Stress and host immunity amplify mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms

Cell Host and Microbe

Volumn 17, Issue 1, 2015, Pages 32-46

  Manina, Giulia ^a   Dhar, Neeraj ^a   McKinney, John D ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; ISONIAZID; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL IMMUNITY; CELL GROWTH; CELL SUBPOPULATION; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; HOST RESISTANCE; METABOLIC ACTIVATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUTRIENT LIMITATION; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RIBOSOME; RNA GENE; SINGLE CELL ANALYSIS; STRESS; TIME-LAPSE VIDEO MICROSCOPY; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; IMMUNOLOGY; LUNG; METABOLISM; MICROBIOLOGY; MICROSCOPY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; TIME LAPSE IMAGING; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MUS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; ISONIAZID; LUNG; MICE, INBRED C57BL; MICROSCOPY; MYCOBACTERIUM TUBERCULOSIS; RIBOSOMES; SINGLE-CELL ANALYSIS; STRESS, PHYSIOLOGICAL; TIME-LAPSE IMAGING; TUBERCULOSIS;

EID: 84920880232     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2014.11.016     Document Type: Article

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