Cholesterol-mediated degradation of 7-dehydrocholesterol reductase switches the balance from cholesterol to Vitamin D synthesis

Journal of Biological Chemistry

Volumn 291, Issue 16, 2016, Pages 8363-8376

  Prabhu, Anika V ^a   Luu, Winnie ^a   Sharpe, Laura J ^a   Brown, Andrew J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYME ACTIVITY; ENZYMES; SUBSTRATES; VITAMINS;

CHOLESTEROL LEVELS; CHOLESTEROL SYNTHESIS; DEVELOPMENTAL DISORDERS; END-PRODUCT INHIBITIONS; ENZYMATIC ACTIVITIES; PROTEASOMAL DEGRADATION; PROTEIN LEVEL; VITAMIN D SYNTHESIS;

CHOLESTEROL;

7 DEHYDROCHOLESTEROL REDUCTASE; CHOLESTEROL; OXIDOREDUCTASE; UNCLASSIFIED DRUG; 7 DEHYDROCHOLESTEROL; 7-DEHYDROCHOLESTEROL; 7-DEHYDROCHOLESTEROL REDUCTASE; PROTEASOME; VITAMIN D;

ARTICLE; BIOACCUMULATION; BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEGRADATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VITAMIN D METABOLISM; ANIMAL; BIOSYNTHESIS; CHO CELL LINE; CRICETULUS; ENZYMOLOGY; GENETICS; HAMSTER; HUMAN; METABOLISM; PATHOLOGY; PROTEIN DEGRADATION; SMITH LEMLI OPITZ SYNDROME;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DEHYDROCHOLESTEROLS; HUMANS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SMITH-LEMLI-OPITZ SYNDROME; VITAMIN D;

EID: 84965182300     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.699546     Document Type: Article

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