Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Nature Communications

Volumn 7, Issue , 2016, Pages

  Wang, Xiaoming ^a   Bey, Alexandra L ^a   Katz, Brittany M ^a   Badea, Alexandra ^a   Kim, Namsoo ^b   David, Lisa K ^b   Duffney, Lara J ^a   Kumar, Sunil ^a   Mague, Stephen D ^b   Hulbert, Samuel W ^a   Dutta, Nisha ^a   Hayrapetyan, Volodya ^b   Yu, Chunxiu ^b   Gaidis, Erin ^b   Zhao, Shengli ^a   Ding, Jin Dong ^b   Xu, Qiong ^a,c   Chung, Leeyup ^a   Rodriguiz, Ramona M ^a   Wang, Fan ^a   Weinberg, Richard J ^d   Wetsel, William C ^a   Dzirasa, Kafui ^a   Yin, Henry ^a,b   Jiang, Yong Hui ^a,b   more..

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

^c FUDAN UNIVERSITY   (China)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ISOPROTEIN; METABOTROPIC RECEPTOR 5; PROTEIN HOMER 1A; PROTEIN HOMER 1B; PROTEIN HOMER 1C; SHANK3 PROTEIN; UNCLASSIFIED DRUG; GRM5 PROTEIN, MOUSE; HOMER SCAFFOLDING PROTEIN; NERVE PROTEIN; SHANK3 PROTEIN, HUMAN; SHANK3 PROTEIN, MOUSE;

BRAIN; CONNECTIVITY; GENE EXPRESSION; LEARNING; NERVOUS SYSTEM DISORDER; PATHOLOGY; PHYSIOLOGY; PROTEIN; RODENT; SOCIAL BEHAVIOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; CINGULATE GYRUS; COMPULSION; CONNECTOME; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DOMINANCE BEHAVIOR; ESCAPE BEHAVIOR; EXON; FEMALE; GENE DELETION; GENE TARGETING; GRAY MATTER; GROOMING; MALE; MOUSE; NERVE CELL PLASTICITY; NEUROIMAGING; NONHUMAN; PRELIMBIC CORTEX; SIGNAL TRANSDUCTION; STRIATE CORTEX; SYNAPTIC TRANSMISSION; VENTRAL HIPPOCAMPUS; ANIMAL; ANIMAL BEHAVIOR; BIOLOGICAL MODEL; BRAIN CORTEX; CORPUS STRIATUM; DEFICIENCY; GENETICS; HUMAN; KNOCKOUT MOUSE; LONG TERM DEPRESSION; METABOLISM; NERVE CELL NETWORK; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SOCIAL BEHAVIOR;

MUS;

ANIMALS; AUTISM SPECTRUM DISORDER; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; CORPUS STRIATUM; FEMALE; HOMER SCAFFOLDING PROTEINS; HUMANS; LONG-TERM SYNAPTIC DEPRESSION; MALE; MICE; MICE, KNOCKOUT; MODELS, NEUROLOGICAL; NERVE NET; NERVE TISSUE PROTEINS; RECEPTOR, METABOTROPIC GLUTAMATE 5; SEQUENCE DELETION; SOCIAL BEHAVIOR;

EID: 84968593296     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11459     Document Type: Article

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