메뉴 건너뛰기




Volumn 6, Issue 7, 2010, Pages 1-17

Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: Delineation of conserved core and lineage-specific transcriptomes during intracellular survival

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; BACTERIAL RNA;

EID: 77957671514     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000988     Document Type: Article
Times cited : (219)

References (88)
  • 1
    • 58149174244 scopus 로고    scopus 로고
    • High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography
    • Hershberg R, Lipatov M, Small PM, Sheffer H, Niemann S, et al. (2008) High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography. PLoS Biol 6: e311.
    • (2008) PLoS Biol , vol.6
    • Hershberg, R.1    Lipatov, M.2    Small, P.M.3    Sheffer, H.4    Niemann, S.5
  • 3
    • 0030722329 scopus 로고    scopus 로고
    • An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon
    • Sousa AO, Salem JI, Lee FK, Verçosa MC, Cruaud P, et al. (1997) An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon. Proceedings of the National Academy of Sciences of the United States of America 94: 13227-13232.
    • (1997) Proceedings of The National Academy of Sciences of The United States of America , vol.94 , pp. 13227-13232
    • Sousa, A.O.1    Salem, J.I.2    Lee, F.K.3    Verçosa, M.C.4    Cruaud, P.5
  • 4
    • 53849111617 scopus 로고    scopus 로고
    • Evolution, population structure, and phylogeography of genetically monomorphic bacterial pathogens
    • Achtman M (2008) Evolution, population structure, and phylogeography of genetically monomorphic bacterial pathogens. Annu Rev Microbiol 62: 53-70.
    • (2008) Annu Rev Microbiol , vol.62 , pp. 53-70
    • Achtman, M.1
  • 5
    • 0038529784 scopus 로고    scopus 로고
    • Modeling bacterial evolution with comparative-genome-based marker systems: Application to Mycobacterium tuberculosis evolution and pathogenesis
    • Alland D, Whittam TS, Murray MB, Cave MD, Hazbon MH, et al. (2003) Modeling bacterial evolution with comparative-genome-based marker systems: application to Mycobacterium tuberculosis evolution and pathogenesis. J Bacteriol 185: 3392-3399.
    • (2003) J Bacteriol , vol.185 , pp. 3392-3399
    • Alland, D.1    Whittam, T.S.2    Murray, M.B.3    Cave, M.D.4    Hazbon, M.H.5
  • 6
    • 0036081576 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro
    • Firmani MA, Riley LW (2002) Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro. Infect Immun 70: 3965-3968.
    • (2002) Infect Immun , vol.70 , pp. 3965-3968
    • Firmani, M.A.1    Riley, L.W.2
  • 7
    • 0028138609 scopus 로고
    • Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro
    • O'Brien L, Carmichael J, Lowrie DB, Andrew PW (1994) Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro. Infect Immun 62: 5187-5190.
    • (1994) Infect Immun , vol.62 , pp. 5187-5190
    • O'Brien, L.1    Carmichael, J.2    Lowrie, D.B.3    Andrew, P.W.4
  • 8
    • 0030988521 scopus 로고    scopus 로고
    • Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates
    • Rhoades ER, Orme IM (1997) Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates. Infect Immun 65: 1189-1195.
    • (1997) Infect Immun , vol.65 , pp. 1189-1195
    • Rhoades, E.R.1    Orme, I.M.2
  • 9
    • 23244465130 scopus 로고    scopus 로고
    • In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates
    • Barczak AK, Domenech P, Boshoff HI, Reed MB, Manca C, et al. (2005) In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates. J Infect Dis 192: 600-606.
    • (2005) J Infect Dis , vol.192 , pp. 600-606
    • Barczak, A.K.1    Domenech, P.2    Boshoff, H.I.3    Reed, M.B.4    Manca, C.5
  • 10
    • 0141668958 scopus 로고    scopus 로고
    • Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis
    • Manabe YC, Dannenberg AM, Jr., Tyagi SK, Hatem CL, Yoder M, et al. (2003) Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis. Infect Immun 71: 6004-6011.
    • (2003) Infect Immun , vol.71 , pp. 6004-6011
    • Manabe, Y.C.1    Dannenberg Jr., A.M.2    Tyagi, S.K.3    Hatem, C.L.4    Yoder, M.5
  • 13
    • 20844439411 scopus 로고    scopus 로고
    • Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    • Tsenova L, Ellison E, Harbacheuski R, Moreira AL, Kurepina N, et al. (2005) Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli. J Infect Dis 192: 98-106.
    • (2005) J Infect Dis , vol.192 , pp. 98-106
    • Tsenova, L.1    Ellison, E.2    Harbacheuski, R.3    Moreira, A.L.4    Kurepina, N.5
  • 14
    • 61849169604 scopus 로고    scopus 로고
    • Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics
    • van der Spuy GD, Kremer K, Ndabambi SL, Beyers N, Dunbar R, et al. (2009) Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics. Tuberculosis (Edinb) 89: 120-125.
    • (2009) Tuberculosis (Edinb) , vol.89 , pp. 120-125
    • van der Spuy, G.D.1    Kremer, K.2    Ndabambi, S.L.3    Beyers, N.4    Dunbar, R.5
  • 15
    • 15544365695 scopus 로고    scopus 로고
    • Effects of genetic variability of Mycobacterium tuberculosis strains on the presentation of disease
    • Malik AN, Godfrey-Faussett P (2005) Effects of genetic variability of Mycobacterium tuberculosis strains on the presentation of disease. Lancet Infect Dis 5: 174-183.
    • (2005) Lancet Infect dis , vol.5 , pp. 174-183
    • Malik, A.N.1    Godfrey-Faussett, P.2
  • 16
    • 50949090423 scopus 로고    scopus 로고
    • The clinical consequences of strain diversity in Mycobacterium tuberculosis
    • Nicol MP, Wilkinson RJ (2008) The clinical consequences of strain diversity in Mycobacterium tuberculosis. Trans R Soc Trop Med Hyg 102: 955-965.
    • (2008) Trans R Soc Trop Med hyg , vol.102 , pp. 955-965
    • Nicol, M.P.1    Wilkinson, R.J.2
  • 17
    • 4544298326 scopus 로고    scopus 로고
    • A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    • Reed MB, Domenech P, Manca C, Su H, Barczak AK, et al. (2004) A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature 431: 84-87.
    • (2004) Nature , vol.431 , pp. 84-87
    • Reed, M.B.1    Domenech, P.2    Manca, C.3    Su, H.4    Barczak, A.K.5
  • 18
    • 46449110348 scopus 로고    scopus 로고
    • The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence
    • Sinsimer D, Huet G, Manca C, Tsenova L, Koo MS, et al. (2008) The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence. Infect Immun 76: 3027-3036.
    • (2008) Infect Immun , vol.76 , pp. 3027-3036
    • Sinsimer, D.1    Huet, G.2    Manca, C.3    Tsenova, L.4    Koo, M.S.5
  • 19
    • 16244381720 scopus 로고    scopus 로고
    • The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: Implications for in vivo growth
    • Keating LA, Wheeler PR, Mansoor H, Inwald JK, Dale J, et al. (2005) The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: implications for in vivo growth. Mol Microbiol 56: 163-174.
    • (2005) Mol Microbiol , vol.56 , pp. 163-174
    • Keating, L.A.1    Wheeler, P.R.2    Mansoor, H.3    Inwald, J.K.4    Dale, J.5
  • 20
    • 34147167504 scopus 로고    scopus 로고
    • The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated
    • Reed MB, Gagneux S, Deriemer K, Small PM, Barry CE, 3rd (2007) The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated. J Bacteriol 189: 2583-2589.
    • (2007) J Bacteriol , vol.189 , pp. 2583-2589
    • Reed, M.B.1    Gagneux, S.2    Deriemer, K.3    Small, P.M.4    Barry III, C.E.5
  • 21
    • 13444269651 scopus 로고    scopus 로고
    • Geneexpression diversity among Mycobacterium tuberculosis clinical isolates
    • Gao Q, Kripke KE, Saldanha AJ, Yan W, Holmes S, et al. (2005) Geneexpression diversity among Mycobacterium tuberculosis clinical isolates. Microbiology 151: 5-14.
    • (2005) Microbiology , vol.151 , pp. 5-14
    • Gao, Q.1    Kripke, K.E.2    Saldanha, A.J.3    Yan, W.4    Holmes, S.5
  • 22
    • 35848943478 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis invasion of macrophages: Linking bacterial gene expression to environmental cues
    • Rohde KH, Abramovitch RB, Russell DG (2007) Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues. Cell Host Microbe 2: 352-364.
    • (2007) Cell Host Microbe , vol.2 , pp. 352-364
    • Rohde, K.H.1    Abramovitch, R.B.2    Russell, D.G.3
  • 23
    • 0043142536 scopus 로고    scopus 로고
    • Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment
    • Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, et al. (2003) Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J Exp Med 198: 693-704.
    • (2003) J Exp Med , vol.198 , pp. 693-704
    • Schnappinger, D.1    Ehrt, S.2    Voskuil, M.I.3    Liu, Y.4    Mangan, J.A.5
  • 24
    • 67749095756 scopus 로고    scopus 로고
    • Igr Genes and Mycobacterium tuberculosis cholesterol metabolism
    • Chang JC, Miner MD, Pandey AK, Gill WP, Harik NS, et al. (2009) Igr Genes and Mycobacterium tuberculosis cholesterol metabolism. J Bacteriol 191: 5232-5239.
    • (2009) J Bacteriol , vol.191 , pp. 5232-5239
    • Chang, J.C.1    Miner, M.D.2    Pandey, A.K.3    Gill, W.P.4    Harik, N.S.5
  • 25
    • 0030042509 scopus 로고    scopus 로고
    • Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: Restricted array of mutations associated with drug resistance
    • Musser JM, Kapur V, Williams DL, Kreiswirth BN, van Soolingen D, et al. (1996) Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance. J Infect Dis 173: 196-202.
    • (1996) J Infect Dis , vol.173 , pp. 196-202
    • Musser, J.M.1    Kapur, V.2    Williams, D.L.3    Kreiswirth, B.N.4    van Soolingen, D.5
  • 26
    • 35349031788 scopus 로고    scopus 로고
    • Beijing family Mycobacterium tuberculosis strains differ in their intracellular growth in THP-1 ma rophages
    • Theus S, Eisenach K, Fomukong N, Silver RF, Cave MD (2007) Beijing family Mycobacterium tuberculosis strains differ in their intracellular growth in THP-1 ma rophages. Int J Tuberc Lung Dis 11: 1087-1093.
    • (2007) Int J Tuberc Lung Dis , vol.11 , pp. 1087-1093
    • Theus, S.1    Eisenach, K.2    Fomukong, N.3    Silver, R.F.4    Cave, M.D.5
  • 27
    • 0036839651 scopus 로고    scopus 로고
    • Differences in rate and variability of intracellular growth of a panel of Mycobacterium tuberculosis clinical isolates within a human monocyte model
    • Li Q, Whalen CC, Albert JM, Larkin R, Zukowski L, et al. (2002) Differences in rate and variability of intracellular growth of a panel of Mycobacterium tuberculosis clinical isolates within a human monocyte model. Infect Immun 70: 6489-6493.
    • (2002) Infect Immun , vol.70 , pp. 6489-6493
    • Li, Q.1    Whalen, C.C.2    Albert, J.M.3    Larkin, R.4    Zukowski, L.5
  • 28
    • 0033046430 scopus 로고    scopus 로고
    • Enhanced capacity of a widespread strain of Mycobacterium tuberculosis to grow in human macrophages
    • Zhang M, Gong J, Yang Z, Samten B, Cave MD, et al. (1999) Enhanced capacity of a widespread strain of Mycobacterium tuberculosis to grow in human macrophages. J Infect Dis 179: 1213-1217.
    • (1999) J Infect Dis , vol.179 , pp. 1213-1217
    • Zhang, M.1    Gong, J.2    Yang, Z.3    Samten, B.4    Cave, M.D.5
  • 29
  • 30
    • 41949119272 scopus 로고    scopus 로고
    • Mycobacterial persistence requires the utilization of host cholesterol
    • Pandey AK, Sassetti CM (2008) Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci USA 105: 4376-4380.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 4376-4380
    • Pandey, A.K.1    Sassetti, C.M.2
  • 31
    • 0031914958 scopus 로고    scopus 로고
    • Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages
    • Schaible UE, Sturgill-Koszycki S, Schlesinger PH, Russell DG (1998) Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. J Immunol 160: 1290-1296.
    • (1998) J Immunol , vol.160 , pp. 1290-1296
    • Schaible, U.E.1    Sturgill-Koszycki, S.2    Schlesinger, P.H.3    Russell, D.G.4
  • 32
    • 0030481130 scopus 로고    scopus 로고
    • Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis
    • Sturgill-Koszycki S, Schaible UE, Russell DG (1996) Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis. Embo J 15: 6960-6968.
    • (1996) Embo J , vol.15 , pp. 6960-6968
    • Sturgill-Koszycki, S.1    Schaible, U.E.2    Russell, D.G.3
  • 33
    • 33847218318 scopus 로고    scopus 로고
    • Two polyketidesynthase- associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis
    • Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR, Jr. (2007) Two polyketidesynthase- associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis. Microbiology 153: 513-520.
    • (2007) Microbiology , vol.153 , pp. 513-520
    • Bhatt, K.1    Gurcha, S.S.2    Bhatt, A.3    Besra, G.S.4    Jacobs Jr., W.R.5
  • 34
    • 67649823424 scopus 로고    scopus 로고
    • PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis
    • Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, et al. (2009) PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem 284: 12745-12751.
    • (2009) J Biol Chem , vol.284 , pp. 12745-12751
    • Hatzios, S.K.1    Schelle, M.W.2    Holsclaw, C.M.3    Behrens, C.R.4    Botyanszki, Z.5
  • 35
    • 0035907336 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis pks2 gene encodes the synthase for the heptaand octamethyl-branched fatty acids required for sulfolipid synthesis
    • Sirakova TD, Thirumala AK, Dubey VS, Sprecher H, Kolattukudy PE (2001) The Mycobacterium tuberculosis pks2 gene encodes the synthase for the heptaand octamethyl-branched fatty acids required for sulfolipid synthesis. J Biol Chem 276: 16833-16839.
    • (2001) J Biol Chem , vol.276 , pp. 16833-16839
    • Sirakova, T.D.1    Thirumala, A.K.2    Dubey, V.S.3    Sprecher, H.4    Kolattukudy, P.E.5
  • 36
    • 62449219456 scopus 로고    scopus 로고
    • Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models
    • Converse PJ, Karakousis PC, Klinkenberg LG, Kesavan AK, Ly LH, et al. (2009) Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models. Infect Immun 77: 1230-1237.
    • (2009) Infect Immun , vol.77 , pp. 1230-1237
    • Converse, P.J.1    Karakousis, P.C.2    Klinkenberg, L.G.3    Kesavan, A.K.4    Ly, L.H.5
  • 37
    • 70350719440 scopus 로고    scopus 로고
    • Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints
    • Niemann S, Koser CU, Gagneux S, Plinke C, Homolka S, et al. (2009) Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints. PLoS One 4: e7407.
    • (2009) PLoS One , vol.4
    • Niemann, S.1    Koser, C.U.2    Gagneux, S.3    Plinke, C.4    Homolka, S.5
  • 38
    • 0036708301 scopus 로고    scopus 로고
    • Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro
    • Firmani MA, Riley LW (2002) Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro. J Clin Microbiol 40: 3162-3166.
    • (2002) J Clin Microbiol , vol.40 , pp. 3162-3166
    • Firmani, M.A.1    Riley, L.W.2
  • 39
    • 20444498713 scopus 로고    scopus 로고
    • Differential pattern of cytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypes
    • Chacon-Salinas R, Serafin-Lopez J, Ramos-Payan R, Mendez-Aragon P, Hernandez-Pando R, et al. (2005) Differential pattern of cytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypes. Clin Exp Immunol 140: 443-449.
    • (2005) Clin Exp Immunol , vol.140 , pp. 443-449
    • Chacon-Salinas, R.1    Serafin-Lopez, J.2    Ramos-Payan, R.3    Mendez-Aragon, P.4    Hernandez-Pando, R.5
  • 40
    • 30144435317 scopus 로고    scopus 로고
    • Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages
    • Park JS, Tamayo MH, Gonzalez-Juarrero M, Orme IM, Ordway DJ (2006) Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages. J Leukoc Biol 79: 80-86.
    • (2006) J Leukoc Biol , vol.79 , pp. 80-86
    • Park, J.S.1    Tamayo, M.H.2    Gonzalez-Juarrero, M.3    Orme, I.M.4    Ordway, D.J.5
  • 41
    • 57649138446 scopus 로고    scopus 로고
    • Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan
    • Torrelles JB, Knaup R, Kolareth A, Slepushkina T, Kaufman TM, et al. (2008) Identification of Mycobacterium tuberculosis clinical isolates with altered phagocytosis by human macrophages due to a truncated lipoarabinomannan. J Biol Chem 283: 31417-31428.
    • (2008) J Biol Chem , vol.283 , pp. 31417-31428
    • Torrelles, J.B.1    Knaup, R.2    Kolareth, A.3    Slepushkina, T.4    Kaufman, T.M.5
  • 42
    • 0034775194 scopus 로고    scopus 로고
    • E. coli methionine sulfoxide reductase with a truncated N terminus or C terminus, or both, retains the ability to reduce methionine sulfoxide
    • Boschi-Muller S, Azza S, Branlant G (2001) E. coli methionine sulfoxide reductase with a truncated N terminus or C terminus, or both, retains the ability to reduce methionine sulfoxide. Protein Sci 10: 2272-2279.
    • (2001) Protein Sci , vol.10 , pp. 2272-2279
    • Boschi-Muller, S.1    Azza, S.2    Branlant, G.3
  • 43
    • 0038496713 scopus 로고    scopus 로고
    • A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes
    • Lopez B, Aguilar D, Orozco H, Burger M, Espitia C, et al. (2003) A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes. Clin Exp Immunol 133: 30-37.
    • (2003) Clin Exp Immunol , vol.133 , pp. 30-37
    • Lopez, B.1    Aguilar, D.2    Orozco, H.3    Burger, M.4    Espitia, C.5
  • 44
    • 0035826721 scopus 로고    scopus 로고
    • Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha/ beta
    • Manca C, Tsenova L, Bergtold A, Freeman S, Tovey M, et al. (2001) Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha/ beta. Proc Natl Acad Sci USA 98: 5752-5757.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5752-5757
    • Manca, C.1    Tsenova, L.2    Bergtold, A.3    Freeman, S.4    Tovey, M.5
  • 45
    • 34247152126 scopus 로고    scopus 로고
    • Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
    • Gagneux S, Small PM (2007) Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development. Lancet Infect Dis 7: 328-337.
    • (2007) Lancet Infect Dis , vol.7 , pp. 328-337
    • Gagneux, S.1    Small, P.M.2
  • 46
    • 77951051763 scopus 로고    scopus 로고
    • Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis
    • Gutierrez MC, Brisse S, Brosch R, Fabre M, Omais B, et al. (2005) Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS Pathog 1: e5.
    • (2005) PLoS Pathog , vol.1
    • Gutierrez, M.C.1    Brisse, S.2    Brosch, R.3    Fabre, M.4    Omais, B.5
  • 47
    • 33746791191 scopus 로고    scopus 로고
    • Characterization of mycobacterial virulence genes through genetic interaction mapping
    • Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, et al. (2006) Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc Natl Acad Sci USA 103: 11760-11765.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11760-11765
    • Joshi, S.M.1    Pandey, A.K.2    Capite, N.3    Fortune, S.M.4    Rubin, E.J.5
  • 48
    • 34447567336 scopus 로고    scopus 로고
    • A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis
    • Kendall SL, Withers M, Soffair CN, Moreland NJ, Gurcha S, et al. (2007) A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol Microbiol 65: 684-699.
    • (2007) Mol Microbiol , vol.65 , pp. 684-699
    • Kendall, S.L.1    Withers, M.2    Soffair, C.N.3    Moreland, N.J.4    Gurcha, S.5
  • 49
    • 38949205260 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice
    • Senaratne RH, Sidders B, Sequeira P, Saunders G, Dunphy K, et al. (2008) Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. J Med Microbiol 57: 164-170.
    • (2008) J Med Microbiol , vol.57 , pp. 164-170
    • Senaratne, R.H.1    Sidders, B.2    Sequeira, P.3    Saunders, G.4    Dunphy, K.5
  • 50
    • 33846904705 scopus 로고    scopus 로고
    • A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
    • Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, et al. (2007) A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci USA 104: 1947-1952.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1947-1952
    • van der Geize, R.1    Yam, K.2    Heuser, T.3    Wilbrink, M.H.4    Hara, H.5
  • 51
    • 0032966018 scopus 로고    scopus 로고
    • Analysis, expression and prevalence of the Mycobacterium tuberculosis homolog of bacterial virulence regulating proteins
    • Gupta S, Jain S, Tyagi AK (1999) Analysis, expression and prevalence of the Mycobacterium tuberculosis homolog of bacterial virulence regulating proteins. FEMS Microbiol Lett 172: 137-143.
    • (1999) FEMS Microbiol Lett , vol.172 , pp. 137-143
    • Gupta, S.1    Jain, S.2    Tyagi, A.K.3
  • 52
    • 20444454266 scopus 로고    scopus 로고
    • Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs
    • Singh A, Gupta R, Vishwakarma RA, Narayanan PR, Paramasivan CN, et al. (2005) Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs. J Bacteriol 187: 4173-4186.
    • (2005) J Bacteriol , vol.187 , pp. 4173-4186
    • Singh, A.1    Gupta, R.2    Vishwakarma, R.A.3    Narayanan, P.R.4    Paramasivan, C.N.5
  • 53
    • 1542648514 scopus 로고    scopus 로고
    • MymA operon of Mycobacterium tuberculosis: Its regulation and importance in the cell envelope
    • Singh A, Jain S, Gupta S, Das T, Tyagi AK (2003) MymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol Lett 227: 53-63.
    • (2003) FEMS Microbiol Lett , vol.227 , pp. 53-63
    • Singh, A.1    Jain, S.2    Gupta, S.3    Das, T.4    Tyagi, A.K.5
  • 54
    • 0033523971 scopus 로고    scopus 로고
    • Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice
    • Cox JS, Chen B, McNeil M, Jacobs WR, Jr. (1999) Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 402: 79-83.
    • (1999) Nature , vol.402 , pp. 79-83
    • Cox, J.S.1    Chen, B.2    McNeil, M.3    Jacobs Jr., W.R.4
  • 55
    • 2442686856 scopus 로고    scopus 로고
    • The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis
    • Domenech P, Reed MB, Dowd CS, Manca C, Kaplan G, et al. (2004) The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. J Biol Chem 279: 21257-21265.
    • (2004) J Biol Chem , vol.279 , pp. 21257-21265
    • Domenech, P.1    Reed, M.B.2    Dowd, C.S.3    Manca, C.4    Kaplan, G.5
  • 56
    • 70349323418 scopus 로고    scopus 로고
    • Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity
    • Murry JP, Pandey AK, Sassetti CM, Rubin EJ (2009) Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis 200: 774-782.
    • (2009) J Infect Dis , vol.200 , pp. 774-782
    • Murry, J.P.1    Pandey, A.K.2    Sassetti, C.M.3    Rubin, E.J.4
  • 57
    • 0035827613 scopus 로고    scopus 로고
    • Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier
    • Camacho LR, Constant P, Raynaud C, Laneelle MA, Triccas JA, et al. (2001) Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J Biol Chem 276: 19845-19854.
    • (2001) J Biol Chem , vol.276 , pp. 19845-19854
    • Camacho, L.R.1    Constant, P.2    Raynaud, C.3    Laneelle, M.A.4    Triccas, J.A.5
  • 58
    • 34247617733 scopus 로고    scopus 로고
    • Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling
    • Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, et al. (2007) Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc Natl Acad Sci USA 104: 5133-5138.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5133-5138
    • Jain, M.1    Petzold, C.J.2    Schelle, M.W.3    Leavell, M.D.4    Mougous, J.D.5
  • 59
    • 70149116303 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response
    • Singh A, Crossman DK, Mai D, Guidry L, Voskuil MI, et al. (2009) Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. PLoS Pathog 5: e1000545.
    • (2009) PLoS Pathog , vol.5
    • Singh, A.1    Crossman, D.K.2    Mai, D.3    Guidry, L.4    Voskuil, M.I.5
  • 60
    • 23744516572 scopus 로고    scopus 로고
    • Molecular evolutionary history of tubercle bacilli assessed by study of the polymorphic nucleotide within the nitrate reductase (narGHJI) operon promoter
    • Goh KS, Rastogi N, Berchel M, Huard RC, Sola C (2005) Molecular evolutionary history of tubercle bacilli assessed by study of the polymorphic nucleotide within the nitrate reductase (narGHJI) operon promoter. J Clin Microbiol 43: 4010-4014.
    • (2005) J Clin Microbiol , vol.43 , pp. 4010-4014
    • Goh, K.S.1    Rastogi, N.2    Berchel, M.3    Huard, R.C.4    Sola, C.5
  • 61
    • 1942443182 scopus 로고    scopus 로고
    • A promoter mutation causes differential nitrate reductase activity of Mycobacterium tuberculosis and Mycobacterium bovis
    • Stermann M, Sedlacek L, Maass S, Bange FC (2004) A promoter mutation causes differential nitrate reductase activity of Mycobacterium tuberculosis and Mycobacterium bovis. J Bacteriol 186: 2856-2861.
    • (2004) J Bacteriol , vol.186 , pp. 2856-2861
    • Stermann, M.1    Sedlacek, L.2    Maass, S.3    Bange, F.C.4
  • 62
    • 0032453525 scopus 로고    scopus 로고
    • Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis
    • Wayne LG, Hayes LG (1998) Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis. Tuber Lung Dis 79: 127-132.
    • (1998) Tuber Lung Dis , vol.79 , pp. 127-132
    • Wayne, L.G.1    Hayes, L.G.2
  • 63
    • 75149164411 scopus 로고    scopus 로고
    • A single-nucleotide mutation in the -10 promoter region inactivates the narK2X promoter in Mycobacterium bovis and Mycobacterium bovis BCG and has an application in diagnosis
    • Chauhan S, Singh A, Tyagi JS (2010) A single-nucleotide mutation in the -10 promoter region inactivates the narK2X promoter in Mycobacterium bovis and Mycobacterium bovis BCG and has an application in diagnosis. FEMS Microbiol Lett 303: 190-196.
    • (2010) FEMS Microbiol Lett , vol.303 , pp. 190-196
    • Chauhan, S.1    Singh, A.2    Tyagi, J.S.3
  • 64
    • 0037492815 scopus 로고    scopus 로고
    • Polymorphic nucleotide within the promoter of nitrate reductase (NarGHJI) is specific for Mycobacterium tuberculosis
    • Stermann M, Bohrssen A, Diephaus C, Maass S, Bange FC (2003) Polymorphic nucleotide within the promoter of nitrate reductase (NarGHJI) is specific for Mycobacterium tuberculosis. J Clin Microbiol 41: 3252-3259.
    • (2003) J Clin Microbiol , vol.41 , pp. 3252-3259
    • Stermann, M.1    Bohrssen, A.2    Diephaus, C.3    Maass, S.4    Bange, F.C.5
  • 65
    • 0036139212 scopus 로고    scopus 로고
    • Dependence of Mycobacterium bovis BCG on anaerobic nitrate reductase for persistence is tissue specific
    • Fritz C, Maass S, Kreft A, Bange FC (2002) Dependence of Mycobacterium bovis BCG on anaerobic nitrate reductase for persistence is tissue specific. Infect Immun 70: 286-291.
    • (2002) Infect Immun , vol.70 , pp. 286-291
    • Fritz, C.1    Maass, S.2    Kreft, A.3    Bange, F.C.4
  • 66
    • 0344666693 scopus 로고    scopus 로고
    • Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis
    • Sohaskey CD, Wayne LG (2003) Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis. J Bacteriol 185: 7247-7256.
    • (2003) J Bacteriol , vol.185 , pp. 7247-7256
    • Sohaskey, C.D.1    Wayne, L.G.2
  • 67
    • 74549118978 scopus 로고    scopus 로고
    • Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains
    • Parwati I, van Crevel R, van Soolingen D (2010) Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains. Lancet Infect Dis 10: 103-111.
    • (2010) Lancet Infect Dis , vol.10 , pp. 103-111
    • Parwati, I.1    van Crevel, R.2    van Soolingen, D.3
  • 68
    • 77950642806 scopus 로고    scopus 로고
    • Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants
    • Fallow A, Domenech P, Reed MB (2010) Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants. J Bacteriol 192: 2228-2238.
    • (2010) J Bacteriol , vol.192 , pp. 2228-2238
    • Fallow, A.1    Domenech, P.2    Reed, M.B.3
  • 69
    • 67651202584 scopus 로고    scopus 로고
    • Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    • Honaker RW, Leistikow RL, Bartek IL, Voskuil MI (2009) Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy. Infect Immun 77: 3258-3263.
    • (2009) Infect Immun , vol.77 , pp. 3258-3263
    • Honaker, R.W.1    Leistikow, R.L.2    Bartek, I.L.3    Voskuil, M.I.4
  • 71
    • 59649120503 scopus 로고    scopus 로고
    • Human genetic influence on susceptibility of tuberculosis: From infection to disease
    • Cheepsattayakorn A, Cheepsattayakorn R (2009) Human genetic influence on susceptibility of tuberculosis: from infection to disease. J Med Assoc Thai 92: 136-141.
    • (2009) J Med Assoc Thai , vol.92 , pp. 136-141
    • Cheepsattayakorn, A.1    Cheepsattayakorn, R.2
  • 72
    • 1842788227 scopus 로고    scopus 로고
    • Stable association between strains of Mycobacterium tuberculosis and their human host populations
    • Hirsh AE, Tsolaki AG, DeRiemer K, Feldman MW, Small PM (2004) Stable association between strains of Mycobacterium tuberculosis and their human host populations. Proc Natl Acad Sci USA 101: 4871-4876.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4871-4876
    • Hirsh, A.E.1    Tsolaki, A.G.2    Deriemer, K.3    Feldman, M.W.4    Small, P.M.5
  • 73
    • 65249145161 scopus 로고    scopus 로고
    • Major Mycobacterium tuberculosis lineages associate with patient country of origin
    • Reed MB, Pichler VK, McIntosh F, Mattia A, Fallow A, et al. (2009) Major Mycobacterium tuberculosis lineages associate with patient country of origin. J Clin Microbiol 47: 1119-1128.
    • (2009) J Clin Microbiol , vol.47 , pp. 1119-1128
    • Reed, M.B.1    Pichler, V.K.2    McIntosh, F.3    Mattia, A.4    Fallow, A.5
  • 74
    • 55849118488 scopus 로고    scopus 로고
    • Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines
    • Cohen T, Colijn C, Murray M (2008) Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines. Proc Natl Acad Sci USA 105: 16302-16307.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16302-16307
    • Cohen, T.1    Colijn, C.2    Murray, M.3
  • 75
    • 0032247547 scopus 로고    scopus 로고
    • Intracellular gene expression. Analysis of RNA from mycobacteria in macrophages using RT-PCR
    • Butcher PD, Mangan JA, Monahan IM (1998) Intracellular gene expression. Analysis of RNA from mycobacteria in macrophages using RT-PCR. Methods Mol Biol 101: 285-306.
    • (1998) Methods Mol Biol , vol.101 , pp. 285-306
    • Butcher, P.D.1    Mangan, J.A.2    Monahan, I.M.3
  • 76
    • 35448940164 scopus 로고    scopus 로고
    • Gene Expression during hostpathogen interactions: Approaches to bacterial mRNA extraction and labeling for microarray analysis
    • Wren BW, Dorrell N, eds., London: Academic Press
    • Mangan JA, Monahan IM, Butcher PD (2002) Gene Expression during hostpathogen interactions: approaches to bacterial mRNA extraction and labeling for microarray analysis. In: Wren BW, Dorrell N, eds. Methods in Microbiology. London: Academic Press. pp 137-151.
    • (2002) Methods in Microbiology , pp. 137-151
    • Mangan, J.A.1    Monahan, I.M.2    Butcher, P.D.3
  • 77
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210.
    • (2002) Nucleic Acids Res , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 79
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 80
    • 3042713693 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses
    • Kendall SL, Movahedzadeh F, Rison SC, Wernisch L, Parish T, et al. (2004) The Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses. Tuberculosis (Edinb) 84: 247-255.
    • (2004) Tuberculosis (Edinb) , vol.84 , pp. 247-255
    • Kendall, S.L.1    Movahedzadeh, F.2    Rison, S.C.3    Wernisch, L.4    Parish, T.5
  • 81
    • 49649095474 scopus 로고    scopus 로고
    • Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    • Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, et al. (2008) Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. J Biol Chem 283: 18032-18039.
    • (2008) J Biol Chem , vol.283 , pp. 18032-18039
    • Kumar, A.1    Deshane, J.S.2    Crossman, D.K.3    Bolisetty, S.4    Yan, B.S.5
  • 82
    • 0038349268 scopus 로고    scopus 로고
    • Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    • Park HD, Guinn KM, Harrell MI, Liao R, Voskuil MI, et al. (2003) Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol Microbiol 48: 833-843.
    • (2003) Mol Microbiol , vol.48 , pp. 833-843
    • Park, H.D.1    Guinn, K.M.2    Harrell, M.I.3    Liao, R.4    Voskuil, M.I.5
  • 83
    • 0042140672 scopus 로고    scopus 로고
    • Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program
    • Voskuil MI, Schnappinger D, Visconti KC, Harrell MI, Dolganov GM, et al. (2003) Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med 198: 705-713.
    • (2003) J Exp Med , vol.198 , pp. 705-713
    • Voskuil, M.I.1    Schnappinger, D.2    Visconti, K.C.3    Harrell, M.I.4    Dolganov, G.M.5
  • 84
    • 33747143027 scopus 로고    scopus 로고
    • Identification of a respiratory-type nitrate reductase and its role for survival of Mycobacterium smegmatis in Wayne model
    • Khan A, Sarkar D (2006) Identification of a respiratory-type nitrate reductase and its role for survival of Mycobacterium smegmatis in Wayne model. Microb Pathog 41: 90-95.
    • (2006) Microb Pathog , vol.41 , pp. 90-95
    • Khan, A.1    Sarkar, D.2
  • 85
    • 0034012134 scopus 로고    scopus 로고
    • Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice
    • Weber I, Fritz C, Ruttkowski S, Kreft A, Bange FC (2000) Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice. Mol Microbiol 35: 1017-1025.
    • (2000) Mol Microbiol , vol.35 , pp. 1017-1025
    • Weber, I.1    Fritz, C.2    Ruttkowski, S.3    Kreft, A.4    Bange, F.C.5
  • 88
    • 1242341327 scopus 로고    scopus 로고
    • Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex
    • Marmiesse M, Brodin P, Buchrieser C, Gutierrez C, Simoes N, et al. (2004) Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex. Microbiology 150: 483-496.
    • (2004) Microbiology , vol.150 , pp. 483-496
    • Marmiesse, M.1    Brodin, P.2    Buchrieser, C.3    Gutierrez, C.4    Simoes, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.