidation in young healthy men with low birth weight: results from 24-h whole-body respiratory chamber measurements. Metabolism 2013;62:709-716
46. Woo M, Isganaitis E, Cerletti M, et al. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev 2011;20:1763-1769