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Volumn 19, Issue 9, 2010, Pages 1846-1855

Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR;

EID: 77952506085     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddq056     Document Type: Article
Times cited : (68)

References (44)
  • 1
    • 61449105725 scopus 로고    scopus 로고
    • Leptin: a pivotal regulator of human energy homeostasis
    • Farooqi, I.S. and O'Rahilly, S. (2009) Leptin: a pivotal regulator of human energy homeostasis. Am. J. Clin. Nutr., 89, 980S-984S.
    • (2009) Am. J. Clin. Nutr. , vol.89
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 2
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J.M. and Halaas, J.L. (1998) Leptin and the regulation of body weight in mammals. Nature, 395, 763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 3
    • 0033835211 scopus 로고    scopus 로고
    • Leptin-much more than a satiety signal
    • Harris, R.B. (2000) Leptin-much more than a satiety signal. Annu. Rev. Nutr., 20, 45-75.
    • (2000) Annu. Rev. Nutr. , vol.20 , pp. 45-75
    • Harris, R.B.1
  • 4
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua, S.C. Jr, Chung, W.K., Wu-Peng, X.S., Zhang, Y., Liu, S.M., Tartaglia, L. and Leibel, R.L. (1996) Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 271, 994-996.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua S.C., Jr.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.M.5    Tartaglia, L.6    Leibel, R.L.7
  • 6
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia, L.A. (1997) The leptin receptor. J. Biol. Chem., 272, 6093-6096.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 7
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Fruhbeck, G. (2006) Intracellular signalling pathways activated by leptin. Biochem. J., 393, 7-20.
    • (2006) Biochem. J. , vol.393 , pp. 7-20
    • Fruhbeck, G.1
  • 8
    • 0037195916 scopus 로고    scopus 로고
    • Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
    • Ge, H., Huang, L., Pourbahrami, T. and Li, C. (2002) Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J. Biol. Chem., 277, 45898-45903.
    • (2002) J. Biol. Chem. , vol.277 , pp. 45898-45903
    • Ge, H.1    Huang, L.2    Pourbahrami, T.3    Li, C.4
  • 9
    • 0030685790 scopus 로고    scopus 로고
    • Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts
    • Chua, S.C. Jr, Koutras, I.K., Han, L., Liu, S.M., Kay, J., Young, S.J., Chung, W.K. and Leibel, R.L. (1997) Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics, 45, 264-270.
    • (1997) Genomics , vol.45 , pp. 264-270
    • Chua S.C., Jr.1    Koutras, I.K.2    Han, L.3    Liu, S.M.4    Kay, J.5    Young, S.J.6    Chung, W.K.7    Leibel, R.L.8
  • 10
    • 0034801977 scopus 로고    scopus 로고
    • Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
    • Maamra, M., Bidlingmaier, M., Postel-Vinay, M.C., Wu, Z., Strasburger, C.J. and Ross, R.J. (2001) Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology, 142, 4389-4393.
    • (2001) Endocrinology , vol.142 , pp. 4389-4393
    • Maamra, M.1    Bidlingmaier, M.2    Postel-Vinay, M.C.3    Wu, Z.4    Strasburger, C.J.5    Ross, R.J.6
  • 11
    • 0036307849 scopus 로고    scopus 로고
    • Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans
    • Chan, J.L., Bluher, S., Yiannakouris, N., Suchard, M.A., Kratzsch, J. and Mantzoros, C.S. (2002) Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes, 51, 2105-2112.
    • (2002) Diabetes , vol.51 , pp. 2105-2112
    • Chan, J.L.1    Bluher, S.2    Yiannakouris, N.3    Suchard, M.A.4    Kratzsch, J.5    Mantzoros, C.S.6
  • 12
  • 14
    • 3042579670 scopus 로고    scopus 로고
    • Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population
    • Ogawa, T., Hirose, H., Yamamoto, Y., Nishikai, K., Miyashita, K., Nakamura, H., Saito, I. and Saruta, T. (2004) Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. Metabolism, 53, 879-885.
    • (2004) Metabolism , vol.53 , pp. 879-885
    • Ogawa, T.1    Hirose, H.2    Yamamoto, Y.3    Nishikai, K.4    Miyashita, K.5    Nakamura, H.6    Saito, I.7    Saruta, T.8
  • 15
    • 77950359650 scopus 로고    scopus 로고
    • Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in US Women: A Prospective Study
    • Sun, Q., van Dam, R.M., Meigs, J.B., Franco, O.H., Mantzoros, C.S. and Hu, F.B. (2010) Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in US Women: A Prospective Study. Diabetes, 59, 611-618.
    • (2010) Diabetes , vol.59 , pp. 611-618
    • Sun, Q.1    van Dam, R.M.2    Meigs, J.B.3    Franco, O.H.4    Mantzoros, C.S.5    Hu, F.B.6
  • 16
    • 3042534522 scopus 로고    scopus 로고
    • Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome
    • Sandhofer, A., Laimer, M., Ebenbichler, C.F., Kaser, S., Paulweber, B. and Patsch, J.R. (2003) Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome. Obes. Res., 11, 760-768.
    • (2003) Obes. Res. , vol.11 , pp. 760-768
    • Sandhofer, A.1    Laimer, M.2    Ebenbichler, C.F.3    Kaser, S.4    Paulweber, B.5    Patsch, J.R.6
  • 19
    • 0036713510 scopus 로고    scopus 로고
    • Human non-synonymous SNPs: server and survey
    • Ramensky, V., Bork, P. and Sunyaev, S. (2002) Human non-synonymous SNPs: server and survey. Nucleic Acids Res., 30, 3894-3900.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3894-3900
    • Ramensky, V.1    Bork, P.2    Sunyaev, S.3
  • 21
    • 0034191958 scopus 로고    scopus 로고
    • Towards a structural basis of human non-synonymous single nucleotide polymorphisms
    • Sunyaev, S., Ramensky, V. and Bork, P. (2000) Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Trends Genet., 16, 198-200.
    • (2000) Trends Genet. , vol.16 , pp. 198-200
    • Sunyaev, S.1    Ramensky, V.2    Bork, P.3
  • 22
    • 0242413107 scopus 로고    scopus 로고
    • Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance
    • Huan, J.N., Li, J., Han, Y., Chen, K., Wu, N. and Zhao, A.Z. (2003) Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J. Biol. Chem., 278, 45638-45650.
    • (2003) J. Biol. Chem. , vol.278 , pp. 45638-45650
    • Huan, J.N.1    Li, J.2    Han, Y.3    Chen, K.4    Wu, N.5    Zhao, A.Z.6
  • 23
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • Morton, G.J., Gelling, R.W., Niswender, K.D., Morrison, C.D., Rhodes, C.J. and Schwartz, M.W. (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab., 2, 411-420.
    • (2005) Cell Metab. , vol.2 , pp. 411-420
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3    Morrison, C.D.4    Rhodes, C.J.5    Schwartz, M.W.6
  • 25
    • 85047683106 scopus 로고    scopus 로고
    • Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2
    • Anderwald, C., Muller, G., Koca, G., Furnsinn, C., Waldhausl, W. and Roden, M. (2002) Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol. Endocrinol., 16, 1612-1628.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 1612-1628
    • Anderwald, C.1    Muller, G.2    Koca, G.3    Furnsinn, C.4    Waldhausl, W.5    Roden, M.6
  • 26
    • 2542444292 scopus 로고    scopus 로고
    • Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
    • Huang, W., Dedousis, N., Bhatt, B.A. and O'Doherty, R.M. (2004) Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J. Biol. Chem., 279, 21695-21700.
    • (2004) J. Biol. Chem. , vol.279 , pp. 21695-21700
    • Huang, W.1    Dedousis, N.2    Bhatt, B.A.3    O'Doherty, R.M.4
  • 27
    • 77952514465 scopus 로고    scopus 로고
    • The National Center for Biotechnology Information dbSNP build 129. Available, (accessed 07 July 2009)
    • The National Center for Biotechnology Information dbSNP build 129. Available: http://www.ncbi.nlm.nih.gov/projects/SNP/ (accessed 07 July 2009).
  • 28
    • 0037902035 scopus 로고    scopus 로고
    • Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns
    • Gavrila, A., Peng, C.K., Chan, J.L., Mietus, J.E., Goldberger, A.L. and Mantzoros, C.S. (2003) Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J. Clin. Endocrinol. Metab., 88, 2838-2843.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2838-2843
    • Gavrila, A.1    Peng, C.K.2    Chan, J.L.3    Mietus, J.E.4    Goldberger, A.L.5    Mantzoros, C.S.6
  • 29
    • 0037381982 scopus 로고    scopus 로고
    • Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year
    • Pischon, T., Hotamisligil, G.S. and Rimm, E.B. (2003) Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. Clin. Chem., 49, 650-652.
    • (2003) Clin. Chem. , vol.49 , pp. 650-652
    • Pischon, T.1    Hotamisligil, G.S.2    Rimm, E.B.3
  • 30
    • 2942718557 scopus 로고    scopus 로고
    • Association of leptin receptor polymorphism with insulin resistance
    • Chiu, K.C., Chu, A., Chuang, L.M. and Saad, M.F. (2004) Association of leptin receptor polymorphism with insulin resistance. Eur. J. Endocrinol., 150, 725-729.
    • (2004) Eur. J. Endocrinol. , vol.150 , pp. 725-729
    • Chiu, K.C.1    Chu, A.2    Chuang, L.M.3    Saad, M.F.4
  • 31
    • 0034917636 scopus 로고    scopus 로고
    • Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance
    • Wauters, M., Mertens, I., Rankinen, T., Chagnon, M., Bouchard, C. and Van Gaal, L. (2001) Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. J. Clin. Endocrinol. Metab., 86, 3227-3232.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3227-3232
    • Wauters, M.1    Mertens, I.2    Rankinen, T.3    Chagnon, M.4    Bouchard, C.5    Van Gaal, L.6
  • 32
    • 0033735438 scopus 로고    scopus 로고
    • Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding
    • Ukkola, O., Tremblay, A., Despres, J.P., Chagnon, Y.C., Campfield, L.A. and Bouchard, C. (2000) Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding. J. Intern. Med., 248, 435-439.
    • (2000) J. Intern. Med. , vol.248 , pp. 435-439
    • Ukkola, O.1    Tremblay, A.2    Despres, J.P.3    Chagnon, Y.C.4    Campfield, L.A.5    Bouchard, C.6
  • 34
    • 2542544450 scopus 로고    scopus 로고
    • Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    • Lakka, T.A., Rankinen, T., Weisnagel, S.J., Chagnon, Y.C., Lakka, H.M., Ukkola, O., Boule, N., Rice, T., Leon, A.S., Skinner, J.S. et al. (2004) Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. Diabetes, 53, 1603-1608.
    • (2004) Diabetes , vol.53 , pp. 1603-1608
    • Lakka, T.A.1    Rankinen, T.2    Weisnagel, S.J.3    Chagnon, Y.C.4    Lakka, H.M.5    Ukkola, O.6    Boule, N.7    Rice, T.8    Leon, A.S.9    Skinner, J.S.10
  • 35
    • 23444460111 scopus 로고    scopus 로고
    • Genetics of leptin and obesity: a HuGE review
    • Paracchini, V., Pedotti, P. and Taioli, E. (2005) Genetics of leptin and obesity: a HuGE review. Am. J. Epidemiol., 162, 101-114.
    • (2005) Am. J. Epidemiol. , vol.162 , pp. 101-114
    • Paracchini, V.1    Pedotti, P.2    Taioli, E.3
  • 36
    • 18244362591 scopus 로고    scopus 로고
    • Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity
    • Heo, M., Leibel, R.L., Boyer, B.B., Chung, W.K., Koulu, M., Karvonen, M.K., Pesonen, U., Rissanen, A., Laakso, M., Uusitupa, M.I. et al. (2001) Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity. Genetics, 159, 1163-1178.
    • (2001) Genetics , vol.159 , pp. 1163-1178
    • Heo, M.1    Leibel, R.L.2    Boyer, B.B.3    Chung, W.K.4    Koulu, M.5    Karvonen, M.K.6    Pesonen, U.7    Rissanen, A.8    Laakso, M.9    Uusitupa, M.I.10
  • 37
    • 0035073893 scopus 로고    scopus 로고
    • A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women
    • Quinton, N.D., Lee, A.J., Ross, R.J., Eastell, R. and Blakemore, A.I. (2001) A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum. Genet., 108, 233-236.
    • (2001) Hum. Genet. , vol.108 , pp. 233-236
    • Quinton, N.D.1    Lee, A.J.2    Ross, R.J.3    Eastell, R.4    Blakemore, A.I.5
  • 42
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. and Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet., 38, 904-909.
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 44
    • 34447324105 scopus 로고    scopus 로고
    • GenABEL: an R library for genome-wide association analysis
    • Aulchenko, Y.S., Ripke, S., Isaacs, A. and van Duijn, C.M. (2007) GenABEL: an R library for genome-wide association analysis. Bioinformatics, 23, 1294-1296.
    • (2007) Bioinformatics , vol.23 , pp. 1294-1296
    • Aulchenko, Y.S.1    Ripke, S.2    Isaacs, A.3    van Duijn, C.M.4


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