Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic β-cells

Biochemical and Biophysical Research Communications

Volumn 392, Issue 2, 2010, Pages 207-211

  Imasawa, Toshiyuki ^a   Koike, Kentaro ^a   Ishii, Isao ^b   Chun, Jerold ^c   Yatomi, Yutaka ^d  

^a Department of Internal Medicine   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Blood glucose; Diabetes; Insulin; S1P2 deficient mice; S1P2 specific antagonist

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; GLUCOSE; INSULIN; RECEPTOR SUBTYPE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; INCIDENCE; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SURVIVAL; WILD TYPE;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; INSULIN-SECRETING CELLS; MICE; MICE, MUTANT STRAINS; PYRAZOLES; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; STREPTOZOCIN;

MUS;

EID: 75749105853     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.016     Document Type: Article

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