Autism-associated insertion mutation (InsG) of shank3 exon 21 causes impaired synaptic transmission and behavioral deficits

Journal of Neuroscience

Volumn 35, Issue 26, 2015, Pages 9648-9665

  Speed, Haley E ^a   Kouser, Mehreen ^a   Xuan, Zhong ^a   Reimers, Jeremy M ^a   Ochoa, Christine F ^a   Gupta, Natasha ^a   Liu, Shunan ^a   Powell, Craig M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autism; Behavior; Phelan McDermid syndrome; Postsynaptic density; Shank3; Synaptic plasticity

Indexed keywords

GUANINE NUCLEOTIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SCAFFOLD PROTEIN; SHANK3 EXON 21; UNCLASSIFIED DRUG; N METHYLASPARTIC ACID; NERVE PROTEIN; SHANK3 PROTEIN, MOUSE; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BEHAVIOR ASSESSMENT; BEHAVIOR DISORDER; BRAIN ELECTROPHYSIOLOGY; FEMALE; GENE MUTATION; GENE TARGETING; GENOTYPE; GROOMING; HUMAN; IMMUNOBLOTTING; MALE; MOTOR COORDINATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PHELAN MCDERMID SYNDROME; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; SPATIAL LEARNING; SYNAPTIC TRANSMISSION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DISEASE MODEL; EXCITATORY POSTSYNAPTIC POTENTIAL; EXON; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; LOCOMOTION; MAZE TEST; MENTAL DISEASE; MUTATION; NESTING; PHYSIOLOGY; PROCEDURES; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; EXONS; EXPLORATORY BEHAVIOR; FEMALE; GROOMING; HIPPOCAMPUS; LOCOMOTION; MALE; MAZE LEARNING; MENTAL DISORDERS; MICE; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; MUTATION; N-METHYLASPARTATE; NERVE TISSUE PROTEINS; NESTING BEHAVIOR; SODIUM CHANNEL BLOCKERS; SYNAPTIC TRANSMISSION; TETRODOTOXIN;

EID: 84936095719     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3125-14.2015     Document Type: Article

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