Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice

Endocrinology

Volumn 157, Issue 5, 2016, Pages 1839-1851

  Kitada, Yoshihiko ^a   Kajita, Kazuo ^a   Taguchi, Koichiro ^a   Mori, Ichiro ^a   Yamauchi, Masahiro ^a   Ikeda, Takahide ^a   Kawashima, Mikako ^a   Asano, Motochika ^a   Kajita, Toshiko ^a   Ishizuka, Tatsuo ^b   Banno, Yoshiko ^a   Kojima, Itaru ^c   Chun, Jerold ^d   Kamata, Shotaro ^e   Ishii, Isao ^e   Morita, Hiroyuki ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Gifu Municipal Hospital   (Japan)

^c GUNMA UNIVERSITY   (Japan)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (3 OCTYLPHENYLCARBAMOYL)ETHYL PHOSPHATE; 4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; ADIPONECTIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ARGINASE 1; CYCLINE; CYM 50358; FATTY ACID BINDING PROTEIN 4; FATTY ACID SYNTHASE; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOPROTEIN P 15095; INDUCIBLE NITRIC OXIDE SYNTHASE; LEPTIN; LIPOPROTEIN LIPASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; PHOSPHOSERINE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; SPHINGOSINE-1-PHOSPHATE RECEPTOR-2, MOUSE;

3T3 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY FAT; CELL DIFFERENTIATION; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; DIET INDUCED OBESITY; EPIDIDYMIS; EPIDIDYMIS FAT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; 3T3-L1 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BODY WEIGHT; CELL ENLARGEMENT; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BODY WEIGHT; CELL DIFFERENTIATION; CELL ENLARGEMENT; CELL PROLIFERATION; DIET, HIGH-FAT; FEMALE; GLUCOSE INTOLERANCE; MALE; MICE; MICE, KNOCKOUT; PHOSPHOSERINE; PYRAZOLES; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION;

EID: 84969872555     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1768     Document Type: Article

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