Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia

Journal of Neurochemistry

Volumn 137, Issue 5, 2016, Pages 770-781

  Jung, Sunmin ^a   Nah, Jihoon ^a   Han, Jonghee ^a   Choi, Seon Guk ^a   Kim, Hyunjoo ^a   Park, Jaesang ^a   Pyo, Ha Kyung ^a   Jung, Yong Keun ^a  

^a Seoul National University   (South Korea)

Author keywords

axonal transport; A generation; DUSP26; hypoxia; secretase regulator

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 26; GAMMA SECRETASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); DUSP26 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ARTICLE; AXON; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; NERVE FIBER TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; BIOSYNTHESIS; BRAIN; CELL HYPOXIA; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AXONAL TRANSPORT; BRAIN; CELL HYPOXIA; CELL LINE, TUMOR; DUAL-SPECIFICITY PHOSPHATASES; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS;

EID: 84969219513     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13597     Document Type: Article

References (47)

1. Bazan N. G., Palacios-Pelaez R., and, Lukiw W. J., (2002) Hypoxia signaling to genes: significance in Alzheimer's disease. Mol. Neurobiol. 26, 283-298.
2. Bieschke J., Herbst M., Wiglenda T., et al,. (2012) Small-molecule conversion of toxic oligomers to nontoxic beta-sheet-rich amyloid fibrils. Nat. Chem. Biol. 8, 93-101.
3. Boutros T., Chevet E., and, Metrakos P., (2008) Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol. Rev. 60, 261-310.
4. Chiba K., Shimada Y., Kinjo M., Suzuki T., and, Uchida S., (2014) Simple and direct assembly of kymographs from movies using KYMOMAKER. Traffic 15, 1-11.
5. Comerford K. M., Cummins E. P., and, Taylor C. T., (2004) c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. Cancer Res. 64, 9057-9061.
6. De Strooper B., and, Annaert W., (2010) Novel research horizons for presenilins and gamma-secretases in cell biology and disease. Annu. Rev. Cell Dev. Biol. 26, 235-260.
7. Encinas M., Iglesias M., Liu Y., Wang H., Muhaisen A., Cena V., Gallego C., and, Comella J. X., (2000) Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J. Neurochem. 75, 991-1003.
8. Frederikse P. H., Garland D., Zigler J. S., Jr, and, Piatigorsky J., (1996) Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells. J. Bio. Chem. 271, 10169-10174.
9. Fu M. M., and, Holzbaur E. L., (2013) JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J. Cell Biol. 202, 495-508.
10. Gwon A. R., Park J. S., Arumugam T. V., et al,. (2012) Oxidative lipid modification of nicastrin enhances amyloidogenic gamma-secretase activity in Alzheimer's disease. Aging Cell 11, 559-568.
11. Han J., Jung S., Jang J., et al,. (2014) OCIAD2 activates gamma-secretase to enhance amyloid beta production by interacting with nicastrin. Cell. Mol. Life Sci. 71, 2561-2576.
12. Holtzman D. M., Morris J. C., and, Goate A. M., (2011) Alzheimer's disease: the challenge of the second century. Sci. Transl. Med. 3, 77sr71.
13. Hu Y., and, Mivechi N. F., (2006) Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol. Cell. Biol. 26, 3282-3294.
14. Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., and, Ihara Y., (1994) Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13, 45-53.
15. Jin N., Hatton N., Swartz D. R., Xia X., Harrington M. A., Larsen S. H., and, Rhoades R. A., (2000) Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries. Am. J. Respir. Cell Mol. Biol. 23, 593-601.
16. Kanatsu K., Morohashi Y., Suzuki M., Kuroda H., Watanabe T., Tomita T., and, Iwatsubo T., (2014) Decreased CALM expression reduces Abeta42 to total Abeta ratio through clathrin-mediated endocytosis of gamma-secretase. Nat. Commun. 5, 3386.
17. Kim H., Lee H. J., Oh Y., et al,. (2014) The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth. Nat. Commun. 5, 3351.
18. Lee M. S., Kao S. C., Lemere C. A., Xia W., Tseng H. C., Zhou Y., Neve R., Ahlijanian M. K., and, Tsai L. H., (2003) APP processing is regulated by cytoplasmic phosphorylation. J. Cell Biol. 163, 83-95.
19. Li L., Zhang X., Yang D., Luo G., Chen S., and, Le W., (2009) Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol. Aging 30, 1091-1098.
20. Matrone C., Ciotti M. T., Mercanti D., Marolda R., and, Calissano P., (2008) NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. Proc. Natl Acad. Sci. USA 105, 13139-13144.
21. Misonou H., Morishima-Kawashima M., and, Ihara Y., (2000) Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 39, 6951-6959.
22. Morohashi Y., and, Tomita T., (2013) Protein trafficking and maturation regulate intramembrane proteolysis. Biochim. Biophys. Acta 1828, 2855-2861.
23. Ono K., Hamaguchi T., Naiki H., and, Yamada M., (2006) Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease. Biochim. Biophys. Acta 1762, 575-586.
24. Patterson K. I., Brummer T., O'Brien P. M., and, Daly R. J., (2009) Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem. J. 418, 475-489.
25. Patterson K. I., Brummer T., Daly R. J., and, O'Brien P. M., (2010) DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. Biochim. Biophys. Acta 1803, 1003-1012.
26. Selkoe D. J., (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
27. Shen C., Chen Y., Liu H., Zhang K., Zhang T., Lin A., and, Jing N., (2008) Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J. Biol. Chem. 283, 17721-17730.
28. Shi Y., Ma I. T., Patel R. H., et al,. (2015) NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 6, e1841.
29. Skoog I., and, Gustafson D., (2006) Update on hypertension and Alzheimer's disease. Neurol. Res. 28, 605-611.
30. Smith M. A., Rottkamp C. A., Nunomura A., Raina A. K., and, Perry G., (2000) Oxidative stress in Alzheimer's disease. Biochim. Biophys. Acta 1502, 139-144.
31. Song M., Park J. E., Park S. G., Lee do H., Choi H. K., Park B. C., Ryu S. E., Kim J. H., and, Cho S., (2009) NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem. Biophys. Res. Commun. 381, 491-495.
32. Staples C. J., Owens D. M., Maier J. V., Cato A. C., and, Keyse S. M., (2010) Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation. J. Biol. Chem. 285, 25928-25940.
33. Swamy M., Siegers G. M., Minguet S., Wollscheid B., and, Schamel W. W., (2006) Blue native polyacrylamide gel electrophoresis (BN-PAGE) for the identification and analysis of multiprotein complexes. Sci STKE, 2006, pl4.
34. Tabner B. J., El-Agnaf O. M., Turnbull S., German M. J., Paleologou K. E., Hayashi Y., Cooper L. J., Fullwood N. J., and, Allsop D., (2005) Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia. J. Biol. Chem. 280, 35789-35792.
35. Takagaki K., Shima H., Tanuma N., Nomura M., Satoh T., Watanabe M., and, Kikuchi K., (2007) Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. Mol. Cell. Biochem. 296, 177-184.
36. Takahashi R. H., Milner T. A., Li F., et al,. (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am. J. Pathol. 161, 1869-1879.
37. Tamagno E., Parola M., Bardini P., et al,. (2005) Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. J. Neurochem. 92, 628-636.
38. Tanuma N., Nomura M., Ikeda M., et al,. (2009) Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Oncogene 28, 752-761.
39. Tong Y., Zhou W., Fung V., Christensen M. A., Qing H., Sun X., and, Song W., (2005) Oxidative stress potentiates BACE1 gene expression and Abeta generation. J. Neural. Transm. 112, 455-469.
40. Vaccari T., Lu H., Kanwar R., Fortini M. E., and, Bilder D., (2008) Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J. Cell Biol. 180, 755-762.
41. Vasudevan S. A., Skoko J., Wang K., Burlingame S. M., Patel P. N., Lazo J. S., Nuchtern J. G., and, Yang J., (2005) MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem. Biophys. Res. Commun. 330, 511-518.
42. Vingtdeux V., Hamdane M., Gompel M., et al,. (2005) Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism. Neurobiol. Dis. 20, 625-637.
43. Wagner E. F., and, Nebreda A. R., (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 9, 537-549.
44. Wang J. Y., Lin C. H., Yang C. H., Tan T. H., and, Chen Y. R., (2006) Biochemical and biological characterization of a neuroendocrine-associated phosphatase. J. Neurochem. 98, 89-101.
45. Wang J. Y., Yang C. H., Yeh C. L., Lin C. H., and, Chen Y. R., (2008) NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells. J. Neurochem. 107, 1544-1555.
46. Wieckowski M. R., Giorgi C., Lebiedzinska M., Duszynski J., and, Pinton P., (2009) Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat. Protoc. 4, 1582-1590.
47. Yu W., Imoto I., Inoue J., Onda M., Emi M., and, Inazawa J., (2007) A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene 26, 1178-1187.