Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress

Molecular Neurobiology

Volumn 54, Issue 5, 2017, Pages 3717-3728

  Ma, Yanbo ^a   Matsuwaki, Takashi ^a   Yamanouchi, Keitaro ^a   Nishihara, Masugi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Immune stress; Microglia; Neurogenesis; Neuroinflammation; Progranulin

Indexed keywords

CATHEPSIN; CATHEPSIN X; CD68 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOZYME; MACROPHAGE INFLAMMATORY PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROGRANULIN; PROSTAGLANDIN E SYNTHASE 1; TUMOR NECROSIS FACTOR; GRN PROTEIN, MOUSE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ACUTE STRESS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DENTATE GYRUS; GENE EXPRESSION; HIPPOCAMPUS; IMMUNE STRESS; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYSOSOME; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; ANIMAL; C57BL MOUSE; DEFICIENCY; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS;

ANIMALS; HIPPOCAMPUS; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; LYSOSOMES; MALE; MICE, INBRED C57BL; MICROGLIA; NEUROGENESIS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES;

EID: 84969816028     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-9939-6     Document Type: Article

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