메뉴 건너뛰기




Volumn 38, Issue 5, 2012, Pages 329-337

Sphingosine-1-phosphate signaling in physiology and diseases

Author keywords

G protein coupled receptor; Lysophospholipid; Sphingosine 1 phosphate

Indexed keywords

CHEMOATTRACTANT; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAC PROTEIN; RHO KINASE; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

EID: 84867713914     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1030     Document Type: Review
Times cited : (108)

References (60)
  • 1
    • 34047251154 scopus 로고    scopus 로고
    • Functions of the multifaceted family of sphingosine kinases and some close relatives
    • Spiegel, S., Milstien, S. (2007) Functions of the multifaceted family of sphingosine kinases and some close relatives. J. Biol. Chem. 282, 2125-2129.
    • (2007) J. Biol. Chem. , vol.282 , pp. 2125-2129
    • Spiegel, S.1    Milstien, S.2
  • 2
    • 50049122673 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase in developmental and disease: sphingolipid metabolism takes flight
    • Fyrst, H., Saba, J. (2008) Sphingosine-1-phosphate lyase in developmental and disease: sphingolipid metabolism takes flight. Biochim. Biophys. Acta. 1781, 448-458.
    • (2008) Biochim. Biophys. Acta. , vol.1781 , pp. 448-458
    • Fyrst, H.1    Saba, J.2
  • 4
    • 58849083220 scopus 로고    scopus 로고
    • The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    • Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A., et al. (2009) The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science 323, 524-527.
    • (2009) Science , vol.323 , pp. 524-527
    • Kawahara, A.1    Nishi, T.2    Hisano, Y.3    Fukui, H.4    Yamaguchi, A.5
  • 5
    • 0037162038 scopus 로고    scopus 로고
    • Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
    • Okajima, F. (2002) Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? Biochim. Biophys. Acta. 1582, 132-137.
    • (2002) Biochim. Biophys. Acta. , vol.1582 , pp. 132-137
    • Okajima, F.1
  • 6
    • 0032489574 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1
    • Lee, M. J., Van Brocklyn, J. R., Thangada, S., Liu, C. H., Hand, A. R., et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279, 1552-1555.
    • Science , vol.279 , pp. 1552-1555
    • Lee, M.J.1    Van Brocklyn, J.R.2    Thangada, S.3    Liu, C.H.4    Hand, A.R.5
  • 7
    • 0032538463 scopus 로고    scopus 로고
    • 2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition
    • 2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. J. Biol. Chem. 273, 27104-27110.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27104-27110
    • Okamoto, H.1    Takuwa, N.2    Gonda, K.3    Okazaki, H.4    Chang, K.5
  • 8
    • 78650141494 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
    • Chun, J., Hla, T., Lynch, K. R., Spiegel, S., Moolenaar, W. H. (2010) International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 62, 579-587.
    • (2010) Pharmacol. Rev. , vol.62 , pp. 579-587
    • Chun, J.1    Hla, T.2    Lynch, K.R.3    Spiegel, S.4    Moolenaar, W.H.5
  • 9
    • 0033783522 scopus 로고    scopus 로고
    • Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    • Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C. X., et al. (2000) Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106, 951-961.
    • (2000) J. Clin. Invest. , vol.106 , pp. 951-961
    • Liu, Y.1    Wada, R.2    Yamashita, T.3    Mi, Y.4    Deng, C.X.5
  • 10
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., et al. (2004) Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360.
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1    Lo, C.G.2    Cinamon, G.3    Lesneski, M.J.4    Xu, Y.5
  • 11
    • 2142851264 scopus 로고    scopus 로고
    • Lysophosphlipid receptors: signaling and biology
    • Ishii, I., Fukushima, N., Ye, X., Chun, J. (2004) Lysophosphlipid receptors: signaling and biology. 73, 321-354.
    • (2004) , vol.73 , pp. 321-354
    • Ishii, I.1    Fukushima, N.2    Ye, X.3    Chun, J.4
  • 12
    • 79957610938 scopus 로고    scopus 로고
    • The outs and the ins of sphingosine-1-phosphate in immunity
    • Spiegel, S., Milstien, S. (2011) The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 11, 403-415.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 403-415
    • Spiegel, S.1    Milstien, S.2
  • 13
    • 67449138784 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor signaling in the heart
    • Means, C. K., Brown, J. H. (2009) Sphingosine-1-phosphate receptor signaling in the heart. Cardiovasc. Res. 82, 193-200.
    • (2009) Cardiovasc. Res. , vol.82 , pp. 193-200
    • Means, C.K.1    Brown, J.H.2
  • 14
    • 77955799815 scopus 로고    scopus 로고
    • Oral fingolimod (FTY720) for relapsing multiple sclerosis
    • FTY720 D2201 Study Group
    • Kappos, L., Antel, J., Comi, G., Montalban, X., O'Connor, P., et al. FTY720 D2201 Study Group (2006) Oral fingolimod (FTY720) for relapsing multiple sclerosis. N. Engl. J. Med. 355, 1124-1140.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1124-1140
    • Kappos, L.1    Antel, J.2    Comi, G.3    Montalban, X.4    O'Connor, P.5
  • 15
    • 9644252866 scopus 로고    scopus 로고
    • Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
    • Chae, S. S., Paik, J. H., Furneaux, H., Hla, T. (2004) Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J. Clin. Invest. 114, 1082-1089.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1082-1089
    • Chae, S.S.1    Paik, J.H.2    Furneaux, H.3    Hla, T.4
  • 16
    • 68849122050 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
    • Camerer, E., Regard, J. B., Cornelissen, I., Srinivasan, Y., Duong, D. N., et al. (2009) Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J. Clin. Invest. 119, 1871-1879.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1871-1879
    • Camerer, E.1    Regard, J.B.2    Cornelissen, I.3    Srinivasan, Y.4    Duong, D.N.5
  • 17
    • 0034608826 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Proc
    • Mandala, S. M., Thornton, R., Galve-Roperh, I., Poulton, S., Peterson, C., et al. (2000) Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Proc. Natl. Acad. Sci. USA 97, 7859-7864.
    • (2000) Natl. Acad. Sci. USA , vol.97 , pp. 7859-7864
    • Mandala, S.M.1    Thornton, R.2    Galve-Roperh, I.3    Poulton, S.4    Peterson, C.5
  • 18
    • 0032775582 scopus 로고    scopus 로고
    • Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction
    • Waggoner, D. W., Xu, J., Singh, I., Jasinska, R., Zhang, Q. X., et al. (1999) Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction. Biochim. Biophys. Acta. 1439, 299-316.
    • (1999) Biochim. Biophys. Acta. , vol.1439 , pp. 299-316
    • Waggoner, D.W.1    Xu, J.2    Singh, I.3    Jasinska, R.4    Zhang, Q.X.5
  • 19
    • 10644260243 scopus 로고    scopus 로고
    • Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
    • Allende, M. L., Sasaki, T., Kawai, H., Olivera, A., Mi, Y., et al. (2004) Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J. Biol. Chem. 279, 52487-52492.
    • (2004) J. Biol. Chem. , vol.279 , pp. 52487-52492
    • Allende, M.L.1    Sasaki, T.2    Kawai, H.3    Olivera, A.4    Mi, Y.5
  • 20
    • 27744552046 scopus 로고    scopus 로고
    • Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720
    • Kharel, Y., Lee, S., Snyder, A. H., Sheasley-O'neill, S. L., Morris, M. A., et al. (2005) Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J. Biol. Chem. 280, 36865-36872.
    • (2005) J. Biol. Chem. , vol.280 , pp. 36865-36872
    • Kharel, Y.1    Lee, S.2    Snyder, A.H.3    Sheasley-O'neill, S.L.4    Morris, M.A.5
  • 21
    • 58149474166 scopus 로고    scopus 로고
    • Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
    • Vogel, P., Donoviel, M. S., Read, R., Hansen, G. M., Hazlewood, J., et al. (2009) Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One. 4, e4112.
    • (2009) PLoS One , vol.4
    • Vogel, P.1    Donoviel, M.S.2    Read, R.3    Hansen, G.M.4    Hazlewood, J.5
  • 22
    • 77951213051 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver
    • Bektas, M., Allende, M. L., Lee, B. G., Chen, W., Amar, M. J., et al. (2010) Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J. Biol. Chem. 285, 10880-10889.
    • (2010) J. Biol. Chem. , vol.285 , pp. 10880-10889
    • Bektas, M.1    Allende, M.L.2    Lee, B.G.3    Chen, W.4    Amar, M.J.5
  • 23
  • 24
    • 66349086742 scopus 로고    scopus 로고
    • Bioactive sphingolipids: metabolism and function
    • Bartke, N., Hannun, Y. A. (2009) Bioactive sphingolipids: metabolism and function. J. Lipid Res. 50 Suppl: S91-S96.
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL
    • Bartke, N.1    Hannun, Y.A.2
  • 25
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab, S. R., Pereira, J. P., Matloubian, M., Xu, Y., Huang, Y., et al. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309, 1735-1739.
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3    Xu, Y.4    Huang, Y.5
  • 26
    • 34247379074 scopus 로고    scopus 로고
    • Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    • Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., et al. (2007) Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316, 295-298.
    • (2007) Science , vol.316 , pp. 295-298
    • Pappu, R.1    Schwab, S.R.2    Cornelissen, I.3    Pereira, J.P.4    Regard, J.B.5
  • 27
    • 41449112571 scopus 로고    scopus 로고
    • Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    • Venkataraman, K., Lee, Y. M., Michaud, J., Thangada, S., Ai, Y., et al. (2008) Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ. Res. 102, 669-676.
    • (2008) Circ. Res. , vol.102 , pp. 669-676
    • Venkataraman, K.1    Lee, Y.M.2    Michaud, J.3    Thangada, S.4    Ai, Y.5
  • 28
    • 0033615537 scopus 로고    scopus 로고
    • Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
    • Lee, M. J., Thangada, S., Claffey, K. P., Ancellin, N., Liu, C. H., et al. (1999) Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99, 301-312.
    • (1999) Cell , vol.99 , pp. 301-312
    • Lee, M.J.1    Thangada, S.2    Claffey, K.P.3    Ancellin, N.4    Liu, C.H.5
  • 30
    • 0034644150 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
    • Kupperman, E., An, S., Osborne, N., Waldron, S., Stainier, D. Y. (2000) Sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature 406, 192-195.
    • (2000) Nature , vol.406 , pp. 192-195
    • Kupperman, E.1    An, S.2    Osborne, N.3    Waldron, S.4    Stainier, D.Y.5
  • 31
    • 76549090692 scopus 로고    scopus 로고
    • S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice
    • Du, W., Takuwa, N., Yoshioka, K., Okamoto, Y., Gonda, K., et al. (2010) S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Res. 70, 772-781.
    • (2010) Cancer Res. , vol.70 , pp. 772-781
    • Du, W.1    Takuwa, N.2    Yoshioka, K.3    Okamoto, Y.4    Gonda, K.5
  • 32
    • 0032959716 scopus 로고    scopus 로고
    • The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signaling pathways
    • Gonda, K., Okamoto, H., Takuwa, N., Yatomi, Y., Okazaki, H., et al. (1999) The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signaling pathways. Biochem. J. 337, 67-75.
    • (1999) Biochem. J. , vol.337 , pp. 67-75
    • Gonda, K.1    Okamoto, H.2    Takuwa, N.3    Yatomi, Y.4    Okazaki, H.5
  • 33
    • 0033600173 scopus 로고    scopus 로고
    • EDG3 is a functional receptor specific for sphingosine-1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16
    • Okamoto, H., Takuwa, N., Yatomi, Y., Gonda, K., Shigematsu, H., et al. (1999) EDG3 is a functional receptor specific for sphingosine-1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. Biochem. Biophys. Res. Commun. 260, 203-208.
    • (1999) Biochem. Biophys. Res. Commun. , vol.260 , pp. 203-208
    • Okamoto, H.1    Takuwa, N.2    Yatomi, Y.3    Gonda, K.4    Shigematsu, H.5
  • 34
    • 34249861932 scopus 로고    scopus 로고
    • Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway
    • Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., et al. (2007) Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. J. Biol. Chem. 282, 10576-10584.
    • (2007) J. Biol. Chem. , vol.282 , pp. 10576-10584
    • Jiang, L.I.1    Collins, J.2    Davis, R.3    Lin, K.M.4    DeCamp, D.5
  • 35
    • 77953966511 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and cancer
    • Pyne, N. J., Pyne, S. (2010) Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer. 10, 489-503.
    • (2010) Nat. Rev. Cancer. , vol.10 , pp. 489-503
    • Pyne, N.J.1    Pyne, S.2
  • 36
    • 84857546158 scopus 로고    scopus 로고
    • Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1-jekyll hidden behind Hyde
    • Takuwa, N., Du, W., Kaneko, E., Okamoto, Y., Yoshioka, K., et al. (2011) Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1-jekyll hidden behind Hyde. Am. J. Cancer Res. 1, 460-481.
    • (2011) Am. J. Cancer Res. , vol.1 , pp. 460-481
    • Takuwa, N.1    Du, W.2    Kaneko, E.3    Okamoto, Y.4    Yoshioka, K.5
  • 37
    • 0026774525 scopus 로고
    • Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness
    • Sadahira, Y., Ruan, F., Hakomori, S., Igarashi, Y. (1992) Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. USA 89, 9686-9690.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9686-9690
    • Sadahira, Y.1    Ruan, F.2    Hakomori, S.3    Igarashi, Y.4
  • 38
    • 0034462185 scopus 로고    scopus 로고
    • Inhibitory regulation of Rac activation, membrane ruffling and cell migration by sphingosine-1-phosphate receptor EDG5, but not EDG1 or EDG3
    • Okamoto, H., Takuwa, N., Yokomizo, T., Sugimoto, N., Sakurada, S., et al. (2000) Inhibitory regulation of Rac activation, membrane ruffling and cell migration by sphingosine-1-phosphate receptor EDG5, but not EDG1 or EDG3. Mol. Cell. Biol. 20, 9247-9261.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9247-9261
    • Okamoto, H.1    Takuwa, N.2    Yokomizo, T.3    Sugimoto, N.4    Sakurada, S.5
  • 39
    • 13444302479 scopus 로고    scopus 로고
    • Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cyclic AMP
    • Nagasawa, S., Takuwa, N., Sugimoto, N., Mabuchi, H., Takuwa, Y. (2005) Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cyclic AMP. Biochem. J. 385, 737-744.
    • (2005) Biochem. J. , vol.385 , pp. 737-744
    • Nagasawa, S.1    Takuwa, N.2    Sugimoto, N.3    Mabuchi, H.4    Takuwa, Y.5
  • 40
    • 15444373513 scopus 로고    scopus 로고
    • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
    • Sanchez, T., Thangada, S., Wu, M. T., Kontos, C. D., Wu, D., et al. (2005) PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 102, 4312-4317.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4312-4317
    • Sanchez, T.1    Thangada, S.2    Wu, M.T.3    Kontos, C.D.4    Wu, D.5
  • 41
    • 49949099544 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system
    • Takuwa, Y., Okamoto, Y., Yoshioka, K., Takuwa, N. (2008) Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Biochim. Biophys. Acta. 1781, 483-488.
    • (2008) Biochim. Biophys. Acta. , vol.1781 , pp. 483-488
    • Takuwa, Y.1    Okamoto, Y.2    Yoshioka, K.3    Takuwa, N.4
  • 42
    • 3142744111 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis
    • Kono, M., Mi, Y., Liu, Y., Sasaki, T., Allende, M. L., et al. (2004) The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J. Biol. Chem. 279, 29367-29373.
    • (2004) J. Biol. Chem. , vol.279 , pp. 29367-29373
    • Kono, M.1    Mi, Y.2    Liu, Y.3    Sasaki, T.4    Allende, M.L.5
  • 43
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • Visentin, B., Vekich, J. A., Sibbald, B. J., Cavalli, A. L., Moreno, K. M., et al. (2006) Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9, 225-238.
    • (2006) Cancer Cell , vol.9 , pp. 225-238
    • Visentin, B.1    Vekich, J.A.2    Sibbald, B.J.3    Cavalli, A.L.4    Moreno, K.M.5
  • 44
    • 0141679087 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and hematogenous metastasis of melanoma cells
    • Yamaguchi, H., Kitayama, J., Takuwa, N., Arikawa, K., Inoki, I., et al. (2003) Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and hematogenous metastasis of melanoma cells. Biochem. J. 374, 715-722.
    • (2003) Biochem. J. , vol.374 , pp. 715-722
    • Yamaguchi, H.1    Kitayama, J.2    Takuwa, N.3    Arikawa, K.4    Inoki, I.5
  • 45
    • 34848892421 scopus 로고    scopus 로고
    • Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina
    • Skoura, A., Sanchez, T., Claffey, K., Mandala, S. M., Proia, R. L., et al. (2007) Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J. Clin. Invest. 117, 2506-2516.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2506-2516
    • Skoura, A.1    Sanchez, T.2    Claffey, K.3    Mandala, S.M.4    Proia, R.L.5
  • 46
    • 72249096210 scopus 로고    scopus 로고
    • Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
    • Cattoretti, G., Mandelbaum, J., Lee, N., Chaves, A. H., Mahler, A. M., et al. (2009) Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res. 69, 8686-8692.
    • (2009) Cancer Res. , vol.69 , pp. 8686-8692
    • Cattoretti, G.1    Mandelbaum, J.2    Lee, N.3    Chaves, A.H.4    Mahler, A.M.5
  • 47
    • 67449152428 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and modulation of vascular tone
    • Igarashi, J., Michel, T. (2009) Sphingosine-1-phosphate and modulation of vascular tone. Cardiovasc. Res. 82, 212-220.
    • (2009) Cardiovasc. Res. , vol.82 , pp. 212-220
    • Igarashi, J.1    Michel, T.2
  • 49
    • 0034799675 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    • Garcia, J. G., Liu, F., Verin, A. D., Birukova, A., Dechert, M. A., et al. (2001) Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J. Clin. Invest. 108, 689-701.
    • (2001) J. Clin. Invest. , vol.108 , pp. 689-701
    • Garcia, J.G.1    Liu, F.2    Verin, A.D.3    Birukova, A.4    Dechert, M.A.5
  • 50
    • 34249280944 scopus 로고    scopus 로고
    • Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler
    • Sanchez, T., Skoura, A., Wu, M. T., Casserly, B., Harrington, E. O., et al. (2007 Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler. Thromb. Vasc. Biol. 27, 1312-1318.
    • (2007) Thromb. Vasc. Biol. , vol.27 , pp. 1312-1318
    • Sanchez, T.1    Skoura, A.2    Wu, M.T.3    Casserly, B.4    Harrington, E.O.5
  • 51
    • 77952327561 scopus 로고    scopus 로고
    • Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am. J. Respir
    • Sammani, S., Moreno-Vinasco, L., Mirzapoiazova, T., Singleton, P. A., Chiang, E. T., et al. (2010) Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am. J. Respir. Cell. Mol. Biol. 43, 394-402.
    • (2010) Cell. Mol. Biol. , vol.43 , pp. 394-402
    • Sammani, S.1    Moreno-Vinasco, L.2    Mirzapoiazova, T.3    Singleton, P.A.4    Chiang, E.T.5
  • 53
    • 79957925060 scopus 로고    scopus 로고
    • Engagement of S1P1-degradative mechanisms leads to vascular leak in mice
    • Oo, M. L., Chang, S. H., Thangada, S., Wu, M. T., Rezaul, K., et al. (2011) Engagement of S1P1-degradative mechanisms leads to vascular leak in mice. J. Clin. Invest. 121, 2290-2300.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2290-2300
    • Oo, M.L.1    Chang, S.H.2    Thangada, S.3    Wu, M.T.4    Rezaul, K.5
  • 54
    • 77951817430 scopus 로고    scopus 로고
    • Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
    • Olivera, A., Eisner, C., Kitamura, Y., Dillahunt, S., Allende, L., et al. (2010) Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J. Clin. Invest. 120, 1429-1440.
    • (2010) J. Clin. Invest. , vol.120 , pp. 1429-1440
    • Olivera, A.1    Eisner, C.2    Kitamura, Y.3    Dillahunt, S.4    Allende, L.5
  • 55
    • 77953923379 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    • Alvarez, S. E., Harikumar, K. B., Hait, N. C., Allegood, J., Strub, G. M., et al. (2010) Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465: 1084-1088.
    • (2010) Nature , vol.465 , pp. 1084-1088
    • Alvarez, S.E.1    Harikumar, K.B.2    Hait, N.C.3    Allegood, J.4    Strub, G.M.5
  • 56
    • 33847131347 scopus 로고    scopus 로고
    • Tipping the gatekeeper: S1P regulation of endothelial barrier function
    • Rosen, H., Sanna, M. G., Cahalan, S. M., Gonzalez-Cabrera, P. J. (2007) Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends Immunol. 28, 102-107.
    • (2007) Trends Immunol. , vol.28 , pp. 102-107
    • Rosen, H.1    Sanna, M.G.2    Cahalan, S.M.3    Gonzalez-Cabrera, P.J.4
  • 57
    • 79959377393 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor S1P maintains the homeostasis of germinal center B cells and promotes niche confinement
    • Green, J. A., Suzuki, K., Cho, B., Willison, L. D., Palmer, D., et al. (2011) The sphingosine 1-phosphate receptor S1P maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat. Immunol. 12, 672-680.
    • (2011) Nat. Immunol. , vol.12 , pp. 672-680
    • Green, J.A.1    Suzuki, K.2    Cho, B.3    Willison, L.D.4    Palmer, D.5
  • 59
    • 69949113620 scopus 로고    scopus 로고
    • Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
    • Hait, N. C., Allegood, J., Maceyka, M., Strub, G. M., Harikumar, K. B., et al. (2009) Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325: 1254-1257.
    • (2009) Science , vol.325 , pp. 1254-1257
    • Hait, N.C.1    Allegood, J.2    Maceyka, M.3    Strub, G.M.4    Harikumar, K.B.5
  • 60
    • 79551648970 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
    • Strub, G. M., Paillard, M., Liang, J., Gomez, L., Allegood, J. C., et al. (2011) Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. Faseb J 25: 600-612.
    • (2011) Faseb J , vol.25 , pp. 600-612
    • Strub, G.M.1    Paillard, M.2    Liang, J.3    Gomez, L.4    Allegood, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.