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Volumn 45, Issue 3, 2011, Pages 549-560

Cellular effects of progranulin in health and disease

Author keywords

Frontotemporal degeneration; Inflammation; Microglia; Progranulin; Tumorigenesis

Indexed keywords

COLLAGENASE 3; MATRIX METALLOPROTEINASE 17; PROGRANULIN; PROGRANULIN RECEPTOR; PROTEIN P53; RECEPTOR; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 80855144136     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9553-z     Document Type: Conference Paper
Times cited : (96)

References (112)
  • 1
    • 77954578417 scopus 로고    scopus 로고
    • Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
    • 20522652 1:CAS:528:DC%2BC3cXpslCrs7g%3D 10.2353/ajpath.2010.090915
    • Z Ahmed H Sheng Y-F Xu, et al. 2010 Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging Am J Pathol 177 311 324 20522652 1:CAS:528:DC%2BC3cXpslCrs7g%3D 10.2353/ajpath.2010.090915
    • (2010) Am J Pathol , vol.177 , pp. 311-324
    • Ahmed, Z.1    Sheng, H.2    Xu, Y.-F.3
  • 2
    • 0025248770 scopus 로고
    • Acrosome biogenesis begins during meiosis: Evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis
    • 1692485 1:CAS:528:DyaK3cXitFCgu74%3D 10.1095/biolreprod42.2.317
    • OO Anakwe GL Gerton 1990 Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis Biol Reprod 42 317 328 1692485 1:CAS:528:DyaK3cXitFCgu74%3D 10.1095/biolreprod42.2.317
    • (1990) Biol Reprod , vol.42 , pp. 317-328
    • Anakwe, O.O.1    Gerton, G.L.2
  • 3
    • 33750716074 scopus 로고    scopus 로고
    • TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • 17084815 1:CAS:528:DC%2BD28Xht1SmsbbJ 10.1016/j.bbrc.2006.10.093
    • T Arai M Hasegawa H Akiyama, et al. 2006 TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Biochem Biophys Res Commun 351 602 611 17084815 1:CAS:528:DC%2BD28Xht1SmsbbJ 10.1016/j.bbrc.2006.10.093
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 602-611
    • Arai, T.1    Hasegawa, M.2    Akiyama, H.3
  • 4
    • 0033787069 scopus 로고    scopus 로고
    • Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing
    • 11017147 1:CAS:528:DC%2BD3cXntlKnurc%3D 10.1038/80489
    • GS Ashcroft K Lei W Jin, et al. 2000 Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing Nat Med 6 1147 1153 11017147 1:CAS:528:DC%2BD3cXntlKnurc%3D 10.1038/80489
    • (2000) Nat Med , vol.6 , pp. 1147-1153
    • Ashcroft, G.S.1    Lei, K.2    Jin, W.3
  • 5
    • 67651207673 scopus 로고    scopus 로고
    • ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor
    • 19487464 1:CAS:528:DC%2BD1MXptFehtro%3D 10.1128/MCB.00056-09
    • X-H Bai D-W Wang L Kong, et al. 2009 ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor Mol Cell Biol 29 4201 4219 19487464 1:CAS:528:DC%2BD1MXptFehtro%3D 10.1128/MCB.00056-09
    • (2009) Mol Cell Biol , vol.29 , pp. 4201-4219
    • Bai, X.-H.1    Wang, D.-W.2    Kong, L.3
  • 6
    • 0037457875 scopus 로고    scopus 로고
    • Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease
    • 12525699 1:CAS:528:DC%2BD3sXnvVKltA%3D%3D 10.1073/pnas.0237313100
    • CA Baker L Manuelidis 2003 Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease Proc Natl Acad Sci 100 675 679 12525699 1:CAS:528:DC%2BD3sXnvVKltA%3D%3D 10.1073/pnas.0237313100
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 675-679
    • Baker, C.A.1    Manuelidis, L.2
  • 7
    • 33746919083 scopus 로고    scopus 로고
    • Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
    • 16862116 1:CAS:528:DC%2BD28XosVOgurc%3D 10.1038/nature05016
    • M Baker IR Mackenzie SM Pickering-Brown, et al. 2006 Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 Nature 442 916 919 16862116 1:CAS:528:DC%2BD28XosVOgurc%3D 10.1038/nature05016
    • (2006) Nature , vol.442 , pp. 916-919
    • Baker, M.1    MacKenzie, I.R.2    Pickering-Brown, S.M.3
  • 8
    • 0036295562 scopus 로고    scopus 로고
    • The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system
    • 11846389 10.1006/bbrc.2002.6431 1:CAS:528:DC%2BD38Xht1Ggtrs%3D
    • V Baladrón MJ Ruiz-Hidalgo E Bonvini E Gubina V Notario J Laborda 2002 The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system Biochem Biophys Res Commun 291 193 204 11846389 10.1006/bbrc.2002.6431 1:CAS:528: DC%2BD38Xht1Ggtrs%3D
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 193-204
    • Baladrón, V.1    Ruiz-Hidalgo, M.J.2    Bonvini, E.3    Gubina, E.4    Notario, V.5    Laborda, J.6
  • 9
    • 34547734976 scopus 로고    scopus 로고
    • The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
    • 17664292 1:CAS:528:DC%2BD2sXptVyjsLc%3D 10.1084/jem.20070494
    • C Benarafa GP Priebe E Remold-O'Donnell 2007 The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection J Exp Med 204 1901 1909 17664292 1:CAS:528: DC%2BD2sXptVyjsLc%3D 10.1084/jem.20070494
    • (2007) J Exp Med , vol.204 , pp. 1901-1909
    • Benarafa, C.1    Priebe, G.P.2    Remold-O'Donnell, E.3
  • 10
    • 0026457912 scopus 로고
    • Structure and chromosomal location of the human granulin gene
    • 1417868 1:CAS:528:DyaK3sXlslCqu7c%3D 10.1016/0006-291X(92)92349-3
    • V Bhandari A Bateman 1992 Structure and chromosomal location of the human granulin gene Biochem Biophys Res Commun 188 57 63 1417868 1:CAS:528: DyaK3sXlslCqu7c%3D 10.1016/0006-291X(92)92349-3
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 57-63
    • Bhandari, V.1    Bateman, A.2
  • 11
    • 0026580016 scopus 로고
    • Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains
    • 1542665 1:CAS:528:DyaK3sXhvV2ltrg%3D 10.1073/pnas.89.5.1715
    • V Bhandari RG Palfree A Bateman 1992 Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains Proc Natl Acad Sci 89 1715 1719 1542665 1:CAS:528: DyaK3sXhvV2ltrg%3D 10.1073/pnas.89.5.1715
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 1715-1719
    • Bhandari, V.1    Palfree, R.G.2    Bateman, A.3
  • 12
    • 47949123468 scopus 로고    scopus 로고
    • Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: Dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding
    • 18505826 1:CAS:528:DC%2BD1cXptF2luro%3D 10.1128/MCB.01775-07
    • GS Butler RA Dean EM Tam CM Overall 2008 Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding Mol Cell Biol 28 4896 4914 18505826 1:CAS:528:DC%2BD1cXptF2luro%3D 10.1128/MCB.01775-07
    • (2008) Mol Cell Biol , vol.28 , pp. 4896-4914
    • Butler, G.S.1    Dean, R.A.2    Tam, E.M.3    Overall, C.M.4
  • 13
    • 78650535968 scopus 로고    scopus 로고
    • GEP, a local growth factor, is critical for odontogenesis and amelogenesis
    • 21152114 1:CAS:528:DC%2BC3cXhsFWkt7zO
    • Z Cao B Jiang Y Xie C-J Liu JQ Feng 2010 GEP, a local growth factor, is critical for odontogenesis and amelogenesis Int J Biol Sci 6 719 729 21152114 1:CAS:528:DC%2BC3cXhsFWkt7zO
    • (2010) Int J Biol Sci , vol.6 , pp. 719-729
    • Cao, Z.1    Jiang, B.2    Xie, Y.3    Liu, C.-J.4    Feng, J.Q.5
  • 14
    • 78649796276 scopus 로고    scopus 로고
    • Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma
    • 21087763 1:CAS:528:DC%2BC3cXhsFags7fJ 10.1016/j.ajhg.2010.11.002
    • MM Carrasquillo AM Nicholson N Finch, et al. 2010 Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma Am J Hum Genet 87 890 897 21087763 1:CAS:528:DC%2BC3cXhsFags7fJ 10.1016/j.ajhg.2010.11.002
    • (2010) Am J Hum Genet , vol.87 , pp. 890-897
    • Carrasquillo, M.M.1    Nicholson, A.M.2    Finch, N.3
  • 15
    • 51149096388 scopus 로고    scopus 로고
    • Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance
    • 18706200 1:CAS:528:DC%2BD1cXnslGqtr4%3D
    • X-Y Chen J-S Li Q-P Liang D-Z He J Zhao 2008 Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance Chin Med J 121 881 886 18706200 1:CAS:528:DC%2BD1cXnslGqtr4%3D
    • (2008) Chin Med J , vol.121 , pp. 881-886
    • Chen, X.-Y.1    Li, J.-S.2    Liang, Q.-P.3    He, D.-Z.4    Zhao, J.5
  • 16
    • 77950867149 scopus 로고    scopus 로고
    • TAR DNA-binding protein 43 in neurodegenerative disease
    • 20234357 1:CAS:528:DC%2BC3cXksVehurc%3D 10.1038/nrneurol.2010.18
    • AS Chen-Plotkin VMY Lee JQ Trojanowski 2010 TAR DNA-binding protein 43 in neurodegenerative disease Nat Rev Neurol 6 211 220 20234357 1:CAS:528:DC%2BC3cXksVehurc%3D 10.1038/nrneurol.2010.18
    • (2010) Nat Rev Neurol , vol.6 , pp. 211-220
    • Chen-Plotkin, A.S.1    Lee, V.M.Y.2    Trojanowski, J.Q.3
  • 17
    • 9344229795 scopus 로고    scopus 로고
    • Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma
    • 15569995 1:CAS:528:DC%2BD2cXhtVanurzJ 10.1158/1078-0432.CCR-04-0960
    • ST Cheung SY Wong KL Leung, et al. 2004 Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma Clin Cancer Res 10 7629 7636 15569995 1:CAS:528:DC%2BD2cXhtVanurzJ 10.1158/1078-0432.CCR-04-0960
    • (2004) Clin Cancer Res , vol.10 , pp. 7629-7636
    • Cheung, S.T.1    Wong, S.Y.2    Leung, K.L.3
  • 18
    • 39049195644 scopus 로고    scopus 로고
    • GEP associates with wild-type p53 in hepatocellular carcinoma
    • 16685387 1:CAS:528:DC%2BD28XlvVOis7s%3D
    • ST Cheung SY Wong YT Lee ST Fan 2006 GEP associates with wild-type p53 in hepatocellular carcinoma Oncol Rep 15 1507 1511 16685387 1:CAS:528: DC%2BD28XlvVOis7s%3D
    • (2006) Oncol Rep , vol.15 , pp. 1507-1511
    • Cheung, S.T.1    Wong, S.Y.2    Lee, Y.T.3    Fan, S.T.4
  • 19
    • 78650511134 scopus 로고    scopus 로고
    • Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance
    • 20682318 1:CAS:528:DC%2BC3cXhsFyltLnL 10.1053/j.gastro.2010.07.049
    • ST Cheung PFY Cheung CKC Cheng NCL Wong ST Fan 2011 Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance Gastroenterology 140 344 355 20682318 1:CAS:528: DC%2BC3cXhsFyltLnL 10.1053/j.gastro.2010.07.049
    • (2011) Gastroenterology , vol.140 , pp. 344-355
    • Cheung, S.T.1    Cheung, P.F.Y.2    Cheng, C.K.C.3    Wong, N.C.L.4    Fan, S.T.5
  • 20
    • 77957818067 scopus 로고    scopus 로고
    • Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of survival motor neuron 1
    • 20946666 10.1186/1750-1326-5-41 1:CAS:528:DC%2BC3cXhtlamsbbF
    • BP Chitramuthu DC Baranowski DG Kay A Bateman HP Bennett 2010 Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of survival motor neuron 1 Mol Neurodegener 5 41 20946666 10.1186/1750-1326-5-41 1:CAS:528:DC%2BC3cXhtlamsbbF
    • (2010) Mol Neurodegener , vol.5 , pp. 41
    • Chitramuthu, B.P.1    Baranowski, D.C.2    Kay, D.G.3    Bateman, A.4    Bennett, H.P.5
  • 21
    • 48949093046 scopus 로고    scopus 로고
    • Gene expression study on peripheral blood identifies progranulin mutations
    • 18551524 1:CAS:528:DC%2BD1cXhtVKnsrnK 10.1002/ana.21397
    • G Coppola A Karyda R Rademakers, et al. 2008 Gene expression study on peripheral blood identifies progranulin mutations Ann Neurol 64 92 96 18551524 1:CAS:528:DC%2BD1cXhtVKnsrnK 10.1002/ana.21397
    • (2008) Ann Neurol , vol.64 , pp. 92-96
    • Coppola, G.1    Karyda, A.2    Rademakers, R.3
  • 22
    • 67651091752 scopus 로고    scopus 로고
    • Cortical atrophy and language network reorganization associated with a novel progranulin mutation
    • 19020205 10.1093/cercor/bhn202
    • C Cruchaga MA Fernández-Seara M Seijo-Martínez, et al. 2009 Cortical atrophy and language network reorganization associated with a novel progranulin mutation Cereb Cortex 19 1751 1760 19020205 10.1093/cercor/bhn202
    • (2009) Cereb Cortex , vol.19 , pp. 1751-1760
    • Cruchaga, C.1    Fernández-Seara, M.A.2    Seijo-Martínez, M.3
  • 23
    • 33746910649 scopus 로고    scopus 로고
    • Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    • 16862115 1:CAS:528:DC%2BD28XosVOgu74%3D 10.1038/nature05017
    • M Cruts I Gijselinck J van der Zee, et al. 2006 Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 Nature 442 920 924 16862115 1:CAS:528:DC%2BD28XosVOgu74%3D 10.1038/nature05017
    • (2006) Nature , vol.442 , pp. 920-924
    • Cruts, M.1    Gijselinck, I.2    Van Der Zee, J.3
  • 24
    • 0027215753 scopus 로고
    • Biochemical analysis of the epithelin receptor
    • 8387520 1:CAS:528:DyaK3sXktVWktr4%3D
    • JM Culouscou GW Carlton M Shoyab 1993 Biochemical analysis of the epithelin receptor J Biol Chem 268 10458 10462 8387520 1:CAS:528: DyaK3sXktVWktr4%3D
    • (1993) J Biol Chem , vol.268 , pp. 10458-10462
    • Culouscou, J.M.1    Carlton, G.W.2    Shoyab, M.3
  • 25
    • 0033917655 scopus 로고    scopus 로고
    • Cellular localization of gene expression for progranulin
    • 10858277 1:CAS:528:DC%2BD3cXksFyjtLY%3D 10.1177/002215540004800713
    • R Daniel Z He KP Carmichael J Halper A Bateman 2000 Cellular localization of gene expression for progranulin J Histochem Cytochem 48 999 1009 10858277 1:CAS:528:DC%2BD3cXksFyjtLY%3D 10.1177/002215540004800713
    • (2000) J Histochem Cytochem , vol.48 , pp. 999-1009
    • Daniel, R.1    He, Z.2    Carmichael, K.P.3    Halper, J.4    Bateman, A.5
  • 26
    • 0042635680 scopus 로고    scopus 로고
    • Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development
    • 12889069 1:CAS:528:DC%2BD3sXntVyhsLw%3D 10.1002/dvdy.10341
    • R Daniel E Daniels Z He A Bateman 2003 Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development Dev Dyn 227 593 599 12889069 1:CAS:528:DC%2BD3sXntVyhsLw%3D 10.1002/dvdy.10341
    • (2003) Dev Dyn , vol.227 , pp. 593-599
    • Daniel, R.1    Daniels, E.2    He, Z.3    Bateman, A.4
  • 27
    • 0342980940 scopus 로고    scopus 로고
    • Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor)
    • 10625564 10.1006/dbio.1999.9564 1:CAS:528:DC%2BD3cXhs1Wqsw%3D%3D
    • L Díaz-Cueto P Stein A Jacobs RM Schultz GL Gerton 2000 Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor) Dev Biol 217 406 418 10625564 10.1006/dbio.1999.9564 1:CAS:528:DC%2BD3cXhs1Wqsw%3D%3D
    • (2000) Dev Biol , vol.217 , pp. 406-418
    • Díaz-Cueto, L.1    Stein, P.2    Jacobs, A.3    Schultz, R.M.4    Gerton, G.L.5
  • 28
    • 67650432367 scopus 로고    scopus 로고
    • Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
    • 19522733 1:CAS:528:DC%2BD1MXptlensb8%3D 10.1111/j.1471-4159.2009.06211.x
    • D Dormann A Capell AM Carlson, et al. 2009 Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin J Neurochem 110 1082 1094 19522733 1:CAS:528:DC%2BD1MXptlensb8%3D 10.1111/j.1471-4159.2009.06211.x
    • (2009) J Neurochem , vol.110 , pp. 1082-1094
    • Dormann, D.1    Capell, A.2    Carlson, A.M.3
  • 29
    • 79551519982 scopus 로고    scopus 로고
    • Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
    • 21266779 1:CAS:528:DC%2BC3MXhsl2qsrc%3D 10.1172/JCI43757
    • M Elkabets AM Gifford C Scheel, et al. 2011 Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice J Clin Invest 121 784 799 21266779 1:CAS:528:DC%2BC3MXhsl2qsrc%3D 10.1172/JCI43757
    • (2011) J Clin Invest , vol.121 , pp. 784-799
    • Elkabets, M.1    Gifford, A.M.2    Scheel, C.3
  • 30
    • 77953530644 scopus 로고    scopus 로고
    • Granulin epithelin precursor: A bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
    • 20124436 1:CAS:528:DC%2BC3cXnt1Oju7g%3D 10.1096/fj.09-144659
    • JQ Feng F-J Guo B-C Jiang, et al. 2010 Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis FASEB J 24 1879 1892 20124436 1:CAS:528:DC%2BC3cXnt1Oju7g%3D 10.1096/fj.09-144659
    • (2010) FASEB J , vol.24 , pp. 1879-1892
    • Feng, J.Q.1    Guo, F.-J.2    Jiang, B.-C.3
  • 31
    • 64849103956 scopus 로고    scopus 로고
    • Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
    • 19158106 10.1093/brain/awn352
    • N Finch M Baker R Crook, et al. 2009 Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members Brain 132 583 591 19158106 10.1093/brain/awn352
    • (2009) Brain , vol.132 , pp. 583-591
    • Finch, N.1    Baker, M.2    Crook, R.3
  • 32
    • 79953221473 scopus 로고    scopus 로고
    • Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
    • 21204008 1:CAS:528:DC%2BC3cXoslelt70%3D 10.1007/s13238-010-0067-1
    • X Gao AP Joselin L Wang, et al. 2010 Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β Protein Cell 1 552 562 21204008 1:CAS:528:DC%2BC3cXoslelt70%3D 10.1007/s13238-010-0067-1
    • (2010) Protein Cell , vol.1 , pp. 552-562
    • Gao, X.1    Joselin, A.P.2    Wang, L.3
  • 33
    • 54449085260 scopus 로고    scopus 로고
    • Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration
    • 18768919 1:CAS:528:DC%2BD1cXht1SntLfF 10.1212/01.wnl.0000325058.10218.fc
    • R Ghidoni L Benussi M Glionna M Franzoni G Binetti 2008 Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration Neurology 71 1235 1239 18768919 1:CAS:528:DC%2BD1cXht1SntLfF 10.1212/01.wnl.0000325058.10218.fc
    • (2008) Neurology , vol.71 , pp. 1235-1239
    • Ghidoni, R.1    Benussi, L.2    Glionna, M.3    Franzoni, M.4    Binetti, G.5
  • 34
    • 0141755382 scopus 로고    scopus 로고
    • A novel interaction between perlecan protein core and progranulin-potential effects on tumor growth
    • 12900424 1:CAS:528:DC%2BD3sXnslSqtr0%3D 10.1074/jbc.C300310200
    • E Gonzalez M Mongiat S Slater R Baffa R Iozzo 2003 A novel interaction between perlecan protein core and progranulin-potential effects on tumor growth J Biol Chem 278 38113 38116 12900424 1:CAS:528:DC%2BD3sXnslSqtr0%3D 10.1074/jbc.C300310200
    • (2003) J Biol Chem , vol.278 , pp. 38113-38116
    • Gonzalez, E.1    Mongiat, M.2    Slater, S.3    Baffa, R.4    Iozzo, R.5
  • 35
    • 37549049344 scopus 로고    scopus 로고
    • Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis
    • 18092235 1:CAS:528:DC%2BD2sXhsVCgsbnK 10.1080/08977190701781222
    • RR Guerra L Kriazhev FJ Hernandez-Blazquez A Bateman 2007 Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis Growth Factors 25 280 285 18092235 1:CAS:528:DC%2BD2sXhsVCgsbnK 10.1080/ 08977190701781222
    • (2007) Growth Factors , vol.25 , pp. 280-285
    • Guerra, R.R.1    Kriazhev, L.2    Hernandez-Blazquez, F.J.3    Bateman, A.4
  • 36
    • 77954222578 scopus 로고    scopus 로고
    • Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein
    • 20506400 1:CAS:528:DC%2BC3cXht1aqsLzP
    • F Guo Y Lai Q Tian EA Lin L Kong C Liu 2010 Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein Arthritis Rheum 62 2023 2036 20506400 1:CAS:528:DC%2BC3cXht1aqsLzP
    • (2010) Arthritis Rheum , vol.62 , pp. 2023-2036
    • Guo, F.1    Lai, Y.2    Tian, Q.3    Lin, E.A.4    Kong, L.5    Liu, C.6
  • 37
    • 78649904881 scopus 로고    scopus 로고
    • Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers
    • 20950846 1:CAS:528:DC%2BC3cXhsFWqtb3P 10.1016/j.ygyno.2010.09.006
    • JJ Han M Yu N Houston SM Steinberg EC Kohn 2011 Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers Gynecol Oncol 120 5 10 20950846 1:CAS:528:DC%2BC3cXhsFWqtb3P 10.1016/j.ygyno.2010.09.006
    • (2011) Gynecol Oncol , vol.120 , pp. 5-10
    • Han, J.J.1    Yu, M.2    Houston, N.3    Steinberg, S.M.4    Kohn, E.C.5
  • 38
    • 0033168521 scopus 로고    scopus 로고
    • Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo
    • 10397269 1:CAS:528:DyaK1MXksVGjsrw%3D
    • Z He A Bateman 1999 Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo Cancer Res 59 3222 3229 10397269 1:CAS:528:DyaK1MXksVGjsrw%3D
    • (1999) Cancer Res , vol.59 , pp. 3222-3229
    • He, Z.1    Bateman, A.2
  • 39
    • 0242320195 scopus 로고    scopus 로고
    • Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis
    • 12928786 1:CAS:528:DC%2BD3sXotVars7o%3D 10.1007/s00109-003-0474-3
    • Z He A Bateman 2003 Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis J Mol Med 81 600 612 12928786 1:CAS:528:DC%2BD3sXotVars7o%3D 10.1007/s00109-003-0474-3
    • (2003) J Mol Med , vol.81 , pp. 600-612
    • He, Z.1    Bateman, A.2
  • 40
    • 0036792137 scopus 로고    scopus 로고
    • Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival
    • 12359772 1:CAS:528:DC%2BD38Xnsl2lsbg%3D
    • Z He A Ismail L Kriazhev G Sadvakassova A Bateman 2002 Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival Cancer Res 62 5590 5596 12359772 1:CAS:528:DC%2BD38Xnsl2lsbg%3D
    • (2002) Cancer Res , vol.62 , pp. 5590-5596
    • He, Z.1    Ismail, A.2    Kriazhev, L.3    Sadvakassova, G.4    Bateman, A.5
  • 41
    • 0037329891 scopus 로고    scopus 로고
    • Progranulin is a mediator of the wound response
    • 12524533 1:CAS:528:DC%2BD3sXotlShtQ%3D%3D 10.1038/nm816
    • Z He CHP Ong J Halper A Bateman 2003 Progranulin is a mediator of the wound response Nat Med 9 225 229 12524533 1:CAS:528:DC%2BD3sXotlShtQ%3D%3D 10.1038/nm816
    • (2003) Nat Med , vol.9 , pp. 225-229
    • He, Z.1    Ong, C.H.P.2    Halper, J.3    Bateman, A.4
  • 42
    • 43949142502 scopus 로고    scopus 로고
    • Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma
    • 18393387 1:CAS:528:DC%2BD1cXmvVChs7g%3D 10.1002/hep.22191
    • JC Ho YC Ip ST Cheung, et al. 2008 Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma Hepatology 47 1524 1532 18393387 1:CAS:528:DC%2BD1cXmvVChs7g%3D 10.1002/hep.22191
    • (2008) Hepatology , vol.47 , pp. 1524-1532
    • Ho, J.C.1    Ip, Y.C.2    Cheung, S.T.3
  • 43
    • 0037371643 scopus 로고    scopus 로고
    • The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription
    • 12588988 1:CAS:528:DC%2BD3sXhs1Sgs78%3D 10.1128/MCB.23.5.1688-1702.2003
    • M Hoque TM Young C-G Lee G Serrero MB Mathews T Pe'ery 2003 The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription Mol Cell Biol 23 1688 1702 12588988 1:CAS:528:DC%2BD3sXhs1Sgs78%3D 10.1128/MCB.23.5.1688-1702.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 1688-1702
    • Hoque, M.1    Young, T.M.2    Lee, C.-G.3    Serrero, G.4    Mathews, M.B.5    Pe'Ery, T.6
  • 44
    • 17144430455 scopus 로고    scopus 로고
    • Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation
    • 15653695 1:CAS:528:DC%2BD2MXivV2ktLg%3D 10.1074/jbc.M409575200
    • M Hoque B Tian MB Mathews T Pe'ery 2005 Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation J Biol Chem 280 13648 13657 15653695 1:CAS:528:DC%2BD2MXivV2ktLg%3D 10.1074/jbc.M409575200
    • (2005) J Biol Chem , vol.280 , pp. 13648-13657
    • Hoque, M.1    Tian, B.2    Mathews, M.B.3    Pe'Ery, T.4
  • 45
    • 75749109793 scopus 로고    scopus 로고
    • Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters
    • 20054825 1:CAS:528:DC%2BC3cXhtlSitbw%3D
    • M Hoque MB Mathews T Pe'ery 2010 Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters J Cell Physiol 223 224 233 20054825 1:CAS:528: DC%2BC3cXhtlSitbw%3D
    • (2010) J Cell Physiol , vol.223 , pp. 224-233
    • Hoque, M.1    Mathews, M.B.2    Pe'Ery, T.3
  • 46
    • 0029780955 scopus 로고    scopus 로고
    • The hairpin stack fold, a novel protein architecture for a new family of protein growth factors
    • 8784346 1:CAS:528:DyaK28XlsFyktLc%3D 10.1038/nsb0996-747
    • R Hrabal Z Chen S James HP Bennett F Ni 1996 The hairpin stack fold, a novel protein architecture for a new family of protein growth factors Nat Struct Biol 3 747 752 8784346 1:CAS:528:DyaK28XlsFyktLc%3D 10.1038/nsb0996-747
    • (1996) Nat Struct Biol , vol.3 , pp. 747-752
    • Hrabal, R.1    Chen, Z.2    James, S.3    Bennett, H.P.4    Ni, F.5
  • 47
    • 78449286213 scopus 로고    scopus 로고
    • Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin
    • 21092856 1:CAS:528:DC%2BC3cXhsVGntb3E 10.1016/j.neuron.2010.09.034
    • F Hu T Padukkavidana CB Vægter, et al. 2010 Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin Neuron 68 654 667 21092856 1:CAS:528:DC%2BC3cXhsVGntb3E 10.1016/j.neuron.2010.09.034
    • (2010) Neuron , vol.68 , pp. 654-667
    • Hu, F.1    Padukkavidana, T.2    Vægter, C.B.3
  • 48
    • 0034797275 scopus 로고    scopus 로고
    • Identification of genes involved in the host response to neurovirulent alphavirus infection
    • 11581411 1:CAS:528:DC%2BD3MXns1Whtb8%3D 10.1128/JVI.75.21.10431-10445. 2001
    • C Johnston W Jiang T Chu B Levine 2001 Identification of genes involved in the host response to neurovirulent alphavirus infection J Virol 75 10431 10445 11581411 1:CAS:528:DC%2BD3MXns1Whtb8%3D 10.1128/JVI.75.21.10431-10445.2001
    • (2001) J Virol , vol.75 , pp. 10431-10445
    • Johnston, C.1    Jiang, W.2    Chu, T.3    Levine, B.4
  • 49
    • 12244281813 scopus 로고    scopus 로고
    • The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer
    • 12538450 1:CAS:528:DC%2BD3sXnt1yjsg%3D%3D
    • MB Jones CM Michener JO Blanchette, et al. 2003 The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer Clin Cancer Res 9 44 51 12538450 1:CAS:528:DC%2BD3sXnt1yjsg%3D%3D
    • (2003) Clin Cancer Res , vol.9 , pp. 44-51
    • Jones, M.B.1    Michener, C.M.2    Blanchette, J.O.3
  • 50
    • 79952712455 scopus 로고    scopus 로고
    • A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells
    • 21368173 1:CAS:528:DC%2BC3MXisFOht74%3D 10.1073/pnas.1100650108
    • AW Kao RJ Eisenhut LH Martens, et al. 2011 A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells Proc Natl Acad Sci 108 4441 4446 21368173 1:CAS:528:DC%2BC3MXisFOht74%3D 10.1073/pnas.1100650108
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 4441-4446
    • Kao, A.W.1    Eisenhut, R.J.2    Martens, L.H.3
  • 51
    • 58649098755 scopus 로고    scopus 로고
    • Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth
    • 19091514 1:CAS:528:DC%2BD1MXhtlKlurg%3D 10.1016/j.jdermsci.2008.10.002
    • M Kato N Hasunuma R Nakayama, et al. 2009 Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth J Dermatol Sci 53 234 236 19091514 1:CAS:528:DC%2BD1MXhtlKlurg%3D 10.1016/j.jdermsci.2008.10.002
    • (2009) J Dermatol Sci , vol.53 , pp. 234-236
    • Kato, M.1    Hasunuma, N.2    Nakayama, R.3
  • 52
    • 46749083014 scopus 로고    scopus 로고
    • Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin
    • 18568075 1:CAS:528:DC%2BD1cXot1Ontrc%3D
    • K Kessenbrock L Fröhlich M Sixt, et al. 2008 Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin J Clin Invest 118 2438 2447 18568075 1:CAS:528:DC%2BD1cXot1Ontrc%3D
    • (2008) J Clin Invest , vol.118 , pp. 2438-2447
    • Kessenbrock, K.1    Fröhlich, L.2    Sixt, M.3
  • 53
    • 34247345082 scopus 로고    scopus 로고
    • PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells
    • 16857791 1:CAS:528:DC%2BD28XntFSms7s%3D 10.1158/1078-0432.CCR-05-2663
    • WE Kim G Serrero 2006 PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells Clin Cancer Res 12 4192 4199 16857791 1:CAS:528: DC%2BD28XntFSms7s%3D 10.1158/1078-0432.CCR-05-2663
    • (2006) Clin Cancer Res , vol.12 , pp. 4192-4199
    • Kim, W.E.1    Serrero, G.2
  • 54
    • 68949200351 scopus 로고    scopus 로고
    • Progranulin expression in advanced human atherosclerotic plaque
    • 19321167 1:CAS:528:DC%2BD1MXhtVKlsL%2FK 10.1016/j.atherosclerosis.2009. 02.017
    • Y Kojima K Ono K Inoue, et al. 2009 Progranulin expression in advanced human atherosclerotic plaque Atherosclerosis 206 102 108 19321167 1:CAS:528:DC%2BD1MXhtVKlsL%2FK 10.1016/j.atherosclerosis.2009.02.017
    • (2009) Atherosclerosis , vol.206 , pp. 102-108
    • Kojima, Y.1    Ono, K.2    Inoue, K.3
  • 55
    • 78149429744 scopus 로고    scopus 로고
    • Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy
    • 20967127 10.1371/journal.pone.0013368 1:CAS:528:DC%2BC3cXhtlels7nJ
    • AS Laird A Van Hoecke L De Muynck, et al. 2010 Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy PLoS ONE 5 e13368 20967127 10.1371/journal.pone.0013368 1:CAS:528: DC%2BC3cXhtlels7nJ
    • (2010) PLoS ONE , vol.5 , pp. 13368
    • Laird, A.S.1    Van Hoecke, A.2    De Muynck, L.3
  • 56
    • 0037159513 scopus 로고    scopus 로고
    • IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program
    • 12221085 1:CAS:528:DC%2BD38Xosl2lsrk%3D 10.1074/jbc.M205165200
    • X Li PE Massa A Hanidu, et al. 2002 IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program J Biol Chem 277 45129 45140 12221085 1:CAS:528:DC%2BD38Xosl2lsrk%3D 10.1074/jbc.M205165200
    • (2002) J Biol Chem , vol.277 , pp. 45129-45140
    • Li, X.1    Massa, P.E.2    Hanidu, A.3
  • 57
    • 78650329734 scopus 로고    scopus 로고
    • Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish
    • 20961855 1:CAS:528:DC%2BC3cXhsFynsbzK 10.1074/jbc.M110.138743
    • Y-H Li MH-C Chen H-Y Gong, et al. 2010 Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish J Biol Chem 285 41001 41009 20961855 1:CAS:528:DC%2BC3cXhsFynsbzK 10.1074/jbc.M110.138743
    • (2010) J Biol Chem , vol.285 , pp. 41001-41009
    • Li, Y.-H.1    Mh-C, C.2    Gong, H.-Y.3
  • 58
    • 0034163549 scopus 로고    scopus 로고
    • Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption
    • 10728698 1:CAS:528:DC%2BD3cXhvFWrt7k%3D
    • LM Liau RL Lallone RS Seitz, et al. 2000 Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption Cancer Res 60 1353 1360 10728698 1:CAS:528: DC%2BD3cXhvFWrt7k%3D
    • (2000) Cancer Res , vol.60 , pp. 1353-1360
    • Liau, L.M.1    Lallone, R.L.2    Seitz, R.S.3
  • 59
    • 80855153348 scopus 로고    scopus 로고
    • Progranulin is located in secretory granules and vesicles of neutrophils and macrophages by immunogold electron microscopy: 41.7
    • 10.1097/01.jnen.0000268990.82771.11
    • W-L Lin C Zehr J Lewis DW Dickson 2007 Progranulin is located in secretory granules and vesicles of neutrophils and macrophages by immunogold electron microscopy: 41.7 J Neuropathol Exp Neurol 66 422 10.1097/01.jnen. 0000268990.82771.11
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 422
    • Lin, W.-L.1    Zehr, C.2    Lewis, J.3    Dickson, D.W.4
  • 60
    • 0034636005 scopus 로고    scopus 로고
    • Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468
    • 10760271 1:CAS:528:DC%2BD3cXislSgt7o%3D 10.1073/pnas.97.8.3993
    • R Lu G Serrero 2000 Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468 Proc Natl Acad Sci 97 3993 3998 10760271 1:CAS:528:DC%2BD3cXislSgt7o%3D 10.1073/pnas.97.8.3993
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 3993-3998
    • Lu, R.1    Serrero, G.2
  • 61
    • 0035793102 scopus 로고    scopus 로고
    • Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor)
    • 11134521 1:CAS:528:DC%2BD3MXkslKrtA%3D%3D 10.1073/pnas.011525198
    • R Lu G Serrero 2001 Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor) Proc Natl Acad Sci 98 142 147 11134521 1:CAS:528: DC%2BD3MXkslKrtA%3D%3D 10.1073/pnas.011525198
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 142-147
    • Lu, R.1    Serrero, G.2
  • 62
    • 33750590113 scopus 로고    scopus 로고
    • The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene
    • 17071926 10.1093/brain/awl271
    • IRA Mackenzie M Baker S Pickering-Brown, et al. 2006 The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene Brain 129 3081 3090 17071926 10.1093/brain/awl271
    • (2006) Brain , vol.129 , pp. 3081-3090
    • MacKenzie, I.R.A.1    Baker, M.2    Pickering-Brown, S.3
  • 63
    • 0035085455 scopus 로고    scopus 로고
    • Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays
    • 11279269 1:CAS:528:DC%2BD3MXis1Klt7c%3D 10.1046/j.1471-4159.2001.t01-1- 00231.x
    • A Malaspina N Kaushik J de Belleroche 2001 Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays J Neurochem 77 132 145 11279269 1:CAS:528:DC%2BD3MXis1Klt7c%3D 10.1046/j.1471-4159.2001.t01-1-00231.x
    • (2001) J Neurochem , vol.77 , pp. 132-145
    • Malaspina, A.1    Kaushik, N.2    De Belleroche, J.3
  • 64
    • 33645047659 scopus 로고    scopus 로고
    • Oncogenic property of acrogranin in human uterine leiomyosarcoma: Direct evidence of genetic contribution in in vivo tumorigenesis
    • 16533762 1:CAS:528:DC%2BD28XitVGmsr8%3D 10.1158/1078-0432.CCR-05-2003
    • N Matsumura M Mandai M Miyanishi, et al. 2006 Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis Clin Cancer Res 12 1402 1411 16533762 1:CAS:528:DC%2BD28XitVGmsr8%3D 10.1158/1078-0432.CCR-05-2003
    • (2006) Clin Cancer Res , vol.12 , pp. 1402-1411
    • Matsumura, N.1    Mandai, M.2    Miyanishi, M.3
  • 65
    • 0036500643 scopus 로고    scopus 로고
    • High-density microarray analysis of hippocampal gene expression following experimental brain injury
    • 11891777 1:CAS:528:DC%2BD38XisVKnsbs%3D 10.1002/jnr.10157
    • DA Matzilevich JM Rall AN Moore RJ Grill PK Dash 2002 High-density microarray analysis of hippocampal gene expression following experimental brain injury J Neurosci Res 67 646 663 11891777 1:CAS:528:DC%2BD38XisVKnsbs%3D 10.1002/jnr.10157
    • (2002) J Neurosci Res , vol.67 , pp. 646-663
    • Matzilevich, D.A.1    Rall, J.M.2    Moore, A.N.3    Grill, R.J.4    Dash, P.K.5
  • 66
    • 33947727094 scopus 로고    scopus 로고
    • Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression
    • 17203169 1:CAS:528:DC%2BD2sXhvFyltbY%3D
    • M Miyanishi M Mandai N Matsumura, et al. 2007 Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression Oncol Rep 17 329 333 17203169 1:CAS:528:DC%2BD2sXhvFyltbY%3D
    • (2007) Oncol Rep , vol.17 , pp. 329-333
    • Miyanishi, M.1    Mandai, M.2    Matsumura, N.3
  • 67
    • 58049221032 scopus 로고    scopus 로고
    • Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury
    • 19046946 1:CAS:528:DC%2BD1MXht1ajtA%3D%3D 10.1016/j.brainres.2008.10.021
    • K Moisse K Volkening C Leystra-Lantz I Welch T Hill MJ Strong 2009 Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury Brain Res 1249 202 211 19046946 1:CAS:528:DC%2BD1MXht1ajtA%3D%3D 10.1016/j.brainres.2008.10.021
    • (2009) Brain Res , vol.1249 , pp. 202-211
    • Moisse, K.1    Volkening, K.2    Leystra-Lantz, C.3    Welch, I.4    Hill, T.5    Strong, M.J.6
  • 68
    • 33746865874 scopus 로고    scopus 로고
    • Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex
    • 16849556 1:CAS:528:DC%2BD28XmvFGkt7s%3D 10.1158/0008-5472.CAN-06-0633
    • G Monami EM Gonzalez M Hellman, et al. 2006 Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex Cancer Res 66 7103 7110 16849556 1:CAS:528:DC%2BD28XmvFGkt7s%3D 10.1158/0008-5472.CAN-06-0633
    • (2006) Cancer Res , vol.66 , pp. 7103-7110
    • Monami, G.1    Gonzalez, E.M.2    Hellman, M.3
  • 69
    • 62549091390 scopus 로고    scopus 로고
    • Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth
    • 19179604 1:CAS:528:DC%2BD1MXjs1Wgs7k%3D 10.2353/ajpath.2009.080735
    • G Monami V Emiliozzi A Bitto, et al. 2009 Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth Am J Pathol 174 1037 1047 19179604 1:CAS:528:DC%2BD1MXjs1Wgs7k%3D 10.2353/ajpath.2009.080735
    • (2009) Am J Pathol , vol.174 , pp. 1037-1047
    • Monami, G.1    Emiliozzi, V.2    Bitto, A.3
  • 70
    • 42049108445 scopus 로고    scopus 로고
    • Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia
    • 18183624 1:CAS:528:DC%2BD1cXlslWlsL4%3D 10.1002/humu.20681
    • O Mukherjee J Wang MA Gitcho, et al. 2008 Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia Hum Mutat 29 512 521 18183624 1:CAS:528:DC%2BD1cXlslWlsL4%3D 10.1002/humu.20681
    • (2008) Hum Mutat , vol.29 , pp. 512-521
    • Mukherjee, O.1    Wang, J.2    Gitcho, M.A.3
  • 71
    • 77649192710 scopus 로고    scopus 로고
    • Progranulin expression is upregulated after spinal contusion in mice
    • 19946692 1:CAS:528:DC%2BC3cXjtlCgsA%3D%3D 10.1007/s00401-009-0616-y
    • SB Naphade KA Kigerl LB Jakeman SK Kostyk PG Popovich J Kuret 2010 Progranulin expression is upregulated after spinal contusion in mice Acta Neuropathol 119 123 133 19946692 1:CAS:528:DC%2BC3cXjtlCgsA%3D%3D 10.1007/s00401-009-0616-y
    • (2010) Acta Neuropathol , vol.119 , pp. 123-133
    • Naphade, S.B.1    Kigerl, K.A.2    Jakeman, L.B.3    Kostyk, S.K.4    Popovich, P.G.5    Kuret, J.6
  • 72
    • 26844447994 scopus 로고    scopus 로고
    • Frontotemporal dementia
    • 16239184 10.1016/S1474-4422(05)70223-4
    • D Neary J Snowden D Mann 2005 Frontotemporal dementia Lancet Neurol 4 771 780 16239184 10.1016/S1474-4422(05)70223-4
    • (2005) Lancet Neurol , vol.4 , pp. 771-780
    • Neary, D.1    Snowden, J.2    Mann, D.3
  • 73
    • 33749632259 scopus 로고    scopus 로고
    • Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • 17023659 1:CAS:528:DC%2BD28XhtVCiurrL 10.1126/science.1134108
    • M Neumann DM Sampathu LK Kwong, et al. 2006 Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 314 130 133 17023659 1:CAS:528:DC%2BD28XhtVCiurrL 10.1126/science.1134108
    • (2006) Science , vol.314 , pp. 130-133
    • Neumann, M.1    Sampathu, D.M.2    Kwong, L.K.3
  • 74
    • 0037452606 scopus 로고    scopus 로고
    • Activated microglia in cortex of mouse models of mucopolysaccharidoses i and IIIB
    • 12576554 1:CAS:528:DC%2BD3sXhsFGrs78%3D 10.1073/pnas.252784899
    • K Ohmi DS Greenberg KS Rajavel S Ryazantsev HH Li EF Neufeld 2003 Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB Proc Natl Acad Sci 100 1902 1907 12576554 1:CAS:528:DC%2BD3sXhsFGrs78%3D 10.1073/pnas.252784899
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 1902-1907
    • Ohmi, K.1    Greenberg, D.S.2    Rajavel, K.S.3    Ryazantsev, S.4    Li, H.H.5    Neufeld, E.F.6
  • 75
    • 77954717645 scopus 로고    scopus 로고
    • HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins
    • 20215705 1:CAS:528:DC%2BC3MXhvVert7g%3D 10.5551/jat.3921
    • H Okura S Yamashita T Ohama, et al. 2010 HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins J Atheroscler Thromb 17 568 577 20215705 1:CAS:528:DC%2BC3MXhvVert7g%3D 10.5551/jat.3921
    • (2010) J Atheroscler Thromb , vol.17 , pp. 568-577
    • Okura, H.1    Yamashita, S.2    Ohama, T.3
  • 76
    • 77955707871 scopus 로고    scopus 로고
    • Progranulin expression in the developing and adult murine brain
    • 20737593 10.1002/cne.22430
    • TL Petkau SJ Neal PC Orban, et al. 2010 Progranulin expression in the developing and adult murine brain J Comp Neurol 518 3931 3947 20737593 10.1002/cne.22430
    • (2010) J Comp Neurol , vol.518 , pp. 3931-3947
    • Petkau, T.L.1    Neal, S.J.2    Orban, P.C.3
  • 77
    • 79951704433 scopus 로고    scopus 로고
    • Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease
    • 21349440 1:CAS:528:DC%2BC3MXit1Wktr8%3D 10.1016/S1474-4422(11)70015-1
    • T Philips W Robberecht 2011 Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease Lancet Neurol 10 253 263 21349440 1:CAS:528:DC%2BC3MXit1Wktr8%3D 10.1016/S1474-4422(11)70015-1
    • (2011) Lancet Neurol , vol.10 , pp. 253-263
    • Philips, T.1    Robberecht, W.2
  • 78
    • 78650178041 scopus 로고    scopus 로고
    • Microglial upregulation of progranulin as a marker of motor neuron degeneration
    • 21107132 1:CAS:528:DC%2BC3cXhsV2nsr7J 10.1097/NEN.0b013e3181fc9aea
    • T Philips L De Muynck HNT Thu, et al. 2010 Microglial upregulation of progranulin as a marker of motor neuron degeneration J Neuropathol Exp Neurol 69 1191 1200 21107132 1:CAS:528:DC%2BC3cXhsV2nsr7J 10.1097/NEN.0b013e3181fc9aea
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 1191-1200
    • Philips, T.1    De Muynck, L.2    Thu, H.N.T.3
  • 79
    • 79251482777 scopus 로고    scopus 로고
    • Progranulin is a chemoattractant for microglia and stimulates their endocytic activity
    • 21224065 1:CAS:528:DC%2BC3MXitFGjsL0%3D 10.1016/j.ajpath.2010.11.002
    • F Pickford J Marcus LM Camargo, et al. 2011 Progranulin is a chemoattractant for microglia and stimulates their endocytic activity Am J Pathol 178 284 295 21224065 1:CAS:528:DC%2BC3MXitFGjsL0%3D 10.1016/j.ajpath. 2010.11.002
    • (2011) Am J Pathol , vol.178 , pp. 284-295
    • Pickford, F.1    Marcus, J.2    Camargo, L.M.3
  • 80
    • 34247359882 scopus 로고    scopus 로고
    • Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse
    • 17266030 1:CAS:528:DC%2BD2sXksFSktb4%3D 10.1002/ijc.22559
    • GO Pizarro XC Zhou A Koch, et al. 2007 Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse Int J Cancer 120 2339 2343 17266030 1:CAS:528:DC%2BD2sXksFSktb4%3D 10.1002/ijc.22559
    • (2007) Int J Cancer , vol.120 , pp. 2339-2343
    • Pizarro, G.O.1    Zhou, X.C.2    Koch, A.3
  • 81
    • 0026717054 scopus 로고
    • The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth
    • 1618805 1:CAS:528:DyaK3sXisVygtbY%3D
    • GD Plowman JM Green MG Neubauer, et al. 1992 The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth J Biol Chem 267 13073 13078 1618805 1:CAS:528:DyaK3sXisVygtbY%3D
    • (1992) J Biol Chem , vol.267 , pp. 13073-13078
    • Plowman, G.D.1    Green, J.M.2    Neubauer, M.G.3
  • 82
    • 23844556836 scopus 로고    scopus 로고
    • Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse
    • 15901638 1:CAS:528:DC%2BD2MXovV2qt70%3D 10.1095/biolreprod.105.040030
    • J Qin L Díaz-Cueto J Schwarze, et al. 2005 Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse Biol Reprod 73 434 442 15901638 1:CAS:528:DC%2BD2MXovV2qt70%3D 10.1095/biolreprod. 105.040030
    • (2005) Biol Reprod , vol.73 , pp. 434-442
    • Qin, J.1    Díaz-Cueto, L.2    Schwarze, J.3
  • 83
    • 0037062609 scopus 로고    scopus 로고
    • The prevalence of frontotemporal dementia
    • 12058088 1:STN:280:DC%2BD38zhsFWguw%3D%3D
    • E Ratnavalli C Brayne K Dawson JR Hodges 2002 The prevalence of frontotemporal dementia Neurology 58 1615 1621 12058088 1:STN:280: DC%2BD38zhsFWguw%3D%3D
    • (2002) Neurology , vol.58 , pp. 1615-1621
    • Ratnavalli, E.1    Brayne, C.2    Dawson, K.3    Hodges, J.R.4
  • 84
    • 70749120467 scopus 로고    scopus 로고
    • Progranulin is expressed within motor neurons and promotes neuronal cell survival
    • 19860916 10.1186/1471-2202-10-130 1:CAS:528:DC%2BD1MXhtlOhurvL
    • CL Ryan DC Baranowski BP Chitramuthu, et al. 2009 Progranulin is expressed within motor neurons and promotes neuronal cell survival BMC Neurosci 10 130 19860916 10.1186/1471-2202-10-130 1:CAS:528:DC%2BD1MXhtlOhurvL
    • (2009) BMC Neurosci , vol.10 , pp. 130
    • Ryan, C.L.1    Baranowski, D.C.2    Chitramuthu, B.P.3
  • 85
    • 38349173569 scopus 로고    scopus 로고
    • Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion
    • 17984093 1:CAS:528:DC%2BD1cXks1CitQ%3D%3D 10.1074/jbc.M705115200
    • SS Shankaran A Capell AT Hruscha, et al. 2008 Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion J Biol Chem 283 1744 1753 17984093 1:CAS:528:DC%2BD1cXks1CitQ%3D%3D 10.1074/jbc.M705115200
    • (2008) J Biol Chem , vol.283 , pp. 1744-1753
    • Shankaran, S.S.1    Capell, A.2    Hruscha, A.T.3
  • 86
    • 0025133297 scopus 로고
    • Epithelins 1 and 2: Isolation and characterization of two cysteine-rich growth-modulating proteins
    • 2236009 1:CAS:528:DyaK3MXnsFejtg%3D%3D 10.1073/pnas.87.20.7912
    • M Shoyab VL McDonald C Byles GJ Todaro GD Plowman 1990 Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins Proc Natl Acad Sci 87 7912 7916 2236009 1:CAS:528:DyaK3MXnsFejtg%3D%3D 10.1073/pnas.87.20.7912
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 7912-7916
    • Shoyab, M.1    McDonald, V.L.2    Byles, C.3    Todaro, G.J.4    Plowman, G.D.5
  • 87
    • 67249111266 scopus 로고    scopus 로고
    • Serum biomarker for progranulin-associated frontotemporal lobar degeneration
    • 19288468 1:CAS:528:DC%2BD1MXnvFahsb4%3D 10.1002/ana.21621
    • K Sleegers N Brouwers P Van Damme, et al. 2009 Serum biomarker for progranulin-associated frontotemporal lobar degeneration Ann Neurol 65 603 609 19288468 1:CAS:528:DC%2BD1MXnvFahsb4%3D 10.1002/ana.21621
    • (2009) Ann Neurol , vol.65 , pp. 603-609
    • Sleegers, K.1    Brouwers, N.2    Van Damme, P.3
  • 88
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • 15784165 1:CAS:528:DC%2BD2MXlt1eqtLo%3D 10.1111/j.1582-4934.2005.tb00337. x
    • G Song G Ouyang S Bao 2005 The activation of Akt/PKB signaling pathway and cell survival J Cell Mol Med 9 59 71 15784165 1:CAS:528:DC%2BD2MXlt1eqtLo%3D 10.1111/j.1582-4934.2005.tb00337.x
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 89
    • 79957538748 scopus 로고    scopus 로고
    • Expression pattern of progranulin in the human placenta and its effect on cell proliferation in the choriocarcinoma cell line BeWo
    • Stubert J, Richter D-U, Gerber B, Briese V (2010) Expression pattern of progranulin in the human placenta and its effect on cell proliferation in the choriocarcinoma cell line BeWo. J Reprod Dev 57:229-235
    • (2010) J Reprod Dev , vol.57 , pp. 229-235
    • Stubert, J.1    Richter, D.-U.2    Gerber, B.3    Briese, V.4
  • 90
    • 0034667758 scopus 로고    scopus 로고
    • Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase
    • 11068878 1:CAS:528:DC%2BD3cXntVWguro%3D 10.1006/abbi.2000.2019
    • D Sui JE Wilson 2000 Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase Arch Biochem Biophys 382 262 274 11068878 1:CAS:528:DC%2BD3cXntVWguro%3D 10.1006/abbi.2000.2019
    • (2000) Arch Biochem Biophys , vol.382 , pp. 262-274
    • Sui, D.1    Wilson, J.E.2
  • 91
    • 79955477738 scopus 로고    scopus 로고
    • The growth factor progranulin binds to tnf receptors and is therapeutic against inflammatory arthritis in mice
    • 21393509 1:CAS:528:DC%2BC3MXkvValsrY%3D 10.1126/science.1199214
    • W Tang Y Lu Q-Y Tian, et al. 2011 The growth factor progranulin binds to tnf receptors and is therapeutic against inflammatory arthritis in mice Science 332 478 484 21393509 1:CAS:528:DC%2BC3MXkvValsrY%3D 10.1126/science.1199214
    • (2011) Science , vol.332 , pp. 478-484
    • Tang, W.1    Lu, Y.2    Tian, Q.-Y.3
  • 92
    • 4544367851 scopus 로고    scopus 로고
    • PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells
    • 15117809 1:CAS:528:DC%2BD2cXntFahsr8%3D 10.1093/carcin/bgh171
    • W Tangkeangsirisin G Serrero 2004 PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells Carcinogenesis 25 1587 1592 15117809 1:CAS:528:DC%2BD2cXntFahsr8%3D 10.1093/carcin/bgh171
    • (2004) Carcinogenesis , vol.25 , pp. 1587-1592
    • Tangkeangsirisin, W.1    Serrero, G.2
  • 93
    • 1642266452 scopus 로고    scopus 로고
    • PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells
    • 14996734 1:CAS:528:DC%2BD2cXhsleku74%3D 10.1158/0008-5472.CAN-03-2364
    • W Tangkeangsirisin J Hayashi G Serrero 2004 PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells Cancer Res 64 1737 1743 14996734 1:CAS:528:DC%2BD2cXhsleku74%3D 10.1158/0008-5472.CAN-03-2364
    • (2004) Cancer Res , vol.64 , pp. 1737-1743
    • Tangkeangsirisin, W.1    Hayashi, J.2    Serrero, G.3
  • 94
    • 0033574221 scopus 로고    scopus 로고
    • Epithelin/granulin growth factors: Extracellular cofactors for HIV-1 and HIV-2 Tat proteins
    • 10079180 1:CAS:528:DyaK1MXhvVaiurg%3D 10.1006/bbrc.1999.0317
    • DP Trinh KM Brown KT Jeang 1999 Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins Biochem Biophys Res Commun 256 299 306 10079180 1:CAS:528:DyaK1MXhvVaiurg%3D 10.1006/bbrc.1999.0317
    • (1999) Biochem Biophys Res Commun , vol.256 , pp. 299-306
    • Trinh, D.P.1    Brown, K.M.2    Jeang, K.T.3
  • 95
    • 0029102880 scopus 로고
    • Somatostatin-, vasoactive intestinal eptide-, and granulin-like peptides isolated from intestinal extracts of goldfish, Carassius auratus
    • 8536941 1:CAS:528:DyaK2MXnvVeks7k%3D 10.1006/gcen.1995.1113
    • T Uesaka K Yano M Yamasaki M Ando 1995 Somatostatin-, vasoactive intestinal eptide-, and granulin-like peptides isolated from intestinal extracts of goldfish, Carassius auratus Gen Comp Endocrinol 99 298 306 8536941 1:CAS:528:DyaK2MXnvVeks7k%3D 10.1006/gcen.1995.1113
    • (1995) Gen Comp Endocrinol , vol.99 , pp. 298-306
    • Uesaka, T.1    Yano, K.2    Yamasaki, M.3    Ando, M.4
  • 96
    • 42049087853 scopus 로고    scopus 로고
    • Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    • 18378771 10.1083/jcb.200712039 1:CAS:528:DC%2BD1cXks1Gktbk%3D
    • P Van Damme A Van Hoecke D Lambrechts, et al. 2008 Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival J Cell Biol 181 37 41 18378771 10.1083/jcb.200712039 1:CAS:528:DC%2BD1cXks1Gktbk%3D
    • (2008) J Cell Biol , vol.181 , pp. 37-41
    • Van Damme, P.1    Van Hoecke, A.2    Lambrechts, D.3
  • 97
    • 34247868937 scopus 로고    scopus 로고
    • Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia
    • 17345602
    • J van der Zee I Le Ber S Maurer-Stroh, et al. 2007 Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia Hum Mutat 28 416 17345602
    • (2007) Hum Mutat , vol.28 , pp. 416
    • Van Der Zee, J.1    Le Ber, I.2    Maurer-Stroh, S.3
  • 98
    • 0038514929 scopus 로고    scopus 로고
    • PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma
    • 12796389 1:CAS:528:DC%2BD3sXksVWqu7c%3D
    • W Wang J Hayashi WE Kim G Serrero 2003 PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma Clin Cancer Res 9 2221 2228 12796389 1:CAS:528:DC%2BD3sXksVWqu7c%3D
    • (2003) Clin Cancer Res , vol.9 , pp. 2221-2228
    • Wang, W.1    Hayashi, J.2    Kim, W.E.3    Serrero, G.4
  • 99
    • 31544434306 scopus 로고    scopus 로고
    • PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma
    • 16397023 1:CAS:528:DC%2BD28Xht1Grug%3D%3D 10.1158/1078-0432.CCR-05-0929
    • W Wang J Hayashi G Serrero 2006 PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma Clin Cancer Res 12 49 56 16397023 1:CAS:528:DC%2BD28Xht1Grug%3D%3D 10.1158/1078-0432.CCR-05-0929
    • (2006) Clin Cancer Res , vol.12 , pp. 49-56
    • Wang, W.1    Hayashi, J.2    Serrero, G.3
  • 100
    • 75949130374 scopus 로고    scopus 로고
    • Pathogenic cysteine mutations affect progranulin function and production of mature granulins
    • 20028451 1:CAS:528:DC%2BC3cXisVCis70%3D 10.1111/j.1471-4159.2009.06546.x
    • J Wang P Van Damme C Cruchaga, et al. 2010 Pathogenic cysteine mutations affect progranulin function and production of mature granulins J Neurochem 112 1305 1315 20028451 1:CAS:528:DC%2BC3cXisVCis70%3D 10.1111/j.1471-4159.2009. 06546.x
    • (2010) J Neurochem , vol.112 , pp. 1305-1315
    • Wang, J.1    Van Damme, P.2    Cruchaga, C.3
  • 101
    • 0032540126 scopus 로고    scopus 로고
    • Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts
    • 9571191 1:CAS:528:DyaK1cXivVyjsLo%3D 10.1006/bbrc.1998.8498
    • X Xia G Serrero 1998 Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts Biochem Biophys Res Commun 245 539 543 9571191 1:CAS:528:DyaK1cXivVyjsLo%3D 10.1006/bbrc.1998.8498
    • (1998) Biochem Biophys Res Commun , vol.245 , pp. 539-543
    • Xia, X.1    Serrero, G.2
  • 102
    • 0032493827 scopus 로고    scopus 로고
    • The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro
    • 9685348 1:CAS:528:DyaK1cXlsVWgsLY%3D 10.1074/jbc.273.32.20078
    • SQ Xu D Tang S Chamberlain, et al. 1998 The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro J Biol Chem 273 20078 20083 9685348 1:CAS:528:DyaK1cXlsVWgsLY%3D 10.1074/jbc.273.32.20078
    • (1998) J Biol Chem , vol.273 , pp. 20078-20083
    • Xu, S.Q.1    Tang, D.2    Chamberlain, S.3
  • 103
    • 34249683186 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation
    • 17307734 1:CAS:528:DC%2BD2sXjvFagt7g%3D 10.1074/jbc.M608744200
    • K Xu Y Zhang K Ilalov, et al. 2007 Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation J Biol Chem 282 11347 11355 17307734 1:CAS:528:DC%2BD2sXjvFagt7g%3D 10.1074/jbc.M608744200
    • (2007) J Biol Chem , vol.282 , pp. 11347-11355
    • Xu, K.1    Zhang, Y.2    Ilalov, K.3
  • 104
    • 57049104077 scopus 로고    scopus 로고
    • Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach
    • 18596065 1:CAS:528:DC%2BD1cXhsVaqsL%2FE 10.1074/mcp.M800095-MCP200
    • D Xu N Suenaga MJ Edelmann R Fridman RJ Muschel BM Kessler 2008 Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach Mol Cell Proteomics 7 2215 2228 18596065 1:CAS:528:DC%2BD1cXhsVaqsL%2FE 10.1074/mcp.M800095-MCP200
    • (2008) Mol Cell Proteomics , vol.7 , pp. 2215-2228
    • Xu, D.1    Suenaga, N.2    Edelmann, M.J.3    Fridman, R.4    Muschel, R.J.5    Kessler, B.M.6
  • 105
    • 76149118401 scopus 로고    scopus 로고
    • Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice
    • 20026663 1:CAS:528:DC%2BC3cXht1ektrY%3D 10.1084/jem.20091568
    • F Yin R Banerjee B Thomas, et al. 2010 Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice J Exp Med 207 117 128 20026663 1:CAS:528:DC%2BC3cXht1ektrY%3D 10.1084/jem.20091568
    • (2010) J Exp Med , vol.207 , pp. 117-128
    • Yin, F.1    Banerjee, R.2    Thomas, B.3
  • 106
    • 78149296002 scopus 로고    scopus 로고
    • Behavioral deficits and progressive neuropathology in progranulin-deficient mice: A mouse model of frontotemporal dementia
    • 20667979 1:CAS:528:DC%2BC3cXhsFOms7zM 10.1096/fj.10-161471
    • F Yin M Dumont R Banerjee, et al. 2010 Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia FASEB J 24 4639 4647 20667979 1:CAS:528: DC%2BC3cXhsFOms7zM 10.1096/fj.10-161471
    • (2010) FASEB J , vol.24 , pp. 4639-4647
    • Yin, F.1    Dumont, M.2    Banerjee, R.3
  • 107
    • 62749143509 scopus 로고    scopus 로고
    • Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue
    • 19056610 1:CAS:528:DC%2BD1MXjt1Wktr4%3D 10.2337/db08-1147
    • B-S Youn S-I Bang N Kloeting, et al. 2009 Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue Diabetes 58 627 636 19056610 1:CAS:528:DC%2BD1MXjt1Wktr4%3D 10.2337/db08-1147
    • (2009) Diabetes , vol.58 , pp. 627-636
    • Youn, B.-S.1    Bang, S.-I.2    Kloeting, N.3
  • 108
    • 0032749572 scopus 로고    scopus 로고
    • Biological activities and signaling pathways of the granulin/epithelin precursor
    • 10537317 1:CAS:528:DyaK1MXmvFeltrw%3D
    • T Zanocco-Marani A Bateman G Romano B Valentinis ZH He R Baserga 1999 Biological activities and signaling pathways of the granulin/epithelin precursor Cancer Res 59 5331 5340 10537317 1:CAS:528:DyaK1MXmvFeltrw%3D
    • (1999) Cancer Res , vol.59 , pp. 5331-5340
    • Zanocco-Marani, T.1    Bateman, A.2    Romano, G.3    Valentinis, B.4    He, Z.H.5    Baserga, R.6
  • 109
    • 0032564360 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)
    • 9826678 1:CAS:528:DyaK1cXns1GmurY%3D 10.1073/pnas.95.24.14202
    • H Zhang G Serrero 1998 Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) Proc Natl Acad Sci 95 14202 14207 9826678 1:CAS:528:DyaK1cXns1GmurY%3D 10.1073/pnas.95.24.14202
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 14202-14207
    • Zhang, H.1    Serrero, G.2
  • 110
    • 34848921202 scopus 로고    scopus 로고
    • Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
    • 17898224 1:CAS:528:DC%2BD2sXhtFGmt7fO 10.1523/JNEUROSCI.3421-07.2007
    • Y-J Zhang Y-F Xu CA Dickey, et al. 2007 Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43 J Neurosci 27 10530 10534 17898224 1:CAS:528:DC%2BD2sXhtFGmt7fO 10.1523/JNEUROSCI.3421-07.2007
    • (2007) J Neurosci , vol.27 , pp. 10530-10534
    • Zhang, Y.-J.1    Xu, Y.-F.2    Dickey, C.A.3
  • 111
    • 0027241980 scopus 로고
    • Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line
    • 8496151 1:CAS:528:DyaK3sXksVWrsLo%3D
    • J Zhou G Gao JW Crabb G Serrero 1993 Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line J Biol Chem 268 10863 10869 8496151 1:CAS:528:DyaK3sXksVWrsLo%3D
    • (1993) J Biol Chem , vol.268 , pp. 10863-10869
    • Zhou, J.1    Gao, G.2    Crabb, J.W.3    Serrero, G.4
  • 112
    • 0037074016 scopus 로고    scopus 로고
    • Conversion of proepithelin to epithelins: Roles of SLPI and elastase in host defense and wound repair
    • 12526812 1:CAS:528:DC%2BD3sXhtVyksw%3D%3D 10.1016/S0092-8674(02)01141-8
    • J Zhu C Nathan W Jin, et al. 2002 Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair Cell 111 867 878 12526812 1:CAS:528:DC%2BD3sXhtVyksw%3D%3D 10.1016/S0092-8674(02)01141-8
    • (2002) Cell , vol.111 , pp. 867-878
    • Zhu, J.1    Nathan, C.2    Jin, W.3


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