Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 991-1003

  Encinas, Mario ^a,b,c   Iglesias, Montse ^a,b,c   Liu, Yuhui ^a,b,c   Wang, Hongyin ^a,b,c   Muhaisen, Ashraf ^a,b,c   Ceña, Valentin ^a,b,c   Gallego, Carme ^a,b,c   Comella, Joan X ^a,b,c  

^a UNIVERSITY OF LLEIDA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Cell cycle; Neuroblastoma; Neurodegenerative disease; Neurotrophin; SHSY5Y cells

Indexed keywords

NEUROTROPHIC FACTOR; NEUROTROPHIN; RETINOIC ACID;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELL POLARITY; CELL SURVIVAL; DEGENERATIVE DISEASE; HUMAN; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASES; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; HUMANS; IN SITU NICK-END LABELING; KINETICS; MICROTUBULE-ASSOCIATED PROTEINS; NEUROBLASTOMA; NEUROFILAMENT PROTEINS; NEURONS; TAU PROTEINS; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0033844835     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0750991.x     Document Type: Article

References (66)

1. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-jun immunoreactivity, relationship to brain area, and effect of post mortem delay
2. A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside
3. Modulation of HERG current and herg gene expression during retinoic acid treatment of human neuroblastoma cells: Potentiating effects of BDNF
4. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture
5. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
6. Programmed cell death in the developing nervous system
7. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
8. Catecholamine secretion, calcium levels and calcium influx in response to membrane depolarization in bovine chromaffin cells
9. Phenotypic diversification in human neuroblastoma cells: Expression of distinct neural crest lineages
10. Proteases to die for
11. The role of neurotrophins in the developing nervous system
12. Cytosine arabinoside induces apoptosis in cerebellar neurons in culture
13. Retinoic acid promotes the differentiation of adrenergic cells and melanocytes in quail neural crest cultures
14. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y
15. Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death
16. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in β-amyloid-induced neuronal death
17. Molecular characterization of microtubule-associated proteins tau and MAP2
18. Role of neurotrophic factors in neuronal development
19. Retinoic acid selectively promotes the survival and proliferation of neurogenic precursors in cultured neural crest cell populations
20. The induction of multiple cell cycle events precedes target-related neuronal death
21. Characterization of the cholinergic neuronal differentiation of the human neuroblastoma LAN-5 after treatment with retinoic acid
22. Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
23. Phenotypic differentiation of aphidicolin-selected human neuroblastoma cultures after long-term exposure to nerve growth factor
24. Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells
25. pRb and the Cdks in apoptosis and the cell cycle
26. Cell cycle regulation and apoptosis
27. Role of neurotrophins in mouse neuronal development
28. Cyclin D1 is an essential mediator of apoptotic neuronal cell death
29. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
30. Insulin-like growth factor-II as a paracrine growth factor in human neuroblastoma cells
31. Physiology of the neurotrophins
32. pRb and E2f-1 in mouse development and tumorigenesis
33. Regulation of insulin-like growth factor-II expression and its role in autocrine growth of human neuroblastoma cells
34. Bi-modal differentiation pattern in a new human neuroblastoma cell line in vitro
35. p53-Dependent apoptosis produced by Rb-deficiency in the developing mouse lens
36. 3H]noradrenaline from human neuroblastoma cells, SH-SY5Y
37. Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy
38. Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions
39. Cell death during development of the nervous system
40. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
41. Retinotic acid-induced differentiation of cultured human neuroblastoma cells: A comparison with phorbol ester-induced differentiation
42. Differentiation and survival influences of growth factors in human neuroblastoma
43. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor supressor gene function in development
44. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
45. Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
46. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons
47. Staurosporine differentiated human SH-SY5Y neuroblastoma cultures exhibit transient apoptosis and trophic factor independence
48. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
49. Retinoic acid induces NGF-dependent survival response and high-affinity NGF receptors in immature chick sympathetic neurons
50. Cell division and the nervous system: Regulating the cycle from neural differentiation to death
51. Coordinate morphological and biochemical interconversion of human neuroblastoma cells
52. Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line
53. Cytosine arabinoside is neurotoxic to chick embryo spinal cord motoneurons in culture
54. Development of a neural phenotype in differentiated ganglion cell-derived human neuroblastoma cells
55. Deregulated expression of E2f-1 induces S-phase entry and leads to apoptosis
56. Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells
57. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
58. p53-Dependent apoptosis suppresses tumor growth and progression in vivo
59. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures
60. Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: A modulator of in vivo programmed cell death?
61. Mutation of E2f-1 suppresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos
62. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
63. Retinoic acid-mediated increase in TrkA expression is sufficient to elicit NGF-dependent survival of sympathetic neurons
64. TrkA expression levels of sympathetic neurons correlate with NGF-dependent survival during development and after treatment with retinoic acid
65. p53 and E2F-1 cooperate to mediate apoptosis
66. Regulation of neurotrophin receptor expression by retinoic acid in mouse sympathetic neuroblasts