TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation

FASEB Journal

Volumn 27, Issue 11, 2013, Pages 4532-4546

  Cencetti, Francesca ^a,b   Bernacchioni, Caterina ^a,b   Tonelli, Francesca ^a,b,d   Roberts, Edward ^c   Donati, Chiara ^a,b   Bruni, Paola ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Interuniversity Institute of Myology   (Italy)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

C2C12 myoblasts; S1P4; Skeletal muscle cells; Sphingosine 1 phosphate; Transforming growth factor

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY ADP RIBOSYL TRANSFERASE; RHO KINASE; RHO KINASE 2; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE 4; SPHINGOSINE KINASE 2; TRANSFERASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; MOUSE; MUSCLE CELL; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSACTIVATION; UPREGULATION;

C2C12 MYOBLASTS; S1P4; SKELETAL MUSCLE CELLS; SPHINGOSINE 1-PHOSPHATE; TRANSFORMING GROWTH FACTOR Β;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; MICE; MYOBLASTS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84887047652     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-228528     Document Type: Article

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