The role of autophagic and lysosomal pathways in ischemic brain injury

Neural Regeneration Research

Volumn 8, Issue 23, 2013, Pages 2117-2125

  Gu, Zhaohua ^a   Sun, Yinyi ^b   Liu, Kangyong ^a,b   Wang, Fen ^c   Zhang, Ting ^b   Li, Qiang ^b   Shen, Liwei ^d   Zhou, Ling ^d   Dong, Liang ^a   Shi, Nan ^a   Zhang, Qian ^a   Zhang, Wei ^a   Zhao, Meizhen ^a   Sun, Xiaojiang ^b  

^a Shanghai Pudong New Area Zhoupu Hospital   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^c MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

Autophagy; Brain injury; Cathepsin B; Cerebral ischemia; Grants supported paper; Light chain 3; Lysosome; Neural regeneration; Neuron; Neuroprotection; Neuroregeneration

Indexed keywords

3 METHYLADENINE; CATHEPSIN B; LIGHT CHAIN 3 PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL DEATH; CELL ULTRASTRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIGHT CHAIN; LYSOSOME; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ADULT; CELL VACUOLE; CRANIOTOMY; ELECTRON MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUANTITATIVE ANALYSIS; UPREGULATION;

EID: 84886677968     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2013.23.001     Document Type: Article

References (32)

1. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22(9):391-397.
2. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79(4):1431-1568.
3. Adhami F, Liao G, Morozov YM, et al. Cerebral ischemiahypoxia induces intravascular coagulation and autophagy. Am J Pathol. 2006;169(2):566-583.
4. Adhami F, Schloemer A, Kuan CY. The roles of autophagy in cerebral ischemia. Autophagy. 2007;3(1):42-44.
5. Koike M, Shibata M, Tadakoshi M, et al. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol. 2008;172(2): 454-469.
6. Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science. 2000;290(5497):1717-1721.
7. Punnonen EL, Autio S, Kaija H, et al. Autophagic vacuoles fuse with the prelysosomal compartment in cultured rat fibroblasts. Eur J Cell Biol. 1993;61(1):54-66.
8. Glaumann H, Ericsson JL, Marzella L. Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles. Int Rev Cytol. 1981;73:149-182.
9. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000; 19(21):5720-5728.
10. Kabeya Y, Mizushima N, Yamamoto A, et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci. 2004;117(Pt 13):2805-2812.
11. Nixon RA. Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends Neurosci. 2006;29(9): 528-535.
12. Clarke PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl). 1990;181(3):195-213.
13. Reggiori F, Klionsky DJ. Autophagy in the eukaryotic cell. Eukaryot Cell. 2002;1(1):11-21.
14. Liu K, Gui B, Sun Y, et al. Inhibition of L-type Ca(2+) channels by curcumin requires a novel protein kinasetheta isoform in rat hippocampal neurons. Cell Calcium. 2013;53(3):195-203.
15. Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem. 2002;269(8):1996-2002.
16. Hu BR, Martone ME, Jones YZ, et al. Protein aggregation after transient cerebral ischemia. J Neurosci. 2000;20(9): 3191-3199.
17. Klionsky DJ. Neurodegeneration: good riddance to bad rubbish. Nature. 2006;441(7095):819-820.
18. Wen YD, Sheng R, Zhang LS, et al. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy. 2008;4(6):762-769.
19. Zhu C, Wang X, Xu F, et al. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ. 2005;12(2):162-176.
20. Zhu C, Xu F, Wang X, et al. Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem. 2006;96(4):1016-1027.
21. Moore MN, Allen JI, Somerfield PJ. Autophagy: role in surviving environmental stress. Mar Environ Res. 2006;62 Suppl:S420-425.
22. Swanson MS. Autophagy: eating for good health. J Immunol. 2006;177(8):4945-4951.
23. Shi JJ, Liu KY, Yang YP. Autophagy in the pathogenesis of Parkinson's disease. Sheng Li Ke Xue Jin Zhan. 2009; 40(1):67-71.
24. Bowen ID, Mullarkey K, Morgan SM. Programmed cell death during metamorphosis in the blow-fly Calliphora vomitoria. Microsc Res Tech. 1996;34(3):202-217.
25. Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol. 2004;16(6): 663-669.
26. Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med. 2006; 27(5-6):495-502.
27. Nishino I. Autophagic vacuolar myopathy. Semin Pediatr Neurol. 2006;13(2):90-95.
28. Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441(7095):880-884.
29. Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006;441(7095):885-889.
30. Liu K, Shi N, Sun Y, et al. Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice. Neurochem Res. 2013;38(1):201-207.
31. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84-91.
32. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 5th ed. London: Academic Press, UK. 2005.