메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages 5.66.1-5.66.26

Overview of mouse models of autism spectrum disorders

Author keywords

ASDs; Autism spectrum disorders; Behavior; Genetically engineered; Mouse models; Therapeutic interventions

Indexed keywords

1,4 BENZODIOXAN 6 CARBOXYLIC ACID PIPERIDIDE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; CLONAZEPAM; CONTACTIN ASSOCIATED PROTEIN LIKE 2; CYCLOSERINE; FRAGILE X MENTAL RETARDATION PROTEIN; METHYL CPG BINDING PROTEIN 2; MEVINOLIN; NEUREXIN; NEUREXIN 1; NEUROLIGIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; RISPERIDONE; SCAFFOLD PROTEIN; SHANK1 PROTEIN; SHANK2 PROTEIN; SHANK3 PROTEIN; SODIUM CHANNEL NAV1.1; SOMATOMEDIN C; TUBERIN; UNCLASSIFIED DRUG;

EID: 84949255396     PISSN: 19348282     EISSN: 19348290     Source Type: Journal    
DOI: 10.1002/0471141755.ph0566s66     Document Type: Article
Times cited : (49)

References (96)
  • 2
    • 0003472502 scopus 로고    scopus 로고
    • 5th ed. American Psychiatric Publishing, Arlington, Virginia
    • American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. American Psychiatric Publishing, Arlington, Virginia.
    • (2013) Diagnostic and Statistical Manual of Mental Disorders
  • 4
    • 84898957499 scopus 로고    scopus 로고
    • Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2010
    • Autism Developmental Disabilities Monitoring Network. 2014. Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2010. Morbid. Mortal. Weekly Rep. Surveill. Summ. 63:1-21.
    • (2014) Morbid. Mortal. Weekly Rep. Surveill. Summ , vol.63 , pp. 1-21
  • 7
    • 84898886133 scopus 로고    scopus 로고
    • A mouse model of Timothy syndrome: A complex autistic disorder resulting from a point mutation in Cav1.2
    • Bett, G.C., Lis, A., Wersinger, S.R., Baizer, J.S., Duffey, M.E., and Rasmusson, R.L. 2012. A mouse model of Timothy syndrome: A complex autistic disorder resulting from a point mutation in Cav1.2. N. Am. J. Med. Sci. 5:135-140.
    • (2012) N. Am. J. Med. Sci , vol.5 , pp. 135-140
    • Bett, G.C.1    Lis, A.2    Wersinger, S.R.3    Baizer, J.S.4    Duffey, M.E.5    Rasmusson, R.L.6
  • 8
    • 84862637069 scopus 로고    scopus 로고
    • The pathophysiology of fragile X (and what it teaches us about synapses)
    • Bhakar, A.L., Dolen, G., and Bear, M.F. 2012. The pathophysiology of fragile X (and what it teaches us about synapses). Annu. Rev. Neurosci. 35:417-443.
    • (2012) Annu. Rev. Neurosci , vol.35 , pp. 417-443
    • Bhakar, A.L.1    Dolen, G.2    Bear, M.F.3
  • 12
    • 84877331677 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay
    • Bozdagi, O., Tavassoli, T., and Buxbaum, J.D. 2013. Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay. Mol. Autism 4:9.
    • (2013) Mol. Autism , vol.4 , pp. 9
    • Bozdagi, O.1    Tavassoli, T.2    Buxbaum, J.D.3
  • 13
    • 84878804982 scopus 로고    scopus 로고
    • D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling
    • Burket, J.A., Benson, A.D., Tang, A.H., and Deutsch, S.I. 2013. D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling. Brain Res. Bull. 96:62-70.
    • (2013) Brain Res. Bull , vol.96 , pp. 62-70
    • Burket, J.A.1    Benson, A.D.2    Tang, A.H.3    Deutsch, S.I.4
  • 14
    • 84890811053 scopus 로고    scopus 로고
    • Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders
    • Burket, J.A., Benson, A.D., Tang, A.H., and Deutsch, S.I. 2014. Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders. Brain Res. Bull. 100:70-75.
    • (2014) Brain Res. Bull , vol.100 , pp. 70-75
    • Burket, J.A.1    Benson, A.D.2    Tang, A.H.3    Deutsch, S.I.4
  • 17
    • 75349088719 scopus 로고    scopus 로고
    • Genetic causes of syndromic and nonsyndromic autism
    • Caglayan, A.O. 2010. Genetic causes of syndromic and nonsyndromic autism. Dev. Med. Child Neurol. 52:130-138.
    • (2010) Dev. Med. Child Neurol , vol.52 , pp. 130-138
    • Caglayan, A.O.1
  • 18
    • 78751513645 scopus 로고    scopus 로고
    • Experimental models of Rett syndrome based on MECP2 dysfunction
    • Calfa, G., Percy, A.K., and Pozzo-Miller, L. 2011. Experimental models of Rett syndrome based on MECP2 dysfunction. Exp. Biol. Med. 236:3-19.
    • (2011) Exp. Biol. Med , vol.236 , pp. 3-19
    • Calfa, G.1    Percy, A.K.2    Pozzo-Miller, L.3
  • 20
    • 77952885487 scopus 로고    scopus 로고
    • Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11-q13
    • Chamberlain, S.J. and Lalande, M. 2010. Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11-q13. Neurobiol. Dis. 39:13-20.
    • (2010) Neurobiol. Dis , vol.39 , pp. 13-20
    • Chamberlain, S.J.1    Lalande, M.2
  • 21
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    • Chen, R.Z., Akbarian, S., Tudor, M., and Jaenisch, R. 2001. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet. 27:327-331.
    • (2001) Nat. Genet , vol.27 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2    Tudor, M.3    Jaenisch, R.4
  • 22
    • 84876775572 scopus 로고    scopus 로고
    • Synaptic plasticity in mouse models of autism spectrum disorders
    • Chung, L., Bey, A.L., and Jiang, Y.H. 2012. Synaptic plasticity in mouse models of autism spectrum disorders. Kor. J. Physiol. Pharmacol. 16:369-378.
    • (2012) Kor. J. Physiol. Pharmacol , vol.16 , pp. 369-378
    • Chung, L.1    Bey, A.L.2    Jiang, Y.H.3
  • 26
    • 84885112466 scopus 로고    scopus 로고
    • PTEN hamartoma tumor syndrome (PHTS)
    • (R.A. Pagon, M.P. Adam, H.H. Ardinger, T.D. Bird, C.R. Dolan, C.T. Fong, R.J.H. Smith, and K. Stephens, eds.). National Center for Biotechnology Information, Bethesda, Md
    • Eng, C. 2014. PTEN hamartoma tumor syndrome (PHTS). In GeneReviews (R.A. Pagon, M.P. Adam, H.H. Ardinger, T.D. Bird, C.R. Dolan, C.T. Fong, R.J.H. Smith, and K. Stephens, eds.). http://www.ncbi.nlm.nih.gov/books/NBK1488. National Center for Biotechnology Information, Bethesda, Md.
    • (2014) GeneReviews
    • Eng, C.1
  • 27
    • 70449686185 scopus 로고    scopus 로고
    • Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
    • Etherton, M.R., Blaiss, C.A., Powell, C.M., and Sudhof, T.C. 2009. Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc. Natl. Acad. Sci. U.S.A. 106:17998-18003.
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 17998-18003
    • Etherton, M.R.1    Blaiss, C.A.2    Powell, C.M.3    Sudhof, T.C.4
  • 29
    • 34147168331 scopus 로고    scopus 로고
    • The lifetime distribution of the incremental societal costs of autism
    • Ganz, M.L. 2007. The lifetime distribution of the incremental societal costs of autism. Arch. Pediatrics Adol. Med. 161:343-349.
    • (2007) Arch. Pediatrics Adol. Med , vol.161 , pp. 343-349
    • Ganz, M.L.1
  • 34
    • 84879522237 scopus 로고    scopus 로고
    • Altered social behaviours in neurexin-1-a knockout mice resemble core symptoms in neurodevelopmental disorders
    • Grayton, H.M., Missler, M., Collier, D.A., and Fernandes, C. 2013. Altered social behaviours in neurexin-1-a knockout mice resemble core symptoms in neurodevelopmental disorders. PloS One 8:e67114.
    • (2013) PloS One , vol.8
    • Grayton, H.M.1    Missler, M.2    Collier, D.A.3    Fernandes, C.4
  • 40
    • 84898917488 scopus 로고    scopus 로고
    • Autism-related neuroligin-3 mutation alters social behavior and spatial learning
    • Jaramillo, T.C., Liu, S., Pettersen, A., Birnbaum, S.G., and Powell, C.M. 2014. Autism-related neuroligin-3 mutation alters social behavior and spatial learning. Autism Res. 7:264-272.
    • (2014) Autism Res , vol.7 , pp. 264-272
    • Jaramillo, T.C.1    Liu, S.2    Pettersen, A.3    Birnbaum, S.G.4    Powell, C.M.5
  • 41
    • 84876070991 scopus 로고    scopus 로고
    • Modeling autism by Shank gene mutations in mice
    • Jiang, Y.H. and Ehlers, M.D. 2013. Modeling autism by Shank gene mutations in mice. Neuron 78:8-27.
    • (2013) Neuron , vol.78 , pp. 8-27
    • Jiang, Y.H.1    Ehlers, M.D.2
  • 42
    • 84907910047 scopus 로고    scopus 로고
    • Genetic diagnosis of autism spectrum disorders: The opportunity and challenge in the genomics era
    • [Epub ahead of print]
    • Jiang, Y.H., Wang, Y., Xiu, X., Choy, K.W., Pursley, A.N., and Cheung, S.W. 2014. Genetic diagnosis of autism spectrum disorders: The opportunity and challenge in the genomics era. Crit. Rev. Cl. Lab. Sci. doi:10.3109/10408363.2014.910747. [Epub ahead of print].
    • (2014) Crit. Rev. Cl. Lab. Sci
    • Jiang, Y.H.1    Wang, Y.2    Xiu, X.3    Choy, K.W.4    Pursley, A.N.5    Cheung, S.W.6
  • 47
    • 84864010114 scopus 로고    scopus 로고
    • Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits
    • Lacaria, M., Spencer, C., Gu, W., Paylor, R., and Lupski, J.R. 2012. Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits. Hum. Mol. Genet. 21:3083-3096.
    • (2012) Hum. Mol. Genet , vol.21 , pp. 3083-3096
    • Lacaria, M.1    Spencer, C.2    Gu, W.3    Paylor, R.4    Lupski, J.R.5
  • 49
    • 79959602137 scopus 로고    scopus 로고
    • Autism in Dravet syndrome: Prevalence, features, and relationship to the clinical characteristics of epilepsy and mental retardation
    • Li, B.M., Liu, X.R., Yi, Y.H., Deng, Y.H., Su, T., Zou, X., and Liao, W.P. 2011. Autism in Dravet syndrome: Prevalence, features, and relationship to the clinical characteristics of epilepsy and mental retardation. Epilepsy Behav. 21:291-295.
    • (2011) Epilepsy Behav , vol.21 , pp. 291-295
    • Li, B.M.1    Liu, X.R.2    Yi, Y.H.3    Deng, Y.H.4    Su, T.5    Zou, X.6    Liao, W.P.7
  • 51
    • 79955030459 scopus 로고    scopus 로고
    • Autism spectrum disorders-a genetics review
    • Miles, J.H. 2011. Autism spectrum disorders-a genetics review. Genet. Med. 13:278-294.
    • (2011) Genet. Med , vol.13 , pp. 278-294
    • Miles, J.H.1
  • 52
    • 82355172328 scopus 로고    scopus 로고
    • 16p11.2 microdeletion
    • (R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, and K. Stephens, eds.). National Center for Biotechnology Information. Bethesda, Md
    • Miller, D.T., Nasir, R., Sobeih, M.M., Shen, Y., Wu, B.L., and Hanson, E. 2011. 16p11.2 microdeletion. In GeneReviews (R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, and K. Stephens, eds.). http://www.ncbi.nlm.nih.gov/books/NBK11167. National Center for Biotechnology Information. Bethesda, Md.
    • (2011) GeneReviews
    • Miller, D.T.1    Nasir, R.2    Sobeih, M.M.3    Shen, Y.4    Wu, B.L.5    Hanson, E.6
  • 55
    • 33646683567 scopus 로고    scopus 로고
    • MeCP2 dysfunction in Rett syndrome and related disorders
    • Moretti, P. and Zoghbi, H.Y. 2006. MeCP2 dysfunction in Rett syndrome and related disorders. Curr. Opin. Genet. Dev. 16:276-281.
    • (2006) Curr. Opin. Genet. Dev , vol.16 , pp. 276-281
    • Moretti, P.1    Zoghbi, H.Y.2
  • 56
    • 37249006214 scopus 로고    scopus 로고
    • Advances in behavioral genetics: Mouse models of autism
    • Moy, S.S. and Nadler, J.J. 2008. Advances in behavioral genetics: Mouse models of autism. Mol. Psychiatry 13:4-26.
    • (2008) Mol. Psychiatry , vol.13 , pp. 4-26
    • Moy, S.S.1    Nadler, J.J.2
  • 59
    • 84875776798 scopus 로고    scopus 로고
    • The relationship of Rett syndrome and MECP2 disorders to autism
    • Neul, J.L. 2012. The relationship of Rett syndrome and MECP2 disorders to autism. Dialog. Clin. Neurosci. 14:253-262.
    • (2012) Dialog. Clin. Neurosci , vol.14 , pp. 253-262
    • Neul, J.L.1
  • 66
    • 84872679699 scopus 로고    scopus 로고
    • Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex
    • Reith, R.M., McKenna, J., Wu, H., Hashmi, S.S., Cho, S.H., Dash, P.K., and Gambello, M.J. 2013. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiol. Dis. 51:93-103.
    • (2013) Neurobiol. Dis , vol.51 , pp. 93-103
    • Reith, R.M.1    McKenna, J.2    Wu, H.3    Hashmi, S.S.4    Cho, S.H.5    Dash, P.K.6    Gambello, M.J.7
  • 69
    • 84871765155 scopus 로고    scopus 로고
    • Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
    • Sato, A., Kasai, S., Kobayashi, T., Takamatsu, Y., Hino, O., Ikeda, K., and Mizuguchi, M. 2012. Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex. Nat. Comm. 3:1292.
    • (2012) Nat. Comm , vol.3 , pp. 1292
    • Sato, A.1    Kasai, S.2    Kobayashi, T.3    Takamatsu, Y.4    Hino, O.5    Ikeda, K.6    Mizuguchi, M.7
  • 71
    • 84890256389 scopus 로고    scopus 로고
    • Channelopathy pathogenesis in autism spectrum disorders
    • Schmunk, G. and Gargus, J.J. 2013. Channelopathy pathogenesis in autism spectrum disorders. Frontiers Genet. 4:222.
    • (2013) Frontiers Genet , vol.4 , pp. 222
    • Schmunk, G.1    Gargus, J.J.2
  • 73
    • 76749128438 scopus 로고    scopus 로고
    • Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP
    • Silverman, J.L., Tolu, S.S., Barkan, C.L., and Crawley, J.N. 2010a. Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 35:976-989.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 976-989
    • Silverman, J.L.1    Tolu, S.S.2    Barkan, C.L.3    Crawley, J.N.4
  • 74
    • 77953800799 scopus 로고    scopus 로고
    • Behavioural phenotyping assays for mouse models of autism
    • Silverman, J.L., Yang, M., Lord, C., and Crawley, J.N. 2010b. Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 11:490-502.
    • (2010) Nat. Rev. Neurosci , vol.11 , pp. 490-502
    • Silverman, J.L.1    Yang, M.2    Lord, C.3    Crawley, J.N.4
  • 76
    • 80053626726 scopus 로고    scopus 로고
    • Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice
    • Smith, S.E., Zhou, Y.D., Zhang, G., Jin, Z., Stoppel, D.C., and Anderson, M.P. 2011. Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Sci. Transl. Med. 3:103ra197.
    • (2011) Sci. Transl. Med , vol.3
    • Smith, S.E.1    Zhou, Y.D.2    Zhang, G.3    Jin, Z.4    Stoppel, D.C.5    Anderson, M.P.6
  • 78
    • 84868688840 scopus 로고    scopus 로고
    • Timothy Syndrome
    • (R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, and K. Stephens, eds.). National Center for Biotechnology Information. Bethesda, Md
    • Splawski, I., Timothy, K.W., Priori, S.G., Napolitano, C., and Bloise, R. 2011. Timothy Syndrome. In GeneReviews (R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, and K. Stephens, eds.). http://www.ncbi.nlm.nih.gov/books/NBK1403. National Center for Biotechnology Information. Bethesda, Md.
    • (2011) GeneReviews
    • Splawski, I.1    Timothy, K.W.2    Priori, S.G.3    Napolitano, C.4    Bloise, R.5
  • 80
    • 54049091941 scopus 로고    scopus 로고
    • Neuroligins and neurexins link synaptic function to cognitive disease
    • Sudhof, T.C. 2008. Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455:903-911.
    • (2008) Nature , vol.455 , pp. 903-911
    • Sudhof, T.C.1
  • 81
    • 35148858044 scopus 로고    scopus 로고
    • A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    • Tabuchi, K., Blundell, J., Etherton, M.R., Hammer, R.E., Liu, X., Powell, C.M., and Sudhof, T.C. 2007. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318:71-76.
    • (2007) Science , vol.318 , pp. 71-76
    • Tabuchi, K.1    Blundell, J.2    Etherton, M.R.3    Hammer, R.E.4    Liu, X.5    Powell, C.M.6    Sudhof, T.C.7
  • 82
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: A model to study fragile X mental retardation
    • The Dutch-Belgian Fragile X Consortium. 1994. Fmr1 knockout mice: A model to study fragile X mental retardation. Cell 78:23-33.
    • (1994) Cell , vol.78 , pp. 23-33
  • 84
    • 0037965627 scopus 로고    scopus 로고
    • Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: Phenotypic consequences of gene dosage imbalance
    • Walz, K., Caratini-Rivera, S., Bi, W., Fonseca, P., Mansouri, D.L., Lynch, J., Vogel, H., Noebels, J.L., Bradley, A., and Lupski, J.R. 2003. Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: Phenotypic consequences of gene dosage imbalance. Mol. Cell. Biol. 23:3646-3655.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 3646-3655
    • Walz, K.1    Caratini-Rivera, S.2    Bi, W.3    Fonseca, P.4    Mansouri, D.L.5    Lynch, J.6    Vogel, H.7    Noebels, J.L.8    Bradley, A.9    Lupski, J.R.10
  • 85
    • 33749049474 scopus 로고    scopus 로고
    • Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)
    • Walz, K., Paylor, R., Yan, J., Bi, W., and Lupski, J.R. 2006. Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2). J. Clin. Invest. 116:3035-3041.
    • (2006) J. Clin. Invest , vol.116 , pp. 3035-3041
    • Walz, K.1    Paylor, R.2    Yan, J.3    Bi, W.4    Lupski, J.R.5
  • 88
    • 79958260360 scopus 로고    scopus 로고
    • Communication impairments in mice lacking Shank1: Reduced levels of ultrasonic vocalizations and scent marking behavior
    • Wohr, M., Roullet, F.I., Hung, A.Y., Sheng, M., and Crawley, J.N. 2011. Communication impairments in mice lacking Shank1: Reduced levels of ultrasonic vocalizations and scent marking behavior. PloS One 6:e20631.
    • (2011) PloS One , vol.6
    • Wohr, M.1    Roullet, F.I.2    Hung, A.Y.3    Sheng, M.4    Crawley, J.N.5
  • 89
    • 84880329347 scopus 로고    scopus 로고
    • Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2
    • Wohr, M., Silverman, J.L., Scattoni, M.L., Turner, S.M., Harris, M.J., Saxena, R., and Crawley, J.N. 2013. Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2. Behav. Brain Res. 251:50-64.
    • (2013) Behav. Brain Res , vol.251 , pp. 50-64
    • Wohr, M.1    Silverman, J.L.2    Scattoni, M.L.3    Turner, S.M.4    Harris, M.J.5    Saxena, R.6    Crawley, J.N.7
  • 93
    • 77954648172 scopus 로고    scopus 로고
    • Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism
    • Young, D.M., Schenk, A.K., Yang, S.B., Jan, Y.N., and Jan, L.Y. 2010. Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc. Natl. Acad. Sci. U.S.A. 107:11074-11079.
    • (2010) Proc. Natl. Acad. Sci. U.S.A , vol.107 , pp. 11074-11079
    • Young, D.M.1    Schenk, A.K.2    Yang, S.B.3    Jan, Y.N.4    Jan, L.Y.5
  • 94
    • 79955797580 scopus 로고    scopus 로고
    • A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort
    • Yu, J., He, X., Yao, D., Li, Z., Li, H., and Zhao, Z. 2011. A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort. Behav. Brain Funct. 7:13.
    • (2011) Behav. Brain Funct , vol.7 , pp. 13
    • Yu, J.1    He, X.2    Yao, D.3    Li, Z.4    Li, H.5    Zhao, Z.6
  • 95
    • 60849109211 scopus 로고    scopus 로고
    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • Zhou, J., Blundell, J., Ogawa, S., Kwon, C.H., Zhang, W., Sinton, C., Powell, C.M., and Parada, L.F. 2009. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J. Neurosci. 29:1773-1783.
    • (2009) J. Neurosci , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3    Kwon, C.H.4    Zhang, W.5    Sinton, C.6    Powell, C.M.7    Parada, L.F.8
  • 96
    • 84862659562 scopus 로고    scopus 로고
    • Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities
    • Zoghbi, H.Y. and Bear, M.F. 2012. Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb. Perspect. Biol. 4:pii:a009886.
    • (2012) Cold Spring Harb. Perspect. Biol , vol.4
    • Zoghbi, H.Y.1    Bear, M.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.