A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers

Journal of Biological Chemistry

Volumn 291, Issue 7, 2016, Pages 3197-3208

  Kosasih, Hansen J ^a,b   Last, Karena ^a,b   Rogerson, Fraser M ^a,b   Golub, Suzanne B ^a,b   Gauci, Stephanie J ^b   Russo, Vincenzo C ^b   Stanton, Heather ^a,b   Wilson, Richard ^d   Lamande, Shireen R ^b   Holden, Paul ^c   Fosang, Amanda J ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF TASMANIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; GLYCOPROTEINS; OLIGOMERIZATION;

CATALYTIC DOMAINS; DOMINANT NEGATIVE; INTERMOLECULAR INTERACTIONS; METALLOPROTEINASES; MOUSE CARTILAGE; MULTI-DOMAIN ENZYMES; PROTEOGLYCANS; THROMBOSPONDIN MOTIFS;

OLIGOMERS;

AGGRECAN; AGGRECANASE; AGGRECANASE 2; AGGRECANASE INHIBITOR; ENZYME INHIBITOR; EPITOPE; MUTANT PROTEIN; OLIGOMER; PROTEOGLYCAN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN; ADAMTS5 PROTEIN, MOUSE; AGC1 PROTEIN, MOUSE; CROSS LINKING REAGENT; HYBRID PROTEIN; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE; CATALYSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; ELUTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CHEMISTRY; CROSS BREEDING; DIMERIZATION; ENZYME ACTIVATION; ENZYMOLOGY; EXPERIMENTAL ARTHRITIS; GENE DELETION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; ISOLATION AND PURIFICATION; KNEE; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; PROTEIN DEGRADATION; PROTEIN DOMAIN;

ADAM PROTEINS; ADAMTS5 PROTEIN; AGGRECANS; ANIMALS; ARTHRITIS, EXPERIMENTAL; CATALYTIC DOMAIN; CROSS-LINKING REAGENTS; CROSSES, GENETIC; DIMERIZATION; ENZYME ACTIVATION; GENE DELETION; HEK293 CELLS; HUMANS; KNEE JOINT; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOLECULAR WEIGHT; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS;

EID: 84969266852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.704817     Document Type: Article

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