메뉴 건너뛰기




Volumn 213, Issue 5, 2016, Pages 809-825

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ISONIAZID; RIFAMPICIN;

EID: 84969244646     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151248     Document Type: Article
Times cited : (155)

References (62)
  • 1
    • 79955031171 scopus 로고    scopus 로고
    • aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome
    • Abramovitch, R.B., K.H. Rohde, F.F. Hsu, and D.G. Russell. 2011. aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome. Mol. Microbiol. 80:678-694. http://dx.doi.org/10.1111/j.1365-2958.2011.07601.x
    • (2011) Mol. Microbiol , vol.80 , pp. 678-694
    • Abramovitch, R.B.1    Rohde, K.H.2    Hsu, F.F.3    Russell, D.G.4
  • 3
    • 84958780791 scopus 로고    scopus 로고
    • The spectrum of drug susceptibility in Mycobacteria. Microbiol. Spectr
    • MGM2-0031-2013
    • Aldridge, B.B., I. Keren, and S.M. Fortune. 2014. The spectrum of drug susceptibility in Mycobacteria. Microbiol. Spectr. 2:MGM2-0031-2013. http://dx.doi.org/10.1128/microbiolspec.MGM2-0031
    • (2014) , vol.2
    • Aldridge, B.B.1    Keren, I.2    Fortune, S.M.3
  • 4
    • 0032573095 scopus 로고    scopus 로고
    • Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DEC AL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis
    • Alland, D., I. Kramnik, T.R. Weisbrod, L. Otsubo, R. Cerny, L.P. Miller, W.R. Jacobs Jr., and B.R. Bloom. 1998. Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DEC AL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. 95:13227-1 3232.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13227-13232
    • Alland, D.1    Kramnik, I.2    Weisbrod, T.R.3    Otsubo, L.4    Cerny, R.5    Miller, L.P.6    Jacobs, W.R.7    Bloom, B.R.8
  • 5
    • 79958058975 scopus 로고    scopus 로고
    • Metabolic regulation of mycobacterial growth and antibiotic sensitivity
    • Baek, S.H., A.H. Li, and C.M. Sassetti. 2011. Metabolic regulation of mycobacterial growth and antibiotic sensitivity. PLoS Biol. 9:e1001065. http://dx.doi.org/10.1371/journal.pbio.1001065
    • (2011) PLoS Biol. , vol.9
    • Baek, S.H.1    Li, A.H.2    Sassetti, C.M.3
  • 6
    • 27744449032 scopus 로고    scopus 로고
    • Mt), a cyclic AMP receptor protein-like DNA binding protein
    • Mt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 187:7795-7804. http://dx.doi.org/10.1128/JB.187.22.7795-7804.2005
    • (2005) J. Bacteriol. , vol.187 , pp. 7795-7804
    • Bai, G.1    McCue, L.A.2    McDonough, K.A.3
  • 7
    • 0036270739 scopus 로고    scopus 로고
    • Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
    • Betts, J.C., P.T. Lukey, L.C. Robb, R.A. McAdam, and K. Duncan. 2002. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43:717-731. http://dx.doi.org/10.1046/j.1365-2958.2002.02779.x
    • (2002) Mol. Microbiol. , vol.43 , pp. 717-731
    • Betts, J.C.1    Lukey, P.T.2    Robb, L.C.3    McAdam, R.A.4    Duncan, K.5
  • 8
    • 0041922652 scopus 로고    scopus 로고
    • Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis
    • Betts, J.C., A. McLaren, M.G. Lennon, F.M. Kelly, P.T. Lukey, S.J. Blakemore, and K. Duncan. 2003. Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 47:2903-2913. http://dx.doi.org/10.1128/AAC.47.9.2903-2913.2003
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2903-2913
    • Betts, J.C.1    McLaren, A.2    Lennon, M.G.3    Kelly, F.M.4    Lukey, P.T.5    Blakemore, S.J.6    Duncan, K.7
  • 9
    • 84893730144 scopus 로고    scopus 로고
    • Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection
    • Bhaskar, A., M. Chawla, M. Mehta, P. Parikh, P. Chandra, D. Bhave, D. Kumar, K.S. Carroll, and A. Singh. 2014. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. PLoS Pathog. 10:e1003902. http://dx.doi.org/10.1371/journal.ppat.1003902
    • (2014) PLoS Pathog. , vol.10
    • Bhaskar, A.1    Chawla, M.2    Mehta, M.3    Parikh, P.4    Chandra, P.5    Bhave, D.6    Kumar, D.7    Carroll, K.S.8    Singh, A.9
  • 10
    • 4544312369 scopus 로고    scopus 로고
    • The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action
    • Boshoff, H.I., T.G. Myers, B.R. Copp, M.R. McNeil, M.A. Wilson, and C.E. Barry III. 2004. The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J. Biol. Chem. 279:40174-40184. http://dx.doi.org/10.1074/jbc.M406796200
    • (2004) J. Biol. Chem. , vol.279 , pp. 40174-40184
    • Boshoff, H.I.1    Myers, T.G.2    Copp, B.R.3    McNeil, M.R.4    Wilson, M.A.5    Barry, C.E.6
  • 11
    • 84884287648 scopus 로고    scopus 로고
    • Regulation of the KstR2 regulon of Mycobacterium tuberculosis by a cholesterol catabolite
    • Casabon, I., S.H. Zhu, H. Otani, J. Liu, W.W. Mohn, and L.D. Eltis. 2013. Regulation of the KstR2 regulon of Mycobacterium tuberculosis by a cholesterol catabolite. Mol. Microbiol. 89:1201-1212. http://dx.doi.org/10.1111/mmi.12340
    • (2013) Mol. Microbiol. , vol.89 , pp. 1201-1212
    • Casabon, I.1    Zhu, S.H.2    Otani, H.3    Liu, J.4    Mohn, W.W.5    Eltis, L.D.6
  • 12
    • 84887276558 scopus 로고    scopus 로고
    • Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression
    • Cunningham-Bussel, A., T. Zhang, and C.F. Nathan. 2013. Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proc. Natl. Acad. Sci. USA. 110:E4256-E4265. http://dx.doi.org/10.1073/pnas.1316894110
    • (2013) Proc. Natl. Acad. Sci. USA. , vol.110 , pp. E4256-E4265
    • Cunningham-Bussel, A.1    Zhang, T.2    Nathan, C.F.3
  • 13
    • 67650655950 scopus 로고    scopus 로고
    • A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen
    • Deb, C., C.M. Lee, V.S. Dubey, J. Daniel, B. Abomoelak, T.D. Sirakova, S. Pawar, L. Rogers, and P.E. Kolattukudy. 2009. A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. PLoS One. 4:e6077. http://dx.doi.org/10.1371/journal.pone.0006077
    • (2009) PLoS One. , vol.4
    • Deb, C.1    Lee, C.M.2    Dubey, V.S.3    Daniel, J.4    Abomoelak, B.5    Sirakova, T.D.6    Pawar, S.7    Rogers, L.8    Kolattukudy, P.E.9
  • 14
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar, R., M. Domrachev, and A.E. Lash. 2002. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207-210. http://dx.doi.org/10.1093/nar/30.1.207
    • (2002) Nucleic Acids Res. , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 15
    • 0035887504 scopus 로고    scopus 로고
    • Reprogramming of the macrophage transcriptome in response to interferon-γ and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase
    • Ehrt, S., D. Schnappinger, S. Bekiranov, J. Drenkow, S. Shi, T.R. Gingeras, T. Gaasterland, G. Schoolnik, and C. Nathan. 2001. Reprogramming of the macrophage transcriptome in response to interferon-γ and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194:1123-1140. http://dx.doi.org/10.1084/jem.194.8.1123
    • (2001) J. Exp. Med. , vol.194 , pp. 1123-1140
    • Ehrt, S.1    Schnappinger, D.2    Bekiranov, S.3    Drenkow, J.4    Shi, S.5    Gingeras, T.R.6    Gaasterland, T.7    Schoolnik, G.8    Nathan, C.9
  • 16
    • 0036299641 scopus 로고    scopus 로고
    • Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes
    • Fisher, M.A., B.B. Plikaytis, and T.M. Shinnick. 2002. Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J. Bacteriol. 184:4025-4032. http://dx.doi.org/10.1128/JB.184.14.4025-4032.2002
    • (2002) J. Bacteriol. , vol.184 , pp. 4025-4032
    • Fisher, M.A.1    Plikaytis, B.B.2    Shinnick, T.M.3
  • 17
    • 76849095708 scopus 로고    scopus 로고
    • Nutrient-starved, nonreplicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
    • Gengenbacher, M., S.P. Rao, K. Pethe, and T. Dick. 2010. Nutrient-starved, nonreplicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability. Microbiology. 156:81-87. http://dx.doi.org/10.1099/mic.0.033084-0
    • (2010) Microbiology. , vol.156 , pp. 81-87
    • Gengenbacher, M.1    Rao, S.P.2    Pethe, K.3    Dick, T.4
  • 18
    • 3042790827 scopus 로고    scopus 로고
    • Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms?
    • Hampshire, T., S. Soneji, J. Bacon, B.W. James, J. Hinds, K. Laing, R.A. Stabler, P.D. Marsh, and P.D. Butcher. 2004. Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms? Tuberculosis (Edinb.). 84:228-238. http://dx.doi.org/10.1016/j.tube.2003.12.010
    • (2004) Tuberculosis (Edinb.). , vol.84 , pp. 228-238
    • Hampshire, T.1    Soneji, S.2    Bacon, J.3    James, B.W.4    Hinds, J.5    Laing, K.6    Stabler, R.A.7    Marsh, P.D.8    Butcher, P.D.9
  • 19
    • 33644857465 scopus 로고    scopus 로고
    • MprAB is a stres-sresponsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis
    • He, H., R. Hovey, J. Kane, V. Singh, and T.C. Zahrt. 2006. MprAB is a stres-sresponsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 188:2134-2143. http://dx.doi.org/10.1128/JB.188.6.2134-2143.2006
    • (2006) J. Bacteriol. , vol.188 , pp. 2134-2143
    • He, H.1    Hovey, R.2    Kane, J.3    Singh, V.4    Zahrt, T.C.5
  • 20
    • 84892181925 scopus 로고    scopus 로고
    • Internalization of Salmonella by macrophages induces formation of nonreplicating persisters
    • Helaine, S., A.M. Cheverton, K.G. Watson, L.M. Faure, S.A. Matthews, and D.W. Holden. 2014. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science. 343:204-208. http://dx.doi.org/10.1126/science.1244705
    • (2014) Science. , vol.343 , pp. 204-208
    • Helaine, S.1    Cheverton, A.M.2    Watson, K.G.3    Faure, L.M.4    Matthews, S.A.5    Holden, D.W.6
  • 21
    • 77957671514 scopus 로고    scopus 로고
    • Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival
    • Homolka, S., S. Niemann, D.G. Russell, and K.H. Rohde. 2010. Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival. PLoS Pathog. 6:e1000988. http://dx.doi.org/10.1371/journal.ppat.1000988
    • (2010) PLoS Pathog. , vol.6
    • Homolka, S.1    Niemann, S.2    Russell, D.G.3    Rohde, K.H.4
  • 22
    • 77952370884 scopus 로고    scopus 로고
    • Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2
    • Kendall, S.L., P. Burgess, R. Balhana, M. Withers, A. Ten Bokum, J.S. Lott, C. Gao, I. Uhia-Castro, and N.G. Stoker. 2010. Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2. Microbiology. 156:1362-1371. http://dx.doi.org/10.1099/mic.0.034538-0
    • (2010) Microbiology. , vol.156 , pp. 1362-1371
    • Kendall, S.L.1    Burgess, P.2    Balhana, R.3    Withers, M.4    Ten Bokum, A.5    Lott, J.S.6    Gao, C.7    Uhia-Castro, I.8    Stoker, N.G.9
  • 23
    • 49649095474 scopus 로고    scopus 로고
    • Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    • Kumar, A., J.S. Deshane, D.K. Crossman, S. Bolisetty, B.S. Yan, I. Kramnik, A. Agarwal, and A.J. Steyn. 2008. Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. J. Biol. Chem. 283:18032-18039. http://dx.doi.org/10.1074/jbc.M802274200
    • (2008) J. Biol. Chem. , vol.283 , pp. 18032-18039
    • Kumar, A.1    Deshane, J.S.2    Crossman, D.K.3    Bolisetty, S.4    Yan, B.S.5    Kramnik, I.6    Agarwal, A.7    Steyn, A.J.8
  • 24
    • 19544364888 scopus 로고    scopus 로고
    • Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models
    • Lenaerts, A.J., V. Gruppo, K.S. Marietta, C.M. Johnson, D.K. Driscoll, N.M. Tompkins, J.D. Rose, R.C. Reynolds, and I.M. Orme. 2005. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob. Agents Chemother. 49:2294-2301. http://dx.doi.org/10.1128/AAC.49.6.2294-2301.2005
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2294-2301
    • Lenaerts, A.J.1    Gruppo, V.2    Marietta, K.S.3    Johnson, C.M.4    Driscoll, D.K.5    Tompkins, N.M.6    Rose, J.D.7    Reynolds, R.C.8    Orme, I.M.9
  • 25
    • 84883342218 scopus 로고    scopus 로고
    • (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity
    • Maisonneuve, E., M. Castro-Camargo, and K. Gerdes. 2013. (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell. 154:1140-1150. http://dx.doi.org/10.1016/j.cell.2013.07.048
    • (2013) Cell , vol.154 , pp. 1140-1150
    • Maisonneuve, E.1    Castro-Camargo, M.2    Gerdes, K.3
  • 26
    • 0034903883 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis ECF sigma factor sE: role in global gene expression and survival in macrophages
    • Manganelli, R., M.I. Voskuil, G.K. Schoolnik, and I. Smith. 2001. The Mycobacterium tuberculosis ECF sigma factor sE: role in global gene expression and survival in macrophages. Mol. Microbiol. 41:423-437. http://dx.doi.org/10.1046/j.1365-2958.2001.02525.x
    • (2001) Mol. Microbiol. , vol.41 , pp. 423-437
    • Manganelli, R.1    Voskuil, M.I.2    Schoolnik, G.K.3    Smith, I.4
  • 27
    • 84920880232 scopus 로고    scopus 로고
    • Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms
    • Manina, G., N. Dhar, and J.D. McKinney. 2015. Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms. Cell Host Microbe. 17:32-46. http://dx.doi.org/10.1016/j.chom.2014.11.016
    • (2015) Cell Host Microbe. , vol.17 , pp. 32-46
    • Manina, G.1    Dhar, N.2    McKinney, J.D.3
  • 28
    • 84880126124 scopus 로고    scopus 로고
    • Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
    • Mattila, J.T., O.O. Ojo, D. Kepka-Lenhart, S. Marino, J.H. Kim, S.Y. Eum, L.E. Via, C.E. Barry III, E. Klein, D.E. Kirschner, et al. 2013. Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. J. Immunol. 191:773-784. http://dx.doi.org/10.4049/jimmunol.1300113
    • (2013) J. Immunol. , vol.191 , pp. 773-784
    • Mattila, J.T.1    Ojo, O.O.2    Kepka-Lenhart, D.3    Marino, S.4    Kim, J.H.5    Eum, S.Y.6    Via, L.E.7    Barry, C.E.8    Klein, E.9    Kirschner, D.E.10
  • 29
    • 0000164959 scopus 로고
    • Fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. I. The persistence of drug-susceptible tubercle bacilli in the tissues despite prolonged antimicrobial therapy
    • McCune, R.M. Jr., and R. Tompsett. 1956. Fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. I. The persistence of drug-susceptible tubercle bacilli in the tissues despite prolonged antimicrobial therapy. J. Exp. Med. 104:737-762. http://dx.doi.org/10.1084/jem.104.5.737
    • (1956) J. Exp. Med. , vol.104 , pp. 737-762
    • McCune, R.M.1    Tompsett, R.2
  • 30
    • 84960961533 scopus 로고
    • The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. II. The conversion of tuberculous infection to the latent state by the administration of pyrazinamide and a companion drug
    • McCune, R.M. Jr., W. McDermott, and R. Tompsett. 1956. The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. II. The conversion of tuberculous infection to the latent state by the administration of pyrazinamide and a companion drug. J. Exp. Med. 104:763-802. http://dx.doi.org/10.1084/jem.104.5.763
    • (1956) J. Exp. Med. , vol.104 , pp. 763-802
    • McCune, R.M.1    McDermott, W.2    Tompsett, R.3
  • 31
    • 84903593464 scopus 로고    scopus 로고
    • Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis
    • Nandakumar, M., C. Nathan, and K.Y. Rhee. 2014. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nat. Commun. 5:4306. http://dx.doi.org/10.1038/ncomms5306
    • (2014) Nat. Commun. , vol.5 , pp. 4306
    • Nandakumar, M.1    Nathan, C.2    Rhee, K.Y.3
  • 32
    • 0034255209 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
    • Nathan, C., and M.U. Shiloh. 2000. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. USA. 97:8841-8848. http://dx.doi.org/10.1073/pnas.97.16.8841
    • (2000) Proc. Natl. Acad. Sci. USA. , vol.97 , pp. 8841-8848
    • Nathan, C.1    Shiloh, M.U.2
  • 33
    • 0041827138 scopus 로고    scopus 로고
    • The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis
    • Ohno, H., G. Zhu, V.P. Mohan, D. Chu, S. Kohno, W.R. Jacobs Jr., and J. Chan. 2003. The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis. Cell. Microbiol. 5:637-648. http://dx.doi.org/10.1046/j.1462-5822.2003.00307.x
    • (2003) Cell. Microbiol. , vol.5 , pp. 637-648
    • Ohno, H.1    Zhu, G.2    Mohan, V.P.3    Chu, D.4    Kohno, S.5    Jacobs, W.R.6    Chan, J.7
  • 34
    • 0038349268 scopus 로고    scopus 로고
    • Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    • Park, H.D., K.M. Guinn, M.I. Harrell, R. Liao, M.I. Voskuil, M. Tompa, G.K. Schoolnik, and D.R. Sherman. 2003. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 48:833-843. http://dx.doi.org/10.1046/j.1365-2958.2003.03474.x
    • (2003) Mol. Microbiol. , vol.48 , pp. 833-843
    • Park, H.D.1    Guinn, K.M.2    Harrell, M.I.3    Liao, R.4    Voskuil, M.I.5    Tompa, M.6    Schoolnik, G.K.7    Sherman, D.R.8
  • 35
    • 84874064350 scopus 로고    scopus 로고
    • Activities of drug combinations against Mycobacterium tuberculosis grown in aerobic and hypoxic acidic conditions
    • Piccaro, G., F. Giannoni, P. Filippini, A. Mustazzolu, and L. Fattorini. 2013. Activities of drug combinations against Mycobacterium tuberculosis grown in aerobic and hypoxic acidic conditions. Antimicrob. Agents Chemother. 57:1428-1433. http://dx.doi.org/10.1128/AAC.02154-12
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 1428-1433
    • Piccaro, G.1    Giannoni, F.2    Filippini, P.3    Mustazzolu, A.4    Fattorini, L.5
  • 36
    • 84877829544 scopus 로고    scopus 로고
    • Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function
    • Podinovskaia, M., W. Lee, S. Caldwell, and D.G. Russell. 2013. Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function. Cell. Microbiol. 15:843-859. http://dx.doi.org/10.1111/cmi.12092
    • (2013) Cell. Microbiol. , vol.15 , pp. 843-859
    • Podinovskaia, M.1    Lee, W.2    Caldwell, S.3    Russell, D.G.4
  • 38
    • 0034805644 scopus 로고    scopus 로고
    • The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis
    • Raman, S., T. Song, X. Puyang, S. Bardarov, W.R. Jacobs Jr., and R.N. Husson. 2001. The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. J. Bacteriol. 183:6119-6125. http://dx.doi.org/10.1128/JB.183.20.6119-6125.2001
    • (2001) J. Bacteriol. , vol.183 , pp. 6119-6125
    • Raman, S.1    Song, T.2    Puyang, X.3    Bardarov, S.4    Jacobs, W.R.5    Husson, R.N.6
  • 39
    • 33947415761 scopus 로고    scopus 로고
    • Identification of mycobacterial sigma factor binding sites by chromatin immunoprecipitation assays
    • Rodrigue, S., J. Brodeur, P.E. Jacques, A.L. Gervais, R. Brzezinski, and L. Gaudreau. 2007. Identification of mycobacterial sigma factor binding sites by chromatin immunoprecipitation assays. J. Bacteriol. 189:1505-1513. http://dx.doi.org/10.1128/JB.01371-06
    • (2007) J. Bacteriol. , vol.189 , pp. 1505-1513
    • Rodrigue, S.1    Brodeur, J.2    Jacques, P.E.3    Gervais, A.L.4    Brzezinski, R.5    Gaudreau, L.6
  • 40
    • 35848943478 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues
    • Rohde, K.H., R.B. Abramovitch, and D.G. Russell. 2007. Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues. Cell Host Microbe. 2:352-364. http://dx.doi.org/10.1016/j.chom.2007.09.006
    • (2007) Cell Host Microbe. , vol.2 , pp. 352-364
    • Rohde, K.H.1    Abramovitch, R.B.2    Russell, D.G.3
  • 41
    • 84864044868 scopus 로고    scopus 로고
    • Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection
    • Rohde, K.H., D.F. Veiga, S. Caldwell, G. Balázsi, and D.G. Russell. 2012. Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection. PLoS Pathog. 8:e1002769. http://dx.doi.org/10.1371/journal.ppat.1002769
    • (2012) PLoS Pathog. , vol.8
    • Rohde, K.H.1    Veiga, D.F.2    Caldwell, S.3    Balázsi, G.4    Russell, D.G.5
  • 42
    • 84965191948 scopus 로고    scopus 로고
    • Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network
    • Rustad, T.R., K.J. Minch, S. Ma, J.K. Winkler, S. Hobbs, M. Hickey, W. Brabant, S. Turkarslan, N.D. Price, N.S. Baliga, and D.R. Sherman. 2014. Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network. Genome Biol. 15:502. http://dx.doi.org/10.1186/s13059-014-0502-3
    • (2014) Genome Biol. , vol.15 , pp. 502
    • Rustad, T.R.1    Minch, K.J.2    Ma, S.3    Winkler, J.K.4    Hobbs, S.5    Hickey, M.6    Brabant, W.7    Turkarslan, S.8    Price, N.D.9    Baliga, N.S.10    Sherman, D.R.11
  • 43
    • 33750695632 scopus 로고    scopus 로고
    • Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis
    • Saïd-Salim, B., S. Mostowy, A.S. Kristof, and M.A. Behr. 2006. Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis. Mol. Microbiol. 62:1251-1263. http://dx.doi.org/10.1111/j.1365-2958.2006.05455.x
    • (2006) Mol. Microbiol. , vol.62 , pp. 1251-1263
    • Saïd-Salim, B.1    Mostowy, S.2    Kristof, A.S.3    Behr, M.A.4
  • 44
    • 84897904160 scopus 로고    scopus 로고
    • Multiple toxin-antitoxin systems in Mycobacterium tuberculosis
    • Sala, A., P. Bordes, and P. Genevaux. 2014. Multiple toxin-antitoxin systems in Mycobacterium tuberculosis. Toxins (Basel). 6:1002-1020. http://dx.doi.org/10.3390/toxins6031002
    • (2014) Toxins (Basel). , vol.6 , pp. 1002-1020
    • Sala, A.1    Bordes, P.2    Genevaux, P.3
  • 47
    • 43049170080 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection
    • Shiloh, M.U., P. Manzanillo, and J.S. Cox. 2008. Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection. Cell Host Microbe. 3:323-330. http://dx.doi.org/10.1016/j.chom.2008.03.007
    • (2008) Cell Host Microbe. , vol.3 , pp. 323-330
    • Shiloh, M.U.1    Manzanillo, P.2    Cox, J.S.3
  • 48
    • 84911207256 scopus 로고    scopus 로고
    • Beyond macrophages: the diversity of mononuclear cells in tuberculosis
    • Srivastava, S., J.D. Ernst, and L. Desvignes. 2014. Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Immunol. Rev. 262:179-192. http://dx.doi.org/10.1111/imr.12217
    • (2014) Immunol. Rev. , vol.262 , pp. 179-192
    • Srivastava, S.1    Ernst, J.D.2    Desvignes, L.3
  • 50
    • 84907584291 scopus 로고    scopus 로고
    • Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection
    • Sukumar, N., S. Tan, B.B. Aldridge, and D.G. Russell. 2014. Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection. PLoS Pathog. 10:e1004394. http://dx.doi.org/10.1371/journal.ppat.1004394
    • (2014) PLoS Pathog. , vol.10
    • Sukumar, N.1    Tan, S.2    Aldridge, B.B.3    Russell, D.G.4
  • 51
    • 67249088639 scopus 로고    scopus 로고
    • Bactericidal activity of moxifloxacin on exponential and stationary phase cultures of Mycobacterium tuberculosis
    • Sulochana, S., D.A. Mitchison, G. Kubendiren, P. Venkatesan, and C.N. Paramasivan. 2009. Bactericidal activity of moxifloxacin on exponential and stationary phase cultures of Mycobacterium tuberculosis. J. Chemother. 21:127-134. http://dx.doi.org/10.1179/joc.2009.21.2.127
    • (2009) J. Chemother. , vol.21 , pp. 127-134
    • Sulochana, S.1    Mitchison, D.A.2    Kubendiren, G.3    Venkatesan, P.4    Paramasivan, C.N.5
  • 52
    • 84876853741 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell
    • Tan, S., N. Sukumar, R.B. Abramovitch, T. Parish, and D.G. Russell. 2013. Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell. PLoS Pathog. 9:e1003282. http://dx.doi.org/10.1371/journal.ppat.1003282
    • (2013) PLoS Pathog. , vol.9
    • Tan, S.1    Sukumar, N.2    Abramovitch, R.B.3    Parish, T.4    Russell, D.G.5
  • 53
    • 84945272909 scopus 로고    scopus 로고
    • MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs
    • Tiwari, P., G. Arora, M. Singh, S. Kidwai, O.P. Narayan, and R. Singh. 2015. MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs. Nat. Commun. 6:6059. http://dx.doi.org/10.1038/ncomms7059
    • (2015) Nat. Commun. , vol.6 , pp. 6059
    • Tiwari, P.1    Arora, G.2    Singh, M.3    Kidwai, S.4    Narayan, O.P.5    Singh, R.6
  • 54
    • 84924351877 scopus 로고    scopus 로고
    • Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment
    • VanderVen, B.C., R.J. Fahey, W. Lee, Y. Liu, R.B. Abramovitch, C. Memmott, A.M. Crowe, L.D. Eltis, E. Perola, D.D. Deininger, et al. 2015. Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathog. 11:e1004679. http://dx.doi.org/10.1371/journal.ppat.1004679
    • (2015) PLoS Pathog. , vol.11
    • VanderVen, B.C.1    Fahey, R.J.2    Lee, W.3    Liu, Y.4    Abramovitch, R.B.5    Memmott, C.6    Crowe, A.M.7    Eltis, L.D.8    Perola, E.9    Deininger, D.D.10
  • 55
    • 35848935866 scopus 로고    scopus 로고
    • The mechanism of isoniazid killing: clarity through the scope of genetics
    • Vilchèze, C., and W.R. Jacobs Jr. 2007. The mechanism of isoniazid killing: clarity through the scope of genetics. Annu. Rev. Microbiol. 61:35-50. http://dx.doi.org/10.1146/annurev.micro.61.111606.122346
    • (2007) Annu. Rev. Microbiol. , vol.61 , pp. 35-50
    • Vilchèze, C.1    Jacobs, W.R.2
  • 57
    • 84859645414 scopus 로고    scopus 로고
    • The response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species
    • Voskuil, M.I., I.L. Bartek, K. Visconti, and G.K. Schoolnik. 2011. The response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species. Front. Microbiol. 2:105. http://dx.doi.org/10.3389/fmicb.2011.00105
    • (2011) Front. Microbiol. , vol.2 , pp. 105
    • Voskuil, M.I.1    Bartek, I.L.2    Visconti, K.3    Schoolnik, G.K.4
  • 59
    • 84855928950 scopus 로고    scopus 로고
    • Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide
    • Wallis, R.S., W. Jakubiec, M. Mitton-Fry, L. Ladutko, S. Campbell, D. Paige, A. Silvia, and P.F. Miller. 2012. Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide. PLoS One. 7:e30479. http://dx.doi.org/10.1371/journal.pone.0030479
    • (2012) PLoS One. , vol.7
    • Wallis, R.S.1    Jakubiec, W.2    Mitton-Fry, M.3    Ladutko, L.4    Campbell, S.5    Paige, D.6    Silvia, A.7    Miller, P.F.8
  • 60
    • 33746493349 scopus 로고    scopus 로고
    • Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy
    • Warner, D.F., and V. Mizrahi. 2006. Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy. Clin. Microbiol. Rev. 19:558-570. http://dx.doi.org/10.1128/CMR.00060-05
    • (2006) Clin. Microbiol. Rev. , vol.19 , pp. 558-570
    • Warner, D.F.1    Mizrahi, V.2
  • 61
    • 0033607188 scopus 로고    scopus 로고
    • Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
    • Wilson, M., J. DeRisi, H.H. Kristensen, P. Imboden, S. Rane, P.O. Brown, and G.K. Schoolnik. 1999. Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization. Proc. Natl. Acad. Sci. USA. 96:12833-12838. http://dx.doi.org/10.1073/pnas.96.22.12833
    • (1999) Proc. Natl. Acad. Sci. USA. , vol.96 , pp. 12833-12838
    • Wilson, M.1    DeRisi, J.2    Kristensen, H.H.3    Imboden, P.4    Rane, S.5    Brown, P.O.6    Schoolnik, G.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.