DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1803, Issue 9, 2010, Pages 1003-1012

  Patterson, Kate I ^a   Brummer, Tilman ^b   Daly, Roger J ^a   O'Brien, Philippa M ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Dual specificity phosphatase; MAP kinase; Phosphatase

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 26; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; DUSP26 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE;

ACINAR CELL; ARTICLE; BRAIN CANCER; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME REGULATION; EPIGENETICS; EPITHELIUM CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; NEUROBLASTOMA; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHLOROCEBUS AETHIOPS; CHO CELL LINE; COS 1 CELL LINE; CPG ISLAND; CRICETULUS; GENETICS; HAMSTER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CPG ISLANDS; CRICETINAE; CRICETULUS; DUAL-SPECIFICITY PHOSPHATASES; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE KNOCKDOWN TECHNIQUES; GENES, TUMOR SUPPRESSOR; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; PHOSPHORYLATION;

EID: 77954951974     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2010.03.014     Document Type: Article

References (57)

1. Alonso A., Sasin J., Bottini N., Friedberg I., Osterman A., Godzik A., Hunter T., Dixon J., Mustelin T. Protein tyrosine phosphatases in the human genome. Cell 2004, 117:699-711.
2. Mustelin T. A brief introduction to the protein phosphatase Families. Protein Phosphatase Protocols 2006, 9-22. Humana Press, Totowa, NJ. G. Moorhead (Ed.).
3. Keyse S.M. An emerging family of dual specificity MAP kinase phosphatases. Biochim. Biophys. Acta 1995, 1265:152-160.
4. Tonks N.K. Protein tyrosine phosphatases: from genes, to function, to disease. Nat. Rev. Mol. Cell. Biol. 2006, 7:833-846.
5. Pulido R., van Huijsduijnen R.H. Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease. FEBS J. 2008, 275:848-866.
6. Camps M., Nichols A., Arkinstall S. Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 2000, 14:6-16.
7. Keyse S.M. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 2000, 12:186-192.
8. Dickinson R.J., Keyse S.M. Diverse physiological functions for dual-specificity MAP kinase phosphatases. J. Cell Sci. 2006, 119:4607-4615.
9. Farooq A., Zhou M.M. Structure and regulation of MAPK phosphatases. Cell. Signal. 2004, 16:769-779.
10. Jeffrey K.L., Camps M., Rommel C., Mackay C.R. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat. Rev. Drug Discov. 2007, 6:391-403.
11. Furukawa T., Sunamura M., Motoi F., Matsuno S., Horii A. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am. J. Pathol. 2003, 162:1807-1815.
12. Furukawa T., Yatsuoka T., Youssef E.M., Abe T., Yokoyama T., Fukushige S., Soeda E., Hoshi M., Hayashi Y., Sunamura M., Kobari M., Horii A. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. Cytogenet. Cell Genet. 1998, 82:156-159.
13. Schullerus D., Herbers J., Chudek J., Kanamaru H., Kovacs G. Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas. J. Pathol. 1997, 183:151-155.
14. Emmert-Buck M.R., Vocke C.D., Pozzatti R.O., Duray P.H., Jennings S.B., Florence C.D., Zhuang Z., Bostwick D.G., Liotta L.A., Linehan W.M. Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res. 1995, 55:2959-2962.
15. Brown M.R., Chuaqui R., Vocke C.D., Berchuck A., Middleton L.P., Emmert-Buck M.R., Kohn E.C. Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors. Gynecol. Oncol. 1999, 74:98-102.
16. Hoornaert I., Marynen P., Goris J., Sciot R., Baens M. MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation. Oncogene 2003, 22:7728-7736.
17. Adams J., Williams S.V., Aveyard J.S., Knowles M.A. Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss. Cancer. Res 2005, 65:66-75.
18. Liu K., Lemon B., Traktman P. The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro. J. Virol. 1995, 69:7823-7834.
19. Aoki N., Aoyama K., Nagata M., Matsuda T. A growing family of dual specificity phosphatases with low molecular masses. J. Biochem. (Tokyo) 2001, 130:133-140.
20. Patterson K.I., Brummer T., O'Brien P.M., Daly R.J. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem. J. 2009, 418:475-489.
21. Vasudevan S.A., Skoko J., Wang K., Burlingame S.M., Patel P.N., Lazo J.S., Nuchtern J.G., Yang J. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem. Biophys. Res. Commun. 2005, 330:511-518.
22. Hu Y., Mivechi N.F. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol. Cell. Biol. 2006, 26:3282-3294.
23. Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene 2006, 26:1178-1187.
24. Takagaki K., Shima H., Tanuma N., Nomura M., Satoh T., Watanabe M., Kikuchi K. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. Mol. Cell. Biochem. 2006, 296:177-184.
25. Wang J.Y., Lin C.H., Yang C.H., Tan T.H., Chen Y.R. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. J. Neurochem. 2006, 98:89-101.
26. Wang J.Y., Yang C.H., Yeh C.L., Lin C.H., Chen Y.R. NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells. J. Neurochem. 2008, 107(6):1544-1555.
27. Tanuma N., Nomura M., Ikeda M., Kasugai I., Tsubaki Y., Takagaki K., Kawamura T., Yamashita Y., Sato I., Sato M., Katakura R., Kikuchi K., Shima H. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Oncogene 2009, 28(5):752-761.
28. Song M., Park J.E., Park S.G., Lee Test H. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem. Biophys. Res. Commun. 2009, 381:491-495.
29. Armes J.E., Hammet F., de Silva M., Ciciulla J., Ramus S.J., Soo W.K., Mahoney A., Yarovaya N., Henderson M.A., Gish K., Hutchins A.M., Price G.R., Venter D.J. Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers. Oncogene 2004, 23:5697-5702.
30. Pribill I., Speiser P., Leary J., Leodolter S., Hacker N.F., Friedlander M.L., Birnbaum D., Zeillinger R., Krainer M. High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma. Cancer Genet. Cytogenet. 2001, 129:23-29.
31. Arnold J.M., Woollatt E., Chenevix-Trench G. Chromosome 8 genetic analysis and phenotypic characterization of 21 ovarian cancer cell lines. Cancer Genet. Cytogenet. 2002, 139:109-114.
32. Brummer T., Schramek D., Hayes V.M., Bennett H.L., Caldon C.E., Musgrove E.A., Daly R.J. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J. Biol. Chem. 2006, 281:626-637.
33. Tsao S.W., Mok S.C., Fey E.G., Fletcher J.A., Wan T.S., Chew E.C., Muto M.G., Knapp R.C., Berkowitz R.S. Characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes (HPV-E6E7 ORFs). Exp. Cell Res. 1995, 218:499-507.
34. Van Parijs L., Refaeli Y., Lord J.D., Nelson B.H., Abbas A.K., Baltimore D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 1999, 11:281-288.
35. Jeffrey K.L., Brummer T., Rolph M.S., Liu S.M., Callejas N.A., Grumont R.J., Gillieron C., Mackay F., Grey S., Camps M., Rommel C., Gerondakis S.D., Mackay C.R. Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat. Immunol. 2006, 7:274-283.
36. Frost J.A., Steen H., Shapiro P., Lewis T., Ahn N., Shaw P.E., Cobb M.H. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 1997, 16:6426-6438.
37. Debnath J., Muthuswamy S.K., Brugge J.S. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003, 30:256-268.
38. Clark S.J., Harrison J., Paul C.L., Frommer M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 1994, 22:2990-2997.
39. Wu J., Jin Y.J., Calaf G.M., Huang W.L., Yin Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene 2007, 26:6526-6535.
40. Chu Y., Solski P.A., Khosravi-Far R., Der C.J., Kelly K. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J. Biol. Chem. 1996, 271:6497-6501.
41. Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter C., Cobb M.H., Shaw P.E. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 1995, 14:951-962.
42. Cruzalegui F.H., Cano E., Treisman R. ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 1999, 18:7948-7957.
43. Gille H., Strahl T., Shaw P.E. Activation of ternary complex factor Elk-1 by stress-activated protein kinases. Curr. Biol. 1995, 5:1191-1200.
44. Whitmarsh A.J., Yang S.H., Su M.S., Sharrocks A.D., Davis R.J. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol. Cell. Biol. 1997, 17:2360-2371.
45. Sanai N., Alvarez-Buylla A., Berger M.S. Neural stem cells and the origin of gliomas. N. Engl. J. Med. 2005, 353:811-822.
46. Baylin S.B. DNA methylation and gene silencing in cancer. Nat. Clin. Pract. 2005, 2(Suppl 1):S4-11.
47. Munoz-Alonso M.J., Guillemain G., Kassis N., Girard J., Burnol A.F., Leturque A. A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate. J. Biol. Chem. 2000, 275:32406-32412.
48. Hoyt R., Zhu W., Cerignoli F., Alonso A., Mustelin T., David M. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J. Immunol. 2007, 179:3402-3406.
49. Shen Y., Luche R., Wei B., Gordon M.L., Diltz C.D., Tonks N.K. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:13613-13618.
50. Chen A.J., Zhou G., Juan T., Colicos S.M., Cannon J.P., Cabriera-Hansen M., Meyer C.F., Jurecic R., Copeland N.G., Gilbert D.J., Jenkins N.A., Fletcher F., Tan T.H., Belmont J.W. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J. Biol. Chem. 2002, 277:36592-36601.
51. Yuan Y., Li D.M., Sun H. PIR1, a novel phosphatase that exhibits high affinity to RNA. ribonucleoprotein complexes. J. Biol. Chem. 1998, 273:20347-20353.
52. Song M., Park J.E., Park S.G., Lee do H., Choi H.K., Park B.C., Ryu S.E., Kim J.H., Cho S. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem. Biophys. Res. Commun. 2009, 381:491-495.
53. Camps M., Nichols A., Gillieron C., Antonsson B., Muda M., Chabert C., Boschert U., Arkinstall S. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science 1998, 280:1262-1265.
54. Zhou B., Zhang J., Liu S., Reddy S., Wang F., Zhang Z.Y. Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry. J. Biol. Chem. 2006, 281:38834-38844.
55. Wu C., Ramirez A., Cui B., Ding J., Delcroix J.D., Valletta J.S., Liu J.J., Yang Y., Chu S., Mobley W.C. A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic (Copenhagen, Denmark) 2007, 8:1503-1520.
56. Srikanth S., Franklin C.C., Duke R.C., Kraft R.S. Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis. Mol. Cell. Biochem. 1999, 199:169-178.
57. Pervin S., Singh R., Freije W.A., Chaudhuri G. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer Res. 2003, 63:8853-8860.